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The map label for this gene is atoC [H]

Identifier: 78222032

GI number: 78222032

Start: 894240

End: 895601

Strand: Reverse

Name: atoC [H]

Synonym: Gmet_0812

Alternate gene names: 78222032

Gene position: 895601-894240 (Counterclockwise)

Preceding gene: 78222035

Following gene: 78222020

Centisome position: 22.4

GC content: 63.07

Gene sequence:

>1362_bases
ATGAAAGAACGGACCCGCATCCTCCTCATCGATGACGAAGAATCGGGGCGCGAAGCTCTCACCCTCATCCTCAGGAATGC
CGGCCACCACGTCACGGGGGCGGCATCGGGGCGGGAAGCGGCCCAGCACCTTGCTCGGGACAAGTTCGACATCATCATTA
CCGACCTCTTCCTTCCCGACACCAACGGCATTGACATCCTCAAGGACGTCAAGAACGATTCCCCCCTCACCGAGGTGATC
CTCATCACCGGCCACGCCTCCGCCGAAACCGCCGTGCGGGCCATGAAAGAGGGGGCCTACGACTACATCACCAAGCCCCT
CAACATCGACGAACTCAGGATCATCATCGCCAAGGCCGTGGAGAAGCACCAGCTCCTCTCCGAAAACGTCTACCTCAGGA
AACAGCTCCGGGACAAATTCGAGTTCGCCAACATCATCGGCGCCTCGCCTGCCATGCAGCAGGTCTTCGCCCTCATGAAG
CGGATCGTCAAGACCGACTCCACGGTCCTCATCGCCGGCGAGTCGGGGACCGGTAAGGAAATCGTGGCCAAGGCGATCCA
TTTCAACGGCTCACGGCGCGAGCGGCCGTTCATCGCCGTCCACTGCGGCGCCATACCGGAGAATCTCCTGGAGTCGGAAC
TGTTCGGCTACGTGAAGGGGGCTTTCACCGGCGCGGTGAGGGACAAGATCGGCAAGTTCGAGGCGGCCAACGGCGGTACC
ATCTTCCTGGACGAGATCGGGACCATGCCGCTGCAGCTCCAGACAAAGCTCCTGCGGGTCCTGCAGGAGCAGGAGGTGGA
GCGGGTCGGTTCCACCCGTCCCATCAAGATCGACGTGCGGATCATCTCGGCCACCAACCTGGACCTGGCCGAGGAAGTGA
AGAAGGGGACCTTCCGCGAAGACCTCTACTACCGGCTCAACGTCATCCCCCTGGGCCTGCCGCCGCTCCGGGACCGGGTC
GAGGACATCCTCCCCCTGGCGAAGCACTTTCTCGCCAAGTACTGCAAAGAGATGCAGCGCCGCCGGATGACCCTCGCCAC
GGAAGCGGTGGAGGCCCTTGAAGGGTATCGATGGGGAGGGAACGTGAGGGAACTGGAGAACGTCATGGAGCGGGTCGTGG
CCCTCACCGAGGCGGACACCATCACCCTCCACGACCTCCCCCCCAACATCCGCGAGGAATCCCTCACTCGGGTCACCGAA
CGGGGTGTCGACCTCGTGAAAGTGATCGCCGAAATCGAGCGGAGCATGATCACCGACGCCCTGGCCCTCACCGACGGTGT
CAAGGCCCGGGCCGCGGCGCTCCTGAACCTGAACCGGACCACCCTCGTGGAAAAGATGCGCCGGCTCGGCATGCCGCTGT
AA

Upstream 100 bases:

>100_bases
TCACAGTATACCCGGCGCGGCGCGGCAGTCAACGTGACGGGAGGCTTGCCAAGGGCGACCCATTGGTGCTATGTATCAAA
CCTGCTCACGGGAGGCACCA

Downstream 100 bases:

>100_bases
CGTTTACGAATCTCCCTTCCCGTCAGAATAAATTCCCACGGTTTTCATCAATCTCTTTCCGCATTCACTGCTCCGCTGGA
AACCGTCCGAAACCGAAAAG

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKERTRILLIDDEESGREALTLILRNAGHHVTGAASGREAAQHLARDKFDIIITDLFLPDTNGIDILKDVKNDSPLTEVI
LITGHASAETAVRAMKEGAYDYITKPLNIDELRIIIAKAVEKHQLLSENVYLRKQLRDKFEFANIIGASPAMQQVFALMK
RIVKTDSTVLIAGESGTGKEIVAKAIHFNGSRRERPFIAVHCGAIPENLLESELFGYVKGAFTGAVRDKIGKFEAANGGT
IFLDEIGTMPLQLQTKLLRVLQEQEVERVGSTRPIKIDVRIISATNLDLAEEVKKGTFREDLYYRLNVIPLGLPPLRDRV
EDILPLAKHFLAKYCKEMQRRRMTLATEAVEALEGYRWGGNVRELENVMERVVALTEADTITLHDLPPNIREESLTRVTE
RGVDLVKVIAEIERSMITDALALTDGVKARAAALLNLNRTTLVEKMRRLGMPL

Sequences:

>Translated_453_residues
MKERTRILLIDDEESGREALTLILRNAGHHVTGAASGREAAQHLARDKFDIIITDLFLPDTNGIDILKDVKNDSPLTEVI
LITGHASAETAVRAMKEGAYDYITKPLNIDELRIIIAKAVEKHQLLSENVYLRKQLRDKFEFANIIGASPAMQQVFALMK
RIVKTDSTVLIAGESGTGKEIVAKAIHFNGSRRERPFIAVHCGAIPENLLESELFGYVKGAFTGAVRDKIGKFEAANGGT
IFLDEIGTMPLQLQTKLLRVLQEQEVERVGSTRPIKIDVRIISATNLDLAEEVKKGTFREDLYYRLNVIPLGLPPLRDRV
EDILPLAKHFLAKYCKEMQRRRMTLATEAVEALEGYRWGGNVRELENVMERVVALTEADTITLHDLPPNIREESLTRVTE
RGVDLVKVIAEIERSMITDALALTDGVKARAAALLNLNRTTLVEKMRRLGMPL
>Mature_453_residues
MKERTRILLIDDEESGREALTLILRNAGHHVTGAASGREAAQHLARDKFDIIITDLFLPDTNGIDILKDVKNDSPLTEVI
LITGHASAETAVRAMKEGAYDYITKPLNIDELRIIIAKAVEKHQLLSENVYLRKQLRDKFEFANIIGASPAMQQVFALMK
RIVKTDSTVLIAGESGTGKEIVAKAIHFNGSRRERPFIAVHCGAIPENLLESELFGYVKGAFTGAVRDKIGKFEAANGGT
IFLDEIGTMPLQLQTKLLRVLQEQEVERVGSTRPIKIDVRIISATNLDLAEEVKKGTFREDLYYRLNVIPLGLPPLRDRV
EDILPLAKHFLAKYCKEMQRRRMTLATEAVEALEGYRWGGNVRELENVMERVVALTEADTITLHDLPPNIREESLTRVTE
RGVDLVKVIAEIERSMITDALALTDGVKARAAALLNLNRTTLVEKMRRLGMPL

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=454, Percent_Identity=44.7136563876652, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1790299, Length=473, Percent_Identity=40.8033826638478, Blast_Score=344, Evalue=6e-96,
Organism=Escherichia coli, GI1790437, Length=443, Percent_Identity=41.5349887133183, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1788905, Length=442, Percent_Identity=40.0452488687783, Blast_Score=307, Evalue=1e-84,
Organism=Escherichia coli, GI87082117, Length=344, Percent_Identity=47.6744186046512, Blast_Score=304, Evalue=9e-84,
Organism=Escherichia coli, GI1789087, Length=334, Percent_Identity=47.9041916167665, Blast_Score=281, Evalue=6e-77,
Organism=Escherichia coli, GI1789233, Length=323, Percent_Identity=45.5108359133127, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1786524, Length=334, Percent_Identity=43.1137724550898, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI87082152, Length=321, Percent_Identity=42.6791277258567, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI87081872, Length=305, Percent_Identity=40.9836065573771, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1787583, Length=348, Percent_Identity=37.0689655172414, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI87081858, Length=314, Percent_Identity=30.8917197452229, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1789828, Length=266, Percent_Identity=32.7067669172932, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1787375, Length=107, Percent_Identity=31.7757009345794, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI87082012, Length=125, Percent_Identity=30.4, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1789809, Length=112, Percent_Identity=30.3571428571429, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786599, Length=109, Percent_Identity=33.9449541284404, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786911, Length=119, Percent_Identity=31.9327731092437, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1786784, Length=107, Percent_Identity=32.7102803738318, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50615; Mature: 50615

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKERTRILLIDDEESGREALTLILRNAGHHVTGAASGREAAQHLARDKFDIIITDLFLPD
CCCCCEEEEEECCCCCHHHHHHHHHCCCCCEECCCCHHHHHHHHHCCCCEEEEEEEECCC
TNGIDILKDVKNDSPLTEVILITGHASAETAVRAMKEGAYDYITKPLNIDELRIIIAKAV
CCCHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHH
EKHQLLSENVYLRKQLRDKFEFANIIGASPAMQQVFALMKRIVKTDSTVLIAGESGTGKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
IVAKAIHFNGSRRERPFIAVHCGAIPENLLESELFGYVKGAFTGAVRDKIGKFEAANGGT
HHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCE
IFLDEIGTMPLQLQTKLLRVLQEQEVERVGSTRPIKIDVRIISATNLDLAEEVKKGTFRE
EEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCHHHHHHCCCCHH
DLYYRLNVIPLGLPPLRDRVEDILPLAKHFLAKYCKEMQRRRMTLATEAVEALEGYRWGG
HHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NVRELENVMERVVALTEADTITLHDLPPNIREESLTRVTERGVDLVKVIAEIERSMITDA
CHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALTDGVKARAAALLNLNRTTLVEKMRRLGMPL
HHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKERTRILLIDDEESGREALTLILRNAGHHVTGAASGREAAQHLARDKFDIIITDLFLPD
CCCCCEEEEEECCCCCHHHHHHHHHCCCCCEECCCCHHHHHHHHHCCCCEEEEEEEECCC
TNGIDILKDVKNDSPLTEVILITGHASAETAVRAMKEGAYDYITKPLNIDELRIIIAKAV
CCCHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHH
EKHQLLSENVYLRKQLRDKFEFANIIGASPAMQQVFALMKRIVKTDSTVLIAGESGTGKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
IVAKAIHFNGSRRERPFIAVHCGAIPENLLESELFGYVKGAFTGAVRDKIGKFEAANGGT
HHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCE
IFLDEIGTMPLQLQTKLLRVLQEQEVERVGSTRPIKIDVRIISATNLDLAEEVKKGTFRE
EEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCHHHHHHCCCCHH
DLYYRLNVIPLGLPPLRDRVEDILPLAKHFLAKYCKEMQRRRMTLATEAVEALEGYRWGG
HHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NVRELENVMERVVALTEADTITLHDLPPNIREESLTRVTERGVDLVKVIAEIERSMITDA
CHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALTDGVKARAAALLNLNRTTLVEKMRRLGMPL
HHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]