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The map label for this gene is mmgA [H]

Identifier: 78223472

GI number: 78223472

Start: 2570329

End: 2571558

Strand: Reverse

Name: mmgA [H]

Synonym: Gmet_2268

Alternate gene names: 78223472

Gene position: 2571558-2570329 (Counterclockwise)

Preceding gene: 78223473

Following gene: 78223471

Centisome position: 64.33

GC content: 59.02

Gene sequence:

>1230_bases
ATGGGCAATCAGAACGATATCGTCATTATAAGCGCGGCGCGGACGCCGTTCAGCAAGTTCGGCGGGTTATTGAAGCAGAT
TCATAGCATTGAGCTCGGTGCGATGATCATCAGGGAAGTTCTGCAGCGGTCCGGCTTGAAGGGGAGCGACATCGACGAGG
TGTATTACGGGATGTGCATCCAGTCGGAAGCTGCGCTCAAGTATAACGTTGTGGCGCGGCAGGCCATGCTGCATGCGGGG
CTGCCACCCGAAACCCTTTCTCTGACGGTTGACCGGGCTTGCTGTTCGTCGCTCGCCGCGGTCCAGCTCGGGAGAAAGTC
TTTGCTGCTGGATGAGGCAAAGGTCTGTATGGCTGTCGGAGCTGAGAACATGAGCAACACTCCCGTGGTGCTCAATGGCC
ATCGCTGGGGGACGGGGCTGGGAAAACCCGAGATGGTGGACCACCTCAATCCGATCATGTACGTGGGGTTCAATTCTCTT
GCCGGTGATGCGGGGGCGGTCGCGCTGGAATATGATGTGTCGAGGGAGATGCAGGATGCCTGGGCCTATGCCTCCCAGAT
GAAATATCAGGCAGCCAAGGCCGCCGGCAAGTTCAGGCCGGGTGAAGAGGTGGCTGCCATCGAACTCTCCCAGAAAAAGG
GCGATCCAGTCATTTTTGCTGAAGACGAATTCCCCAAACCTAACACCACCCCGGAAGGGTTGGCAAAACTCCCACCAGTC
TACGGCAGTGCTACGGTGACTGCCGGCAATGCCCCGGGGCTTGACGCCGGTGCGTCGGCCTTGATCATCACCAAACGTGC
AACTGCGGACGCGTTGGGTGTCAAGCCGCTGGGCGTCATTCTTTCGGTTGCCAGCGTGGCCAGTGCGCCGCGCGGGATAG
CCGAGGTTCCGGCATTTGCGATTCAGAAGGCGCTCGACCGGGCGTCCGTGCAACTCGAGAACGTTGATCTGATCGAGATC
AACGAGGCGTTCGCAGCCATGCCGCTGGTGTCAACCAAGATCCTTGCTGATGGCGATCAGACAAAATGGGAAGAGTTGCT
GGCCAAAACCAACCCGAACGGCGGAGCCATAGCCATCGGCCATCCTGTCGGTGCAAGTGGGGCCAGGATTTTGATGACCG
CCATGTACGAACTGCGCAGGAGAGGTGGCGGGGTTGGTGTGGTCGGTATCTGCGGCGGTCTGGCCCAAGGGGACGCAGCC
GTTATCAGCGTTGATGAGAGTTGTCTGTAG

Upstream 100 bases:

>100_bases
GCTGGGAAGGAAGTCGGGAGAGGGGTGGTACAAGTACGATAAATAGCTTACTCCGCAGCTGGAAAATATCGCTGGCGAAA
GCCATGTAAGGATGGTGCAA

Downstream 100 bases:

>100_bases
AAGGAAAGAAGCTTTTTGATCAGAGACAGATGTGCGACGGTTCATTCTTAGTGTCGCCGAGAGTGAGAGAACCATGGAAC
AGACACTTGTTTCACCAGCT

Product: thiolase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MGNQNDIVIISAARTPFSKFGGLLKQIHSIELGAMIIREVLQRSGLKGSDIDEVYYGMCIQSEAALKYNVVARQAMLHAG
LPPETLSLTVDRACCSSLAAVQLGRKSLLLDEAKVCMAVGAENMSNTPVVLNGHRWGTGLGKPEMVDHLNPIMYVGFNSL
AGDAGAVALEYDVSREMQDAWAYASQMKYQAAKAAGKFRPGEEVAAIELSQKKGDPVIFAEDEFPKPNTTPEGLAKLPPV
YGSATVTAGNAPGLDAGASALIITKRATADALGVKPLGVILSVASVASAPRGIAEVPAFAIQKALDRASVQLENVDLIEI
NEAFAAMPLVSTKILADGDQTKWEELLAKTNPNGGAIAIGHPVGASGARILMTAMYELRRRGGGVGVVGICGGLAQGDAA
VISVDESCL

Sequences:

>Translated_409_residues
MGNQNDIVIISAARTPFSKFGGLLKQIHSIELGAMIIREVLQRSGLKGSDIDEVYYGMCIQSEAALKYNVVARQAMLHAG
LPPETLSLTVDRACCSSLAAVQLGRKSLLLDEAKVCMAVGAENMSNTPVVLNGHRWGTGLGKPEMVDHLNPIMYVGFNSL
AGDAGAVALEYDVSREMQDAWAYASQMKYQAAKAAGKFRPGEEVAAIELSQKKGDPVIFAEDEFPKPNTTPEGLAKLPPV
YGSATVTAGNAPGLDAGASALIITKRATADALGVKPLGVILSVASVASAPRGIAEVPAFAIQKALDRASVQLENVDLIEI
NEAFAAMPLVSTKILADGDQTKWEELLAKTNPNGGAIAIGHPVGASGARILMTAMYELRRRGGGVGVVGICGGLAQGDAA
VISVDESCL
>Mature_408_residues
GNQNDIVIISAARTPFSKFGGLLKQIHSIELGAMIIREVLQRSGLKGSDIDEVYYGMCIQSEAALKYNVVARQAMLHAGL
PPETLSLTVDRACCSSLAAVQLGRKSLLLDEAKVCMAVGAENMSNTPVVLNGHRWGTGLGKPEMVDHLNPIMYVGFNSLA
GDAGAVALEYDVSREMQDAWAYASQMKYQAAKAAGKFRPGEEVAAIELSQKKGDPVIFAEDEFPKPNTTPEGLAKLPPVY
GSATVTAGNAPGLDAGASALIITKRATADALGVKPLGVILSVASVASAPRGIAEVPAFAIQKALDRASVQLENVDLIEIN
EAFAAMPLVSTKILADGDQTKWEELLAKTNPNGGAIAIGHPVGASGARILMTAMYELRRRGGGVGVVGICGGLAQGDAAV
ISVDESCL

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=405, Percent_Identity=37.037037037037, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI148539872, Length=404, Percent_Identity=36.3861386138614, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4557237, Length=399, Percent_Identity=32.5814536340852, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI4501853, Length=403, Percent_Identity=33.4987593052109, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4504327, Length=432, Percent_Identity=29.1666666666667, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI194353979, Length=404, Percent_Identity=27.4752475247525, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87082165, Length=405, Percent_Identity=37.5308641975309, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1788554, Length=402, Percent_Identity=39.8009950248756, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=35.1485148514851, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=33.0845771144279, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1788683, Length=417, Percent_Identity=30.6954436450839, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=400, Percent_Identity=33.75, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI25147385, Length=394, Percent_Identity=31.4720812182741, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17535921, Length=410, Percent_Identity=30.9756097560976, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17551802, Length=427, Percent_Identity=29.9765807962529, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17535917, Length=397, Percent_Identity=25.9445843828715, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6325229, Length=399, Percent_Identity=33.5839598997494, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322031, Length=407, Percent_Identity=31.6953316953317, Blast_Score=153, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24655093, Length=396, Percent_Identity=35.3535353535354, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI17648125, Length=405, Percent_Identity=36.5432098765432, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24640423, Length=396, Percent_Identity=33.8383838383838, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17137578, Length=433, Percent_Identity=31.4087759815243, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42712; Mature: 42580

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNQNDIVIISAARTPFSKFGGLLKQIHSIELGAMIIREVLQRSGLKGSDIDEVYYGMCI
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEE
QSEAALKYNVVARQAMLHAGLPPETLSLTVDRACCSSLAAVQLGRKSLLLDEAKVCMAVG
CCCCCHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
AENMSNTPVVLNGHRWGTGLGKPEMVDHLNPIMYVGFNSLAGDAGAVALEYDVSREMQDA
CCCCCCCCEEEECCCCCCCCCCCHHHHHCCCEEEECCHHHCCCCCEEEEEECHHHHHHHH
WAYASQMKYQAAKAAGKFRPGEEVAAIELSQKKGDPVIFAEDEFPKPNTTPEGLAKLPPV
HHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHCCCC
YGSATVTAGNAPGLDAGASALIITKRATADALGVKPLGVILSVASVASAPRGIAEVPAFA
CCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
IQKALDRASVQLENVDLIEINEAFAAMPLVSTKILADGDQTKWEELLAKTNPNGGAIAIG
HHHHHHHHHEEECCCCEEEECHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCCCCEEEEC
HPVGASGARILMTAMYELRRRGGGVGVVGICGGLAQGDAAVISVDESCL
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCCC
>Mature Secondary Structure 
GNQNDIVIISAARTPFSKFGGLLKQIHSIELGAMIIREVLQRSGLKGSDIDEVYYGMCI
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEE
QSEAALKYNVVARQAMLHAGLPPETLSLTVDRACCSSLAAVQLGRKSLLLDEAKVCMAVG
CCCCCHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
AENMSNTPVVLNGHRWGTGLGKPEMVDHLNPIMYVGFNSLAGDAGAVALEYDVSREMQDA
CCCCCCCCEEEECCCCCCCCCCCHHHHHCCCEEEECCHHHCCCCCEEEEEECHHHHHHHH
WAYASQMKYQAAKAAGKFRPGEEVAAIELSQKKGDPVIFAEDEFPKPNTTPEGLAKLPPV
HHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHCCCC
YGSATVTAGNAPGLDAGASALIITKRATADALGVKPLGVILSVASVASAPRGIAEVPAFA
CCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
IQKALDRASVQLENVDLIEINEAFAAMPLVSTKILADGDQTKWEELLAKTNPNGGAIAIG
HHHHHHHHHEEECCCCEEEECHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCCCCEEEEC
HPVGASGARILMTAMYELRRRGGGVGVVGICGGLAQGDAAVISVDESCL
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]