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The map label for this gene is hisD

Identifier: 78356055

GI number: 78356055

Start: 1030728

End: 1032032

Strand: Reverse

Name: hisD

Synonym: Dde_1008

Alternate gene names: 78356055

Gene position: 1032032-1030728 (Counterclockwise)

Preceding gene: 78356056

Following gene: 78356054

Centisome position: 27.67

GC content: 59.54

Gene sequence:

>1305_bases
ATGCCCTGTCGTACACTTACCTATTCGTCAGAAGCAGACTGGCAAGGCATCCGTGACATGCTCTGCGGTCGGGAAAATCC
CGAAAATTCCGTTGAGCCTGTCGTACGTGAAATAATGGATGCCATCCGGTCAGACGGGGACGCGGCCCTTGCGGGGTACA
CAAGACGGTTCGACTGTCCCGACTTCGATCCTTCCTCCCTGCGTGTCGCGCCCGATGCCATCGAAAAGGCCGCCCGTGAA
ATCCCCCGGCATGATCTGCAGATCATTACCGAAGCAGCAGACAATATCCGGCATTTTCACTCTGCACAAAAAGAGGAAGC
GTGGTTCATCACCCGCCCTGACGGTACCGTGCTGGGGCAGATGACCCGCCCCGTGGACAGTGCCGGTCTGTATGTTCCCG
GCGGACAGGGCGGTAACACGCCCCTCATATCCAGCCTGCTTATGAACGCCGTCCCGGCGCAGGTTGCAGGGGTTCCCCGC
ATTGCGGTCACCACACCGCCGCGCAAAGACGGCACCCTCAACCCTTATATTCTTGCCGCCGCGCATGTTCTGGGGCTGGA
CGAAATATACTGTGCCGGCTCGGCATGGGCCGTGGCCGCTCTGGCATACGGCACACAGACCATAGCCCCCGTGGATTTCA
TTGCCGGTCCGGGCAACATCTTTGTCACCACCGCCAAACGCATGCTTATCGGCACGGTGGGCATAGACATGATAGCCGGT
CCCAGCGAAATACTGATCATCGCAGACTCTCAGGCCGATGCCGCACACGTTGCCGCCGATATGCTTTCGCAGGCGGAGCA
TGACCCGCTGGCTTCCGCCATACTGGTCACCCCCAGTCCTCAGCTGGCTGCCGCAGTGCACACCGAACTGGAAAAACAGG
TTACCGGTCTTGACCGGGCAGACATAGCACGCGCCTCGCTCCGCGACTGGAGCGCCATAGTGGTGACCCCCGACCTGAAC
TCGGCGGTAGAGCTTTCCAACAAGGTAGCTCCCGAGCATCTGGAACTGCTGGTACAGGATACGTGGGGACTTCTGGGCAG
CATCCGCAATGCCGGTGCCATCTTCATGGGACCGCATTCGCCGGAACCGGTGGGCGACTACTTCGCAGGTCCCAACCACG
TACTGCCCACCATGGGCACTGCCCGCTTTTCTTCGGCGTTGTCTGTGCAGTCTTTCTGTAAAAAATCAAGTATCATTGCC
GCGTCACAGACTTTTACGCAGACAAACGCGGCTAAAATAGCGCGGCTGGCCCGGCTGGAAGGGCTGGAAGCCCACGCCCG
CTCGGTTGAATCGCGTCTTTCATAA

Upstream 100 bases:

>100_bases
GCATACGCCTTCCGCTGTCTCGACTTTTTGTGCCGCCTGCTGTAAAGAACAGGCTCACCGCGCCACATCCGGCGCGGCGA
AGAAAACAAGAGGAACCGCC

Downstream 100 bases:

>100_bases
CCCCGTGCAAGGAAAAACCATGCAGATTGTTACCAAGACTGACATTGCAGAATACAAACTGCTTTCCCGCGGCAAAGTTC
GTGACATTTACGAGGTGGAC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MPCRTLTYSSEADWQGIRDMLCGRENPENSVEPVVREIMDAIRSDGDAALAGYTRRFDCPDFDPSSLRVAPDAIEKAARE
IPRHDLQIITEAADNIRHFHSAQKEEAWFITRPDGTVLGQMTRPVDSAGLYVPGGQGGNTPLISSLLMNAVPAQVAGVPR
IAVTTPPRKDGTLNPYILAAAHVLGLDEIYCAGSAWAVAALAYGTQTIAPVDFIAGPGNIFVTTAKRMLIGTVGIDMIAG
PSEILIIADSQADAAHVAADMLSQAEHDPLASAILVTPSPQLAAAVHTELEKQVTGLDRADIARASLRDWSAIVVTPDLN
SAVELSNKVAPEHLELLVQDTWGLLGSIRNAGAIFMGPHSPEPVGDYFAGPNHVLPTMGTARFSSALSVQSFCKKSSIIA
ASQTFTQTNAAKIARLARLEGLEAHARSVESRLS

Sequences:

>Translated_434_residues
MPCRTLTYSSEADWQGIRDMLCGRENPENSVEPVVREIMDAIRSDGDAALAGYTRRFDCPDFDPSSLRVAPDAIEKAARE
IPRHDLQIITEAADNIRHFHSAQKEEAWFITRPDGTVLGQMTRPVDSAGLYVPGGQGGNTPLISSLLMNAVPAQVAGVPR
IAVTTPPRKDGTLNPYILAAAHVLGLDEIYCAGSAWAVAALAYGTQTIAPVDFIAGPGNIFVTTAKRMLIGTVGIDMIAG
PSEILIIADSQADAAHVAADMLSQAEHDPLASAILVTPSPQLAAAVHTELEKQVTGLDRADIARASLRDWSAIVVTPDLN
SAVELSNKVAPEHLELLVQDTWGLLGSIRNAGAIFMGPHSPEPVGDYFAGPNHVLPTMGTARFSSALSVQSFCKKSSIIA
ASQTFTQTNAAKIARLARLEGLEAHARSVESRLS
>Mature_433_residues
PCRTLTYSSEADWQGIRDMLCGRENPENSVEPVVREIMDAIRSDGDAALAGYTRRFDCPDFDPSSLRVAPDAIEKAAREI
PRHDLQIITEAADNIRHFHSAQKEEAWFITRPDGTVLGQMTRPVDSAGLYVPGGQGGNTPLISSLLMNAVPAQVAGVPRI
AVTTPPRKDGTLNPYILAAAHVLGLDEIYCAGSAWAVAALAYGTQTIAPVDFIAGPGNIFVTTAKRMLIGTVGIDMIAGP
SEILIIADSQADAAHVAADMLSQAEHDPLASAILVTPSPQLAAAVHTELEKQVTGLDRADIARASLRDWSAIVVTPDLNS
AVELSNKVAPEHLELLVQDTWGLLGSIRNAGAIFMGPHSPEPVGDYFAGPNHVLPTMGTARFSSALSVQSFCKKSSIIAA
SQTFTQTNAAKIARLARLEGLEAHARSVESRLS

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=408, Percent_Identity=39.9509803921569, Blast_Score=272, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6319819, Length=415, Percent_Identity=38.3132530120482, Blast_Score=239, Evalue=8e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_DESDG (Q313T7)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_387504.1
- ProteinModelPortal:   Q313T7
- SMR:   Q313T7
- STRING:   Q313T7
- GeneID:   3755510
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1008
- NMPDR:   fig|207559.3.peg.27
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   IEAFHRQ
- ProtClustDB:   PRK00877
- BioCyc:   DDES207559:DDE_1008-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46151; Mature: 46020

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 332-332 ACT_SITE 333-333 BINDING 242-242 BINDING 264-264 BINDING 267-267 BINDING 333-333 BINDING 366-366 BINDING 420-420 BINDING 425-425

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPCRTLTYSSEADWQGIRDMLCGRENPENSVEPVVREIMDAIRSDGDAALAGYTRRFDCP
CCCCEECCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCEECCCC
DFDPSSLRVAPDAIEKAAREIPRHDLQIITEAADNIRHFHSAQKEEAWFITRPDGTVLGQ
CCCCCCEEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEHH
MTRPVDSAGLYVPGGQGGNTPLISSLLMNAVPAQVAGVPRIAVTTPPRKDGTLNPYILAA
HCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCHHHCCCCEEEEECCCCCCCCCCHHHHHH
AHVLGLDEIYCAGSAWAVAALAYGTQTIAPVDFIAGPGNIFVTTAKRMLIGTVGIDMIAG
HHHHCCHHHEECCCHHHHHHHHHCCCCCCCHHEECCCCCEEEEEHHHHHHHHHCHHEECC
PSEILIIADSQADAAHVAADMLSQAEHDPLASAILVTPSPQLAAAVHTELEKQVTGLDRA
CCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHH
DIARASLRDWSAIVVTPDLNSAVELSNKVAPEHLELLVQDTWGLLGSIRNAGAIFMGPHS
HHHHHHHCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
PEPVGDYFAGPNHVLPTMGTARFSSALSVQSFCKKSSIIAASQTFTQTNAAKIARLARLE
CCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHHHHHHC
GLEAHARSVESRLS
CHHHHHHHHHHHCC
>Mature Secondary Structure 
PCRTLTYSSEADWQGIRDMLCGRENPENSVEPVVREIMDAIRSDGDAALAGYTRRFDCP
CCCEECCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCEECCCC
DFDPSSLRVAPDAIEKAAREIPRHDLQIITEAADNIRHFHSAQKEEAWFITRPDGTVLGQ
CCCCCCEEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEHH
MTRPVDSAGLYVPGGQGGNTPLISSLLMNAVPAQVAGVPRIAVTTPPRKDGTLNPYILAA
HCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCHHHCCCCEEEEECCCCCCCCCCHHHHHH
AHVLGLDEIYCAGSAWAVAALAYGTQTIAPVDFIAGPGNIFVTTAKRMLIGTVGIDMIAG
HHHHCCHHHEECCCHHHHHHHHHCCCCCCCHHEECCCCCEEEEEHHHHHHHHHCHHEECC
PSEILIIADSQADAAHVAADMLSQAEHDPLASAILVTPSPQLAAAVHTELEKQVTGLDRA
CCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHH
DIARASLRDWSAIVVTPDLNSAVELSNKVAPEHLELLVQDTWGLLGSIRNAGAIFMGPHS
HHHHHHHCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
PEPVGDYFAGPNHVLPTMGTARFSSALSVQSFCKKSSIIAASQTFTQTNAAKIARLARLE
CCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHHHHHHC
GLEAHARSVESRLS
CHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA