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The map label for this gene is yngE [H]

Identifier: 78224481

GI number: 78224481

Start: 3702037

End: 3703644

Strand: Direct

Name: yngE [H]

Synonym: Gmet_3290

Alternate gene names: 78224481

Gene position: 3702037-3703644 (Clockwise)

Preceding gene: 78224480

Following gene: 78224482

Centisome position: 92.61

GC content: 64.43

Gene sequence:

>1608_bases
ATGAGCGTACTGAAAAGTTCCATCAACACAACTACCGAAGAGTTCCGCACCAATGCCGACGTGATGAGGGGGCTGGTGGC
CGACCTGGAGGACAAGGTCGCCCAGATCAAGCTGGGTGGCGGCGAAAAGGCTCGCGCCAAGCACGTTGAGCGGGGAAAGC
TCCTTCCGCGGGAGCGTATCCGCCAGCTCCTGGACGTGGGTTCCCCCTTCCTGGAGCTGTCACAGCTAGCTGCCTGGGGA
ATGTACAGTGGTGACGTCGCCTCCGGCGGCGTCATCACCGGCATCGGCCGAGTCTCGGGCCGGGAGTGCATGATCGTTGC
CAATGACGCCACGGTCAAGGGGGGGAGTTACTTTCCCAGCACGGTCAAAAAACACCTGCGGGCCCAGGAGATTGCCGAGG
CGAACCACCTCCCCTGCATCTACCTGGTGGATTCCGGCGGAGCCAACCTCCCCCAGCAGGACGAGGTCTTCCCCGACCGG
GATCACTTCGGCCGGATCTTTTACAACCAGGCGAACATGTCGGGCAAAGGAATTCCCCAGATTGCCGTGGTGATGGGCTC
CTGCACCGCCGGCGGGGCCTATGTCCCGGCCATGTCCGACGAGAGCGTCATCGTCCGGTGCCAGGGGACCATCTTCCTGG
GCGGCCCCCCCCTGGTGAAGGCGGCTACCGGCGAGGTGGTGAGCGCCGAGGACCTGGGTGGCGCCGACGTCCACTGCCGC
ACCTCCGGCGTCACCGACCACTATGCCGCCAACGACGGCCACGCCCTGGAGGTGGCCCGCCGGATCGTATCAAACCTGAA
CCGCGTCAAGCGCCCCGAGCTCGCCCTCCGGGAGCCGGCAGGCCCTCTCTACAACCCGGCTGAGCTCTACGGCGTCATCC
CCACCGACACTCGCAAGCCCTATGACGTGCGGGAGGTTATCGCCCGCATCGTGGACGGCTCGGAGTTCGACGAATTCAAG
CAACTCTATGGCACCACGCTCGTCTGCGGCTTCGCCCACATCTTTGGCTACCCGGTGGGGATCGTGGCCAACAACGGAAT
TCTCTTCTCCGAGTCGGCCCTCAAAGGGGCCCATTTCGTCGAGCTCTGCAGCCAGCGGGGGATCCCCCTCATCTTCCTCC
AGAACATCACCGGCTTCATGGTGGGAAGCAAGTACGAATCGGGGGGGATCGCCAAGGACGGGGCCAAAATGGTGACCGCC
GTGGCCTGCGCCAAGGTCCCCAAGTTCACGGTCATCATCGGCGGAAGCTATGGAGCCGGCAACTATGGCATGTGCGGCCG
GGCCTACTCGCCGCGCTTCCTCTGGATGTGGCCCAATGCCCGGATCTCGGTCATGGGGGGAGAGCAGGCGGCCAGCGTCC
TGGCCCAGGTAAAGCGAGACGGAATAGAGGCCCAGGGGAAAACCTGGCCCGCCGACGAGGAAGAGGAATTCAGGAGACCC
ATCCGAGAGCAGTACGAGACCCAGGGGCACCCCTACTATGCCAGCGCCCGGCTCTGGGACGACGGAATCATCGACCCGGC
CGACACCCGGATGGTGTTGGGGCTCGGCATCTCGGCGACCCTCAACGCACCGCCCATGAAGACCGATTTCGGCGTCTTCC
GGATGTAA

Upstream 100 bases:

>100_bases
AATGCTCATCGGCCGCGAACTGTTCGAGGAAACGGTCCACGCCTGAGGAAGCGGCGGCAGACGCCTGAACACGCAGAAAC
GACGAGGAGACCAACCCGCC

Downstream 100 bases:

>100_bases
GTGAACGCGGCTTTTCCGCAATCTCTGCGTTTATCTTCGGAATTTGCTTGTGCGACGTAGCGCTGCTACGCCTCCGCGCA
ATTCCTAGATCGCCTTGACC

Product: carboxyl transferase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MSVLKSSINTTTEEFRTNADVMRGLVADLEDKVAQIKLGGGEKARAKHVERGKLLPRERIRQLLDVGSPFLELSQLAAWG
MYSGDVASGGVITGIGRVSGRECMIVANDATVKGGSYFPSTVKKHLRAQEIAEANHLPCIYLVDSGGANLPQQDEVFPDR
DHFGRIFYNQANMSGKGIPQIAVVMGSCTAGGAYVPAMSDESVIVRCQGTIFLGGPPLVKAATGEVVSAEDLGGADVHCR
TSGVTDHYAANDGHALEVARRIVSNLNRVKRPELALREPAGPLYNPAELYGVIPTDTRKPYDVREVIARIVDGSEFDEFK
QLYGTTLVCGFAHIFGYPVGIVANNGILFSESALKGAHFVELCSQRGIPLIFLQNITGFMVGSKYESGGIAKDGAKMVTA
VACAKVPKFTVIIGGSYGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLAQVKRDGIEAQGKTWPADEEEEFRRP
IREQYETQGHPYYASARLWDDGIIDPADTRMVLGLGISATLNAPPMKTDFGVFRM

Sequences:

>Translated_535_residues
MSVLKSSINTTTEEFRTNADVMRGLVADLEDKVAQIKLGGGEKARAKHVERGKLLPRERIRQLLDVGSPFLELSQLAAWG
MYSGDVASGGVITGIGRVSGRECMIVANDATVKGGSYFPSTVKKHLRAQEIAEANHLPCIYLVDSGGANLPQQDEVFPDR
DHFGRIFYNQANMSGKGIPQIAVVMGSCTAGGAYVPAMSDESVIVRCQGTIFLGGPPLVKAATGEVVSAEDLGGADVHCR
TSGVTDHYAANDGHALEVARRIVSNLNRVKRPELALREPAGPLYNPAELYGVIPTDTRKPYDVREVIARIVDGSEFDEFK
QLYGTTLVCGFAHIFGYPVGIVANNGILFSESALKGAHFVELCSQRGIPLIFLQNITGFMVGSKYESGGIAKDGAKMVTA
VACAKVPKFTVIIGGSYGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLAQVKRDGIEAQGKTWPADEEEEFRRP
IREQYETQGHPYYASARLWDDGIIDPADTRMVLGLGISATLNAPPMKTDFGVFRM
>Mature_534_residues
SVLKSSINTTTEEFRTNADVMRGLVADLEDKVAQIKLGGGEKARAKHVERGKLLPRERIRQLLDVGSPFLELSQLAAWGM
YSGDVASGGVITGIGRVSGRECMIVANDATVKGGSYFPSTVKKHLRAQEIAEANHLPCIYLVDSGGANLPQQDEVFPDRD
HFGRIFYNQANMSGKGIPQIAVVMGSCTAGGAYVPAMSDESVIVRCQGTIFLGGPPLVKAATGEVVSAEDLGGADVHCRT
SGVTDHYAANDGHALEVARRIVSNLNRVKRPELALREPAGPLYNPAELYGVIPTDTRKPYDVREVIARIVDGSEFDEFKQ
LYGTTLVCGFAHIFGYPVGIVANNGILFSESALKGAHFVELCSQRGIPLIFLQNITGFMVGSKYESGGIAKDGAKMVTAV
ACAKVPKFTVIIGGSYGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLAQVKRDGIEAQGKTWPADEEEEFRRPI
REQYETQGHPYYASARLWDDGIIDPADTRMVLGLGISATLNAPPMKTDFGVFRM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=522, Percent_Identity=69.3486590038314, Blast_Score=737, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=527, Percent_Identity=33.2068311195446, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI295821216, Length=547, Percent_Identity=32.1755027422303, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI310133460, Length=132, Percent_Identity=65.9090909090909, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=63.9774859287054, Blast_Score=716, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=485, Percent_Identity=34.639175257732, Blast_Score=236, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI25147362, Length=485, Percent_Identity=34.639175257732, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24586065, Length=554, Percent_Identity=65.884476534296, Blast_Score=752, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57735; Mature: 57603

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLKSSINTTTEEFRTNADVMRGLVADLEDKVAQIKLGGGEKARAKHVERGKLLPRERI
CCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHCCCCCHHHH
RQLLDVGSPFLELSQLAAWGMYSGDVASGGVITGIGRVSGRECMIVANDATVKGGSYFPS
HHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCEECCCCCCHH
TVKKHLRAQEIAEANHLPCIYLVDSGGANLPQQDEVFPDRDHFGRIFYNQANMSGKGIPQ
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCE
IAVVMGSCTAGGAYVPAMSDESVIVRCQGTIFLGGPPLVKAATGEVVSAEDLGGADVHCR
EEEEEECCCCCCEECCCCCCCCEEEEEECEEEECCCCEEEECCCCEEECCCCCCCCEEEE
TSGVTDHYAANDGHALEVARRIVSNLNRVKRPELALREPAGPLYNPAELYGVIPTDTRKP
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHEEEECCCCCCCC
YDVREVIARIVDGSEFDEFKQLYGTTLVCGFAHIFGYPVGIVANNGILFSESALKGAHFV
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEECHHHCCHHHH
ELCSQRGIPLIFLQNITGFMVGSKYESGGIAKDGAKMVTAVACAKVPKFTVIIGGSYGAG
HHHHHCCCCEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLAQVKRDGIEAQGKTWPADEEEEFRRP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
IREQYETQGHPYYASARLWDDGIIDPADTRMVLGLGISATLNAPPMKTDFGVFRM
HHHHHHCCCCCEEEEEEECCCCCCCCCCCEEEEEECCEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
SVLKSSINTTTEEFRTNADVMRGLVADLEDKVAQIKLGGGEKARAKHVERGKLLPRERI
CHHHHHHCCCHHHHHCCHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHCCCCCHHHH
RQLLDVGSPFLELSQLAAWGMYSGDVASGGVITGIGRVSGRECMIVANDATVKGGSYFPS
HHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCEECCCCCCHH
TVKKHLRAQEIAEANHLPCIYLVDSGGANLPQQDEVFPDRDHFGRIFYNQANMSGKGIPQ
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCE
IAVVMGSCTAGGAYVPAMSDESVIVRCQGTIFLGGPPLVKAATGEVVSAEDLGGADVHCR
EEEEEECCCCCCEECCCCCCCCEEEEEECEEEECCCCEEEECCCCEEECCCCCCCCEEEE
TSGVTDHYAANDGHALEVARRIVSNLNRVKRPELALREPAGPLYNPAELYGVIPTDTRKP
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHEEEECCCCCCCC
YDVREVIARIVDGSEFDEFKQLYGTTLVCGFAHIFGYPVGIVANNGILFSESALKGAHFV
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEECHHHCCHHHH
ELCSQRGIPLIFLQNITGFMVGSKYESGGIAKDGAKMVTAVACAKVPKFTVIIGGSYGAG
HHHHHCCCCEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLAQVKRDGIEAQGKTWPADEEEEFRRP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
IREQYETQGHPYYASARLWDDGIIDPADTRMVLGLGISATLNAPPMKTDFGVFRM
HHHHHHCCCCCEEEEEEECCCCCCCCCCCEEEEEECCEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]