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The map label for this gene is hbd [H]

Identifier: 78223473

GI number: 78223473

Start: 2571613

End: 2572503

Strand: Reverse

Name: hbd [H]

Synonym: Gmet_2269

Alternate gene names: 78223473

Gene position: 2572503-2571613 (Counterclockwise)

Preceding gene: 78223474

Following gene: 78223472

Centisome position: 64.35

GC content: 55.44

Gene sequence:

>891_bases
TTGAACAGCGACAACAAACTGCGCGGGGAGGAATCCATGGGTATTGGGAAAGTGGCGGTTATCGGATCGGGAATCATGGG
GCATGGCATATCGCAGGTGGTTGCGACGGCCGGCATCAACGTAGCGCTGAACGATATATCTGATCAGGTTCTTGAGAAAG
CGAAATCACACATTGCGGCATCACTTGACCGCGGCATCCAGCGGGGGAAACTGACCGAAGAGGACAAAAAGTCCATTCTT
GGACGGATCTCATACACGACTGACATCGCCCAGGCAGTGAAAGATGCCGATCTTGTCGTCGAGGCTGCCCCGGAAAACCT
GGAGCTGAAACATTCGATCTTCAGGAAGCTCGACCAGTACTGCAAACCGGAGGCTATACTGGCATCCAATACCTCCCAGT
ACAGTATTACCGAGTTGGCATCGGTTGTGGCAAATCCGAGCAGAGTGATCGGGATGCACTGGTTCAACCCGCCAGTGGCC
ATGAAATTGATCGAGATCATCAGGGGGCTGGAGACATCCGACGCGGTGCTGAACGAAATTGAGACGTTTTCCGCCGCGGT
GGGGAAGGAGACGGTCGTCTGCAAGGATTCGCAGGGGTTCATCAGCACGCGGGTTCTCGTAGCGATGCGCCTTGAGTGTT
ATCGCCTGGTGGAGGAGGGGATCGCAACCCCCGAAGATATCGACAAGACACTGCGACTTGCCTTTGGCCATCCGATGGGA
CAGTTCGAGCTTGCCGATTTTTCAGGACTGGATATCGAGCCTGCCGCCTGCGAGGCCCTGACAAAGACCTTTGGTGACCG
TTTCCGTGCCCCACAGATCCTGCTGCACCGCGTCAAAGCCGGAAAGCTGGGAAGGAAGTCGGGAGAGGGGTGGTACAAGT
ACGATAAATAG

Upstream 100 bases:

>100_bases
GAATACTTTTGGAAAATTCGAGCAGATCAGATCGGGTGCGGCTCCGGTCATCAGCATCGGCGAAAAGTCATTTACGGGTT
AAGGGAATGCAGGAGCGGTT

Downstream 100 bases:

>100_bases
CTTACTCCGCAGCTGGAAAATATCGCTGGCGAAAGCCATGTAAGGATGGTGCAAATGGGCAATCAGAACGATATCGTCAT
TATAAGCGCGGCGCGGACGC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MNSDNKLRGEESMGIGKVAVIGSGIMGHGISQVVATAGINVALNDISDQVLEKAKSHIAASLDRGIQRGKLTEEDKKSIL
GRISYTTDIAQAVKDADLVVEAAPENLELKHSIFRKLDQYCKPEAILASNTSQYSITELASVVANPSRVIGMHWFNPPVA
MKLIEIIRGLETSDAVLNEIETFSAAVGKETVVCKDSQGFISTRVLVAMRLECYRLVEEGIATPEDIDKTLRLAFGHPMG
QFELADFSGLDIEPAACEALTKTFGDRFRAPQILLHRVKAGKLGRKSGEGWYKYDK

Sequences:

>Translated_296_residues
MNSDNKLRGEESMGIGKVAVIGSGIMGHGISQVVATAGINVALNDISDQVLEKAKSHIAASLDRGIQRGKLTEEDKKSIL
GRISYTTDIAQAVKDADLVVEAAPENLELKHSIFRKLDQYCKPEAILASNTSQYSITELASVVANPSRVIGMHWFNPPVA
MKLIEIIRGLETSDAVLNEIETFSAAVGKETVVCKDSQGFISTRVLVAMRLECYRLVEEGIATPEDIDKTLRLAFGHPMG
QFELADFSGLDIEPAACEALTKTFGDRFRAPQILLHRVKAGKLGRKSGEGWYKYDK
>Mature_296_residues
MNSDNKLRGEESMGIGKVAVIGSGIMGHGISQVVATAGINVALNDISDQVLEKAKSHIAASLDRGIQRGKLTEEDKKSIL
GRISYTTDIAQAVKDADLVVEAAPENLELKHSIFRKLDQYCKPEAILASNTSQYSITELASVVANPSRVIGMHWFNPPVA
MKLIEIIRGLETSDAVLNEIETFSAAVGKETVVCKDSQGFISTRVLVAMRLECYRLVEEGIATPEDIDKTLRLAFGHPMG
QFELADFSGLDIEPAACEALTKTFGDRFRAPQILLHRVKAGKLGRKSGEGWYKYDK

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=40.2777777777778, Blast_Score=205, Evalue=3e-53,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=38.0327868852459, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI20127408, Length=279, Percent_Identity=36.2007168458781, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI261878539, Length=294, Percent_Identity=32.6530612244898, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI68989263, Length=294, Percent_Identity=32.6530612244898, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI115430219, Length=244, Percent_Identity=31.1475409836066, Blast_Score=109, Evalue=2e-24,
Organism=Escherichia coli, GI1787661, Length=284, Percent_Identity=41.5492957746479, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1788682, Length=261, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1790281, Length=262, Percent_Identity=32.0610687022901, Blast_Score=134, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=40.9722222222222, Blast_Score=227, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=40.7665505226481, Blast_Score=220, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=36.5853658536585, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25144276, Length=286, Percent_Identity=36.7132867132867, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17508951, Length=286, Percent_Identity=36.7132867132867, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17508953, Length=286, Percent_Identity=36.7132867132867, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17558304, Length=286, Percent_Identity=35.6643356643357, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71985923, Length=285, Percent_Identity=31.2280701754386, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71985930, Length=285, Percent_Identity=29.4736842105263, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI193203623, Length=197, Percent_Identity=28.4263959390863, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115533614, Length=197, Percent_Identity=28.4263959390863, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921000, Length=289, Percent_Identity=32.5259515570934, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24583077, Length=289, Percent_Identity=32.5259515570934, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24583079, Length=289, Percent_Identity=32.5259515570934, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI45549573, Length=234, Percent_Identity=31.1965811965812, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI20129993, Length=229, Percent_Identity=27.5109170305677, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 32277; Mature: 32277

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSDNKLRGEESMGIGKVAVIGSGIMGHGISQVVATAGINVALNDISDQVLEKAKSHIAA
CCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHH
SLDRGIQRGKLTEEDKKSILGRISYTTDIAQAVKDADLVVEAAPENLELKHSIFRKLDQY
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHH
CKPEAILASNTSQYSITELASVVANPSRVIGMHWFNPPVAMKLIEIIRGLETSDAVLNEI
CCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHH
ETFSAAVGKETVVCKDSQGFISTRVLVAMRLECYRLVEEGIATPEDIDKTLRLAFGHPMG
HHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
QFELADFSGLDIEPAACEALTKTFGDRFRAPQILLHRVKAGKLGRKSGEGWYKYDK
CEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNSDNKLRGEESMGIGKVAVIGSGIMGHGISQVVATAGINVALNDISDQVLEKAKSHIAA
CCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHH
SLDRGIQRGKLTEEDKKSILGRISYTTDIAQAVKDADLVVEAAPENLELKHSIFRKLDQY
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHH
CKPEAILASNTSQYSITELASVVANPSRVIGMHWFNPPVAMKLIEIIRGLETSDAVLNEI
CCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHH
ETFSAAVGKETVVCKDSQGFISTRVLVAMRLECYRLVEEGIATPEDIDKTLRLAFGHPMG
HHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
QFELADFSGLDIEPAACEALTKTFGDRFRAPQILLHRVKAGKLGRKSGEGWYKYDK
CEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]