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The map label for this gene is hisG

Identifier: 78223105

GI number: 78223105

Start: 2118883

End: 2119758

Strand: Direct

Name: hisG

Synonym: Gmet_1898

Alternate gene names: 78223105

Gene position: 2118883-2119758 (Clockwise)

Preceding gene: 78223104

Following gene: 78223116

Centisome position: 53.01

GC content: 63.24

Gene sequence:

>876_bases
ATGAGCAACCTCCTGAACCTCGGCATCCCCAAGGGGAGCCTCGAAAACGCCACCGTGGAGCTCTTCAGGAAATCGGGATG
GCAGATCAGCATCTCCTCCCGCAGCTACTTCCCCGGCGTTGATGACGACGAGCTGAACTGCAAGCTGATCCGCCCCCAGG
AGATGGGGAAATACGTGGAGCGCGGCACCATCGACGCCGGCATCGCCGGCCGCGACTGGGTCCGTGAGAACGACTCCGAC
GTGGTGGAAGTCTGCGAGATGGTCTACTCCAAAGTCTCCCGCCGCCCGGCCCGCTGGGTGCTGGTGGTCACCAAGGACTC
GACGGTGCAGAAGCCCGAAGACCTCCACGGCGCCACCATCTCCACCGAGCTGGTCGGTTTCACCAAGCGCTACTTCGCCG
AGCGCAACATCCCGGTGAACGTGGAGTTCTCCTGGGGGGCCACCGAGGCCAAGGTGGTGGATGGCCTCTGCGACGCCATC
GTTGAGGTGACCGAAACCGGCTCCACCATCAAGGCCAACGGCCTGCGCATCGTCTGCGACCTCATGGAGTCGGTGCCGGT
CCTCATCGCCAACAAGGCCGCCTGGGCCGATCCCTGGAAGCGCCAGAAGATCGAGACCATCGCCACGCTCCTCAAGGCGT
CCCTGGCCGCCGAAGGGATGGTGGGTCTCAAGATGAACGCCCCCAACGACAAGGTCGAGGCCATCACGGAAATCCTTCCC
AGCCTCAACCGTCCCACGGTTTCCCATCTCTACAAATCGGAGTGGGTCTCCATCGAGAGCGTGCTCCACGAGAAGGAAGT
GCGGCGGATAGTGCCGCAACTCCTGGCCCTCGGTGCCCAGGGGATCATCGAGTACTCGCTGAACAAGGTGCTGTGA

Upstream 100 bases:

>100_bases
GCCACACCGGCAACCGGAGCTGCTTCTACGTGCGGTGGGAGGGTGGCCAGTGGGTAGAGCACTCCAACCCCCTCTTCGAT
CCGAAGGAGGTCTACAAAAA

Downstream 100 bases:

>100_bases
TTCCTTTCTGGGAGGAACAGCCAGACCCGTTTGACGGTCAGCGGAACGGGCGCCGGCTGCGCTAAATGCTGTACGCAGCC
TCGCCTGCCGCTTCCCGATG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT 1; ATP-PRTase 1 [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSNLLNLGIPKGSLENATVELFRKSGWQISISSRSYFPGVDDDELNCKLIRPQEMGKYVERGTIDAGIAGRDWVRENDSD
VVEVCEMVYSKVSRRPARWVLVVTKDSTVQKPEDLHGATISTELVGFTKRYFAERNIPVNVEFSWGATEAKVVDGLCDAI
VEVTETGSTIKANGLRIVCDLMESVPVLIANKAAWADPWKRQKIETIATLLKASLAAEGMVGLKMNAPNDKVEAITEILP
SLNRPTVSHLYKSEWVSIESVLHEKEVRRIVPQLLALGAQGIIEYSLNKVL

Sequences:

>Translated_291_residues
MSNLLNLGIPKGSLENATVELFRKSGWQISISSRSYFPGVDDDELNCKLIRPQEMGKYVERGTIDAGIAGRDWVRENDSD
VVEVCEMVYSKVSRRPARWVLVVTKDSTVQKPEDLHGATISTELVGFTKRYFAERNIPVNVEFSWGATEAKVVDGLCDAI
VEVTETGSTIKANGLRIVCDLMESVPVLIANKAAWADPWKRQKIETIATLLKASLAAEGMVGLKMNAPNDKVEAITEILP
SLNRPTVSHLYKSEWVSIESVLHEKEVRRIVPQLLALGAQGIIEYSLNKVL
>Mature_290_residues
SNLLNLGIPKGSLENATVELFRKSGWQISISSRSYFPGVDDDELNCKLIRPQEMGKYVERGTIDAGIAGRDWVRENDSDV
VEVCEMVYSKVSRRPARWVLVVTKDSTVQKPEDLHGATISTELVGFTKRYFAERNIPVNVEFSWGATEAKVVDGLCDAIV
EVTETGSTIKANGLRIVCDLMESVPVLIANKAAWADPWKRQKIETIATLLKASLAAEGMVGLKMNAPNDKVEAITEILPS
LNRPTVSHLYKSEWVSIESVLHEKEVRRIVPQLLALGAQGIIEYSLNKVL

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=285, Percent_Identity=25.2631578947368, Blast_Score=82, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320896, Length=237, Percent_Identity=28.2700421940928, Blast_Score=103, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 32253; Mature: 32122

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLLNLGIPKGSLENATVELFRKSGWQISISSRSYFPGVDDDELNCKLIRPQEMGKYVE
CCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHH
RGTIDAGIAGRDWVRENDSDVVEVCEMVYSKVSRRPARWVLVVTKDSTVQKPEDLHGATI
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCH
STELVGFTKRYFAERNIPVNVEFSWGATEAKVVDGLCDAIVEVTETGSTIKANGLRIVCD
HHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHH
LMESVPVLIANKAAWADPWKRQKIETIATLLKASLAAEGMVGLKMNAPNDKVEAITEILP
HHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
SLNRPTVSHLYKSEWVSIESVLHEKEVRRIVPQLLALGAQGIIEYSLNKVL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
SNLLNLGIPKGSLENATVELFRKSGWQISISSRSYFPGVDDDELNCKLIRPQEMGKYVE
CCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHH
RGTIDAGIAGRDWVRENDSDVVEVCEMVYSKVSRRPARWVLVVTKDSTVQKPEDLHGATI
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCH
STELVGFTKRYFAERNIPVNVEFSWGATEAKVVDGLCDAIVEVTETGSTIKANGLRIVCD
HHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHH
LMESVPVLIANKAAWADPWKRQKIETIATLLKASLAAEGMVGLKMNAPNDKVEAITEILP
HHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
SLNRPTVSHLYKSEWVSIESVLHEKEVRRIVPQLLALGAQGIIEYSLNKVL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA