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The map label for this gene is cobD [H]

Identifier: 78188978

GI number: 78188978

Start: 1352481

End: 1353599

Strand: Reverse

Name: cobD [H]

Synonym: Cag_1011

Alternate gene names: 78188978

Gene position: 1353599-1352481 (Counterclockwise)

Preceding gene: 78188979

Following gene: 78188977

Centisome position: 52.63

GC content: 51.74

Gene sequence:

>1119_bases
ATGAACAATCTCTTTTGCCATAAACATGGCGGCGCTCCCATAAAGAGCAATCAACCCGATTTTAGCGTGAATATCAGCCC
CATTATGCCGCCCATTGGCTCGCTTTCACTCAGCGACTTTGCCCTGCATAACTATCCCTCCATTGATGGAAGCGGCATTC
GCGACTTTTACGTTGCTCGCTTTGGGCTTGATGGCGATACGGTGCTGCCAACCAATGGTGCCATTGAAGCCATTTACCTT
GTGCCACGCGCACTCGGCGTGCGCCGTGTGCTAACGCTCACCCCCTCTTTTCACGACTACGAACGTGCCTCGCTTGTAGC
GGGAGCTACCGTTAGCCATCTGCCGCTTGATGCCGAAACGGGCTTTGCGTTACCATCGCTTGAGCAGTTTGCCACAGCTT
TGCAAGAGGCGGAAGCTGACGCACTTTTTGTAGGTAACCCCAACAATCCCACAGGTACGGCAATTGAACCTGAGGTTATT
ATGGCGCTTGCCAGCCGCTTTCCGTGGATGTGGTTTATTGTGGATGAAGCATTTATTCAGTTCACAGCTAACTTTCCCCA
CAATTCGCTTATGAAACAGGTAAGCGCGTTACGCAACATTATTGTAGTACACTCGCTTACGAAATTTTACGCCTTACCCG
GCTTACGGCTCGGAGCGGTTGTAGCGCATCCTGACGTCATTAACCGTTTGCTTGATGTAAAAGAGCCTTGGACGGTTAAT
GCAATTGCCGAAGAGGTGGCACGGCGTTTACTACACTGTAGCGATTACGATGCAGAGGTGCGCTCAATAATTGCGGCTGA
ACGCCTTCGCATGAGTGCCCAATTTGCTCGCAGTGGTGAAATTGTGTTAGTGGGGGGAGCGGCTAACTTTTTTCTTGCTC
GTTGGATAGGAGGCTGTTCACTTGACGTGCTTTTTGCTCGCCTTGCAGAGCGCAACCTTTACGTGCGCGATTGCCGCAAC
TTCCGCGGGCTTGAAGCCAACTATTTCCGCTTTGCCATTCGCACCCCAGCCGAAAATGAGCGTTTGCTTGAAGCGTTGCT
ACCCGCCATTCGTCCAACAACGGCAACAATGCGCACAACCGCCTATCAGCGCAACTTTAGCCGCACCCCTTTTTGTTAG

Upstream 100 bases:

>100_bases
TTGCAGCCGCATGAACGTGGGCGGCAGGAGAGTTACGAGTTGTTAGCCGATCACTTTCGGCAACATCTTGATGTAAATAA
ACTTTTTGAATTGATAGACT

Downstream 100 bases:

>100_bases
CAGTGTTGTAAGCGTATAAGTTGACCGAATAAGTTTAACACAAACCGATACTAAGGCGCTTCATTTTTTTGCTATGCCAC
AAGAGCAATACGTTGAAAGT

Product: L-threonine-O-3-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MNNLFCHKHGGAPIKSNQPDFSVNISPIMPPIGSLSLSDFALHNYPSIDGSGIRDFYVARFGLDGDTVLPTNGAIEAIYL
VPRALGVRRVLTLTPSFHDYERASLVAGATVSHLPLDAETGFALPSLEQFATALQEAEADALFVGNPNNPTGTAIEPEVI
MALASRFPWMWFIVDEAFIQFTANFPHNSLMKQVSALRNIIVVHSLTKFYALPGLRLGAVVAHPDVINRLLDVKEPWTVN
AIAEEVARRLLHCSDYDAEVRSIIAAERLRMSAQFARSGEIVLVGGAANFFLARWIGGCSLDVLFARLAERNLYVRDCRN
FRGLEANYFRFAIRTPAENERLLEALLPAIRPTTATMRTTAYQRNFSRTPFC

Sequences:

>Translated_372_residues
MNNLFCHKHGGAPIKSNQPDFSVNISPIMPPIGSLSLSDFALHNYPSIDGSGIRDFYVARFGLDGDTVLPTNGAIEAIYL
VPRALGVRRVLTLTPSFHDYERASLVAGATVSHLPLDAETGFALPSLEQFATALQEAEADALFVGNPNNPTGTAIEPEVI
MALASRFPWMWFIVDEAFIQFTANFPHNSLMKQVSALRNIIVVHSLTKFYALPGLRLGAVVAHPDVINRLLDVKEPWTVN
AIAEEVARRLLHCSDYDAEVRSIIAAERLRMSAQFARSGEIVLVGGAANFFLARWIGGCSLDVLFARLAERNLYVRDCRN
FRGLEANYFRFAIRTPAENERLLEALLPAIRPTTATMRTTAYQRNFSRTPFC
>Mature_372_residues
MNNLFCHKHGGAPIKSNQPDFSVNISPIMPPIGSLSLSDFALHNYPSIDGSGIRDFYVARFGLDGDTVLPTNGAIEAIYL
VPRALGVRRVLTLTPSFHDYERASLVAGATVSHLPLDAETGFALPSLEQFATALQEAEADALFVGNPNNPTGTAIEPEVI
MALASRFPWMWFIVDEAFIQFTANFPHNSLMKQVSALRNIIVVHSLTKFYALPGLRLGAVVAHPDVINRLLDVKEPWTVN
AIAEEVARRLLHCSDYDAEVRSIIAAERLRMSAQFARSGEIVLVGGAANFFLARWIGGCSLDVLFARLAERNLYVRDCRN
FRGLEANYFRFAIRTPAENERLLEALLPAIRPTTATMRTTAYQRNFSRTPFC

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=329, Percent_Identity=25.531914893617, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322075, Length=297, Percent_Identity=26.5993265993266, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 41167; Mature: 41167

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLFCHKHGGAPIKSNQPDFSVNISPIMPPIGSLSLSDFALHNYPSIDGSGIRDFYVAR
CCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCHHEEEEE
FGLDGDTVLPTNGAIEAIYLVPRALGVRRVLTLTPSFHDYERASLVAGATVSHLPLDAET
ECCCCCEECCCCCCEEEEEEHHHHHCCEEEEEECCCCCCHHHHHHHCCCCHHCCCCCCCC
GFALPSLEQFATALQEAEADALFVGNPNNPTGTAIEPEVIMALASRFPWMWFIVDEAFIQ
CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEEEEHHHHHE
FTANFPHNSLMKQVSALRNIIVVHSLTKFYALPGLRLGAVVAHPDVINRLLDVKEPWTVN
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHCCCCCCCHH
AIAEEVARRLLHCSDYDAEVRSIIAAERLRMSAQFARSGEIVLVGGAANFFLARWIGGCS
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHCCCH
LDVLFARLAERNLYVRDCRNFRGLEANYFRFAIRTPAENERLLEALLPAIRPTTATMRTT
HHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHH
AYQRNFSRTPFC
HHHCCCCCCCCC
>Mature Secondary Structure
MNNLFCHKHGGAPIKSNQPDFSVNISPIMPPIGSLSLSDFALHNYPSIDGSGIRDFYVAR
CCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCHHEEEEE
FGLDGDTVLPTNGAIEAIYLVPRALGVRRVLTLTPSFHDYERASLVAGATVSHLPLDAET
ECCCCCEECCCCCCEEEEEEHHHHHCCEEEEEECCCCCCHHHHHHHCCCCHHCCCCCCCC
GFALPSLEQFATALQEAEADALFVGNPNNPTGTAIEPEVIMALASRFPWMWFIVDEAFIQ
CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEEEEHHHHHE
FTANFPHNSLMKQVSALRNIIVVHSLTKFYALPGLRLGAVVAHPDVINRLLDVKEPWTVN
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHCCCCCCCHH
AIAEEVARRLLHCSDYDAEVRSIIAAERLRMSAQFARSGEIVLVGGAANFFLARWIGGCS
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHCCCH
LDVLFARLAERNLYVRDCRNFRGLEANYFRFAIRTPAENERLLEALLPAIRPTTATMRTT
HHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHH
AYQRNFSRTPFC
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]