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The map label for this gene is prsA [H]

Identifier: 78222035

GI number: 78222035

Start: 897972

End: 898991

Strand: Reverse

Name: prsA [H]

Synonym: Gmet_0815

Alternate gene names: 78222035

Gene position: 898991-897972 (Counterclockwise)

Preceding gene: 78222039

Following gene: 78222032

Centisome position: 22.49

GC content: 59.71

Gene sequence:

>1020_bases
ATGAACGTATTCAAAACAGCCCGCAGACAGATCATCGCCCTCTCGGCGATCGCCCTTCTTGCCGGCACTGCCGGGGCGAA
CGCTGCCCCCACAGCCAAGGCGGACGCGAAGGCGGGTGAGGCCCCGTCTGCCACGACAGCGGTTGCCCGGGTGAACGGCG
TCGACATCACCAGAGCCGAACTGGAGCGGGCGAAGAAGATCATCCTCTCCCGGAACCAGATGGCGAGTGCCGCCATGAAC
GACGAGATGTCGAAGAAGGTTGAGGAAGCGGCCCTCAACCAGCTCATCGCCAAGGAACTCCTCTTCCAGGCCGGCAAGAA
GCAGGAGATCAAGGATCTGGACAAGAAGATCCAGGAAAAGGTGGCCGAGCACAAGGCCCGCTTCAAGTCCCAGGCCGACT
ACGAGAAGGCCCTGAAGGAGATGGACATGACCGAGAAGGAGGTCGAGACCTTCACCAGGGAAGACATGGTCATCGGCAAC
CTGATTGAGACGAAGATCGTCGCCAACACCAAGATCACGGACGACGAGGCGAAGAAATTCTACAACGACAACAAGGACAA
GTTCCGCCGGGAGGAAGCGGTCCGCGCCAGCCACATCCTCGTGAGCGCGGATCAGAAGGCATCTCCGGAAGAGAAGAAAA
AGGCCAAGGAGAAGGCCGAGGCCCTGCTCAAGCAACTGAAGGGTGGCGCCGATTTTGCCGAACTGGCCAAGAAGGAATCC
TCCTGCCCCAGTTCCGCCCAGGGTGGTGATCTGGGCTTCTTCGGCAAGGGGCAGATGGTTCCCGAGTTTGAGAAGACCGC
CTTCAACCTCAAGCCGGGTGAGGTGAGCGACGTGGTGGAGACCCAGTTCGGCTACCACATCATCAAGCTGGCCGAGAAGA
AGGATGCTGAAACCGTCCCCTTCGAGGAGGCCAAGGAGCGGATCGTCCAGTTCCTCACCCAGCAGAAGGTGCAGGCCGGG
ATTGGCGAGTACGTGGATGAGCTGAGGAAGAAGGGGAAGGTCGAGATCCTCTCCAAGTAA

Upstream 100 bases:

>100_bases
TGCAAAACCGCCTAAAGACAGTAAAATTTACCCTTAACAACCCCGTCAAGGGGTGGTACGATTTATCGTGCTTTCATTTC
AGCCAAGGAGATAACACCGC

Downstream 100 bases:

>100_bases
CCGCAACTCTTCCCAGAAAACAGAAAAGGCCGCGCCGGACGATCCGGACGCGGCCTTTTCCTTTCCGCCCTCGACAGCTT
ACCCGTTCCTGTCTCCCATC

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MNVFKTARRQIIALSAIALLAGTAGANAAPTAKADAKAGEAPSATTAVARVNGVDITRAELERAKKIILSRNQMASAAMN
DEMSKKVEEAALNQLIAKELLFQAGKKQEIKDLDKKIQEKVAEHKARFKSQADYEKALKEMDMTEKEVETFTREDMVIGN
LIETKIVANTKITDDEAKKFYNDNKDKFRREEAVRASHILVSADQKASPEEKKKAKEKAEALLKQLKGGADFAELAKKES
SCPSSAQGGDLGFFGKGQMVPEFEKTAFNLKPGEVSDVVETQFGYHIIKLAEKKDAETVPFEEAKERIVQFLTQQKVQAG
IGEYVDELRKKGKVEILSK

Sequences:

>Translated_339_residues
MNVFKTARRQIIALSAIALLAGTAGANAAPTAKADAKAGEAPSATTAVARVNGVDITRAELERAKKIILSRNQMASAAMN
DEMSKKVEEAALNQLIAKELLFQAGKKQEIKDLDKKIQEKVAEHKARFKSQADYEKALKEMDMTEKEVETFTREDMVIGN
LIETKIVANTKITDDEAKKFYNDNKDKFRREEAVRASHILVSADQKASPEEKKKAKEKAEALLKQLKGGADFAELAKKES
SCPSSAQGGDLGFFGKGQMVPEFEKTAFNLKPGEVSDVVETQFGYHIIKLAEKKDAETVPFEEAKERIVQFLTQQKVQAG
IGEYVDELRKKGKVEILSK
>Mature_339_residues
MNVFKTARRQIIALSAIALLAGTAGANAAPTAKADAKAGEAPSATTAVARVNGVDITRAELERAKKIILSRNQMASAAMN
DEMSKKVEEAALNQLIAKELLFQAGKKQEIKDLDKKIQEKVAEHKARFKSQADYEKALKEMDMTEKEVETFTREDMVIGN
LIETKIVANTKITDDEAKKFYNDNKDKFRREEAVRASHILVSADQKASPEEKKKAKEKAEALLKQLKGGADFAELAKKES
SCPSSAQGGDLGFFGKGQMVPEFEKTAFNLKPGEVSDVVETQFGYHIIKLAEKKDAETVPFEEAKERIVQFLTQQKVQAG
IGEYVDELRKKGKVEILSK

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI5453898, Length=105, Percent_Identity=40.9523809523809, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1790211, Length=69, Percent_Identity=57.9710144927536, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786645, Length=331, Percent_Identity=22.9607250755287, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786238, Length=149, Percent_Identity=32.2147651006711, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322478, Length=108, Percent_Identity=40.7407407407407, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17647355, Length=105, Percent_Identity=39.0476190476191, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 37411; Mature: 37411

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVFKTARRQIIALSAIALLAGTAGANAAPTAKADAKAGEAPSATTAVARVNGVDITRAE
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHH
LERAKKIILSRNQMASAAMNDEMSKKVEEAALNQLIAKELLFQAGKKQEIKDLDKKIQEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VAEHKARFKSQADYEKALKEMDMTEKEVETFTREDMVIGNLIETKIVANTKITDDEAKKF
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
YNDNKDKFRREEAVRASHILVSADQKASPEEKKKAKEKAEALLKQLKGGADFAELAKKES
HCCCHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
SCPSSAQGGDLGFFGKGQMVPEFEKTAFNLKPGEVSDVVETQFGYHIIKLAEKKDAETVP
CCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
FEEAKERIVQFLTQQKVQAGIGEYVDELRKKGKVEILSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
>Mature Secondary Structure
MNVFKTARRQIIALSAIALLAGTAGANAAPTAKADAKAGEAPSATTAVARVNGVDITRAE
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHH
LERAKKIILSRNQMASAAMNDEMSKKVEEAALNQLIAKELLFQAGKKQEIKDLDKKIQEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VAEHKARFKSQADYEKALKEMDMTEKEVETFTREDMVIGNLIETKIVANTKITDDEAKKF
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
YNDNKDKFRREEAVRASHILVSADQKASPEEKKKAKEKAEALLKQLKGGADFAELAKKES
HCCCHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
SCPSSAQGGDLGFFGKGQMVPEFEKTAFNLKPGEVSDVVETQFGYHIIKLAEKKDAETVP
CCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
FEEAKERIVQFLTQQKVQAGIGEYVDELRKKGKVEILSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]