Click here to switch to the map view.

The map label for this gene is fbp

Identifier: 78357112

GI number: 78357112

Start: 2112363

End: 2113379

Strand: Reverse

Name: fbp

Synonym: Dde_2069

Alternate gene names: 78357112

Gene position: 2113379-2112363 (Counterclockwise)

Preceding gene: 78357113

Following gene: 78357111

Centisome position: 56.66

GC content: 54.77

Gene sequence:

>1017_bases
ATGCGACAGGTTACCGTGACTGAACATCTGCTGCTGCACCAGACTAAATCGCCTGCTGCAACGGGGCAGTTTACAGCACT
GCTGTACGATCTGATTCTGGCTGCCAAAATTATATCCAAGAGTGTGAATAAAGCCGGTCTGCTCGACGTGCTTGGCGGCA
CCGGACAGGTAAACGTGCAGGGTGAACACGTCCAGAAGCTTGATGAATATGCTAACAGAGTGCTCATTCACAGGATGGAA
CGCACCGGTGTGCTGTGCGCCATGGCTTCTGAAGAAAATGCAGATCTCATCAGAGTGCCCGAACGGTTTGAGGCCGGAGA
TTACATTCTGATTTTTGATCCCCTTGACGGTTCTTCCAATATTGATGTCAACATCAACGTGGGGACGATTTTTTCCATCC
TCAAGCGCAAGCCGGGAGCGTCGGGAAGTAAAGACGTGACCTTGGGCGATGTATTGCAGAGCGGGGTGGAGCAGGTTGCC
GCAGGGTATTTCCTGTACGGCCCGTCTACCATGCTGGTGTATTCTTCGGGGCAGGGCGTGCACGGATTTACGCTGGACCC
CAGTGTTGGCGAGTTCCTGCTGTCCCATCCCGATATTCGCTACCCCGAGCAGGGCAGAATTTATTCGGTGAACGAATCGT
ACTGGCACTACTGGGATGAACCCACCCGCGAGGTGGTCAGTTATTTCAAAGGGCCGGACAATCCTCTGGGCAAGCCGTAT
TCGCTGCGCTATGTCGGCTCGCTGGTGGCCGATTTTCACCGCAACCTGTTTTATGGCGGTATCTTTATGTACCCCATGGA
CTACCGGCTTCCCGAAAAGCCTCAGGGCAAGCTGCGTCTGATGTGCGAAGCTTCGCCGCTGGCTTTTCTGGCTGAGCAGG
CAGGAGGTCGTGCCACAGACGGGACAAAGCGCATTCTCGATATCGTACCCGGGGAACTGCATCAGCGGGTGCCGCTCTTT
ATCGGGTCGGCGGGTGATGTTGATGCAGTGGAAGCAATTTACCGGCGTCACTCCTGA

Upstream 100 bases:

>100_bases
GCCGGAACCGGCTTTGATTACAATATAGAGATTCTTGATGCCGGTGTTGTCAGCCGACGCAAGCAATGTCCCTAATACGG
TGAACTGATAAGGAGACATA

Downstream 100 bases:

>100_bases
GGTGCCGGAGCAAGGTGATTCAATGGCCGGCTGTCCTGCTTCCGGGGCTGCCGGCTTCATTTCTGTGCGGTGGGGCGTAT
GCGTTGTTTAGGTATTGAAT

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MRQVTVTEHLLLHQTKSPAATGQFTALLYDLILAAKIISKSVNKAGLLDVLGGTGQVNVQGEHVQKLDEYANRVLIHRME
RTGVLCAMASEENADLIRVPERFEAGDYILIFDPLDGSSNIDVNINVGTIFSILKRKPGASGSKDVTLGDVLQSGVEQVA
AGYFLYGPSTMLVYSSGQGVHGFTLDPSVGEFLLSHPDIRYPEQGRIYSVNESYWHYWDEPTREVVSYFKGPDNPLGKPY
SLRYVGSLVADFHRNLFYGGIFMYPMDYRLPEKPQGKLRLMCEASPLAFLAEQAGGRATDGTKRILDIVPGELHQRVPLF
IGSAGDVDAVEAIYRRHS

Sequences:

>Translated_338_residues
MRQVTVTEHLLLHQTKSPAATGQFTALLYDLILAAKIISKSVNKAGLLDVLGGTGQVNVQGEHVQKLDEYANRVLIHRME
RTGVLCAMASEENADLIRVPERFEAGDYILIFDPLDGSSNIDVNINVGTIFSILKRKPGASGSKDVTLGDVLQSGVEQVA
AGYFLYGPSTMLVYSSGQGVHGFTLDPSVGEFLLSHPDIRYPEQGRIYSVNESYWHYWDEPTREVVSYFKGPDNPLGKPY
SLRYVGSLVADFHRNLFYGGIFMYPMDYRLPEKPQGKLRLMCEASPLAFLAEQAGGRATDGTKRILDIVPGELHQRVPLF
IGSAGDVDAVEAIYRRHS
>Mature_338_residues
MRQVTVTEHLLLHQTKSPAATGQFTALLYDLILAAKIISKSVNKAGLLDVLGGTGQVNVQGEHVQKLDEYANRVLIHRME
RTGVLCAMASEENADLIRVPERFEAGDYILIFDPLDGSSNIDVNINVGTIFSILKRKPGASGSKDVTLGDVLQSGVEQVA
AGYFLYGPSTMLVYSSGQGVHGFTLDPSVGEFLLSHPDIRYPEQGRIYSVNESYWHYWDEPTREVVSYFKGPDNPLGKPY
SLRYVGSLVADFHRNLFYGGIFMYPMDYRLPEKPQGKLRLMCEASPLAFLAEQAGGRATDGTKRILDIVPGELHQRVPLF
IGSAGDVDAVEAIYRRHS

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI22907028, Length=324, Percent_Identity=45.0617283950617, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI189083692, Length=337, Percent_Identity=42.7299703264095, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI16579888, Length=337, Percent_Identity=42.7299703264095, Blast_Score=256, Evalue=2e-68,
Organism=Escherichia coli, GI1790679, Length=332, Percent_Identity=49.0963855421687, Blast_Score=308, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI17508131, Length=325, Percent_Identity=47.3846153846154, Blast_Score=300, Evalue=6e-82,
Organism=Saccharomyces cerevisiae, GI6323409, Length=328, Percent_Identity=44.8170731707317, Blast_Score=279, Evalue=4e-76,
Organism=Drosophila melanogaster, GI45550998, Length=325, Percent_Identity=46.7692307692308, Blast_Score=275, Evalue=3e-74,
Organism=Drosophila melanogaster, GI19921562, Length=325, Percent_Identity=46.7692307692308, Blast_Score=274, Evalue=6e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16PA_DESDG (Q30ZN0)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388561.1
- HSSP:   P0A993
- ProteinModelPortal:   Q30ZN0
- SMR:   Q30ZN0
- STRING:   Q30ZN0
- GeneID:   3757077
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2069
- NMPDR:   fig|207559.3.peg.2284
- eggNOG:   COG0158
- HOGENOM:   HBG731261
- OMA:   HWEAPVQ
- ProtClustDB:   PRK09293
- BioCyc:   DDES207559:DDE_2069-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- PANTHER:   PTHR11556
- PRINTS:   PR00115

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 37340; Mature: 37340

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00124 FBPASE

Important sites: BINDING 211-211 BINDING 244-244 BINDING 277-277

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQVTVTEHLLLHQTKSPAATGQFTALLYDLILAAKIISKSVNKAGLLDVLGGTGQVNVQ
CCCEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCEEEEC
GEHVQKLDEYANRVLIHRMERTGVLCAMASEENADLIRVPERFEAGDYILIFDPLDGSSN
HHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEECCHHCCCCCEEEEEECCCCCCC
IDVNINVGTIFSILKRKPGASGSKDVTLGDVLQSGVEQVAAGYFLYGPSTMLVYSSGQGV
EEEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCEEEEEECCCCC
HGFTLDPSVGEFLLSHPDIRYPEQGRIYSVNESYWHYWDEPTREVVSYFKGPDNPLGKPY
EEEEECCCHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCE
SLRYVGSLVADFHRNLFYGGIFMYPMDYRLPEKPQGKLRLMCEASPLAFLAEQAGGRATD
EHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHCCCCCCC
GTKRILDIVPGELHQRVPLFIGSAGDVDAVEAIYRRHS
CHHHHHHHCCCHHHCCCCEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure
MRQVTVTEHLLLHQTKSPAATGQFTALLYDLILAAKIISKSVNKAGLLDVLGGTGQVNVQ
CCCEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCEEEEC
GEHVQKLDEYANRVLIHRMERTGVLCAMASEENADLIRVPERFEAGDYILIFDPLDGSSN
HHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEECCHHCCCCCEEEEEECCCCCCC
IDVNINVGTIFSILKRKPGASGSKDVTLGDVLQSGVEQVAAGYFLYGPSTMLVYSSGQGV
EEEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCEEEEEECCCCC
HGFTLDPSVGEFLLSHPDIRYPEQGRIYSVNESYWHYWDEPTREVVSYFKGPDNPLGKPY
EEEEECCCHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCE
SLRYVGSLVADFHRNLFYGGIFMYPMDYRLPEKPQGKLRLMCEASPLAFLAEQAGGRATD
EHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHCCCCCCC
GTKRILDIVPGELHQRVPLFIGSAGDVDAVEAIYRRHS
CHHHHHHHCCCHHHCCCCEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA