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The map label for this gene is degU [H]

Identifier: 78356024

GI number: 78356024

Start: 1004919

End: 1005590

Strand: Direct

Name: degU [H]

Synonym: Dde_0977

Alternate gene names: 78356024

Gene position: 1004919-1005590 (Clockwise)

Preceding gene: 78356021

Following gene: 78356044

Centisome position: 26.94

GC content: 55.95

Gene sequence:

>672_bases
ATGGGGGAAGGATATTCACTGATCATTGCCGAAGACCACACCCTTCTGCGCGAGGGGCTGAAGTCGCTGCTGCAGTCTGT
ACCGCATCTTATAGTCACCGGAGAAGCCAGTGACGGACAGATGGCGGTTGACCTGTGTGACAGAAACCAGCCCGAGCTTG
TGCTGATGGATATTTCCATGCCTCGTATGGACGGTGTGCAGGCTACTCGTCTGATAAAAAAGCGCCACCCCGAGGTACGG
GTGCTGGTGCTGACCGTGCACGGTGCCGGCGAGTATGTTTATGCGGCGCTTGCCGCCGGAGCAGACGGGTATGTCTTGAA
AGATGCCAGCAACGACGAGTTTATTCTGGCTGTGGAGTCTGTGCTGGGCGGCAAGATTTATCTGAGTCCGGGCGTTTCCG
ACGCTGTGGTCAAAGGATACCTGAACGACGCCAGAGGGCAGTCTGTCTCGTCCAGCTGGGAAACGCTGACACCACGCGAA
CAGGAAATTTTTCAGCTGGTGGCCGAAGGCTATAAAAACCGTGAAATCGCAGAAATGCTGGTGGTCAGCGTGAAGACGGT
GGAAAAGCACCGTTCCAACCTGATGCAGAAGCTAGGGGTACATTCCGCTGCCGAACTGCGTGCTCTGGCGCTGGAGCGGG
GTATTATTTTGCGCATGCGTTCAGACGGATAG

Upstream 100 bases:

>100_bases
TTCATGGCCGGCATTTTTTTTATTATTATAAATGGGTTGTGATTGTTATTAAGTTGCCGGGGGGGTAGGGAGCCACCTTC
GAACAGGGGGTTACGGAATT

Downstream 100 bases:

>100_bases
CCAGATCTGTAAGATTGTACCGCCGTATCCTGTGGCGCGCCGGATGCTGACTGCCTGAGAACAGCCCTGCGGCAGGCACC
GGCAAAATTACCGGCGGAGA

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MGEGYSLIIAEDHTLLREGLKSLLQSVPHLIVTGEASDGQMAVDLCDRNQPELVLMDISMPRMDGVQATRLIKKRHPEVR
VLVLTVHGAGEYVYAALAAGADGYVLKDASNDEFILAVESVLGGKIYLSPGVSDAVVKGYLNDARGQSVSSSWETLTPRE
QEIFQLVAEGYKNREIAEMLVVSVKTVEKHRSNLMQKLGVHSAAELRALALERGIILRMRSDG

Sequences:

>Translated_223_residues
MGEGYSLIIAEDHTLLREGLKSLLQSVPHLIVTGEASDGQMAVDLCDRNQPELVLMDISMPRMDGVQATRLIKKRHPEVR
VLVLTVHGAGEYVYAALAAGADGYVLKDASNDEFILAVESVLGGKIYLSPGVSDAVVKGYLNDARGQSVSSSWETLTPRE
QEIFQLVAEGYKNREIAEMLVVSVKTVEKHRSNLMQKLGVHSAAELRALALERGIILRMRSDG
>Mature_222_residues
GEGYSLIIAEDHTLLREGLKSLLQSVPHLIVTGEASDGQMAVDLCDRNQPELVLMDISMPRMDGVQATRLIKKRHPEVRV
LVLTVHGAGEYVYAALAAGADGYVLKDASNDEFILAVESVLGGKIYLSPGVSDAVVKGYLNDARGQSVSSSWETLTPREQ
EIFQLVAEGYKNREIAEMLVVSVKTVEKHRSNLMQKLGVHSAAELRALALERGIILRMRSDG

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=210, Percent_Identity=34.7619047619048, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1788521, Length=198, Percent_Identity=31.8181818181818, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1786747, Length=201, Percent_Identity=31.8407960199005, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1787473, Length=188, Percent_Identity=32.9787234042553, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790102, Length=201, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788546, Length=203, Percent_Identity=28.0788177339901, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788712, Length=203, Percent_Identity=26.1083743842365, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24355; Mature: 24224

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEGYSLIIAEDHTLLREGLKSLLQSVPHLIVTGEASDGQMAVDLCDRNQPELVLMDISM
CCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCCCCEEEEECCC
PRMDGVQATRLIKKRHPEVRVLVLTVHGAGEYVYAALAAGADGYVLKDASNDEFILAVES
CCCCCHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHCCCCCEEEECCCCCCEEEEEEH
VLGGKIYLSPGVSDAVVKGYLNDARGQSVSSSWETLTPREQEIFQLVAEGYKNREIAEML
HHCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHH
VVSVKTVEKHRSNLMQKLGVHSAAELRALALERGIILRMRSDG
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCC
>Mature Secondary Structure 
GEGYSLIIAEDHTLLREGLKSLLQSVPHLIVTGEASDGQMAVDLCDRNQPELVLMDISM
CCCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCCCCEEEEECCC
PRMDGVQATRLIKKRHPEVRVLVLTVHGAGEYVYAALAAGADGYVLKDASNDEFILAVES
CCCCCHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHCCCCCEEEECCCCCCEEEEEEH
VLGGKIYLSPGVSDAVVKGYLNDARGQSVSSSWETLTPREQEIFQLVAEGYKNREIAEML
HHCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHH
VVSVKTVEKHRSNLMQKLGVHSAAELRALALERGIILRMRSDG
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]