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The map label for this gene is nuoH1 [H]

Identifier: 78224538

GI number: 78224538

Start: 3763960

End: 3764973

Strand: Reverse

Name: nuoH1 [H]

Synonym: Gmet_3348

Alternate gene names: 78224538

Gene position: 3764973-3763960 (Counterclockwise)

Preceding gene: 78224539

Following gene: 78224537

Centisome position: 94.19

GC content: 49.7

Gene sequence:

>1014_bases
ATGGCATACTACATCGCCATGGTACTCAAGGTTCTCGTGGTGTTCGTCTTCGTACTGCTTACTGTGGCGTACGCCACCTA
TGCTGAACGTAAGATCATTGGTCACATGCAGGTGCGGCTTGGTCCAATGCGCACTGGCTGGCATGGCCTGCTGCAACCGA
TTGCAGACGGTGTTAAGCTATTCTTTAAGGAGGAGATAATCCCTTCGAAAGCGGACAAATTCGCCTTCCTGATAGCTCCT
CTGATAGCGCTCGTCCCAGCGTTCATTGGCTTCGCAGTCATCCCTTTTGGTGAAACAATTGAGGTGGGTGGCTACAAAAT
ACCCCTCCAAATTGCTGCATACTACGACACTGCGTCGGGACAAGTTGTAGACCTCAATGTTGGTGTCCTTTATATCCTTG
CGCTGGCATCAATAGGTGTATATGGCATTGTCTTGGCCGGGTGGTCTTCAAACAGCAAATATTCACTTCTCGGTGGTCTG
CGCTCCTCCGCCCAGATGATCTCTTACGAGTTGGCCGCTGGTCTGGCGATCATTTCGGTCTTTATGCTCTCTGAGTCCCT
TTCGCTCCAGAAGATAGTGGCTGATCAGGCCAATGGTGCCTGGTACGCCTTTAAGCAGCCCTTGGCGTTCATACTTTTCT
TTATCTGCTCCATTGCAGAAATCAACCGGACCCCCTTTGACCTTCCTGAAGCTGAAACAGAGTTGGTTTCCGGTTTCTGC
ACCGAATATTCAAGTATGAAGTACGCCATGTTCTTCATGGCAGAATATGCAAACATGGTAACGGTCTGTGCTGTAACAAC
CACCCTGTTCCTGGGGGGATGGCATGGTCCCAGCTTCTTGCCCGGTTGGTTCTGGTTTATTGCAAAGGTCTATTTCCTGA
TCTTCACGTGCATGTGGATTCGTGCTACCTATCCCCGCTACCGGTATGACCAACTGATGCGTCTCGGATGGAAGGTGTTC
CTGCCTTTGACTCTGATCAATATCGTAGTAACTGGAATTATTGTATCACTCTAG

Upstream 100 bases:

>100_bases
CAATAAGCAAGTAGCTATACTTGGATGTAAAGTCCACTCACAACACCATCACATCAAGAGGGGAAGAGTGCAAATGGGAT
ACGAAATATTGGGATTGCCG

Downstream 100 bases:

>100_bases
TCACAACCTATTACGAGGTTACACGCCATGATAATGCCATTGATTAATGGTCTCAAGATCACCCTGAAGCATATGTTCAT
GAAGCCAGTTACGCTTCAGT

Product: respiratory-chain NADH dehydrogenase subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H 1; NDH-1 subunit H 1 [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MAYYIAMVLKVLVVFVFVLLTVAYATYAERKIIGHMQVRLGPMRTGWHGLLQPIADGVKLFFKEEIIPSKADKFAFLIAP
LIALVPAFIGFAVIPFGETIEVGGYKIPLQIAAYYDTASGQVVDLNVGVLYILALASIGVYGIVLAGWSSNSKYSLLGGL
RSSAQMISYELAAGLAIISVFMLSESLSLQKIVADQANGAWYAFKQPLAFILFFICSIAEINRTPFDLPEAETELVSGFC
TEYSSMKYAMFFMAEYANMVTVCAVTTTLFLGGWHGPSFLPGWFWFIAKVYFLIFTCMWIRATYPRYRYDQLMRLGWKVF
LPLTLINIVVTGIIVSL

Sequences:

>Translated_337_residues
MAYYIAMVLKVLVVFVFVLLTVAYATYAERKIIGHMQVRLGPMRTGWHGLLQPIADGVKLFFKEEIIPSKADKFAFLIAP
LIALVPAFIGFAVIPFGETIEVGGYKIPLQIAAYYDTASGQVVDLNVGVLYILALASIGVYGIVLAGWSSNSKYSLLGGL
RSSAQMISYELAAGLAIISVFMLSESLSLQKIVADQANGAWYAFKQPLAFILFFICSIAEINRTPFDLPEAETELVSGFC
TEYSSMKYAMFFMAEYANMVTVCAVTTTLFLGGWHGPSFLPGWFWFIAKVYFLIFTCMWIRATYPRYRYDQLMRLGWKVF
LPLTLINIVVTGIIVSL
>Mature_336_residues
AYYIAMVLKVLVVFVFVLLTVAYATYAERKIIGHMQVRLGPMRTGWHGLLQPIADGVKLFFKEEIIPSKADKFAFLIAPL
IALVPAFIGFAVIPFGETIEVGGYKIPLQIAAYYDTASGQVVDLNVGVLYILALASIGVYGIVLAGWSSNSKYSLLGGLR
SSAQMISYELAAGLAIISVFMLSESLSLQKIVADQANGAWYAFKQPLAFILFFICSIAEINRTPFDLPEAETELVSGFCT
EYSSMKYAMFFMAEYANMVTVCAVTTTLFLGGWHGPSFLPGWFWFIAKVYFLIFTCMWIRATYPRYRYDQLMRLGWKVFL
PLTLINIVVTGIIVSL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=306, Percent_Identity=41.5032679738562, Blast_Score=226, Evalue=2e-59,
Organism=Escherichia coli, GI1788618, Length=329, Percent_Identity=42.8571428571429, Blast_Score=272, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 37509; Mature: 37378

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00667 COMPLEX1_ND1_1 ; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYYIAMVLKVLVVFVFVLLTVAYATYAERKIIGHMQVRLGPMRTGWHGLLQPIADGVKL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHH
FFKEEIIPSKADKFAFLIAPLIALVPAFIGFAVIPFGETIEVGGYKIPLQIAAYYDTASG
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEEEEEEECCCC
QVVDLNVGVLYILALASIGVYGIVLAGWSSNSKYSLLGGLRSSAQMISYELAAGLAIISV
EEEEECHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FMLSESLSLQKIVADQANGAWYAFKQPLAFILFFICSIAEINRTPFDLPEAETELVSGFC
HHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
TEYSSMKYAMFFMAEYANMVTVCAVTTTLFLGGWHGPSFLPGWFWFIAKVYFLIFTCMWI
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RATYPRYRYDQLMRLGWKVFLPLTLINIVVTGIIVSL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AYYIAMVLKVLVVFVFVLLTVAYATYAERKIIGHMQVRLGPMRTGWHGLLQPIADGVKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHH
FFKEEIIPSKADKFAFLIAPLIALVPAFIGFAVIPFGETIEVGGYKIPLQIAAYYDTASG
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEEEEEEECCCC
QVVDLNVGVLYILALASIGVYGIVLAGWSSNSKYSLLGGLRSSAQMISYELAAGLAIISV
EEEEECHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FMLSESLSLQKIVADQANGAWYAFKQPLAFILFFICSIAEINRTPFDLPEAETELVSGFC
HHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
TEYSSMKYAMFFMAEYANMVTVCAVTTTLFLGGWHGPSFLPGWFWFIAKVYFLIFTCMWI
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RATYPRYRYDQLMRLGWKVFLPLTLINIVVTGIIVSL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA