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The map label for this gene is hisI

Identifier: 78223104

GI number: 78223104

Start: 2118509

End: 2118886

Strand: Direct

Name: hisI

Synonym: Gmet_1897

Alternate gene names: 78223104

Gene position: 2118509-2118886 (Clockwise)

Preceding gene: 78223103

Following gene: 78223105

Centisome position: 53.0

GC content: 57.67

Gene sequence:

>378_bases
ATGATCCAGATCGATTTCCAGAAAATGGGTGGGCTCATTCCCGCCATCATCCAGGACCACGAATCCGGCGAGGTTCTCAT
GGTGGCGTTCATGGACGAAAAAACCCTTAACCTGACCCTTGAGTCGGGCAAAACCTGGTTCTTCAGCCGCACCCGCAACA
AGTACTGGATGAAGGGCGAGGAGTCGGGTAACACCCAGGAGGTTATCGAGGTCCTCACCGACTGCGACGCCGACTCCGTG
GTCATCAAGGTGAAGCAGAACGGTCCGGCCGCCTGCCACACCGGCAACCGGAGCTGCTTCTACGTGCGGTGGGAGGGTGG
CCAGTGGGTAGAGCACTCCAACCCCCTCTTCGATCCGAAGGAGGTCTACAAAAAATGA

Upstream 100 bases:

>100_bases
GAGCAATGGCGTTTCTTCTGTTGACACTTTCTAAGGCGCCACGGTATTAAACACAGGTTGTTTTTCACGAACACTTTCCA
GAGGAGGCGCGTAAAACATT

Downstream 100 bases:

>100_bases
GCAACCTCCTGAACCTCGGCATCCCCAAGGGGAGCCTCGAAAACGCCACCGTGGAGCTCTTCAGGAAATCGGGATGGCAG
ATCAGCATCTCCTCCCGCAG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 125; Mature: 125

Protein sequence:

>125_residues
MIQIDFQKMGGLIPAIIQDHESGEVLMVAFMDEKTLNLTLESGKTWFFSRTRNKYWMKGEESGNTQEVIEVLTDCDADSV
VIKVKQNGPAACHTGNRSCFYVRWEGGQWVEHSNPLFDPKEVYKK

Sequences:

>Translated_125_residues
MIQIDFQKMGGLIPAIIQDHESGEVLMVAFMDEKTLNLTLESGKTWFFSRTRNKYWMKGEESGNTQEVIEVLTDCDADSV
VIKVKQNGPAACHTGNRSCFYVRWEGGQWVEHSNPLFDPKEVYKK
>Mature_125_residues
MIQIDFQKMGGLIPAIIQDHESGEVLMVAFMDEKTLNLTLESGKTWFFSRTRNKYWMKGEESGNTQEVIEVLTDCDADSV
VIKVKQNGPAACHTGNRSCFYVRWEGGQWVEHSNPLFDPKEVYKK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=98, Percent_Identity=46.9387755102041, Blast_Score=101, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319819, Length=75, Percent_Identity=36, Blast_Score=67, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 14305; Mature: 14305

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQIDFQKMGGLIPAIIQDHESGEVLMVAFMDEKTLNLTLESGKTWFFSRTRNKYWMKGE
CEEEEHHHHCCCCEEEEECCCCCCEEEEEEECCCEEEEEEECCCEEEEEECCCEEEECCC
ESGNTQEVIEVLTDCDADSVVIKVKQNGPAACHTGNRSCFYVRWEGGQWVEHSNPLFDPK
CCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCEEEEEECCCEEEECCCCCCCHH
EVYKK
HHHCC
>Mature Secondary Structure
MIQIDFQKMGGLIPAIIQDHESGEVLMVAFMDEKTLNLTLESGKTWFFSRTRNKYWMKGE
CEEEEHHHHCCCCEEEEECCCCCCEEEEEEECCCEEEEEEECCCEEEEEECCCEEEECCC
ESGNTQEVIEVLTDCDADSVVIKVKQNGPAACHTGNRSCFYVRWEGGQWVEHSNPLFDPK
CCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCEEEEEECCCEEEECCCCCCCHH
EVYKK
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA