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The map label for this gene is clpP

Identifier: 78223080

GI number: 78223080

Start: 2088115

End: 2088714

Strand: Reverse

Name: clpP

Synonym: Gmet_1873

Alternate gene names: 78223080

Gene position: 2088714-2088115 (Counterclockwise)

Preceding gene: 78223081

Following gene: 78223079

Centisome position: 52.25

GC content: 51.67

Gene sequence:

>600_bases
ATGCTCGTACCGATCGTGGTCGAACAAACCGGCAGGGGAGAGCGCTCTTACGACATCTATTCGCGCCTTCTGAAGGACCG
GATCATTTTTCTTGGCGGCCCCATTGACGATCACGTGGCAAATCTTGTGATTGCCCAGCTTCTCTTCTTAGAGGCCGAGG
ATCCGGACAAGGATATTCACCTCTATATCAACTCTCCGGGAGGTGTCGTGACTGCCGGTATGGCGATATACGATACCATG
CAGTATATAAAGGCTCCCGTCTCCACGATTTGCGTCGGCCAAGCCGCTTCAATGGGAGCTCTTCTTCTTTCCGGCGGCGA
GAAGGGGAAACGGTTCAGCCTGACCCATTCCCGGATCATGATCCATCAGCCGCTTGGCGGTTTCCAGGGGCAGGCGACCG
ATATTCACATCCACGCCCAGGAAATTTTGAAGATGAAAAAAAGGCTCAATGAGATCATCGCCGAAAATTCAGGGCAGGCT
CTTGAGAAGGTTGAAGCTGACACCGAGCGTGATTATTTTATGTCTGGTGAAGAAGCAAAATCGTATGGTATTATTGACGC
AATTATAGCGCGTAAACCCACCAGCGGAGGTTCTCGGTGA

Upstream 100 bases:

>100_bases
TCTGAACGAGGAAAAAGTCTTGGGGTATCTTCTGGAGAATGCTGTCGTAACGGAAGTGGCCAAGGACGAACTCTAATAAC
ATATGGTTTCCGGAGGGAAT

Downstream 100 bases:

>100_bases
GTAGAAGAAACGACAGCAGCGAAAATCTGACCTGTTCTTTCTGTGGCAAGAGCCAGGATGAGGTGAAGAAGCTCATCGCA
GGGCCGACGGTCTATATTTG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGPIDDHVANLVIAQLLFLEAEDPDKDIHLYINSPGGVVTAGMAIYDTM
QYIKAPVSTICVGQAASMGALLLSGGEKGKRFSLTHSRIMIHQPLGGFQGQATDIHIHAQEILKMKKRLNEIIAENSGQA
LEKVEADTERDYFMSGEEAKSYGIIDAIIARKPTSGGSR

Sequences:

>Translated_199_residues
MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGPIDDHVANLVIAQLLFLEAEDPDKDIHLYINSPGGVVTAGMAIYDTM
QYIKAPVSTICVGQAASMGALLLSGGEKGKRFSLTHSRIMIHQPLGGFQGQATDIHIHAQEILKMKKRLNEIIAENSGQA
LEKVEADTERDYFMSGEEAKSYGIIDAIIARKPTSGGSR
>Mature_199_residues
MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGPIDDHVANLVIAQLLFLEAEDPDKDIHLYINSPGGVVTAGMAIYDTM
QYIKAPVSTICVGQAASMGALLLSGGEKGKRFSLTHSRIMIHQPLGGFQGQATDIHIHAQEILKMKKRLNEIIAENSGQA
LEKVEADTERDYFMSGEEAKSYGIIDAIIARKPTSGGSR

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=195, Percent_Identity=63.5897435897436, Blast_Score=260, Evalue=4e-70,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=69.1099476439791, Blast_Score=293, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=56.989247311828, Blast_Score=229, Evalue=6e-61,
Organism=Drosophila melanogaster, GI20129427, Length=194, Percent_Identity=60.8247422680412, Blast_Score=252, Evalue=9e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_GEOMG (Q39UH2)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384827.1
- ProteinModelPortal:   Q39UH2
- SMR:   Q39UH2
- STRING:   Q39UH2
- MEROPS:   S14.001
- GeneID:   3740271
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1873
- NMPDR:   fig|269799.3.peg.2136
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- PhylomeDB:   Q39UH2
- ProtClustDB:   PRK00277
- BioCyc:   GMET269799:GMET_1873-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21756; Mature: 21756

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 97-97 ACT_SITE 122-122

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGPIDDHVANLVIAQLLFLEAEDPDKDIH
CEEEEEEECCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGVVTAGMAIYDTMQYIKAPVSTICVGQAASMGALLLSGGEKGKRFSLTHSRIM
EEEECCCCEEEHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEECCCCCCEEEEEEEEEE
IHQPLGGFQGQATDIHIHAQEILKMKKRLNEIIAENSGQALEKVEADTERDYFMSGEEAK
EECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHCCCCCCC
SYGIIDAIIARKPTSGGSR
CCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGPIDDHVANLVIAQLLFLEAEDPDKDIH
CEEEEEEECCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGVVTAGMAIYDTMQYIKAPVSTICVGQAASMGALLLSGGEKGKRFSLTHSRIM
EEEECCCCEEEHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEECCCCCCEEEEEEEEEE
IHQPLGGFQGQATDIHIHAQEILKMKKRLNEIIAENSGQALEKVEADTERDYFMSGEEAK
EECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHCCCCCCC
SYGIIDAIIARKPTSGGSR
CCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA