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The map label for this gene is trpF

Identifier: 78223693

GI number: 78223693

Start: 2834485

End: 2835093

Strand: Reverse

Name: trpF

Synonym: Gmet_2492

Alternate gene names: 78223693

Gene position: 2835093-2834485 (Counterclockwise)

Preceding gene: 78223694

Following gene: 78223692

Centisome position: 70.92

GC content: 66.17

Gene sequence:

>609_bases
ATGGTTCGCGTCAAGATCTGCGGCATAACCTCCCTGGAGGACGCCCTCATGGCGGTGGAGGCCGGAGCCGATGCCCTCGG
CTTCGTCTTCCATGAAGACTCTCCCCGTCACGTGCCCCCCGAGCAGGCCACCGGCATCATCGCCGGGCTTCCCCCCTTCG
TGCAGACCGTGGGCCTCTTCGTAAACCGCCCCATCGCATACGTCAACGAAACAGCGGCCCGGTGCCGCATCGACCTGGTC
CAGCTCCACGGCGACGAGCCTCCCGAGTTCTGCGCAGCCGTGGAGCGCCGGGTGATCAAGGCCTTCCGGGTACAGGACAT
CACGAGTCTCGACCCGATCAAGCACTACCGCGTCGCGGCCCATCTCCTCGATGCCTATTCCCCCAAGGCCTACGGCGGCA
CCGGCCTCACCTTCAACTGGGACATCGCAGCGGCGGCCAAGGAGTTCGGCCCGGTCATCCTTGCCGGCGGGCTCACCCCC
GACAACATTCGCGAGGCGGTGGAGGCAGTGAACCCTTACGCCGTGGACGTTTCGGGCGGTGTGGAGAGCGCCCCGGGCCG
AAAGGATGCGGCCAAGGTGCGGGAGTTTATTCGACGGGCGAAAGCATAG

Upstream 100 bases:

>100_bases
TACGACGCCTACCTCTCCGGCGGGCTGGAGGATTTCGAGTATCCCGAGGAGATGATTCGGGAGTCCCTGGCGCGGCTGCC
GAAGGTGGATCTGTAAGCGC

Downstream 100 bases:

>100_bases
AGGCCTGGAGGGGCGGGACAATGTATCGGAAAGGGGACGGAAGGAATTCCAACCCCTTTTCTTGCATGGTCATAGAGAGA
CGAGGTGTAGACACTCTATA

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MVRVKICGITSLEDALMAVEAGADALGFVFHEDSPRHVPPEQATGIIAGLPPFVQTVGLFVNRPIAYVNETAARCRIDLV
QLHGDEPPEFCAAVERRVIKAFRVQDITSLDPIKHYRVAAHLLDAYSPKAYGGTGLTFNWDIAAAAKEFGPVILAGGLTP
DNIREAVEAVNPYAVDVSGGVESAPGRKDAAKVREFIRRAKA

Sequences:

>Translated_202_residues
MVRVKICGITSLEDALMAVEAGADALGFVFHEDSPRHVPPEQATGIIAGLPPFVQTVGLFVNRPIAYVNETAARCRIDLV
QLHGDEPPEFCAAVERRVIKAFRVQDITSLDPIKHYRVAAHLLDAYSPKAYGGTGLTFNWDIAAAAKEFGPVILAGGLTP
DNIREAVEAVNPYAVDVSGGVESAPGRKDAAKVREFIRRAKA
>Mature_202_residues
MVRVKICGITSLEDALMAVEAGADALGFVFHEDSPRHVPPEQATGIIAGLPPFVQTVGLFVNRPIAYVNETAARCRIDLV
QLHGDEPPEFCAAVERRVIKAFRVQDITSLDPIKHYRVAAHLLDAYSPKAYGGTGLTFNWDIAAAAKEFGPVILAGGLTP
DNIREAVEAVNPYAVDVSGGVESAPGRKDAAKVREFIRRAKA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=192, Percent_Identity=35.4166666666667, Blast_Score=91, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6320210, Length=230, Percent_Identity=32.1739130434783, Blast_Score=82, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_GEOMG (Q39SQ9)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_385440.1
- ProteinModelPortal:   Q39SQ9
- SMR:   Q39SQ9
- STRING:   Q39SQ9
- GeneID:   3740168
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_2492
- NMPDR:   fig|269799.3.peg.2658
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   IQLHGRE
- PhylomeDB:   Q39SQ9
- ProtClustDB:   PRK01222
- BioCyc:   GMET269799:GMET_2492-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 21717; Mature: 21717

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRVKICGITSLEDALMAVEAGADALGFVFHEDSPRHVPPEQATGIIAGLPPFVQTVGLF
CEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCEEEECCCHHHHHHHHH
VNRPIAYVNETAARCRIDLVQLHGDEPPEFCAAVERRVIKAFRVQDITSLDPIKHYRVAA
HCCCHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
HLLDAYSPKAYGGTGLTFNWDIAAAAKEFGPVILAGGLTPDNIREAVEAVNPYAVDVSGG
HHHHHCCCCCCCCCCCEEECHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCEEEEECCC
VESAPGRKDAAKVREFIRRAKA
CCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MVRVKICGITSLEDALMAVEAGADALGFVFHEDSPRHVPPEQATGIIAGLPPFVQTVGLF
CEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCEEEECCCHHHHHHHHH
VNRPIAYVNETAARCRIDLVQLHGDEPPEFCAAVERRVIKAFRVQDITSLDPIKHYRVAA
HCCCHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
HLLDAYSPKAYGGTGLTFNWDIAAAAKEFGPVILAGGLTPDNIREAVEAVNPYAVDVSGG
HHHHHCCCCCCCCCCCEEECHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCEEEEECCC
VESAPGRKDAAKVREFIRRAKA
CCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA