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The map label for this gene is gcp

Identifier: 78357111

GI number: 78357111

Start: 2111181

End: 2112284

Strand: Reverse

Name: gcp

Synonym: Dde_2068

Alternate gene names: 78357111

Gene position: 2112284-2111181 (Counterclockwise)

Preceding gene: 78357112

Following gene: 78357110

Centisome position: 56.63

GC content: 57.07

Gene sequence:

>1104_bases
ATGCGTTGTTTAGGTATTGAATCAAGCTGTGACGAGACTGCTCTGGCCATAGTGGATGACGGCCGTCTGGTCGATGCTGT
GATGTCCACACAGGCGGAGCTGCATGCGCTTTTTGGCGGGGTTGTGCCTGAACTGGCCTCGCGCGAGCATTACCGGCTGA
TTGGGCGCATGTTTGATTCGCTTATGCTCCGGTGCGGACTTGGCGTTCAGGATATTGATGTGATTTCTGTAGCCCGTGGG
CCGGGTTTGCTGGGCAGCCTCCTCGTGGGGGTGGGGTTTGCCAAGGGGCTGGCATTGGCCGGAGGCCAGCGGCTGGTAGG
TGTCAATCATCTGCATGCTCACCTGCTGGCTGCGGGGCTGGAGCACCGCCTTGTTTTTCCTGCTCTGGGAGTTCTTGTTT
CCGGCGGGCATACCCATCTTTACCGGATTGATTCGCCTCGTAATTTCACGCTGGTGGGGCGCACTCTGGATGATGCCGCC
GGTGAGGCCTTTGATAAAGTGGCAAAAATGCTCAATCTGCCGTATCCCGGCGGACGTTTTATTGATGTATTGGGGCATAT
GGCTGACCCTGATGACAGCATGTTCCCGCGGCCCTACACCGATAATGACAATCTCGATTTCAGCTTCAGCGGCTTGAAGA
CAGCAGTTTCCACGTGGTTGAAAGCTCACGGTGGCACAGCGCTTGCCGCTCCGCCGGCGGAATCCGAGCTGCAGGCCATG
CTGCAGAACAATGTGCTGCCGTCGGGTATGCCTGCAGATATGCCGCTTGTGTGCGCATCATTTAATGCGGCTGTGGCTGA
TACGTTGTACATTAAAGCCCGCAGGGCGTTGCAGCGTCTGGGAGGGCGTGGGCAAATCCGGTCTGTGGTGGTCGCGGGCG
GGGTGGCTGCAAACAGCCGTGTGCGTACTTCAATGCAACGTCTTGCCGCCGAAGAAGGCCTGCACTTGCATTTGCCGTCC
CCTGCATTATGTACTGACAACGGGGCCATGATTGCCTACACGGGCTGGTTGCTGGCATCCGAAGGGCTTCATCATTCGCT
CGAACTGGAAACTATGCCGAGAGGGCGTGTTATTCCGGATGATTACATTTATGATGCCCACTGA

Upstream 100 bases:

>100_bases
AATTTACCGGCGTCACTCCTGAGGTGCCGGAGCAAGGTGATTCAATGGCCGGCTGTCCTGCTTCCGGGGCTGCCGGCTTC
ATTTCTGTGCGGTGGGGCGT

Downstream 100 bases:

>100_bases
TTCAAATGCGTCCCCAGGCAGCGTTCCCTTGACAGGTTCCGGTTGCCCTAATATCTCTTGTTGAATTGGCTTGTGACTCC
TGACGGGAGTTGCATTTTAG

Product: O-sialoglycoprotein endopeptidase

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MRCLGIESSCDETALAIVDDGRLVDAVMSTQAELHALFGGVVPELASREHYRLIGRMFDSLMLRCGLGVQDIDVISVARG
PGLLGSLLVGVGFAKGLALAGGQRLVGVNHLHAHLLAAGLEHRLVFPALGVLVSGGHTHLYRIDSPRNFTLVGRTLDDAA
GEAFDKVAKMLNLPYPGGRFIDVLGHMADPDDSMFPRPYTDNDNLDFSFSGLKTAVSTWLKAHGGTALAAPPAESELQAM
LQNNVLPSGMPADMPLVCASFNAAVADTLYIKARRALQRLGGRGQIRSVVVAGGVAANSRVRTSMQRLAAEEGLHLHLPS
PALCTDNGAMIAYTGWLLASEGLHHSLELETMPRGRVIPDDYIYDAH

Sequences:

>Translated_367_residues
MRCLGIESSCDETALAIVDDGRLVDAVMSTQAELHALFGGVVPELASREHYRLIGRMFDSLMLRCGLGVQDIDVISVARG
PGLLGSLLVGVGFAKGLALAGGQRLVGVNHLHAHLLAAGLEHRLVFPALGVLVSGGHTHLYRIDSPRNFTLVGRTLDDAA
GEAFDKVAKMLNLPYPGGRFIDVLGHMADPDDSMFPRPYTDNDNLDFSFSGLKTAVSTWLKAHGGTALAAPPAESELQAM
LQNNVLPSGMPADMPLVCASFNAAVADTLYIKARRALQRLGGRGQIRSVVVAGGVAANSRVRTSMQRLAAEEGLHLHLPS
PALCTDNGAMIAYTGWLLASEGLHHSLELETMPRGRVIPDDYIYDAH
>Mature_367_residues
MRCLGIESSCDETALAIVDDGRLVDAVMSTQAELHALFGGVVPELASREHYRLIGRMFDSLMLRCGLGVQDIDVISVARG
PGLLGSLLVGVGFAKGLALAGGQRLVGVNHLHAHLLAAGLEHRLVFPALGVLVSGGHTHLYRIDSPRNFTLVGRTLDDAA
GEAFDKVAKMLNLPYPGGRFIDVLGHMADPDDSMFPRPYTDNDNLDFSFSGLKTAVSTWLKAHGGTALAAPPAESELQAM
LQNNVLPSGMPADMPLVCASFNAAVADTLYIKARRALQRLGGRGQIRSVVVAGGVAANSRVRTSMQRLAAEEGLHLHLPS
PALCTDNGAMIAYTGWLLASEGLHHSLELETMPRGRVIPDDYIYDAH

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=359, Percent_Identity=32.033426183844, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI8923380, Length=342, Percent_Identity=27.7777777777778, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1789445, Length=356, Percent_Identity=39.6067415730337, Blast_Score=236, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17557464, Length=348, Percent_Identity=28.448275862069, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71995670, Length=364, Percent_Identity=26.6483516483516, Blast_Score=95, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320099, Length=361, Percent_Identity=28.2548476454294, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322891, Length=304, Percent_Identity=25.3289473684211, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI20129063, Length=350, Percent_Identity=34.8571428571429, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21357207, Length=352, Percent_Identity=27.5568181818182, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_DESDG (Q30ZN1)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388560.1
- ProteinModelPortal:   Q30ZN1
- SMR:   Q30ZN1
- STRING:   Q30ZN1
- MEROPS:   M22.001
- GeneID:   3757076
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2068
- NMPDR:   fig|207559.3.peg.2283
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   RNCNFSF
- ProtClustDB:   PRK09604
- BioCyc:   DDES207559:DDE_2068-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 39113; Mature: 39113

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCLGIESSCDETALAIVDDGRLVDAVMSTQAELHALFGGVVPELASREHYRLIGRMFDS
CEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
LMLRCGLGVQDIDVISVARGPGLLGSLLVGVGFAKGLALAGGQRLVGVNHLHAHLLAAGL
HHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHH
EHRLVFPALGVLVSGGHTHLYRIDSPRNFTLVGRTLDDAAGEAFDKVAKMLNLPYPGGRF
HHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHH
IDVLGHMADPDDSMFPRPYTDNDNLDFSFSGLKTAVSTWLKAHGGTALAAPPAESELQAM
HHHHCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHH
LQNNVLPSGMPADMPLVCASFNAAVADTLYIKARRALQRLGGRGQIRSVVVAGGVAANSR
HHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHH
VRTSMQRLAAEEGLHLHLPSPALCTDNGAMIAYTGWLLASEGLHHSLELETMPRGRVIPD
HHHHHHHHHHHCCCEEECCCCCEECCCCCEEEEEHHHHHCCCCCCEEEEEECCCCCCCCC
DYIYDAH
CCCCCCC
>Mature Secondary Structure
MRCLGIESSCDETALAIVDDGRLVDAVMSTQAELHALFGGVVPELASREHYRLIGRMFDS
CEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
LMLRCGLGVQDIDVISVARGPGLLGSLLVGVGFAKGLALAGGQRLVGVNHLHAHLLAAGL
HHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHH
EHRLVFPALGVLVSGGHTHLYRIDSPRNFTLVGRTLDDAAGEAFDKVAKMLNLPYPGGRF
HHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHH
IDVLGHMADPDDSMFPRPYTDNDNLDFSFSGLKTAVSTWLKAHGGTALAAPPAESELQAM
HHHHCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHH
LQNNVLPSGMPADMPLVCASFNAAVADTLYIKARRALQRLGGRGQIRSVVVAGGVAANSR
HHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHH
VRTSMQRLAAEEGLHLHLPSPALCTDNGAMIAYTGWLLASEGLHHSLELETMPRGRVIPD
HHHHHHHHHHHCCCEEECCCCCEECCCCCEEEEEHHHHHCCCCCCEEEEEECCCCCCCCC
DYIYDAH
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA