Click here to switch to the map view.

The map label for this gene is purC [H]

Identifier: 78356054

GI number: 78356054

Start: 1029812

End: 1030708

Strand: Reverse

Name: purC [H]

Synonym: Dde_1007

Alternate gene names: 78356054

Gene position: 1030708-1029812 (Counterclockwise)

Preceding gene: 78356055

Following gene: 78356053

Centisome position: 27.63

GC content: 56.19

Gene sequence:

>897_bases
ATGCAGATTGTTACCAAGACTGACATTGCAGAATACAAACTGCTTTCCCGCGGCAAAGTTCGTGACATTTACGAGGTGGA
CGCAGAGACGCTGCTCATTGTGACCACCGACCGCATGTCCGCTTTTGATGTTATCATGGGTGAACCTATTCCCTACAAAG
GGGTCATTCTGAACAGCATCACCCTGTTCTGGATGGAGCGCTTTGCCGATCTGGTGCCCAACCATCTGATAGCTTCCGAC
GTAAAAGATTTTCCGCAGGCGCTGCACAAGTACGCGGATATGCTGGAAGGCCGCGCCGTGCTGGTGCGCAAGGCCGCTCC
GCTGCCGGTCGAATGTATTGTCCGCGGGCATATTACCGGCTCCGGCTGGAAGGATTATCAGAAAACAGGTATGGTCTGCG
GCCACAGCCTGCCCGCCGGTCTGGTAGAGTCGGCCAAGCTGGAAACCCCGCTGTTCACGCCGTCCACCAAGGCGGAACTG
GGTGAACACGACGAAAACATATCAGTGCAGCGGGCGCGCGAACTGGTGGGAGACGACGTAGCCGCCCAGATAGAACGCCT
GTCCATTGAGATATTCTCAAAAGGCCGCGAATACGCCGAAAGCCGCGGCATCATCATTGCCGACACCAAGTTTGAATTCG
GCATCATTGACGGCGCCGTCATTCTGATTGACGAGGTTCTGACTCCTGACTCTTCACGTTTCTGGCCGGTACAGGGGTAC
CAGCCCGGCAAAAGCCAGCCCAGCTTTGACAAACAGTACCTGCGCGACTGGCTTTCGGCACAGGACTGGGATAAAACCCC
GCCCGCACCGGCTCTGCCGCAGGATGTCATAACCGAAACCCGCAACAAGTACGCGGAAGCGTACTCCATCCTGACCGGAA
AAACTCTGAACCTGTAG

Upstream 100 bases:

>100_bases
AACGCGGCTAAAATAGCGCGGCTGGCCCGGCTGGAAGGGCTGGAAGCCCACGCCCGCTCGGTTGAATCGCGTCTTTCATA
ACCCCGTGCAAGGAAAAACC

Downstream 100 bases:

>100_bases
CAGACGGCATACAGGCATTCAGGAGAGACTATGCTGCTGAAAGATAAAAAAATTCTTATTCTTGGCGTGGCCAATAACAA
AAGTATCGCCTACGGCATTG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MQIVTKTDIAEYKLLSRGKVRDIYEVDAETLLIVTTDRMSAFDVIMGEPIPYKGVILNSITLFWMERFADLVPNHLIASD
VKDFPQALHKYADMLEGRAVLVRKAAPLPVECIVRGHITGSGWKDYQKTGMVCGHSLPAGLVESAKLETPLFTPSTKAEL
GEHDENISVQRARELVGDDVAAQIERLSIEIFSKGREYAESRGIIIADTKFEFGIIDGAVILIDEVLTPDSSRFWPVQGY
QPGKSQPSFDKQYLRDWLSAQDWDKTPPAPALPQDVITETRNKYAEAYSILTGKTLNL

Sequences:

>Translated_298_residues
MQIVTKTDIAEYKLLSRGKVRDIYEVDAETLLIVTTDRMSAFDVIMGEPIPYKGVILNSITLFWMERFADLVPNHLIASD
VKDFPQALHKYADMLEGRAVLVRKAAPLPVECIVRGHITGSGWKDYQKTGMVCGHSLPAGLVESAKLETPLFTPSTKAEL
GEHDENISVQRARELVGDDVAAQIERLSIEIFSKGREYAESRGIIIADTKFEFGIIDGAVILIDEVLTPDSSRFWPVQGY
QPGKSQPSFDKQYLRDWLSAQDWDKTPPAPALPQDVITETRNKYAEAYSILTGKTLNL
>Mature_298_residues
MQIVTKTDIAEYKLLSRGKVRDIYEVDAETLLIVTTDRMSAFDVIMGEPIPYKGVILNSITLFWMERFADLVPNHLIASD
VKDFPQALHKYADMLEGRAVLVRKAAPLPVECIVRGHITGSGWKDYQKTGMVCGHSLPAGLVESAKLETPLFTPSTKAEL
GEHDENISVQRARELVGDDVAAQIERLSIEIFSKGREYAESRGIIIADTKFEFGIIDGAVILIDEVLTPDSSRFWPVQGY
QPGKSQPSFDKQYLRDWLSAQDWDKTPPAPALPQDVITETRNKYAEAYSILTGKTLNL

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788820, Length=224, Percent_Identity=26.7857142857143, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319326, Length=300, Percent_Identity=52, Blast_Score=295, Evalue=5e-81,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 33286; Mature: 33286

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIVTKTDIAEYKLLSRGKVRDIYEVDAETLLIVTTDRMSAFDVIMGEPIPYKGVILNSI
CCEECCCCHHHHHHHCCCCCCHHEECCCCEEEEEEECCCCHHHHHHCCCCCCCCHHHHHH
TLFWMERFADLVPNHLIASDVKDFPQALHKYADMLEGRAVLVRKAAPLPVECIVRGHITG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCC
SGWKDYQKTGMVCGHSLPAGLVESAKLETPLFTPSTKAELGEHDENISVQRARELVGDDV
CCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCHH
AAQIERLSIEIFSKGREYAESRGIIIADTKFEFGIIDGAVILIDEVLTPDSSRFWPVQGY
HHHHHHHHHHHHHCCHHHHHHCCEEEEECCEEEEECCCHHEEEHHHCCCCCCCEEECCCC
QPGKSQPSFDKQYLRDWLSAQDWDKTPPAPALPQDVITETRNKYAEAYSILTGKTLNL
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECC
>Mature Secondary Structure
MQIVTKTDIAEYKLLSRGKVRDIYEVDAETLLIVTTDRMSAFDVIMGEPIPYKGVILNSI
CCEECCCCHHHHHHHCCCCCCHHEECCCCEEEEEEECCCCHHHHHHCCCCCCCCHHHHHH
TLFWMERFADLVPNHLIASDVKDFPQALHKYADMLEGRAVLVRKAAPLPVECIVRGHITG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCC
SGWKDYQKTGMVCGHSLPAGLVESAKLETPLFTPSTKAELGEHDENISVQRARELVGDDV
CCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCHH
AAQIERLSIEIFSKGREYAESRGIIIADTKFEFGIIDGAVILIDEVLTPDSSRFWPVQGY
HHHHHHHHHHHHHCCHHHHHHCCEEEEECCEEEEECCCHHEEEHHHCCCCCCCEEECCCC
QPGKSQPSFDKQYLRDWLSAQDWDKTPPAPALPQDVITETRNKYAEAYSILTGKTLNL
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA