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The map label for this gene is groEL

Identifier: 78221257

GI number: 78221257

Start: 34748

End: 36388

Strand: Direct

Name: groEL

Synonym: Gmet_0029

Alternate gene names: 78221257

Gene position: 34748-36388 (Clockwise)

Preceding gene: 78221256

Following gene: 78221258

Centisome position: 0.87

GC content: 61.97

Gene sequence:

>1641_bases
ATGGCAAAGATTATCAAGTTCGATCAGGAAGGGCGCAACGCCATCCTGAAAGGTGTCAATACTCTTGCTGACGCGGTCAA
GGTGACCCTCGGCCCCAAGGGACGCAACGTCATCATCGAGAAGTCGTTCGGCTCCCCGCTCATCACCAAGGACGGCGTCA
CCGTTGCCAAGGAAATTGAGCTGGAGGACAAGTTCGAGAACATGGGCGCCCAGCTGGTGAAGGAAGTCGCCTCCAAGACC
TCCGACGTTGCCGGCGACGGCACCACCACCGCCACGGTTCTCGCCCAGGCCATCTACCGCCAGGGCTCCAAGCTGGTGGC
CGCCGGCCACAACCCCATGGAGATCAAGCGCGGCATCGACAGCGCCGTTGAGACCATCGTGGCCGAGCTCCAGAAGATAT
CCAAGCCGATCAAGGACCACAAGGAGATCGCCCAGGTCGGCACCATCTCCGCCAACAACGACAAGACCATCGGCGGCATC
ATCGCCGAGGCCATGGAGAAGGTCGGCAAGGAAGGGGTCATCACCGTCGAGGAGGCCAAGGCCATGGAAACCAGCCTTGA
GACCGTCGAGGGGATGCAGTTCGACCGCGGCTACCTCTCCCCCTACTTCGTAACCGATCCGGAGCGCATGGAAGCTTCCC
TCGAGAACGCCAACATCCTGATCCACGACAAGAAGATCTCCAACATGAAGGACCTGCTCCCGATCCTTGAGCAGACCGCC
AAGAGCGGCCGTCCGCTGCTGATCATCGCCGAGGACATCGAGGGCGAGGCTCTGGCCACCCTGGTTGTCAACAAGCTGCG
CGGCGTCCTCAACATCTGCGCCGTGAAGGCTCCGGGCTTCGGCGACCGCCGCAAGGCCATGCTGGAAGACATCGCCGTTC
TCACCGGCGGCAAGGTGATTTCCGAAGAGCTCGGCTTCAAGCTCGAGAACGCCACCTTCGACATGCTCGGCACTGCCAAG
CGGGTCACCATCGACAAGGACAACACCACCATTATTGACGGCGACGGTTCTGAAGCCGATATCCAGGGCCGCGTGAAGCA
GATTCGTGCCCAGATCGAAGAAACCAGCAGCGACTATGACCGCGAGAAGCTCCAGGAGCGCCTGGCCAAGCTCGTGGGCG
GCGTTGCCGTCATCAAGGTCGGTGCCGCCACCGAAACCGAGATGAAAGAGAAGAAGGCACGGGTCGAGGACGCCCTCCAC
GCCACCCGCGCAGCCGTTGACGAAGGGATCGTCCCCGGCGGCGGCGTTGCCTATATCCGTTCCCTCGGCGCCCTTGAAGG
TATCAGCCTCCCGGCAGAGCAGCAGTTTGGCGTTACCCTCATCAAGCGCGCCCTTGAGGAGCCGATTCGCCAGATCGCCC
AGAACGCCGGCGTTGACGGCTCCATCGTCGTCGATAAGGTGAAGAACGGCAAAGACGCCTTTGGCTTCAACGCTGCCGAT
GACGAGTACGTGGACATGATCGCGGCCGGCATCATCGACCCGACCAAGGTTTCCCGTTCGGCCCTGCAGAATGCCGCTTC
CGTGGCCGGCCTCATGCTGACCACCGAGGCCATGATTGCCGACAAGCCGAAGGAAGAGGCTGCCATGCCGGCAATGCCCG
GCGGCATGGGCGGAATGGGTGGCATGGGCGGCATGATGTAA

Upstream 100 bases:

>100_bases
CGGCTTCGCCGAAGGTCCATCCGGAGCCTTTGGCCGTGCCATGAAACAGCATAGATAACAACATACGAAGACGAAGATTA
AATAGGGAGGAACGAGTAAC

Downstream 100 bases:

>100_bases
ATCATTCCGGCTCATTCCGGTTGAACATGAAAAGGGGAAGGACTTCGGTCTTTCCCCTTTTTCTGTTTCCGGCCTTTTGC
CATCCCGTTTCTATAGAGTG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAKIIKFDQEGRNAILKGVNTLADAVKVTLGPKGRNVIIEKSFGSPLITKDGVTVAKEIELEDKFENMGAQLVKEVASKT
SDVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGIDSAVETIVAELQKISKPIKDHKEIAQVGTISANNDKTIGGI
IAEAMEKVGKEGVITVEEAKAMETSLETVEGMQFDRGYLSPYFVTDPERMEASLENANILIHDKKISNMKDLLPILEQTA
KSGRPLLIIAEDIEGEALATLVVNKLRGVLNICAVKAPGFGDRRKAMLEDIAVLTGGKVISEELGFKLENATFDMLGTAK
RVTIDKDNTTIIDGDGSEADIQGRVKQIRAQIEETSSDYDREKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDALH
ATRAAVDEGIVPGGGVAYIRSLGALEGISLPAEQQFGVTLIKRALEEPIRQIAQNAGVDGSIVVDKVKNGKDAFGFNAAD
DEYVDMIAAGIIDPTKVSRSALQNAASVAGLMLTTEAMIADKPKEEAAMPAMPGGMGGMGGMGGMM

Sequences:

>Translated_546_residues
MAKIIKFDQEGRNAILKGVNTLADAVKVTLGPKGRNVIIEKSFGSPLITKDGVTVAKEIELEDKFENMGAQLVKEVASKT
SDVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGIDSAVETIVAELQKISKPIKDHKEIAQVGTISANNDKTIGGI
IAEAMEKVGKEGVITVEEAKAMETSLETVEGMQFDRGYLSPYFVTDPERMEASLENANILIHDKKISNMKDLLPILEQTA
KSGRPLLIIAEDIEGEALATLVVNKLRGVLNICAVKAPGFGDRRKAMLEDIAVLTGGKVISEELGFKLENATFDMLGTAK
RVTIDKDNTTIIDGDGSEADIQGRVKQIRAQIEETSSDYDREKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDALH
ATRAAVDEGIVPGGGVAYIRSLGALEGISLPAEQQFGVTLIKRALEEPIRQIAQNAGVDGSIVVDKVKNGKDAFGFNAAD
DEYVDMIAAGIIDPTKVSRSALQNAASVAGLMLTTEAMIADKPKEEAAMPAMPGGMGGMGGMGGMM
>Mature_545_residues
AKIIKFDQEGRNAILKGVNTLADAVKVTLGPKGRNVIIEKSFGSPLITKDGVTVAKEIELEDKFENMGAQLVKEVASKTS
DVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGIDSAVETIVAELQKISKPIKDHKEIAQVGTISANNDKTIGGII
AEAMEKVGKEGVITVEEAKAMETSLETVEGMQFDRGYLSPYFVTDPERMEASLENANILIHDKKISNMKDLLPILEQTAK
SGRPLLIIAEDIEGEALATLVVNKLRGVLNICAVKAPGFGDRRKAMLEDIAVLTGGKVISEELGFKLENATFDMLGTAKR
VTIDKDNTTIIDGDGSEADIQGRVKQIRAQIEETSSDYDREKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDALHA
TRAAVDEGIVPGGGVAYIRSLGALEGISLPAEQQFGVTLIKRALEEPIRQIAQNAGVDGSIVVDKVKNGKDAFGFNAADD
EYVDMIAAGIIDPTKVSRSALQNAASVAGLMLTTEAMIADKPKEEAAMPAMPGGMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=51.3257575757576, Blast_Score=526, Evalue=1e-149,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=51.3257575757576, Blast_Score=526, Evalue=1e-149,
Organism=Homo sapiens, GI38455427, Length=544, Percent_Identity=22.0588235294118, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790586, Length=528, Percent_Identity=67.6136363636364, Blast_Score=699, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=53.3962264150943, Blast_Score=550, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=52.60663507109, Blast_Score=217, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17564182, Length=569, Percent_Identity=22.6713532513181, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=54.7709923664122, Blast_Score=555, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6322350, Length=569, Percent_Identity=23.1985940246046, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322524, Length=360, Percent_Identity=23.0555555555556, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=52.7514231499051, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=52.7514231499051, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=50.6641366223909, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=50.6641366223909, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=50.6641366223909, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI17864606, Length=552, Percent_Identity=44.3840579710145, Blast_Score=459, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24584129, Length=539, Percent_Identity=36.5491651205937, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI19921262, Length=539, Percent_Identity=36.5491651205937, Blast_Score=336, Evalue=2e-92,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58015; Mature: 57884

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIIKFDQEGRNAILKGVNTLADAVKVTLGPKGRNVIIEKSFGSPLITKDGVTVAKEIE
CCCEEECCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCCEEHHCC
LEDKFENMGAQLVKEVASKTSDVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGID
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHH
SAVETIVAELQKISKPIKDHKEIAQVGTISANNDKTIGGIIAEAMEKVGKEGVITVEEAK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHH
AMETSLETVEGMQFDRGYLSPYFVTDPERMEASLENANILIHDKKISNMKDLLPILEQTA
HHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHCCCEEEEECCHHCCHHHHHHHHHHHH
KSGRPLLIIAEDIEGEALATLVVNKLRGVLNICAVKAPGFGDRRKAMLEDIAVLTGGKVI
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHH
SEELGFKLENATFDMLGTAKRVTIDKDNTTIIDGDGSEADIQGRVKQIRAQIEETSSDYD
HHHHCCEECCCCHHHHCCCEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
REKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDALHATRAAVDEGIVPGGGVAYIR
HHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
SLGALEGISLPAEQQFGVTLIKRALEEPIRQIAQNAGVDGSIVVDKVKNGKDAFGFNAAD
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCC
DEYVDMIAAGIIDPTKVSRSALQNAASVAGLMLTTEAMIADKPKEEAAMPAMPGGMGGMG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCC
GMGGMM
CCCCCC
>Mature Secondary Structure 
AKIIKFDQEGRNAILKGVNTLADAVKVTLGPKGRNVIIEKSFGSPLITKDGVTVAKEIE
CCEEECCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCCEEHHCC
LEDKFENMGAQLVKEVASKTSDVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGID
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHH
SAVETIVAELQKISKPIKDHKEIAQVGTISANNDKTIGGIIAEAMEKVGKEGVITVEEAK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHH
AMETSLETVEGMQFDRGYLSPYFVTDPERMEASLENANILIHDKKISNMKDLLPILEQTA
HHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHCCCEEEEECCHHCCHHHHHHHHHHHH
KSGRPLLIIAEDIEGEALATLVVNKLRGVLNICAVKAPGFGDRRKAMLEDIAVLTGGKVI
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHH
SEELGFKLENATFDMLGTAKRVTIDKDNTTIIDGDGSEADIQGRVKQIRAQIEETSSDYD
HHHHCCEECCCCHHHHCCCEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
REKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDALHATRAAVDEGIVPGGGVAYIR
HHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
SLGALEGISLPAEQQFGVTLIKRALEEPIRQIAQNAGVDGSIVVDKVKNGKDAFGFNAAD
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCC
DEYVDMIAAGIIDPTKVSRSALQNAASVAGLMLTTEAMIADKPKEEAAMPAMPGGMGGMG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCC
GMGGMM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA