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The map label for this gene is fabI1 [H]

Identifier: 78356053

GI number: 78356053

Start: 1029017

End: 1029781

Strand: Reverse

Name: fabI1 [H]

Synonym: Dde_1006

Alternate gene names: 78356053

Gene position: 1029781-1029017 (Counterclockwise)

Preceding gene: 78356054

Following gene: 78356052

Centisome position: 27.61

GC content: 56.34

Gene sequence:

>765_bases
ATGCTGCTGAAAGATAAAAAAATTCTTATTCTTGGCGTGGCCAATAACAAAAGTATCGCCTACGGCATTGCACAGGAATT
CAAGGCTCAGGGCGCACGGCTGGCCTTCAGCTACCCCGGCGAAGCCATCCAGAAACGTGTGGACCCCATAAGCGAAGAGC
TGGGCGGCGAATTCACCTTCCGGCTGGATGTCACCGACGATGCGCAGGTGGCCGCGGCAGTGCGCACAGTGGAAGAACAA
TGGGGCAGCGTGGACGTGGTGGTTCATTCCATCGCTTTTGCCCAGCGCGAAGACCTGCACGGCAGATTCATCGATACCAG
CCGCGAAGGTTTCAAGCTGGCCATGGATATTTCCGCCTATTCTCTGGTCTGTGTGTGCAAGGCGTTTGAACCGCTGATGA
CAGAAGGCGGTTCCGTGCTTACCATGACATACTACGGCTCGCAGAAAGTCATAACCAACTACAACGTAATGGGCGTGGCC
AAGGCCGCTCTAGAAGCCTCCGTCAGATATCTGGCTGCAGATATGGGCGAACGGGGCATAAGAGTGAACGCAGTGAGCGC
AGGTCCCATCAAAACGCTGGCAGCCAGCGGCATTTCCGGCTTTAAAACCATCCTCAACCACATTGAGGAACACGCACCGC
TGCGCCGCAATGTAACCACGCAGGACGTAGGCCGCACAGCCGTGTTTCTGGCATCGGACCTTTCCGGCGCCGTCACCGGC
GAAGTGCTGTTTGTGGACGCGGGCTACAACGTGATGGGCATTTAG

Upstream 100 bases:

>100_bases
CATAACCGAAACCCGCAACAAGTACGCGGAAGCGTACTCCATCCTGACCGGAAAAACTCTGAACCTGTAGCAGACGGCAT
ACAGGCATTCAGGAGAGACT

Downstream 100 bases:

>100_bases
ACGCCGCACGCCCGTCGGGAGGTCTGTATGTGGGCTTGGCTCATCCCCCTGGCAATCGTCGTGCTGTGGCTGTATTTCGC
TCCGCGGATACTGCCCATGG

Product: enoyl-[acyl-carrier-protein] reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase 1 [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MLLKDKKILILGVANNKSIAYGIAQEFKAQGARLAFSYPGEAIQKRVDPISEELGGEFTFRLDVTDDAQVAAAVRTVEEQ
WGSVDVVVHSIAFAQREDLHGRFIDTSREGFKLAMDISAYSLVCVCKAFEPLMTEGGSVLTMTYYGSQKVITNYNVMGVA
KAALEASVRYLAADMGERGIRVNAVSAGPIKTLAASGISGFKTILNHIEEHAPLRRNVTTQDVGRTAVFLASDLSGAVTG
EVLFVDAGYNVMGI

Sequences:

>Translated_254_residues
MLLKDKKILILGVANNKSIAYGIAQEFKAQGARLAFSYPGEAIQKRVDPISEELGGEFTFRLDVTDDAQVAAAVRTVEEQ
WGSVDVVVHSIAFAQREDLHGRFIDTSREGFKLAMDISAYSLVCVCKAFEPLMTEGGSVLTMTYYGSQKVITNYNVMGVA
KAALEASVRYLAADMGERGIRVNAVSAGPIKTLAASGISGFKTILNHIEEHAPLRRNVTTQDVGRTAVFLASDLSGAVTG
EVLFVDAGYNVMGI
>Mature_254_residues
MLLKDKKILILGVANNKSIAYGIAQEFKAQGARLAFSYPGEAIQKRVDPISEELGGEFTFRLDVTDDAQVAAAVRTVEEQ
WGSVDVVVHSIAFAQREDLHGRFIDTSREGFKLAMDISAYSLVCVCKAFEPLMTEGGSVLTMTYYGSQKVITNYNVMGVA
KAALEASVRYLAADMGERGIRVNAVSAGPIKTLAASGISGFKTILNHIEEHAPLRRNVTTQDVGRTAVFLASDLSGAVTG
EVLFVDAGYNVMGI

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=259, Percent_Identity=27.7992277992278, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI66933014, Length=223, Percent_Identity=27.8026905829596, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI10190704, Length=261, Percent_Identity=27.5862068965517, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787545, Length=251, Percent_Identity=47.4103585657371, Blast_Score=246, Evalue=7e-67,
Organism=Escherichia coli, GI87082100, Length=259, Percent_Identity=28.957528957529, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787905, Length=234, Percent_Identity=29.0598290598291, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789378, Length=254, Percent_Identity=27.9527559055118, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI2367365, Length=248, Percent_Identity=25.8064516129032, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=198, Percent_Identity=29.2929292929293, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 27332; Mature: 27332

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKDKKILILGVANNKSIAYGIAQEFKAQGARLAFSYPGEAIQKRVDPISEELGGEFTF
CCCCCCEEEEEEECCCCEEEEHHHHHHHCCCCEEEEECCCHHHHHHHCHHHHHHCCEEEE
RLDVTDDAQVAAAVRTVEEQWGSVDVVVHSIAFAQREDLHGRFIDTSREGFKLAMDISAY
EEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECHHH
SLVCVCKAFEPLMTEGGSVLTMTYYGSQKVITNYNVMGVAKAALEASVRYLAADMGERGI
HHHHHHHHHHHHHHCCCCEEEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCE
RVNAVSAGPIKTLAASGISGFKTILNHIEEHAPLRRNVTTQDVGRTAVFLASDLSGAVTG
EEEEECCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHCCCEEEEEECCCCCCEEE
EVLFVDAGYNVMGI
EEEEEECCCEEECC
>Mature Secondary Structure
MLLKDKKILILGVANNKSIAYGIAQEFKAQGARLAFSYPGEAIQKRVDPISEELGGEFTF
CCCCCCEEEEEEECCCCEEEEHHHHHHHCCCCEEEEECCCHHHHHHHCHHHHHHCCEEEE
RLDVTDDAQVAAAVRTVEEQWGSVDVVVHSIAFAQREDLHGRFIDTSREGFKLAMDISAY
EEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECHHH
SLVCVCKAFEPLMTEGGSVLTMTYYGSQKVITNYNVMGVAKAALEASVRYLAADMGERGI
HHHHHHHHHHHHHHCCCCEEEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCE
RVNAVSAGPIKTLAASGISGFKTILNHIEEHAPLRRNVTTQDVGRTAVFLASDLSGAVTG
EEEEECCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHCCCEEEEEECCCCCCEEE
EVLFVDAGYNVMGI
EEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]