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The map label for this gene is dxs [C]

Identifier: 78189159

GI number: 78189159

Start: 1585510

End: 1586493

Strand: Reverse

Name: dxs [C]

Synonym: Cag_1192

Alternate gene names: 78189159

Gene position: 1586493-1585510 (Counterclockwise)

Preceding gene: 78189161

Following gene: 78189158

Centisome position: 61.68

GC content: 47.36

Gene sequence:

>984_bases
ATGGAAGAAAATAAGAGTGGCGAAGTGGCTGAACGCTATGTGTCGCGGGGAAACAAAGCAACACGCGTTGGTTTTGGTAA
TGCCTTGCTTGAAATTGGTAAGGAAGAGAGCAATGTGGTGGCAATGTGTGCCGATTTAACGGGTTCGTTAAATATGAATT
TGTTCCGCGATGCTTTTCCCGAGCGTTTTATTCAAGCGGGAATTGCAGAAGCAAACATGATTTCTATGGCTGCGGGGCTT
GCGGCATCGGGTAAAATTCCTGTGGCTTCAACCTTCGCGGTGTTTGCAACGGGGCGTGTTTACGACCAAATTCGCCAGTC
GGTCTGCTATTCCAACATGAATGTTAAAATTTGCGCTTCGCACGCTGGTTTAACGCTTGGCGAGGATGGCGCAACCCACC
AAATTCTTGAGGATATTGGCTTAATGCGTGGTTTGCCCCGCATGACGGTTGTGGTGCCGTGCGATTACAGCGAAACGATG
CGTGCAACCAAAGCTATTATTAAACATCAAGGTCCCGTTTATCTCCGTTTTGGTCGTCCCAACGTTCCCGACTTTACGCG
CGATGACGATGGTTTTGAGATTGGCAAATCTATTGAAATGCACCCGGGTAAAGATGTTACCGTTATTGCCTGCGGCATTA
TGGTGTGGAAAGCGCTTGAAGCGGCTCGCATTCTTGAAAAAGAGGGGGTTGGCGTGCGCGTTATTAACATGCACACCATT
AAGCCAATTGATACGCTTGCGGTTGTTTGTGCCGCCAACGATACAGGTGCAATTGTAACGGCTGAGGAGCATCAAATTTA
CAATGGACTTGGCGATGCGGTGGCTAACGTTTGTGCACGCAATATTCCCGTGCCTATTGAAATGGTTGGTGTTGAAGATC
AGTTTGGTGAATCAGGTAAGCCTGATGATTTGCTTGAAAAGTATAAGCTCACCACCGCCGATATTCTTGAAAAAATCTAC
CTTGCATTACGCCGTAAATCGTAA

Upstream 100 bases:

>100_bases
ATCATTATTGCGATGATAGATTACTATTCGTTCATTGTTTGCCCGCCGCAAGCGAAGCCGGGCGGAACTACTTTTTCTAA
TTTAAGTTATTCTCATAGTA

Downstream 100 bases:

>100_bases
CGCTGCATAGCAGTTCTAAATATTCCCCTCCTATGGAGGAGTGCCCGAAGGGCGGGGTGGTTATGGATGATGGATTGTAG
GGGCAACCCTTGCGGTTGCC

Product: transketolase-like

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MEENKSGEVAERYVSRGNKATRVGFGNALLEIGKEESNVVAMCADLTGSLNMNLFRDAFPERFIQAGIAEANMISMAAGL
AASGKIPVASTFAVFATGRVYDQIRQSVCYSNMNVKICASHAGLTLGEDGATHQILEDIGLMRGLPRMTVVVPCDYSETM
RATKAIIKHQGPVYLRFGRPNVPDFTRDDDGFEIGKSIEMHPGKDVTVIACGIMVWKALEAARILEKEGVGVRVINMHTI
KPIDTLAVVCAANDTGAIVTAEEHQIYNGLGDAVANVCARNIPVPIEMVGVEDQFGESGKPDDLLEKYKLTTADILEKIY
LALRRKS

Sequences:

>Translated_327_residues
MEENKSGEVAERYVSRGNKATRVGFGNALLEIGKEESNVVAMCADLTGSLNMNLFRDAFPERFIQAGIAEANMISMAAGL
AASGKIPVASTFAVFATGRVYDQIRQSVCYSNMNVKICASHAGLTLGEDGATHQILEDIGLMRGLPRMTVVVPCDYSETM
RATKAIIKHQGPVYLRFGRPNVPDFTRDDDGFEIGKSIEMHPGKDVTVIACGIMVWKALEAARILEKEGVGVRVINMHTI
KPIDTLAVVCAANDTGAIVTAEEHQIYNGLGDAVANVCARNIPVPIEMVGVEDQFGESGKPDDLLEKYKLTTADILEKIY
LALRRKS
>Mature_327_residues
MEENKSGEVAERYVSRGNKATRVGFGNALLEIGKEESNVVAMCADLTGSLNMNLFRDAFPERFIQAGIAEANMISMAAGL
AASGKIPVASTFAVFATGRVYDQIRQSVCYSNMNVKICASHAGLTLGEDGATHQILEDIGLMRGLPRMTVVVPCDYSETM
RATKAIIKHQGPVYLRFGRPNVPDFTRDDDGFEIGKSIEMHPGKDVTVIACGIMVWKALEAARILEKEGVGVRVINMHTI
KPIDTLAVVCAANDTGAIVTAEEHQIYNGLGDAVANVCARNIPVPIEMVGVEDQFGESGKPDDLLEKYKLTTADILEKIY
LALRRKS

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=297, Percent_Identity=35.016835016835, Blast_Score=177, Evalue=8e-45,
Organism=Homo sapiens, GI4507521, Length=297, Percent_Identity=35.016835016835, Blast_Score=177, Evalue=8e-45,
Organism=Homo sapiens, GI225637459, Length=305, Percent_Identity=36.3934426229508, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI225637463, Length=305, Percent_Identity=36.3934426229508, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI225637461, Length=305, Percent_Identity=36.3934426229508, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI133778974, Length=313, Percent_Identity=32.2683706070287, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI291084858, Length=234, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1786622, Length=298, Percent_Identity=27.8523489932886, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1788808, Length=321, Percent_Identity=26.1682242990654, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI48994911, Length=314, Percent_Identity=26.7515923566879, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539652, Length=309, Percent_Identity=33.0097087378641, Blast_Score=164, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6325331, Length=320, Percent_Identity=24.6875, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24666278, Length=313, Percent_Identity=33.2268370607029, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI45551847, Length=311, Percent_Identity=32.7974276527331, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI45550715, Length=311, Percent_Identity=32.7974276527331, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24645119, Length=311, Percent_Identity=32.7974276527331, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI21358145, Length=243, Percent_Identity=27.1604938271605, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24650940, Length=243, Percent_Identity=27.1604938271605, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 35440; Mature: 35440

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEENKSGEVAERYVSRGNKATRVGFGNALLEIGKEESNVVAMCADLTGSLNMNLFRDAFP
CCCCCCCHHHHHHHHCCCCEEEEECCHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHH
ERFIQAGIAEANMISMAAGLAASGKIPVASTFAVFATGRVYDQIRQSVCYSNMNVKICAS
HHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
HAGLTLGEDGATHQILEDIGLMRGLPRMTVVVPCDYSETMRATKAIIKHQGPVYLRFGRP
CCCCEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECCCC
NVPDFTRDDDGFEIGKSIEMHPGKDVTVIACGIMVWKALEAARILEKEGVGVRVINMHTI
CCCCCCCCCCCCCCCCEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
KPIDTLAVVCAANDTGAIVTAEEHQIYNGLGDAVANVCARNIPVPIEMVGVEDQFGESGK
CCHHHEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHCCCCCC
PDDLLEKYKLTTADILEKIYLALRRKS
CHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEENKSGEVAERYVSRGNKATRVGFGNALLEIGKEESNVVAMCADLTGSLNMNLFRDAFP
CCCCCCCHHHHHHHHCCCCEEEEECCHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHH
ERFIQAGIAEANMISMAAGLAASGKIPVASTFAVFATGRVYDQIRQSVCYSNMNVKICAS
HHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
HAGLTLGEDGATHQILEDIGLMRGLPRMTVVVPCDYSETMRATKAIIKHQGPVYLRFGRP
CCCCEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECCCC
NVPDFTRDDDGFEIGKSIEMHPGKDVTVIACGIMVWKALEAARILEKEGVGVRVINMHTI
CCCCCCCCCCCCCCCCEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
KPIDTLAVVCAANDTGAIVTAEEHQIYNGLGDAVANVCARNIPVPIEMVGVEDQFGESGK
CCHHHEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHCCCCCC
PDDLLEKYKLTTADILEKIYLALRRKS
CHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]