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The map label for this gene is proC [H]

Identifier: 78356485

GI number: 78356485

Start: 1464695

End: 1465498

Strand: Direct

Name: proC [H]

Synonym: Dde_1440

Alternate gene names: 78356485

Gene position: 1464695-1465498 (Clockwise)

Preceding gene: 78356484

Following gene: 78356487

Centisome position: 39.27

GC content: 60.45

Gene sequence:

>804_bases
ATGAAAAATACGGTTCTGGGGTGTATCGGTTGCGGCAACATGGGCGGCGCCATCATGCGCGGTCTTGCCGGGGTGGAAGG
ATTGCAGCTGGCCGGCTTTAACCGCAGTGCCCCGAAAGTGGAAGCCCTGCGGGATGAAATAGGCCTTGAGCCTGCTCCTG
ATGCCGTGGCGCTGGCGCGGCGTGCCGACATTATTCTGCTGGGCGTCAAGCCTGATCAGATTTGCGATGTTATAGGGCAG
GTGCGTCCTGTTCTGGATGCCGGCAAGGTGCTGGTTTCCATTGCCGCCGGTGTTTCGCTGGAAGCCATGCGCAGCGCTGC
TCAGGGGGCGGCCCCGGTGGTGCGGGTGATGCCCAATACGCCGGCCATGGTCGGCAGGGGCATTTACGGCATGTGTCTGG
ACGATCCCGCCCTGTCTGCAGAAGCCGCAACCGCTGTCCGGAACCTGTTTGCAGCCATCGGCAAGGTGATTGTACTGCCC
GAACAGAAGTTCGAGGCATTTACCGCTGTGGCCGGATGCGGTCCCGCCTATGTCTTTCATATGATGGAAGCTGTCATCGA
AGCCGCGGTAACCGTAGGGTTTACGCGGCAGCAGGCCACAGAAATGGTGACGGAGCTGTTTTCCGGCTCGTGCGCTCTGG
CCGAACAGACGGGAATACATCCTTCGCTGCTGCGCGAGATGGTCACTTCTCCGGCCGGAACAACCATAGCCGGAACCAAC
CACCTTGACCGCACCGCTGTGCGGGGACACATCATTGATGCCGTGCTGGCAGCCTATGAAAAAGGTCTGGCCATGCGCAG
ATAG

Upstream 100 bases:

>100_bases
CAGAAGGACTTGAGGCAAACTCGGTACACGGTTCCGACGCTGCCGAAACTGCTGCATTTGAAATGGGCTACTTCTTTAAC
GCCATGGAGATAACCGGCTG

Downstream 100 bases:

>100_bases
CCCTGCCGGCAACAGAGAATACAACGGGATGCCCGCAAAGGGCATCCCGTTTTTTTTTGGGATGCGCAGAATAATCCGGC
AGACCGGACAGACAGAATGA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MKNTVLGCIGCGNMGGAIMRGLAGVEGLQLAGFNRSAPKVEALRDEIGLEPAPDAVALARRADIILLGVKPDQICDVIGQ
VRPVLDAGKVLVSIAAGVSLEAMRSAAQGAAPVVRVMPNTPAMVGRGIYGMCLDDPALSAEAATAVRNLFAAIGKVIVLP
EQKFEAFTAVAGCGPAYVFHMMEAVIEAAVTVGFTRQQATEMVTELFSGSCALAEQTGIHPSLLREMVTSPAGTTIAGTN
HLDRTAVRGHIIDAVLAAYEKGLAMRR

Sequences:

>Translated_267_residues
MKNTVLGCIGCGNMGGAIMRGLAGVEGLQLAGFNRSAPKVEALRDEIGLEPAPDAVALARRADIILLGVKPDQICDVIGQ
VRPVLDAGKVLVSIAAGVSLEAMRSAAQGAAPVVRVMPNTPAMVGRGIYGMCLDDPALSAEAATAVRNLFAAIGKVIVLP
EQKFEAFTAVAGCGPAYVFHMMEAVIEAAVTVGFTRQQATEMVTELFSGSCALAEQTGIHPSLLREMVTSPAGTTIAGTN
HLDRTAVRGHIIDAVLAAYEKGLAMRR
>Mature_267_residues
MKNTVLGCIGCGNMGGAIMRGLAGVEGLQLAGFNRSAPKVEALRDEIGLEPAPDAVALARRADIILLGVKPDQICDVIGQ
VRPVLDAGKVLVSIAAGVSLEAMRSAAQGAAPVVRVMPNTPAMVGRGIYGMCLDDPALSAEAATAVRNLFAAIGKVIVLP
EQKFEAFTAVAGCGPAYVFHMMEAVIEAAVTVGFTRQQATEMVTELFSGSCALAEQTGIHPSLLREMVTSPAGTTIAGTN
HLDRTAVRGHIIDAVLAAYEKGLAMRR

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=29.1666666666667, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI21361454, Length=261, Percent_Identity=28.3524904214559, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI24797095, Length=261, Percent_Identity=28.3524904214559, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI24797097, Length=261, Percent_Identity=28.3524904214559, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=35.4716981132075, Blast_Score=150, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=31.0861423220974, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17540664, Length=283, Percent_Identity=27.208480565371, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320861, Length=274, Percent_Identity=30.2919708029197, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24648116, Length=269, Percent_Identity=31.2267657992565, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21358587, Length=254, Percent_Identity=29.9212598425197, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24647700, Length=164, Percent_Identity=34.7560975609756, Blast_Score=91, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27679; Mature: 27679

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTVLGCIGCGNMGGAIMRGLAGVEGLQLAGFNRSAPKVEALRDEIGLEPAPDAVALAR
CCCCEEEEEECCCCCHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHH
RADIILLGVKPDQICDVIGQVRPVLDAGKVLVSIAAGVSLEAMRSAAQGAAPVVRVMPNT
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCCC
PAMVGRGIYGMCLDDPALSAEAATAVRNLFAAIGKVIVLPEQKFEAFTAVAGCGPAYVFH
CHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCHHHHHH
MMEAVIEAAVTVGFTRQQATEMVTELFSGSCALAEQTGIHPSLLREMVTSPAGTTIAGTN
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHCCCCCCEEECCC
HLDRTAVRGHIIDAVLAAYEKGLAMRR
CHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKNTVLGCIGCGNMGGAIMRGLAGVEGLQLAGFNRSAPKVEALRDEIGLEPAPDAVALAR
CCCCEEEEEECCCCCHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHH
RADIILLGVKPDQICDVIGQVRPVLDAGKVLVSIAAGVSLEAMRSAAQGAAPVVRVMPNT
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCCC
PAMVGRGIYGMCLDDPALSAEAATAVRNLFAAIGKVIVLPEQKFEAFTAVAGCGPAYVFH
CHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCHHHHHH
MMEAVIEAAVTVGFTRQQATEMVTELFSGSCALAEQTGIHPSLLREMVTSPAGTTIAGTN
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHCCCCCCEEECCC
HLDRTAVRGHIIDAVLAAYEKGLAMRR
CHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]