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The map label for this gene is trpE [H]

Identifier: 78223698

GI number: 78223698

Start: 2839090

End: 2840565

Strand: Reverse

Name: trpE [H]

Synonym: Gmet_2497

Alternate gene names: 78223698

Gene position: 2840565-2839090 (Counterclockwise)

Preceding gene: 78223706

Following gene: 78223697

Centisome position: 71.06

GC content: 66.33

Gene sequence:

>1476_bases
GTGTATTTTCCCGATTTCGAGACCTTCCGGTCCCTGGCCTCCCAAGGCAACCTGATTCCCGTCTGCCGCGAGATCATGGC
CGATATGGACACGCCGGTCAGCGCCTTCCGCAAGATCGACGACGGTTCCTACTCCTTCCTCCTGGAAAGTATCGAGGGGG
GTGAGAAGTGGGGCCGCTATTCCTTTCTCGGCTCCAACCCTGCCACCGTCATCCGGACCCGCGGCACCACCGTGGAGATC
GTCACCAACGGCGAGACCCGCGCCGTTACCAGCGACGACCCCCTGGGCTTTGTGCGGGAGTATCTGAGCCGGTTCCACCC
CGTGGAGATCCCCGGGCTCCCTCGCTTCTTCGGCGGCGCCGTGGGATACCTGGGGTACGACATGGTGCGCCACTTCGAGC
GGCTTCCCACGGAGAAGCCGGCCGTCATCGGGGCCTGGGATTCCTGCTTCGTCATCACCGACACGATCCTGATCTTCGAC
ACCATGCGGCAGAAAATCACCGTGGTCTCCAACGCCCATCTGGAGGATGGACAGGCTCCTGAGGCCGCCTATGCCGAGGC
CATTGCCCGGGTGGACGCCCTCATCGCCAAGCTCCGAGCCCCCCTGCCGGCAATGCCGGCGACGCCTGCTGTGCGCACGG
TCTCCTTCTCGTCCAACGTTCCCCGCGAAAACTTCGAGGCGGCGGTGGAGAAATGCAAGGAGTACGTCCGGGCCGGGGAC
ATCATCCAGGTGGTCCTCTCCCAGCGCTTCTCCGGCGCGCTCACCGTGGAGCCCCTCGCCATCTACCGCGTGCTGCGGAC
CCTGAACCCTTCCCCCTACATGTTCTTCCTCCGCATGGACGACACCCTGGTGGTGGGGGCCTCCCCCGAGGTCATGGTCC
GCAAGGAGGGAGACCGGGTGGAGCTGCGCCCCATCGCCGGCACCCGCCCCCGGGGCGCGACCCCGGAGGAGGACCAACAA
CTGGCGGAAGAACTCCTGGCCGATCCCAAGGAGCGGGCCGAGCACGTGATGCTCGTGGACCTGGGGCGCAACGACCTGGG
GCGGGTCTGCCGGACCGGCACCGTGAAGGTGTCGGAGCTCATGGTCATCGAGCGCTATTCCCACGTGATGCACATCGTCT
CCAACGTGGAGGGGGAACTGGTCGAGGGGAAGGACGCCTTCGACGTGGTGCGGGCTACCTTCCCGGCGGGTACCCTCTCC
GGCGCCCCCAAGGTGCGGGCCATGGAGATCATCGACGAGCTGGAGCCGGTCCGCCGCGAGGTCTACGGCGGCGCCGTGGG
GTACTTCTCCTTCTCCGGCAACATGGACCTGGCCATCGCCATCCGCACCCTCGTCATCCGCGACGGCATGGTGCACCTCC
AGGCAGGCGCCGGCATCGTGGCCGACTCGGACCCGGCCGCGGAATACCAGGAGACCGTCAACAAGGCCATGGCTGCGGTT
AAGGCCATCGAGACCGCGGAAAAGGGATTGGACTGA

Upstream 100 bases:

>100_bases
TCTTGACACTCTCCGTCCCCGTGTGCTAGTTTAAACTCCTTTAAAAAAGAGCCTTTCCGGGCATTTTCTCCCCTCTGTTT
CCCGTTGATCGGAGCATCCC

Downstream 100 bases:

>100_bases
CATGTTGCTCATGATCGACAATTACGACTCCTTCACCTACAACATCGTCCAGTACTTTGGCGAACTGGGGGAGGATGTGC
GGGTCTTCCGCAACGACGGC

Product: anthranilate synthase, component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MYFPDFETFRSLASQGNLIPVCREIMADMDTPVSAFRKIDDGSYSFLLESIEGGEKWGRYSFLGSNPATVIRTRGTTVEI
VTNGETRAVTSDDPLGFVREYLSRFHPVEIPGLPRFFGGAVGYLGYDMVRHFERLPTEKPAVIGAWDSCFVITDTILIFD
TMRQKITVVSNAHLEDGQAPEAAYAEAIARVDALIAKLRAPLPAMPATPAVRTVSFSSNVPRENFEAAVEKCKEYVRAGD
IIQVVLSQRFSGALTVEPLAIYRVLRTLNPSPYMFFLRMDDTLVVGASPEVMVRKEGDRVELRPIAGTRPRGATPEEDQQ
LAEELLADPKERAEHVMLVDLGRNDLGRVCRTGTVKVSELMVIERYSHVMHIVSNVEGELVEGKDAFDVVRATFPAGTLS
GAPKVRAMEIIDELEPVRREVYGGAVGYFSFSGNMDLAIAIRTLVIRDGMVHLQAGAGIVADSDPAAEYQETVNKAMAAV
KAIETAEKGLD

Sequences:

>Translated_491_residues
MYFPDFETFRSLASQGNLIPVCREIMADMDTPVSAFRKIDDGSYSFLLESIEGGEKWGRYSFLGSNPATVIRTRGTTVEI
VTNGETRAVTSDDPLGFVREYLSRFHPVEIPGLPRFFGGAVGYLGYDMVRHFERLPTEKPAVIGAWDSCFVITDTILIFD
TMRQKITVVSNAHLEDGQAPEAAYAEAIARVDALIAKLRAPLPAMPATPAVRTVSFSSNVPRENFEAAVEKCKEYVRAGD
IIQVVLSQRFSGALTVEPLAIYRVLRTLNPSPYMFFLRMDDTLVVGASPEVMVRKEGDRVELRPIAGTRPRGATPEEDQQ
LAEELLADPKERAEHVMLVDLGRNDLGRVCRTGTVKVSELMVIERYSHVMHIVSNVEGELVEGKDAFDVVRATFPAGTLS
GAPKVRAMEIIDELEPVRREVYGGAVGYFSFSGNMDLAIAIRTLVIRDGMVHLQAGAGIVADSDPAAEYQETVNKAMAAV
KAIETAEKGLD
>Mature_491_residues
MYFPDFETFRSLASQGNLIPVCREIMADMDTPVSAFRKIDDGSYSFLLESIEGGEKWGRYSFLGSNPATVIRTRGTTVEI
VTNGETRAVTSDDPLGFVREYLSRFHPVEIPGLPRFFGGAVGYLGYDMVRHFERLPTEKPAVIGAWDSCFVITDTILIFD
TMRQKITVVSNAHLEDGQAPEAAYAEAIARVDALIAKLRAPLPAMPATPAVRTVSFSSNVPRENFEAAVEKCKEYVRAGD
IIQVVLSQRFSGALTVEPLAIYRVLRTLNPSPYMFFLRMDDTLVVGASPEVMVRKEGDRVELRPIAGTRPRGATPEEDQQ
LAEELLADPKERAEHVMLVDLGRNDLGRVCRTGTVKVSELMVIERYSHVMHIVSNVEGELVEGKDAFDVVRATFPAGTLS
GAPKVRAMEIIDELEPVRREVYGGAVGYFSFSGNMDLAIAIRTLVIRDGMVHLQAGAGIVADSDPAAEYQETVNKAMAAV
KAIETAEKGLD

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=472, Percent_Identity=36.6525423728814, Blast_Score=291, Evalue=6e-80,
Organism=Escherichia coli, GI1787518, Length=383, Percent_Identity=41.77545691906, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1786809, Length=252, Percent_Identity=30.1587301587302, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI87082077, Length=303, Percent_Identity=27.3927392739274, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320935, Length=503, Percent_Identity=42.1471172962227, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6324361, Length=405, Percent_Identity=27.4074074074074, Blast_Score=131, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 53960; Mature: 53960

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYFPDFETFRSLASQGNLIPVCREIMADMDTPVSAFRKIDDGSYSFLLESIEGGEKWGRY
CCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCE
SFLGSNPATVIRTRGTTVEIVTNGETRAVTSDDPLGFVREYLSRFHPVEIPGLPRFFGGA
EEECCCCCEEEEECCCEEEEEECCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
VGYLGYDMVRHFERLPTEKPAVIGAWDSCFVITDTILIFDTMRQKITVVSNAHLEDGQAP
HHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC
EAAYAEAIARVDALIAKLRAPLPAMPATPAVRTVSFSSNVPRENFEAAVEKCKEYVRAGD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IIQVVLSQRFSGALTVEPLAIYRVLRTLNPSPYMFFLRMDDTLVVGASPEVMVRKEGDRV
HHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCEEEEECCCEE
ELRPIAGTRPRGATPEEDQQLAEELLADPKERAEHVMLVDLGRNDLGRVCRTGTVKVSEL
EEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHCCEEEEEECCCCHHHHHHCCCCEEHHHH
MVIERYSHVMHIVSNVEGELVEGKDAFDVVRATFPAGTLSGAPKVRAMEIIDELEPVRRE
HHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
VYGGAVGYFSFSGNMDLAIAIRTLVIRDGMVHLQAGAGIVADSDPAAEYQETVNKAMAAV
HHCCEEEEEEECCCCCHHHHHHHHHHHCCEEEEECCCCEEECCCCHHHHHHHHHHHHHHH
KAIETAEKGLD
HHHHHHHHCCC
>Mature Secondary Structure
MYFPDFETFRSLASQGNLIPVCREIMADMDTPVSAFRKIDDGSYSFLLESIEGGEKWGRY
CCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCE
SFLGSNPATVIRTRGTTVEIVTNGETRAVTSDDPLGFVREYLSRFHPVEIPGLPRFFGGA
EEECCCCCEEEEECCCEEEEEECCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
VGYLGYDMVRHFERLPTEKPAVIGAWDSCFVITDTILIFDTMRQKITVVSNAHLEDGQAP
HHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC
EAAYAEAIARVDALIAKLRAPLPAMPATPAVRTVSFSSNVPRENFEAAVEKCKEYVRAGD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IIQVVLSQRFSGALTVEPLAIYRVLRTLNPSPYMFFLRMDDTLVVGASPEVMVRKEGDRV
HHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCEEEEECCCEE
ELRPIAGTRPRGATPEEDQQLAEELLADPKERAEHVMLVDLGRNDLGRVCRTGTVKVSEL
EEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHCCEEEEEECCCCHHHHHHCCCCEEHHHH
MVIERYSHVMHIVSNVEGELVEGKDAFDVVRATFPAGTLSGAPKVRAMEIIDELEPVRRE
HHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
VYGGAVGYFSFSGNMDLAIAIRTLVIRDGMVHLQAGAGIVADSDPAAEYQETVNKAMAAV
HHCCEEEEEEECCCCCHHHHHHHHHHHCCEEEEECCCCEEECCCCHHHHHHHHHHHHHHH
KAIETAEKGLD
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2732211 [H]