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The map label for this gene is trxA [H]

Identifier: 78224421

GI number: 78224421

Start: 3636182

End: 3636511

Strand: Reverse

Name: trxA [H]

Synonym: Gmet_3230

Alternate gene names: 78224421

Gene position: 3636511-3636182 (Counterclockwise)

Preceding gene: 78224430

Following gene: 78224420

Centisome position: 90.97

GC content: 59.7

Gene sequence:

>330_bases
ATGGCCAGTGAAAAGGTGCTGACGTTCAGTGATGATAACTTCGATACCGATGTGCTCAAGGCTACCGTTCCGGTCCTTGT
GGATTTCTGGGCCACCTGGTGCGCCCCCTGCAAGGCCATCGCCCCGGTCATCGACGCCATTGCCGACGAGTACGACGGCA
AGGTGAAGGTCGGCAAGGTAAACGTGGACGACAACCCCGGCACCCCCGGCAAGTATGGCGTACGCGGCATCCCTACGGTC
ATCCTCTTCAAGGACGGCAAGGTTGTCGACCAGGTCGTAGGGGCTGTTCCCAAGGCTCAGCTTGAGGCCCTCATCAAGAA
GGCGCTCTAG

Upstream 100 bases:

>100_bases
ATTGCCAAGGGGAGGGGAAACGGTGCCGTTTTCCTCCTTGATGTTTCGGGGAAGCTCGTCTATATTCTAAAAGTACAATT
TGTTTGACAAGGAGGCTTCC

Downstream 100 bases:

>100_bases
CTCGAACTAACTCAGGAGTTGTGCCTCTTATGCGGATAGTCCCTGTTTTGAGAGCTTTTGTTGCGGCGGCCGGTTTTACG
ATGGCGGTTGCCTCGCCGTC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MASEKVLTFSDDNFDTDVLKATVPVLVDFWATWCAPCKAIAPVIDAIADEYDGKVKVGKVNVDDNPGTPGKYGVRGIPTV
ILFKDGKVVDQVVGAVPKAQLEALIKKAL

Sequences:

>Translated_109_residues
MASEKVLTFSDDNFDTDVLKATVPVLVDFWATWCAPCKAIAPVIDAIADEYDGKVKVGKVNVDDNPGTPGKYGVRGIPTV
ILFKDGKVVDQVVGAVPKAQLEALIKKAL
>Mature_108_residues
ASEKVLTFSDDNFDTDVLKATVPVLVDFWATWCAPCKAIAPVIDAIADEYDGKVKVGKVNVDDNPGTPGKYGVRGIPTVI
LFKDGKVVDQVVGAVPKAQLEALIKKAL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=40.2061855670103, Blast_Score=81, Evalue=2e-16,
Organism=Homo sapiens, GI21361657, Length=84, Percent_Identity=40.4761904761905, Blast_Score=67, Evalue=3e-12,
Organism=Homo sapiens, GI5031973, Length=86, Percent_Identity=37.2093023255814, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=107, Percent_Identity=57.9439252336449, Blast_Score=138, Evalue=9e-35,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=43.4782608695652, Blast_Score=98, Evalue=1e-22,
Organism=Escherichia coli, GI87081747, Length=110, Percent_Identity=30, Blast_Score=75, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=100, Percent_Identity=35, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17510299, Length=98, Percent_Identity=40.8163265306122, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=108, Percent_Identity=37.037037037037, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=100, Percent_Identity=36, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=83, Percent_Identity=40.9638554216867, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=81, Percent_Identity=35.8024691358025, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=104, Percent_Identity=36.5384615384615, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=79, Percent_Identity=40.5063291139241, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=104, Percent_Identity=36.5384615384615, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=72, Percent_Identity=40.2777777777778, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=72, Percent_Identity=40.2777777777778, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144092, Length=90, Percent_Identity=37.7777777777778, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=84, Percent_Identity=44.047619047619, Blast_Score=71, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=95, Percent_Identity=40, Blast_Score=71, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=90, Percent_Identity=35.5555555555556, Blast_Score=63, Evalue=9e-12,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=34.020618556701, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639826, Length=71, Percent_Identity=45.0704225352113, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921434, Length=81, Percent_Identity=39.5061728395062, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21358065, Length=85, Percent_Identity=38.8235294117647, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664269, Length=71, Percent_Identity=39.4366197183099, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24639068, Length=103, Percent_Identity=32.0388349514563, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17648013, Length=82, Percent_Identity=37.8048780487805, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24583090, Length=82, Percent_Identity=37.8048780487805, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11631; Mature: 11499

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASEKVLTFSDDNFDTDVLKATVPVLVDFWATWCAPCKAIAPVIDAIADEYDGKVKVGKV
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
NVDDNPGTPGKYGVRGIPTVILFKDGKVVDQVVGAVPKAQLEALIKKAL
ECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ASEKVLTFSDDNFDTDVLKATVPVLVDFWATWCAPCKAIAPVIDAIADEYDGKVKVGKV
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
NVDDNPGTPGKYGVRGIPTVILFKDGKVVDQVVGAVPKAQLEALIKKAL
ECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]