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The map label for this gene is lpxK [H]

Identifier: 78223550

GI number: 78223550

Start: 2653398

End: 2654465

Strand: Reverse

Name: lpxK [H]

Synonym: Gmet_2347

Alternate gene names: 78223550

Gene position: 2654465-2653398 (Counterclockwise)

Preceding gene: 78223551

Following gene: 78223549

Centisome position: 66.4

GC content: 63.67

Gene sequence:

>1068_bases
ATGACACTCGAAGGATATTTCCGAAACCTTGTTTCCGGCAAGCGGCGGGGGATGCTGGATCGGCTCGTTCTGGCGCTTCT
CGCTGTTCTTTCCGTTCCGTACGCCCTGGCAGTTCGGTTGCGGGCACTCGCCTATGGTGCGGGGATCTTCCGGGTGAAGC
AGCTGAATCGTCCGGTCATCTCCGTTGGCAACCTCACCGTTGGCGGCACCGGCAAGACCCCCATGGTGGCGCTTGTTGCG
CGTCTGCTCATGGCGCGGGGGAAACGGGTGGCGGTCATCTCCCGGGGGTATGGGGGATCGTTGGAGGGAAAGACGCATAT
CGTCTCGGACGGTCAGAGGGTCTTTCTCTCCGCTGCCGAGGCGGGTGACGAACCGGTGCATCTTGCCACGGCGGTGCCGG
GGCTCATGGCGGTCATCGGTACCGACCGTTACGCTGCCGGGCTCCTGGCCCAGGAGCGGCTTAACCCCGATGTATTCATC
CTGGATGACGGCTTCCAGCATTTGCGGCTTCACCGGGACCTGAACATCCTCCTCATGGACTGTAGCGCTCCCCTCGGCAA
CGGCATGGTCCTCCCGGCGGGTTTGCTCCGGGAACCGCCGTTGGCCCTCAAACGGGCTGACTTGGTGGTCTACACCCGGT
GCACCGGTGCCGAGGCGCCAGCGGTTCACGGAGCCATTCCATCCTGCCGGGCTGGTCATGTGCTGGCTGGGGTGGAGCTT
CTTCCCGGTGGTGAGCGGCAACCGTTCACCGCCCTGTATGGCCGCAGAGGAGTTGCCTTTGCCGGCATTGCCGACCCCGA
CGCATTCTTCGCCTCACTCCGGGAGGAAGGGGTGGACCTTGCGGCAACGGTTTCCTTTGGCGACCACTGCCCCTACGGAG
AGGAAGAGGTAGCGCGGCTCATGGCGGCCCGCCGCACGGCCGGCGCCGATTTCCTCATAACCACCGGCAAGGATGCGGTC
AAGCTCGGACCGGTCCTGAGTCGGCTGGGGATTGTCTATGCGGCGGTGCTGGAGATGAGCCTTATGGATCCGAAACCCCT
CGAAACAGCCATCGACAAAGTGCTTTAA

Upstream 100 bases:

>100_bases
CCGCACGGCATCTGGAGATCATCGGCCCGCTCATTGAGCGAGGTAGCGAGGTAGCGAGGTAGCGAGGTTTTACCATTTTG
CTATCTCACCCGGATGAAAT

Downstream 100 bases:

>100_bases
AAGGAGATGCCCTCTATGGCATTATCAAGCGAATTGCTCAAGATTCTGGCCTGTCCTCAGTGCAAGGGGGAAGTAGTCTT
CCAGGACGACGAGGTGGGGC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTLEGYFRNLVSGKRRGMLDRLVLALLAVLSVPYALAVRLRALAYGAGIFRVKQLNRPVISVGNLTVGGTGKTPMVALVA
RLLMARGKRVAVISRGYGGSLEGKTHIVSDGQRVFLSAAEAGDEPVHLATAVPGLMAVIGTDRYAAGLLAQERLNPDVFI
LDDGFQHLRLHRDLNILLMDCSAPLGNGMVLPAGLLREPPLALKRADLVVYTRCTGAEAPAVHGAIPSCRAGHVLAGVEL
LPGGERQPFTALYGRRGVAFAGIADPDAFFASLREEGVDLAATVSFGDHCPYGEEEVARLMAARRTAGADFLITTGKDAV
KLGPVLSRLGIVYAAVLEMSLMDPKPLETAIDKVL

Sequences:

>Translated_355_residues
MTLEGYFRNLVSGKRRGMLDRLVLALLAVLSVPYALAVRLRALAYGAGIFRVKQLNRPVISVGNLTVGGTGKTPMVALVA
RLLMARGKRVAVISRGYGGSLEGKTHIVSDGQRVFLSAAEAGDEPVHLATAVPGLMAVIGTDRYAAGLLAQERLNPDVFI
LDDGFQHLRLHRDLNILLMDCSAPLGNGMVLPAGLLREPPLALKRADLVVYTRCTGAEAPAVHGAIPSCRAGHVLAGVEL
LPGGERQPFTALYGRRGVAFAGIADPDAFFASLREEGVDLAATVSFGDHCPYGEEEVARLMAARRTAGADFLITTGKDAV
KLGPVLSRLGIVYAAVLEMSLMDPKPLETAIDKVL
>Mature_354_residues
TLEGYFRNLVSGKRRGMLDRLVLALLAVLSVPYALAVRLRALAYGAGIFRVKQLNRPVISVGNLTVGGTGKTPMVALVAR
LLMARGKRVAVISRGYGGSLEGKTHIVSDGQRVFLSAAEAGDEPVHLATAVPGLMAVIGTDRYAAGLLAQERLNPDVFIL
DDGFQHLRLHRDLNILLMDCSAPLGNGMVLPAGLLREPPLALKRADLVVYTRCTGAEAPAVHGAIPSCRAGHVLAGVELL
PGGERQPFTALYGRRGVAFAGIADPDAFFASLREEGVDLAATVSFGDHCPYGEEEVARLMAARRTAGADFLITTGKDAVK
LGPVLSRLGIVYAAVLEMSLMDPKPLETAIDKVL

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=307, Percent_Identity=38.1107491856677, Blast_Score=140, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 37624; Mature: 37492

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLEGYFRNLVSGKRRGMLDRLVLALLAVLSVPYALAVRLRALAYGAGIFRVKQLNRPVI
CCCHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCEE
SVGNLTVGGTGKTPMVALVARLLMARGKRVAVISRGYGGSLEGKTHIVSDGQRVFLSAAE
EECCEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEECCCCEEEEEECC
AGDEPVHLATAVPGLMAVIGTDRYAAGLLAQERLNPDVFILDDGFQHLRLHRDLNILLMD
CCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCEEEEEE
CSAPLGNGMVLPAGLLREPPLALKRADLVVYTRCTGAEAPAVHGAIPSCRAGHVLAGVEL
CCCCCCCCEECCHHHHCCCCCHHEECCEEEEEECCCCCCCCCCCCCCCCCCCCEEECEEE
LPGGERQPFTALYGRRGVAFAGIADPDAFFASLREEGVDLAATVSFGDHCPYGEEEVARL
CCCCCCCCHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHH
MAARRTAGADFLITTGKDAVKLGPVLSRLGIVYAAVLEMSLMDPKPLETAIDKVL
HHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TLEGYFRNLVSGKRRGMLDRLVLALLAVLSVPYALAVRLRALAYGAGIFRVKQLNRPVI
CCHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCEE
SVGNLTVGGTGKTPMVALVARLLMARGKRVAVISRGYGGSLEGKTHIVSDGQRVFLSAAE
EECCEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEECCCCEEEEEECC
AGDEPVHLATAVPGLMAVIGTDRYAAGLLAQERLNPDVFILDDGFQHLRLHRDLNILLMD
CCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCEEEEEE
CSAPLGNGMVLPAGLLREPPLALKRADLVVYTRCTGAEAPAVHGAIPSCRAGHVLAGVEL
CCCCCCCCEECCHHHHCCCCCHHEECCEEEEEECCCCCCCCCCCCCCCCCCCCEEECEEE
LPGGERQPFTALYGRRGVAFAGIADPDAFFASLREEGVDLAATVSFGDHCPYGEEEVARL
CCCCCCCCHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHH
MAARRTAGADFLITTGKDAVKLGPVLSRLGIVYAAVLEMSLMDPKPLETAIDKVL
HHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA