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The map label for this gene is hppA

Identifier: 78224430

GI number: 78224430

Start: 3644496

End: 3646550

Strand: Reverse

Name: hppA

Synonym: Gmet_3239

Alternate gene names: 78224430

Gene position: 3646550-3644496 (Counterclockwise)

Preceding gene: 78224452

Following gene: 78224421

Centisome position: 91.22

GC content: 64.91

Gene sequence:

>2055_bases
ATGGAACAGTATGCAGTTTATTTCGCCCTGGCCTGTGCCGTGGCGGCCGTCGCCTACGGCCTCGTTTCGGCCCAGTGGAT
TCTGGGGCTCCCCCAGGGCAACGACCGGATGCGCCAGATTGCGGCAGCCATCCAGGAGGGTGCCGGCGCCTACATGAAGC
GCCAGTACACCATCATCGCCGTCGTCGGGGTGATCATGTTCATCGCCCTGTTCGCTACCCTGGGGATGAAAACCGCCATC
GGCTTCGCCATCGGCGCCCTCTTCTCGGGACTGACCGGCTTCATCGGCATGTTCGTTTCGGTCCGCGCCAACATCCGCAC
CACGGAAGCGGCCAAATCCGGCATCCACAAGGCCCTCAACGTGGCCTTCAAGGGGGGCGCCATTACCGGCATGCTGGTGG
TGGGTCTGGGGCTCCTGGGTGTTGCCGGTTACTACTTCATCCTCCAGCAGGTCATGCCGGGCGCCCCGGTGAAAGAGGTG
GTCAGCCAGCTTGTGGGCCTCGGCTTCGGCGGCTCGCTCATCTCCATCTTCGCCCGTCTCGGCGGCGGCATCTTCACCAA
GGGTGCCGACGTGGGCGCCGACCTGGTGGGTAAGGTGGAGGCCGGCATCCCCGAGGACGACCCCCGCAACCCGGCGGTCA
TCGCCGACAACGTGGGGGACAACGTGGGTGACTGCGCCGGCATGGCCGCCGACCTGTTCGAGACCTACGCCGTGACCCTC
ATCGCCGCCATGCTCCTCGGCGCCATCGCCTTCACCGGCAATGTCGCCGCCGTCAACTATCCGCTGATCCTCGGCGGCAT
CTCCATCGTCGCCTCCATCATCGGCACCTTCTTCGTGAAGCTGGGCGGCAACCAGAAGATCATGCCCGCACTCTACAAGG
GGCTCATCGCTTCCGGCGTCCTGGCCTGCATCGCCTTCTATGTGGTGACCGCCCAGATGTTCCCCCAGGGGCTGACCACT
GCCGCCGGGGTGACCTATTCGGCCACCAACCTCTTCATCTCCGCCATCGTGGGCCTCGTGGTCACCGGTGCCATCTTCTG
GATCACCGAATACTACACCGCCACCGAGTACGGGCCGGTTAAGCACATCGCCCAGGCCTCCACCACCGGCCACGCCACCA
ACATCATCGCCGGCCTCGGCGTCTCCATGAAGTCCACCGCCATGCCGGTCATCGTCATCGCCGCCGGCATCATCGTCGCC
TTCCAGTGCGCCGGAGTCTACGGCATCGCCATTGCCGCCGTCTCCATGCTGTCGCTGACCGGCATCGTCGTCGCCATGGA
CGCCTACGGCCCCATCACCGACAACGCCGGTGGCATCGCCGAGATGGCCGAGCTGGACGACTCGGTCCGCGCCGTCACCG
ACCCCCTGGACGCCGTGGGGAACACCACCAAGGCGGTCACCAAGGGGTACGCCATTGGCTCCGCCGGCCTTGCCGCGGTC
ATCCTCTTCACCTCCTACGTAGATGAGCTGAAGCTGGCCGGCAAGATTATTGACTTCAACCTGGCCGATCCCTACATCAT
CGTCGGTCTGTTCCTCGGCGGGATGCTCCCCTACTACTTCGCCGCCCTCTGCATGGAGGCGGTTGGCAAGGCGGGCGGGT
CGGTCGTTGAGGAAGTCCGTCGCCAGTTCCGTGAAATCAAGGGAATCATGGAAGGGACCGGCAAGCCGGACTACGCCTCC
TGCGTCGACATCGTGACCAGGACGGCGCTTAAGGAGATGGTCATTCCCGGCATCATCCCCATCGCCGCTCCGATCATCAT
CGGTTTCACCCTCGGCCCCAAGGCCCTGGGCGGGGTCATCGTCGGCACCATCGTCACCGGTATCTTCGTGGCCATCTCCA
TGACCACCGGCGGCGGCGCCTGGGATAACGCCAAGAAGTACATCGAGGACGGCTACCACGGCGGCAAGGGTGGCGACGCC
CACAAGGCCGCCGTCACTGGCGACACCGTCGGCGACCCCTACAAGGATACCGCCGGCCCGGCCGTCAACCCGATGATCAA
GATCATCAACATCGTGTCGCTCCTCATCGTGCCGCTGCTCGCCAAGCTGGGGTAA

Upstream 100 bases:

>100_bases
ACGTTCTATAACAATGTTACGTTTTTTGCTCTCTTGGAGCATTGTCTGGTTCGAGCAGGTTCAAAGCCTTTCGCAGGCTA
TTTTGTCAGGAGGTTGGTAA

Downstream 100 bases:

>100_bases
CGTGACAAGCAGTTTTTGACGCAGAAAGGGCGGCCGGAATTTTCCGGACCGCCCTTTTTTATGCCCCCACTGCGGCCATG
TTCTCCCTCACTCCCGCACG

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 684; Mature: 684

Protein sequence:

>684_residues
MEQYAVYFALACAVAAVAYGLVSAQWILGLPQGNDRMRQIAAAIQEGAGAYMKRQYTIIAVVGVIMFIALFATLGMKTAI
GFAIGALFSGLTGFIGMFVSVRANIRTTEAAKSGIHKALNVAFKGGAITGMLVVGLGLLGVAGYYFILQQVMPGAPVKEV
VSQLVGLGFGGSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTL
IAAMLLGAIAFTGNVAAVNYPLILGGISIVASIIGTFFVKLGGNQKIMPALYKGLIASGVLACIAFYVVTAQMFPQGLTT
AAGVTYSATNLFISAIVGLVVTGAIFWITEYYTATEYGPVKHIAQASTTGHATNIIAGLGVSMKSTAMPVIVIAAGIIVA
FQCAGVYGIAIAAVSMLSLTGIVVAMDAYGPITDNAGGIAEMAELDDSVRAVTDPLDAVGNTTKAVTKGYAIGSAGLAAV
ILFTSYVDELKLAGKIIDFNLADPYIIVGLFLGGMLPYYFAALCMEAVGKAGGSVVEEVRRQFREIKGIMEGTGKPDYAS
CVDIVTRTALKEMVIPGIIPIAAPIIIGFTLGPKALGGVIVGTIVTGIFVAISMTTGGGAWDNAKKYIEDGYHGGKGGDA
HKAAVTGDTVGDPYKDTAGPAVNPMIKIINIVSLLIVPLLAKLG

Sequences:

>Translated_684_residues
MEQYAVYFALACAVAAVAYGLVSAQWILGLPQGNDRMRQIAAAIQEGAGAYMKRQYTIIAVVGVIMFIALFATLGMKTAI
GFAIGALFSGLTGFIGMFVSVRANIRTTEAAKSGIHKALNVAFKGGAITGMLVVGLGLLGVAGYYFILQQVMPGAPVKEV
VSQLVGLGFGGSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTL
IAAMLLGAIAFTGNVAAVNYPLILGGISIVASIIGTFFVKLGGNQKIMPALYKGLIASGVLACIAFYVVTAQMFPQGLTT
AAGVTYSATNLFISAIVGLVVTGAIFWITEYYTATEYGPVKHIAQASTTGHATNIIAGLGVSMKSTAMPVIVIAAGIIVA
FQCAGVYGIAIAAVSMLSLTGIVVAMDAYGPITDNAGGIAEMAELDDSVRAVTDPLDAVGNTTKAVTKGYAIGSAGLAAV
ILFTSYVDELKLAGKIIDFNLADPYIIVGLFLGGMLPYYFAALCMEAVGKAGGSVVEEVRRQFREIKGIMEGTGKPDYAS
CVDIVTRTALKEMVIPGIIPIAAPIIIGFTLGPKALGGVIVGTIVTGIFVAISMTTGGGAWDNAKKYIEDGYHGGKGGDA
HKAAVTGDTVGDPYKDTAGPAVNPMIKIINIVSLLIVPLLAKLG
>Mature_684_residues
MEQYAVYFALACAVAAVAYGLVSAQWILGLPQGNDRMRQIAAAIQEGAGAYMKRQYTIIAVVGVIMFIALFATLGMKTAI
GFAIGALFSGLTGFIGMFVSVRANIRTTEAAKSGIHKALNVAFKGGAITGMLVVGLGLLGVAGYYFILQQVMPGAPVKEV
VSQLVGLGFGGSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTL
IAAMLLGAIAFTGNVAAVNYPLILGGISIVASIIGTFFVKLGGNQKIMPALYKGLIASGVLACIAFYVVTAQMFPQGLTT
AAGVTYSATNLFISAIVGLVVTGAIFWITEYYTATEYGPVKHIAQASTTGHATNIIAGLGVSMKSTAMPVIVIAAGIIVA
FQCAGVYGIAIAAVSMLSLTGIVVAMDAYGPITDNAGGIAEMAELDDSVRAVTDPLDAVGNTTKAVTKGYAIGSAGLAAV
ILFTSYVDELKLAGKIIDFNLADPYIIVGLFLGGMLPYYFAALCMEAVGKAGGSVVEEVRRQFREIKGIMEGTGKPDYAS
CVDIVTRTALKEMVIPGIIPIAAPIIIGFTLGPKALGGVIVGTIVTGIFVAISMTTGGGAWDNAKKYIEDGYHGGKGGDA
HKAAVTGDTVGDPYKDTAGPAVNPMIKIINIVSLLIVPLLAKLG

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 70101; Mature: 70101

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQYAVYFALACAVAAVAYGLVSAQWILGLPQGNDRMRQIAAAIQEGAGAYMKRQYTIIA
CCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
VVGVIMFIALFATLGMKTAIGFAIGALFSGLTGFIGMFVSVRANIRTTEAAKSGIHKALN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAFKGGAITGMLVVGLGLLGVAGYYFILQQVMPGAPVKEVVSQLVGLGFGGSLISIFARL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHH
GGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTL
CCCEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IAAMLLGAIAFTGNVAAVNYPLILGGISIVASIIGTFFVKLGGNQKIMPALYKGLIASGV
HHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LACIAFYVVTAQMFPQGLTTAAGVTYSATNLFISAIVGLVVTGAIFWITEYYTATEYGPV
HHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
KHIAQASTTGHATNIIAGLGVSMKSTAMPVIVIAAGIIVAFQCAGVYGIAIAAVSMLSLT
HHHHHHCCCCCHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIVVAMDAYGPITDNAGGIAEMAELDDSVRAVTDPLDAVGNTTKAVTKGYAIGSAGLAAV
HHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHCCCCCCHHHHHH
ILFTSYVDELKLAGKIIDFNLADPYIIVGLFLGGMLPYYFAALCMEAVGKAGGSVVEEVR
HHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
RQFREIKGIMEGTGKPDYASCVDIVTRTALKEMVIPGIIPIAAPIIIGFTLGPKALGGVI
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHH
VGTIVTGIFVAISMTTGGGAWDNAKKYIEDGYHGGKGGDAHKAAVTGDTVGDPYKDTAGP
HHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCC
AVNPMIKIINIVSLLIVPLLAKLG
CHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEQYAVYFALACAVAAVAYGLVSAQWILGLPQGNDRMRQIAAAIQEGAGAYMKRQYTIIA
CCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
VVGVIMFIALFATLGMKTAIGFAIGALFSGLTGFIGMFVSVRANIRTTEAAKSGIHKALN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAFKGGAITGMLVVGLGLLGVAGYYFILQQVMPGAPVKEVVSQLVGLGFGGSLISIFARL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHH
GGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTL
CCCEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IAAMLLGAIAFTGNVAAVNYPLILGGISIVASIIGTFFVKLGGNQKIMPALYKGLIASGV
HHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LACIAFYVVTAQMFPQGLTTAAGVTYSATNLFISAIVGLVVTGAIFWITEYYTATEYGPV
HHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
KHIAQASTTGHATNIIAGLGVSMKSTAMPVIVIAAGIIVAFQCAGVYGIAIAAVSMLSLT
HHHHHHCCCCCHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIVVAMDAYGPITDNAGGIAEMAELDDSVRAVTDPLDAVGNTTKAVTKGYAIGSAGLAAV
HHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHCCCCCCHHHHHH
ILFTSYVDELKLAGKIIDFNLADPYIIVGLFLGGMLPYYFAALCMEAVGKAGGSVVEEVR
HHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
RQFREIKGIMEGTGKPDYASCVDIVTRTALKEMVIPGIIPIAAPIIIGFTLGPKALGGVI
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHH
VGTIVTGIFVAISMTTGGGAWDNAKKYIEDGYHGGKGGDAHKAAVTGDTVGDPYKDTAGP
HHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCC
AVNPMIKIINIVSLLIVPLLAKLG
CHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]