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The map label for this gene is trxA [H]

Identifier: 78357110

GI number: 78357110

Start: 2110706

End: 2111029

Strand: Reverse

Name: trxA [H]

Synonym: Dde_2067

Alternate gene names: 78357110

Gene position: 2111029-2110706 (Counterclockwise)

Preceding gene: 78357111

Following gene: 304570587

Centisome position: 56.59

GC content: 54.01

Gene sequence:

>324_bases
ATGGCTGTGCAGGTTACCGATAGCAATTTTGAAGCTGAAGTGATCAAGTCTGAACTCCCCACCCTGATTGATTTCTGGGC
ACCCTGGTGCGGCCCGTGCCGTGCTATGGGACCGGTCATCGACGAACTGGCAGCCGAATTCGCCGGAAAGGTGAACATCG
TCAAGATGAATGTTGACGAAAATCCCGCAACCCCCAGCAAGTACGGCATCCGCGCCATCCCCACCCTTATTCTTTTCAAG
GGCGGAGAAGTTGTTGAGCAGATCACCGGCGCAGTGTCCAAGAGCAGCATAAAGGACATGATCACCCAGAAGGCTCTTGG
GTAA

Upstream 100 bases:

>100_bases
TATCTCTTGTTGAATTGGCTTGTGACTCCTGACGGGAGTTGCATTTTAGCTATGAAGCGGCAGAAGCAGTCCGCTAAACG
TTAATGAAAAGGAGCTTCCC

Downstream 100 bases:

>100_bases
TGAAGCTCTACGATTCCATTGTTATCGGAGGGGGGCCGGCAGGCATGACGGCCGCCCTTTATCTTCTTCGTTCCGGTGTT
TCCGTTGCATGGTGCGAAAA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MAVQVTDSNFEAEVIKSELPTLIDFWAPWCGPCRAMGPVIDELAAEFAGKVNIVKMNVDENPATPSKYGIRAIPTLILFK
GGEVVEQITGAVSKSSIKDMITQKALG

Sequences:

>Translated_107_residues
MAVQVTDSNFEAEVIKSELPTLIDFWAPWCGPCRAMGPVIDELAAEFAGKVNIVKMNVDENPATPSKYGIRAIPTLILFK
GGEVVEQITGAVSKSSIKDMITQKALG
>Mature_106_residues
AVQVTDSNFEAEVIKSELPTLIDFWAPWCGPCRAMGPVIDELAAEFAGKVNIVKMNVDENPATPSKYGIRAIPTLILFKG
GEVVEQITGAVSKSSIKDMITQKALG

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=82, Percent_Identity=36.5853658536585, Blast_Score=78, Evalue=1e-15,
Organism=Homo sapiens, GI5031973, Length=99, Percent_Identity=32.3232323232323, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI42794771, Length=104, Percent_Identity=34.6153846153846, Blast_Score=67, Evalue=3e-12,
Organism=Homo sapiens, GI224493972, Length=104, Percent_Identity=34.6153846153846, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI21361657, Length=105, Percent_Identity=31.4285714285714, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI87082331, Length=99, Percent_Identity=48.4848484848485, Blast_Score=122, Evalue=4e-30,
Organism=Escherichia coli, GI1788936, Length=91, Percent_Identity=43.956043956044, Blast_Score=100, Evalue=2e-23,
Organism=Escherichia coli, GI87081747, Length=101, Percent_Identity=27.7227722772277, Blast_Score=64, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=38.7096774193548, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115532378, Length=74, Percent_Identity=40.5405405405405, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115532380, Length=74, Percent_Identity=40.5405405405405, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17544108, Length=74, Percent_Identity=40.5405405405405, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71980562, Length=105, Percent_Identity=36.1904761904762, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71980565, Length=100, Percent_Identity=37, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=100, Percent_Identity=35, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=104, Percent_Identity=34.6153846153846, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=80, Percent_Identity=36.25, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=76, Percent_Identity=38.1578947368421, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=83, Percent_Identity=36.144578313253, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=82, Percent_Identity=36.5853658536585, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=90, Percent_Identity=34.4444444444444, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=100, Percent_Identity=34, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=84, Percent_Identity=32.1428571428571, Blast_Score=66, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=78, Percent_Identity=38.4615384615385, Blast_Score=63, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24639826, Length=79, Percent_Identity=41.7721518987342, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573567, Length=93, Percent_Identity=30.1075268817204, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17648013, Length=103, Percent_Identity=35.9223300970874, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583090, Length=103, Percent_Identity=35.9223300970874, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921434, Length=77, Percent_Identity=35.0649350649351, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664269, Length=70, Percent_Identity=34.2857142857143, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639068, Length=92, Percent_Identity=30.4347826086957, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11509; Mature: 11378

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVQVTDSNFEAEVIKSELPTLIDFWAPWCGPCRAMGPVIDELAAEFAGKVNIVKMNVDE
CEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCC
NPATPSKYGIRAIPTLILFKGGEVVEQITGAVSKSSIKDMITQKALG
CCCCCCCCCHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVQVTDSNFEAEVIKSELPTLIDFWAPWCGPCRAMGPVIDELAAEFAGKVNIVKMNVDE
EEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCC
NPATPSKYGIRAIPTLILFKGGEVVEQITGAVSKSSIKDMITQKALG
CCCCCCCCCHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]