Click here to switch to the map view.

The map label for this gene is phoR [H]

Identifier: 78221571

GI number: 78221571

Start: 389178

End: 390626

Strand: Reverse

Name: phoR [H]

Synonym: Gmet_0350

Alternate gene names: 78221571

Gene position: 390626-389178 (Counterclockwise)

Preceding gene: 78221574

Following gene: 78221566

Centisome position: 9.77

GC content: 62.11

Gene sequence:

>1449_bases
ATGGATCACCAGTTACGCATGCTTATCCTGGAAGACTCCGAAGACGATCTGCTTCTCTTGCTTCGAGAACTGCGCCGTGG
CGGTATCGACCCCGTCTACGAGCGGACCGAAACGGACGCCGGCATGCGCGCTCTCCTGGACGAACGGGAATGGGACGTAA
TCATAGCCGACTACAACATGCCCCGGTTCGGCGCCATGGTGGGGCTGGAGATCGTCAAGGAACGGGAGCTCGACATACCG
TTCATCATTGTTTCAGGCAAGATCGGCGAAGACCTGGCGGTGGCAGCCATGAAGGCCGGCGCCCACGATTATCTCATGAA
GGGCAACCTCTCGCGCCTGGTGCCGGCCATCGAGCGCGAAGTGAGGGAGGCCGGCGAACGCCGGCGCCGGCGCCAGGCCG
AAGCGGCCATGCGGAACCAGTTCAACCAGATCAGCACCATCTTCGACTCCCTCAACGCCCTGGTCTACGTGGTTGACATG
GACAGCTACCGGCTCCTCTACCTGAACAAGTACGGCGCCCAGCTTTTCGGCGAGAACTGGGAGGGGCGCCCCTGCCACGA
GGTGATCCAGGGGGGAAAGACGCTGCCATGCGACTTCTGCACCAACGACAAGCTCCTGCTGGACGGCAAGGCGCTCCCCC
CCTACATCTGGGAATACAAGAACATGACCACCGGCCGTTGGTACCAGTGCATCGACAAGGCGATCCGCTGGACCGACGAC
CGGCTCGTCCGGATGGAGATCGCCATCGACATCACCGAACGCAAAGAGATGGAGCGGATGAAGGACGAGATGATTTCCGC
CGTGAGCCACGAGATGCACACCCCCCTCACGGCCATGATCGGCTTCACCGAATTCCTGCTGGAAAACGAGGTAGACCGGG
AGCAGCAGAAAAACTGCCTCCAGACCATCCACAAGGAAACCGAGCGGCTGAGCGAGCTGATCAACAACTTTCTCCAACTC
CAGCGGCTCAAGGCAAGCATGGTCAAATTCCGGATCATGCCGGTGTCGGTGGGGCTTCTGCTGGCCGACGCCGCGGCCCT
CTACACAGCGGCATCCCGGAAGCACACCATTGTTGTGGAGTGCCCCCCGGATCTTCCACCGGTGCGCGGCAACGAGGAAC
AGCTCTACCAGGTGGCCGGCAACCTCATCTCCAACGCCATCAAGTACTCACCGGCCGGAGGGACCGTCACCCTCGGCGGG
AGGGCCGATGACGACATGGTCGTCTTCTGGGTGAAGGACAACGGGGTCGGCATCTCCCCCGAATTCCAGGAACGGGTTTT
CGAGCGGTTCTTCCGAGTCGACAACAGCGACCGGCGAAAGGTGGGAGGGGCCGGGCTGGGGCTCACCCTCGTGCGGGAAA
TCGTGGCGGCCCACGGCGGGCGGGTGTGGGTGGAGAGCACTCCCGACGCCGGAAGCACCTTCTTCGTCTCCCTGCCGAGA
ATGAAGTAA

Upstream 100 bases:

>100_bases
TAGAATTGTCATGCGAAATGGCCATATGACCGGCACGTCAGTCCGTCATCTCACCACCACACAACCATCGCCGGACACAG
TCCCGGGAACAGGACTCCCC

Downstream 100 bases:

>100_bases
TCCCTTCAGTGGGAAAGCCAGAGGTAATCGGCTTCCTCCGCCTTAATCCGGCCGTTGCGGACCACCGGGTCGGGCAGAAC
CACCCGGCTGGAGAGGCCGG

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MDHQLRMLILEDSEDDLLLLLRELRRGGIDPVYERTETDAGMRALLDEREWDVIIADYNMPRFGAMVGLEIVKERELDIP
FIIVSGKIGEDLAVAAMKAGAHDYLMKGNLSRLVPAIEREVREAGERRRRRQAEAAMRNQFNQISTIFDSLNALVYVVDM
DSYRLLYLNKYGAQLFGENWEGRPCHEVIQGGKTLPCDFCTNDKLLLDGKALPPYIWEYKNMTTGRWYQCIDKAIRWTDD
RLVRMEIAIDITERKEMERMKDEMISAVSHEMHTPLTAMIGFTEFLLENEVDREQQKNCLQTIHKETERLSELINNFLQL
QRLKASMVKFRIMPVSVGLLLADAAALYTAASRKHTIVVECPPDLPPVRGNEEQLYQVAGNLISNAIKYSPAGGTVTLGG
RADDDMVVFWVKDNGVGISPEFQERVFERFFRVDNSDRRKVGGAGLGLTLVREIVAAHGGRVWVESTPDAGSTFFVSLPR
MK

Sequences:

>Translated_482_residues
MDHQLRMLILEDSEDDLLLLLRELRRGGIDPVYERTETDAGMRALLDEREWDVIIADYNMPRFGAMVGLEIVKERELDIP
FIIVSGKIGEDLAVAAMKAGAHDYLMKGNLSRLVPAIEREVREAGERRRRRQAEAAMRNQFNQISTIFDSLNALVYVVDM
DSYRLLYLNKYGAQLFGENWEGRPCHEVIQGGKTLPCDFCTNDKLLLDGKALPPYIWEYKNMTTGRWYQCIDKAIRWTDD
RLVRMEIAIDITERKEMERMKDEMISAVSHEMHTPLTAMIGFTEFLLENEVDREQQKNCLQTIHKETERLSELINNFLQL
QRLKASMVKFRIMPVSVGLLLADAAALYTAASRKHTIVVECPPDLPPVRGNEEQLYQVAGNLISNAIKYSPAGGTVTLGG
RADDDMVVFWVKDNGVGISPEFQERVFERFFRVDNSDRRKVGGAGLGLTLVREIVAAHGGRVWVESTPDAGSTFFVSLPR
MK
>Mature_482_residues
MDHQLRMLILEDSEDDLLLLLRELRRGGIDPVYERTETDAGMRALLDEREWDVIIADYNMPRFGAMVGLEIVKERELDIP
FIIVSGKIGEDLAVAAMKAGAHDYLMKGNLSRLVPAIEREVREAGERRRRRQAEAAMRNQFNQISTIFDSLNALVYVVDM
DSYRLLYLNKYGAQLFGENWEGRPCHEVIQGGKTLPCDFCTNDKLLLDGKALPPYIWEYKNMTTGRWYQCIDKAIRWTDD
RLVRMEIAIDITERKEMERMKDEMISAVSHEMHTPLTAMIGFTEFLLENEVDREQQKNCLQTIHKETERLSELINNFLQL
QRLKASMVKFRIMPVSVGLLLADAAALYTAASRKHTIVVECPPDLPPVRGNEEQLYQVAGNLISNAIKYSPAGGTVTLGG
RADDDMVVFWVKDNGVGISPEFQERVFERFFRVDNSDRRKVGGAGLGLTLVREIVAAHGGRVWVESTPDAGSTFFVSLPR
MK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG5002

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=259, Percent_Identity=31.6602316602317, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI48994928, Length=241, Percent_Identity=32.7800829875519, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1789149, Length=257, Percent_Identity=31.1284046692607, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=31.1965811965812, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1786783, Length=217, Percent_Identity=31.7972350230415, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=26.4822134387352, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=28.3464566929134, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1788393, Length=224, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1788549, Length=242, Percent_Identity=29.3388429752066, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=28.8793103448276, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=25.5506607929515, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790436, Length=245, Percent_Identity=26.530612244898, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1790861, Length=217, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1787894, Length=227, Percent_Identity=28.6343612334802, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789403, Length=201, Percent_Identity=30.8457711442786, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789808, Length=226, Percent_Identity=25.6637168141593, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=25.7383966244726, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788279, Length=230, Percent_Identity=27.8260869565217, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790567, Length=242, Percent_Identity=27.6859504132231, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790300, Length=364, Percent_Identity=23.6263736263736, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54882; Mature: 54882

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS50112 PAS ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHQLRMLILEDSEDDLLLLLRELRRGGIDPVYERTETDAGMRALLDEREWDVIIADYNM
CCCCEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHCCCCCCEEEECCCC
PRFGAMVGLEIVKERELDIPFIIVSGKIGEDLAVAAMKAGAHDYLMKGNLSRLVPAIERE
CHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHH
VREAGERRRRRQAEAAMRNQFNQISTIFDSLNALVYVVDMDSYRLLYLNKYGAQLFGENW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCEEEEEEECCCHHHCCCCC
EGRPCHEVIQGGKTLPCDFCTNDKLLLDGKALPPYIWEYKNMTTGRWYQCIDKAIRWTDD
CCCCHHHHHCCCCCCCCCCCCCCEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCC
RLVRMEIAIDITERKEMERMKDEMISAVSHEMHTPLTAMIGFTEFLLENEVDREQQKNCL
CEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHH
QTIHKETERLSELINNFLQLQRLKASMVKFRIMPVSVGLLLADAAALYTAASRKHTIVVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEE
CPPDLPPVRGNEEQLYQVAGNLISNAIKYSPAGGTVTLGGRADDDMVVFWVKDNGVGISP
CCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEECCCCCCCEEEEEEECCCCCCCH
EFQERVFERFFRVDNSDRRKVGGAGLGLTLVREIVAAHGGRVWVESTPDAGSTFFVSLPR
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCC
MK
CC
>Mature Secondary Structure
MDHQLRMLILEDSEDDLLLLLRELRRGGIDPVYERTETDAGMRALLDEREWDVIIADYNM
CCCCEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHCCCCCCEEEECCCC
PRFGAMVGLEIVKERELDIPFIIVSGKIGEDLAVAAMKAGAHDYLMKGNLSRLVPAIERE
CHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHH
VREAGERRRRRQAEAAMRNQFNQISTIFDSLNALVYVVDMDSYRLLYLNKYGAQLFGENW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCEEEEEEECCCHHHCCCCC
EGRPCHEVIQGGKTLPCDFCTNDKLLLDGKALPPYIWEYKNMTTGRWYQCIDKAIRWTDD
CCCCHHHHHCCCCCCCCCCCCCCEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCC
RLVRMEIAIDITERKEMERMKDEMISAVSHEMHTPLTAMIGFTEFLLENEVDREQQKNCL
CEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHH
QTIHKETERLSELINNFLQLQRLKASMVKFRIMPVSVGLLLADAAALYTAASRKHTIVVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEE
CPPDLPPVRGNEEQLYQVAGNLISNAIKYSPAGGTVTLGGRADDDMVVFWVKDNGVGISP
CCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEECCCCCCCEEEEEEECCCCCCCH
EFQERVFERFFRVDNSDRRKVGGAGLGLTLVREIVAAHGGRVWVESTPDAGSTFFVSLPR
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCC
MK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]