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The map label for this gene is ndk

Identifier: 78356484

GI number: 78356484

Start: 1464276

End: 1464695

Strand: Direct

Name: ndk

Synonym: Dde_1439

Alternate gene names: 78356484

Gene position: 1464276-1464695 (Clockwise)

Preceding gene: 78356483

Following gene: 78356485

Centisome position: 39.25

GC content: 53.81

Gene sequence:

>420_bases
ATGGCAGAAAGAACCTTTGCCATCATCAAGCCTGACGCCACAAGACGCAATCTTGAAGGCCCCATTCTGTCCGTCATTCA
GCAGAACGGACTGCGCGTGGTCGCCATGAAAAAAATGCGGCTGACAAGAGAGCAGGCCGAAGGCTTTTATCATGTTCATA
AAGAGCGCCCCTTTTTCGCCAGCCTGACGGATTTCATGACATCAGGCCCCATTGTGGCCATGGTGCTGGAAGGGGATAAT
GCCGTGGCCCGCTGGCGTGAGCTGATGGGGGCCACCAATCCTGAAAATGCGGCAGAAGGCACCATTCGCAGACAGTTTGC
AGAAGGACTTGAGGCAAACTCGGTACACGGTTCCGACGCTGCCGAAACTGCTGCATTTGAAATGGGCTACTTCTTTAACG
CCATGGAGATAACCGGCTGA

Upstream 100 bases:

>100_bases
TGCGGCATCGCAGGCAATAAACACTGTCGGCGCGCGGATGCGTACCGCGTGCCTAATGCACACACATCACACAAACACAC
TGCATCGGAGGAACGAACAC

Downstream 100 bases:

>100_bases
TGAAAAATACGGTTCTGGGGTGTATCGGTTGCGGCAACATGGGCGGCGCCATCATGCGCGGTCTTGCCGGGGTGGAAGGA
TTGCAGCTGGCCGGCTTTAA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MAERTFAIIKPDATRRNLEGPILSVIQQNGLRVVAMKKMRLTREQAEGFYHVHKERPFFASLTDFMTSGPIVAMVLEGDN
AVARWRELMGATNPENAAEGTIRRQFAEGLEANSVHGSDAAETAAFEMGYFFNAMEITG

Sequences:

>Translated_139_residues
MAERTFAIIKPDATRRNLEGPILSVIQQNGLRVVAMKKMRLTREQAEGFYHVHKERPFFASLTDFMTSGPIVAMVLEGDN
AVARWRELMGATNPENAAEGTIRRQFAEGLEANSVHGSDAAETAAFEMGYFFNAMEITG
>Mature_138_residues
AERTFAIIKPDATRRNLEGPILSVIQQNGLRVVAMKKMRLTREQAEGFYHVHKERPFFASLTDFMTSGPIVAMVLEGDNA
VARWRELMGATNPENAAEGTIRRQFAEGLEANSVHGSDAAETAAFEMGYFFNAMEITG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=43.0656934306569, Blast_Score=119, Evalue=9e-28,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=43.0656934306569, Blast_Score=118, Evalue=1e-27,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=43.3823529411765, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=43.3823529411765, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=43.3823529411765, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=43.3823529411765, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=43.3823529411765, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=41.4814814814815, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=39.0977443609023, Blast_Score=97, Evalue=3e-21,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=39.0977443609023, Blast_Score=97, Evalue=4e-21,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=35.2941176470588, Blast_Score=96, Evalue=8e-21,
Organism=Homo sapiens, GI4505413, Length=134, Percent_Identity=35.8208955223881, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=36.2962962962963, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI148839372, Length=125, Percent_Identity=38.4, Blast_Score=80, Evalue=4e-16,
Organism=Homo sapiens, GI30023828, Length=141, Percent_Identity=29.7872340425532, Blast_Score=63, Evalue=7e-11,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=52.2058823529412, Blast_Score=148, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.962962962963, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=40.4411764705882, Blast_Score=109, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=42.6470588235294, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=33.5820895522388, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_DESDG (Q312A8)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_387933.1
- ProteinModelPortal:   Q312A8
- SMR:   Q312A8
- STRING:   Q312A8
- GeneID:   3756109
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1439
- NMPDR:   fig|207559.3.peg.646
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   FHFAGRE
- BioCyc:   DDES207559:DDE_1439-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15426; Mature: 15295

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 116-116 BINDING 10-10 BINDING 58-58 BINDING 86-86 BINDING 92-92 BINDING 103-103 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERTFAIIKPDATRRNLEGPILSVIQQNGLRVVAMKKMRLTREQAEGFYHVHKERPFFA
CCCCEEEEECCCCCCCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHCCEEEECCCCCHHH
SLTDFMTSGPIVAMVLEGDNAVARWRELMGATNPENAAEGTIRRQFAEGLEANSVHGSDA
HHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCH
AETAAFEMGYFFNAMEITG
HHHHHHHHHHHEEEEEECC
>Mature Secondary Structure 
AERTFAIIKPDATRRNLEGPILSVIQQNGLRVVAMKKMRLTREQAEGFYHVHKERPFFA
CCCEEEEECCCCCCCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHCCEEEECCCCCHHH
SLTDFMTSGPIVAMVLEGDNAVARWRELMGATNPENAAEGTIRRQFAEGLEANSVHGSDA
HHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCH
AETAAFEMGYFFNAMEITG
HHHHHHHHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA