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The map label for this gene is mmgC [H]

Identifier: 78224480

GI number: 78224480

Start: 3700810

End: 3701982

Strand: Direct

Name: mmgC [H]

Synonym: Gmet_3289

Alternate gene names: 78224480

Gene position: 3700810-3701982 (Clockwise)

Preceding gene: 78224479

Following gene: 78224481

Centisome position: 92.58

GC content: 63.17

Gene sequence:

>1173_bases
ATGAAAGCATATCCAACTCTTAATTTCGATCTCGGCGAGACCAGCAGCATCCTCAGGGAAACGGTAAAGGAGTTTGCAGC
TAAGGAGATCACGCCGCGTGCCACCGACATCGACCGGGACAACCACTTCCCCATGGACCTCTGGCCCAAGATGGGGCAAC
TGGGGCTCCTAGGGGTCACTGTTTCCGAGGAGTACGGCGGCGCCGCCATGGGGTACCTGGAGCACGTCATCGCCATGGAG
GAGCTCTCCCGGGCTTCGGCCTCGGTGGGGCTGGCCTACGGCGCCCACTCAAACCTCTGCGTCAACCAGATCTTCCGCAA
CGGCAACGAGTCCCAAAGGCGGAAGTACCTCCCCAAACTCATCAGCGGCGAGCACGTGGGCGCCCTGGCAATGAGCGAGC
CCGGCGCCGGCTCCGACGTGGTCAGCATGCGCCTGCGGGCCGACAAAAAAGGAGACCGCTTCATTCTTAACGGCAACAAG
ATGTGGATCACCAACGGCCCCCACGCCGACACCCTGGTGGTCTACGCCAAGACCGACATGAACGCGGGCCCCCGCGGCAT
TACCGCCTTCCTCATCGAGAAGGGATTCAAGGGGTTTTCCACGGCCCAGAAGCTGGACAAGCTCGGGATGAGGGGCTCCG
ACACCTGCGAGCTGGTCTTCGAAAACTGTGAGGTACCCGAAGAAAACATCCTCGGCGGCGTGGGCCGGGGGGTCAACGTA
CTCATGAGCGGCCTCGACTACGAGCGGGCGGTCTTGGCCTCCGGTCCGCTGGGGATCATGCAGGCCTGCATGGACGTGGT
CGTCCCCTACCTCCACGAGCGGAAGCAGTTCGATCAGCCCATCGGCCAGTTCCAACTCATGCAGGGGAAGATCGCCGACA
TGTACACCACCCTGAACGCCTCCCGGGCCTACGTCTACGCCGTCGCCAACGCCTGCACCCGTGGCGAAACAAGCCGCAAG
GACTGCGCCGGCGCCATCCTCTACGCAGCGGAAAAGGCCACCTGGATGGCCCTGGAGGCGATCCAGTGCCTCGGCGGCAA
CGGTTACATCAACGAGTACCCCACCGGTCGCCTCCTGCGGGACGCCAAGCTCTACGAGATCGGCGCCGGCACCAGCGAAA
TCCGCAGAATGCTCATCGGCCGCGAACTGTTCGAGGAAACGGTCCACGCCTGA

Upstream 100 bases:

>100_bases
TTACCTTTGCGTAAATAGCACACACACGGAAATCAGGCATGCAACCCTCTTCTCTCATAAGAGGGCGCCATTTCCGAAAA
AAACACAGGAGGGAGCAACG

Downstream 100 bases:

>100_bases
GGAAGCGGCGGCAGACGCCTGAACACGCAGAAACGACGAGGAGACCAACCCGCCATGAGCGTACTGAAAAGTTCCATCAA
CACAACTACCGAAGAGTTCC

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKAYPTLNFDLGETSSILRETVKEFAAKEITPRATDIDRDNHFPMDLWPKMGQLGLLGVTVSEEYGGAAMGYLEHVIAME
ELSRASASVGLAYGAHSNLCVNQIFRNGNESQRRKYLPKLISGEHVGALAMSEPGAGSDVVSMRLRADKKGDRFILNGNK
MWITNGPHADTLVVYAKTDMNAGPRGITAFLIEKGFKGFSTAQKLDKLGMRGSDTCELVFENCEVPEENILGGVGRGVNV
LMSGLDYERAVLASGPLGIMQACMDVVVPYLHERKQFDQPIGQFQLMQGKIADMYTTLNASRAYVYAVANACTRGETSRK
DCAGAILYAAEKATWMALEAIQCLGGNGYINEYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFEETVHA

Sequences:

>Translated_390_residues
MKAYPTLNFDLGETSSILRETVKEFAAKEITPRATDIDRDNHFPMDLWPKMGQLGLLGVTVSEEYGGAAMGYLEHVIAME
ELSRASASVGLAYGAHSNLCVNQIFRNGNESQRRKYLPKLISGEHVGALAMSEPGAGSDVVSMRLRADKKGDRFILNGNK
MWITNGPHADTLVVYAKTDMNAGPRGITAFLIEKGFKGFSTAQKLDKLGMRGSDTCELVFENCEVPEENILGGVGRGVNV
LMSGLDYERAVLASGPLGIMQACMDVVVPYLHERKQFDQPIGQFQLMQGKIADMYTTLNASRAYVYAVANACTRGETSRK
DCAGAILYAAEKATWMALEAIQCLGGNGYINEYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFEETVHA
>Mature_390_residues
MKAYPTLNFDLGETSSILRETVKEFAAKEITPRATDIDRDNHFPMDLWPKMGQLGLLGVTVSEEYGGAAMGYLEHVIAME
ELSRASASVGLAYGAHSNLCVNQIFRNGNESQRRKYLPKLISGEHVGALAMSEPGAGSDVVSMRLRADKKGDRFILNGNK
MWITNGPHADTLVVYAKTDMNAGPRGITAFLIEKGFKGFSTAQKLDKLGMRGSDTCELVFENCEVPEENILGGVGRGVNV
LMSGLDYERAVLASGPLGIMQACMDVVVPYLHERKQFDQPIGQFQLMQGKIADMYTTLNASRAYVYAVANACTRGETSRK
DCAGAILYAAEKATWMALEAIQCLGGNGYINEYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFEETVHA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=65.3333333333333, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI226958414, Length=338, Percent_Identity=68.6390532544379, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=40.5835543766578, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=36.7847411444142, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI21361497, Length=373, Percent_Identity=38.0697050938338, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI4557231, Length=379, Percent_Identity=34.3007915567282, Blast_Score=231, Evalue=6e-61,
Organism=Homo sapiens, GI187960098, Length=379, Percent_Identity=34.3007915567282, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI7656849, Length=380, Percent_Identity=34.4736842105263, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI4501857, Length=372, Percent_Identity=33.6021505376344, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI76496475, Length=381, Percent_Identity=32.2834645669291, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI4557235, Length=381, Percent_Identity=32.2834645669291, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI4503943, Length=376, Percent_Identity=31.9148936170213, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI7669494, Length=372, Percent_Identity=32.5268817204301, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI48976061, Length=286, Percent_Identity=23.7762237762238, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI211971008, Length=286, Percent_Identity=23.7762237762238, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI38505218, Length=278, Percent_Identity=21.5827338129496, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=26.7716535433071, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=28.1984334203655, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87082384, Length=258, Percent_Identity=27.5193798449612, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081702, Length=303, Percent_Identity=26.4026402640264, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=388, Percent_Identity=64.4329896907217, Blast_Score=521, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=36.3874345549738, Blast_Score=251, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=35.0404312668464, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17534899, Length=383, Percent_Identity=35.7702349869452, Blast_Score=244, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17506239, Length=377, Percent_Identity=34.7480106100796, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=32.8083989501312, Blast_Score=227, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI17533517, Length=371, Percent_Identity=34.7708894878706, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=39.9280575539568, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=31.4285714285714, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=38.0952380952381, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71982178, Length=267, Percent_Identity=36.7041198501873, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17534353, Length=379, Percent_Identity=29.8153034300792, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=30.6451612903226, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17551932, Length=368, Percent_Identity=30.7065217391304, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71985192, Length=284, Percent_Identity=31.3380281690141, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17531909, Length=247, Percent_Identity=29.5546558704453, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI86563381, Length=281, Percent_Identity=28.1138790035587, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=281, Percent_Identity=28.1138790035587, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355753, Length=389, Percent_Identity=62.4678663239075, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI21356377, Length=376, Percent_Identity=39.8936170212766, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=38.8297872340425, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=34.7480106100796, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24660351, Length=381, Percent_Identity=35.9580052493438, Blast_Score=241, Evalue=4e-64,
Organism=Drosophila melanogaster, GI281363737, Length=353, Percent_Identity=32.0113314447592, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19920834, Length=385, Percent_Identity=29.6103896103896, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42676; Mature: 42676

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAYPTLNFDLGETSSILRETVKEFAAKEITPRATDIDRDNHFPMDLWPKMGQLGLLGVT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCEEEEEE
VSEEYGGAAMGYLEHVIAMEELSRASASVGLAYGAHSNLCVNQIFRNGNESQRRKYLPKL
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCHHHHHHHHHHH
ISGEHVGALAMSEPGAGSDVVSMRLRADKKGDRFILNGNKMWITNGPHADTLVVYAKTDM
HCCCCCCEEEECCCCCCCHHHEEEECCCCCCCEEEECCCEEEEECCCCCCEEEEEEECCC
NAGPRGITAFLIEKGFKGFSTAQKLDKLGMRGSDTCELVFENCEVPEENILGGVGRGVNV
CCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHCCCCCCCHHH
LMSGLDYERAVLASGPLGIMQACMDVVVPYLHERKQFDQPIGQFQLMQGKIADMYTTLNA
HHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHCCC
SRAYVYAVANACTRGETSRKDCAGAILYAAEKATWMALEAIQCLGGNGYINEYPTGRLLR
CCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
DAKLYEIGAGTSEIRRMLIGRELFEETVHA
CCEEEEECCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAYPTLNFDLGETSSILRETVKEFAAKEITPRATDIDRDNHFPMDLWPKMGQLGLLGVT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCEEEEEE
VSEEYGGAAMGYLEHVIAMEELSRASASVGLAYGAHSNLCVNQIFRNGNESQRRKYLPKL
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCHHHHHHHHHHH
ISGEHVGALAMSEPGAGSDVVSMRLRADKKGDRFILNGNKMWITNGPHADTLVVYAKTDM
HCCCCCCEEEECCCCCCCHHHEEEECCCCCCCEEEECCCEEEEECCCCCCEEEEEEECCC
NAGPRGITAFLIEKGFKGFSTAQKLDKLGMRGSDTCELVFENCEVPEENILGGVGRGVNV
CCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHCCCCCCCHHH
LMSGLDYERAVLASGPLGIMQACMDVVVPYLHERKQFDQPIGQFQLMQGKIADMYTTLNA
HHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHCCC
SRAYVYAVANACTRGETSRKDCAGAILYAAEKATWMALEAIQCLGGNGYINEYPTGRLLR
CCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
DAKLYEIGAGTSEIRRMLIGRELFEETVHA
CCEEEEECCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]