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The map label for this gene is gcvPA

Identifier: 78356735

GI number: 78356735

Start: 1744763

End: 1746094

Strand: Reverse

Name: gcvPA

Synonym: Dde_1692

Alternate gene names: 78356735

Gene position: 1746094-1744763 (Counterclockwise)

Preceding gene: 78356736

Following gene: 78356734

Centisome position: 46.81

GC content: 56.76

Gene sequence:

>1332_bases
ATGCCCTACACTCCGCACACTCCCGAAGAAATCCGCCAGATGCTGGATGTCATCGGGGTGAAAAGCATTGATGACCTGTT
TGCTGAAATACCGCCCGAAATGCAGCCGCGCAGCTTTGATATTCCGGAAGGAATGAGCGAGATGGAAGTCTGCGCCCGCA
TCCAGCGTATGGCCGCAAAAAACCGTATAGATCTTGTCAGCTATCTGGGAGCTGGGTTCTACGATCATCACATTCCCAAA
GCTGTGGACAACCTTGTTTCGCGGGGTGAGTTTTATACGGCGTACACCCCCTACCAGCCCGAAGCATCACAGGGAACCCT
GCAGGCCATTTTTGAATACCAGACCGCCGTCTGCCGCCTGATGGAAATGGAAGTGGCTAACGCCTCGGTATATGACGGCG
GTTCGGCCATTTTCGAGGCCATGATGATGGCCGCCAGAGCAACCAGACGCAGCAAGCTTGTCATTGATGAAGCCCTGAGC
CCCATCTACCGCACCATGCTTGCCTCGTACACGTCCAACCTGAATATGGAACTGGTGACCGTTGCGCACAACGAAGGCCG
GTCGGACAAACAGGCGCTGATGGATGCCGTAGACGATAAATGCGCTGCTGTGGTGGTACAGAACCCCAACTTCTTCGGGG
CGGTGGATGATTTTACCGAACTGTTCACCCACGCCCGTTCCTGCAACGCTCTGGGAGTGATTTCCGTTTATCCGGTCATG
CAGTCTGTGCTCAAAACCCCCGGTGAGATGGGCGCGGATATCGCCGTTGCAGACGGACAGTCGCTGGGGATGCCCCTGAG
CTTCGGCGGCCCCTATCTGGGCATAATGACCTGCACCAAAAAACTGGCGCGGCAGATTCCGGGCAGAATAGCCGGACGAA
CAAAAGATGTGGACGGCAAAACCGGATATGTACTGACGCTGCAGGCACGTGAACAGCATATCCGCAGGGCCAAGGCCACT
TCGAACATATGCTCCAATCAGGCGCTGTGCGCGCTGAGGGCTATCATCCACATGTGCCTGACAGGCCCTGAGGGCCTGGT
CCGCACCGCAGAGCTGAGCATGGAGCGCGCTCATTATGCCGCAGACAGACTCACGGCTCTGCCGGGCGTTTCACTGCTGC
ACGATGCCCCGTTCTGCAACGAATTCGCTTTGCGGCTGCCGGTCAGCGCCTATGATGTTGTGGACCGGCTGGTAAACCAT
GGTGTCGTCCCCGGTTTCCCGCTGGGCGGATACTACGCCGGCATGGATGACGTGCTGCTTGTGGCATGCACTGAAAAGCA
TTCATTTGAACAGATCGGCATAATGGCTGAACTGGTGGGAGGCATGCTCTAA

Upstream 100 bases:

>100_bases
GAAGGTCAAAGTGTCTGCCGTGGCTGGCAGTCTGCTTTCCGCAGAAGAATACGCAGCCCTCATCGAAAGCGAAGCGCACT
AGGCCGCAAGGAGAACTTTC

Downstream 100 bases:

>100_bases
TGAAGACCGTATTTTCACAGTCTGTACCGGGCCGCATGGCCTGCGTTCCCCCCGAAGCAGAAGAGCACGCAGCCGACTTC
ATCCCGAAGAACCTGCTGCG

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MPYTPHTPEEIRQMLDVIGVKSIDDLFAEIPPEMQPRSFDIPEGMSEMEVCARIQRMAAKNRIDLVSYLGAGFYDHHIPK
AVDNLVSRGEFYTAYTPYQPEASQGTLQAIFEYQTAVCRLMEMEVANASVYDGGSAIFEAMMMAARATRRSKLVIDEALS
PIYRTMLASYTSNLNMELVTVAHNEGRSDKQALMDAVDDKCAAVVVQNPNFFGAVDDFTELFTHARSCNALGVISVYPVM
QSVLKTPGEMGADIAVADGQSLGMPLSFGGPYLGIMTCTKKLARQIPGRIAGRTKDVDGKTGYVLTLQAREQHIRRAKAT
SNICSNQALCALRAIIHMCLTGPEGLVRTAELSMERAHYAADRLTALPGVSLLHDAPFCNEFALRLPVSAYDVVDRLVNH
GVVPGFPLGGYYAGMDDVLLVACTEKHSFEQIGIMAELVGGML

Sequences:

>Translated_443_residues
MPYTPHTPEEIRQMLDVIGVKSIDDLFAEIPPEMQPRSFDIPEGMSEMEVCARIQRMAAKNRIDLVSYLGAGFYDHHIPK
AVDNLVSRGEFYTAYTPYQPEASQGTLQAIFEYQTAVCRLMEMEVANASVYDGGSAIFEAMMMAARATRRSKLVIDEALS
PIYRTMLASYTSNLNMELVTVAHNEGRSDKQALMDAVDDKCAAVVVQNPNFFGAVDDFTELFTHARSCNALGVISVYPVM
QSVLKTPGEMGADIAVADGQSLGMPLSFGGPYLGIMTCTKKLARQIPGRIAGRTKDVDGKTGYVLTLQAREQHIRRAKAT
SNICSNQALCALRAIIHMCLTGPEGLVRTAELSMERAHYAADRLTALPGVSLLHDAPFCNEFALRLPVSAYDVVDRLVNH
GVVPGFPLGGYYAGMDDVLLVACTEKHSFEQIGIMAELVGGML
>Mature_442_residues
PYTPHTPEEIRQMLDVIGVKSIDDLFAEIPPEMQPRSFDIPEGMSEMEVCARIQRMAAKNRIDLVSYLGAGFYDHHIPKA
VDNLVSRGEFYTAYTPYQPEASQGTLQAIFEYQTAVCRLMEMEVANASVYDGGSAIFEAMMMAARATRRSKLVIDEALSP
IYRTMLASYTSNLNMELVTVAHNEGRSDKQALMDAVDDKCAAVVVQNPNFFGAVDDFTELFTHARSCNALGVISVYPVMQ
SVLKTPGEMGADIAVADGQSLGMPLSFGGPYLGIMTCTKKLARQIPGRIAGRTKDVDGKTGYVLTLQAREQHIRRAKATS
NICSNQALCALRAIIHMCLTGPEGLVRTAELSMERAHYAADRLTALPGVSLLHDAPFCNEFALRLPVSAYDVVDRLVNHG
VVPGFPLGGYYAGMDDVLLVACTEKHSFEQIGIMAELVGGML

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=394, Percent_Identity=35.2791878172589, Blast_Score=216, Evalue=4e-56,
Organism=Escherichia coli, GI1789269, Length=386, Percent_Identity=31.0880829015544, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17535605, Length=349, Percent_Identity=37.8223495702006, Blast_Score=221, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6323843, Length=361, Percent_Identity=34.9030470914127, Blast_Score=213, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24645648, Length=336, Percent_Identity=38.0952380952381, Blast_Score=236, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_DESDG (Q311A7)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388184.1
- ProteinModelPortal:   Q311A7
- SMR:   Q311A7
- STRING:   Q311A7
- GeneID:   3756690
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1692
- NMPDR:   fig|207559.3.peg.1485
- eggNOG:   COG0403
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   DDES207559:DDE_1692-MONOMER
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 48396; Mature: 48265

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYTPHTPEEIRQMLDVIGVKSIDDLFAEIPPEMQPRSFDIPEGMSEMEVCARIQRMAAK
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
NRIDLVSYLGAGFYDHHIPKAVDNLVSRGEFYTAYTPYQPEASQGTLQAIFEYQTAVCRL
CHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
MEMEVANASVYDGGSAIFEAMMMAARATRRSKLVIDEALSPIYRTMLASYTSNLNMELVT
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VAHNEGRSDKQALMDAVDDKCAAVVVQNPNFFGAVDDFTELFTHARSCNALGVISVYPVM
EECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
QSVLKTPGEMGADIAVADGQSLGMPLSFGGPYLGIMTCTKKLARQIPGRIAGRTKDVDGK
HHHHCCCHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCCC
TGYVLTLQAREQHIRRAKATSNICSNQALCALRAIIHMCLTGPEGLVRTAELSMERAHYA
CCEEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ADRLTALPGVSLLHDAPFCNEFALRLPVSAYDVVDRLVNHGVVPGFPLGGYYAGMDDVLL
HHHHHHCCCCHHHHCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
VACTEKHSFEQIGIMAELVGGML
EEECCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PYTPHTPEEIRQMLDVIGVKSIDDLFAEIPPEMQPRSFDIPEGMSEMEVCARIQRMAAK
CCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
NRIDLVSYLGAGFYDHHIPKAVDNLVSRGEFYTAYTPYQPEASQGTLQAIFEYQTAVCRL
CHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
MEMEVANASVYDGGSAIFEAMMMAARATRRSKLVIDEALSPIYRTMLASYTSNLNMELVT
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VAHNEGRSDKQALMDAVDDKCAAVVVQNPNFFGAVDDFTELFTHARSCNALGVISVYPVM
EECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
QSVLKTPGEMGADIAVADGQSLGMPLSFGGPYLGIMTCTKKLARQIPGRIAGRTKDVDGK
HHHHCCCHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCCC
TGYVLTLQAREQHIRRAKATSNICSNQALCALRAIIHMCLTGPEGLVRTAELSMERAHYA
CCEEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ADRLTALPGVSLLHDAPFCNEFALRLPVSAYDVVDRLVNHGVVPGFPLGGYYAGMDDVLL
HHHHHHCCCCHHHHCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
VACTEKHSFEQIGIMAELVGGML
EEECCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA