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The map label for this gene is cobQ

Identifier: 78188979

GI number: 78188979

Start: 1353577

End: 1355097

Strand: Reverse

Name: cobQ

Synonym: Cag_1012

Alternate gene names: 78188979

Gene position: 1355097-1353577 (Counterclockwise)

Preceding gene: 78188980

Following gene: 78188978

Centisome position: 52.68

GC content: 50.76

Gene sequence:

>1521_bases
ATGGTAACGCCCACTAAAACCTATCGTTCGCTTGCAATTCTTGGCACCGCTTCGGATGTGGGCAAAAGCATTGTAGCTAC
GGCGCTCTGCCGCATTTTTCGTAATGCGGGGATTGATGTTGCGCCGTACAAAGCGCAAAATATGTCGAACAATTCAGGCG
TTACGCCCGATGGTTTGGAAATTGGGCGGGCGCAAATTGCTCAGGCGGAGGCGGCGTGCGTGGTTCCTACGGCTGATATG
AATCCCGTGTTGCTCAAGCCGAACACCGATATTGGAGCGCAGGTTGTGCTGCAAGGCAGAGTGTGCTCTAACGAGAGCGC
CCAAGGCTATTTTCGCGACACCTCGCGTTGGGCAGAAGCCGCGCGTGAAAGTCTGCTTCGGCTCAAGCAAAAGCATGAGT
TGTTGGTGATTGAAGGGGCTGGCTCGTGTGCTGAAATGAATTTGTACCCGCGCGATTTTGTGAACTTCCGTACCGCGCGT
GAAGCGGACGCTGCCGTTATTCTTGTTGCCGATATTGATCGTGGCGGCGTTTTTGCGCAAGTGGTGGGAACGCTTGCCGT
TATTCCGCCCGAAGATCGAGCGCTTGTTAAAGGGGTGATTATTAACCGTTTTCGGGGCGATAGCGAGCTCTTTCGCGAAG
GCATAACCATGCTTGAGGAGATGAGTGGCGTACCCGTGTTGGGCGTTATTCCTTACTTCCGCCATTTTGCCATTGATGCC
GAAGATGCCGTGCCGCTCTCCGCAAAAGTTGATCCTGCTCAAGAACCCGAAACGGGCAAAGTTGGCGTGGCAGCCATTTA
CTTTCCCCACATTTCAAACTTTACCGACCTTTCGCCGCTTGAGCACGATCCATCAGTTACGTTACACTATCTCCACCATC
CAAAACCGCTAAGCGCTTACAAGGTGCTAATTTTGCCCGGCTCAAAAAATGTACGGGGCGACTATGCGTGGCTTCAGCAA
ATGGGGTGGGAAAAAGAGATTCGTGCTTTTCGTGAAGCGGGTGGATTGGTGATTGGCATTTGCGGCGGTTACCAAATGCT
TGGGTGTTCAATTGCCGATCCTTACGGTGTGGAAGGGGAGTCGGGCACAACGCAAACACTTGGATTGTTAGAGACTGAAA
CCCTGCTTGAGCAAGAAAAATATCTTGCCAATAGCGAAGGCGTGTTGGTTGGCACCTCCATTAAAGCCTTTGGGTATGAA
ATTCATAATGGACGCACCACCGTTGGCGCCAATTGTCATCCACTGATGAATATTGTTGCTCGCAACAACCATCCCGAAAG
CGATGTTGATGGCGTTGTAAGCGCTGATGGTCGAGTTATTGGCACCTACTTCCACGGCATTTTTAATGAACCTGCCGTCA
AGCAATGGTTCCTTCAACAAGCCGATTCCACCTACACATTGCAGCCGCATGAACGTGGGCGGCAGGAGAGTTACGAGTTG
TTAGCCGATCACTTTCGGCAACATCTTGATGTAAATAAACTTTTTGAATTGATAGACTATGAACAATCTCTTTTGCCATA
A

Upstream 100 bases:

>100_bases
TTTGCATGGGCTACGTCAGCTTTTTCCATGAAACTCCTGAGCTTCAACAAGCGGGTTGGTTGCCTCGCCTTGAGCTTGAA
ACCCTTGTCCATCACGAAAC

Downstream 100 bases:

>100_bases
ACATGGCGGCGCTCCCATAAAGAGCAATCAACCCGATTTTAGCGTGAATATCAGCCCCATTATGCCGCCCATTGGCTCGC
TTTCACTCAGCGACTTTGCC

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MVTPTKTYRSLAILGTASDVGKSIVATALCRIFRNAGIDVAPYKAQNMSNNSGVTPDGLEIGRAQIAQAEAACVVPTADM
NPVLLKPNTDIGAQVVLQGRVCSNESAQGYFRDTSRWAEAARESLLRLKQKHELLVIEGAGSCAEMNLYPRDFVNFRTAR
EADAAVILVADIDRGGVFAQVVGTLAVIPPEDRALVKGVIINRFRGDSELFREGITMLEEMSGVPVLGVIPYFRHFAIDA
EDAVPLSAKVDPAQEPETGKVGVAAIYFPHISNFTDLSPLEHDPSVTLHYLHHPKPLSAYKVLILPGSKNVRGDYAWLQQ
MGWEKEIRAFREAGGLVIGICGGYQMLGCSIADPYGVEGESGTTQTLGLLETETLLEQEKYLANSEGVLVGTSIKAFGYE
IHNGRTTVGANCHPLMNIVARNNHPESDVDGVVSADGRVIGTYFHGIFNEPAVKQWFLQQADSTYTLQPHERGRQESYEL
LADHFRQHLDVNKLFELIDYEQSLLP

Sequences:

>Translated_506_residues
MVTPTKTYRSLAILGTASDVGKSIVATALCRIFRNAGIDVAPYKAQNMSNNSGVTPDGLEIGRAQIAQAEAACVVPTADM
NPVLLKPNTDIGAQVVLQGRVCSNESAQGYFRDTSRWAEAARESLLRLKQKHELLVIEGAGSCAEMNLYPRDFVNFRTAR
EADAAVILVADIDRGGVFAQVVGTLAVIPPEDRALVKGVIINRFRGDSELFREGITMLEEMSGVPVLGVIPYFRHFAIDA
EDAVPLSAKVDPAQEPETGKVGVAAIYFPHISNFTDLSPLEHDPSVTLHYLHHPKPLSAYKVLILPGSKNVRGDYAWLQQ
MGWEKEIRAFREAGGLVIGICGGYQMLGCSIADPYGVEGESGTTQTLGLLETETLLEQEKYLANSEGVLVGTSIKAFGYE
IHNGRTTVGANCHPLMNIVARNNHPESDVDGVVSADGRVIGTYFHGIFNEPAVKQWFLQQADSTYTLQPHERGRQESYEL
LADHFRQHLDVNKLFELIDYEQSLLP
>Mature_506_residues
MVTPTKTYRSLAILGTASDVGKSIVATALCRIFRNAGIDVAPYKAQNMSNNSGVTPDGLEIGRAQIAQAEAACVVPTADM
NPVLLKPNTDIGAQVVLQGRVCSNESAQGYFRDTSRWAEAARESLLRLKQKHELLVIEGAGSCAEMNLYPRDFVNFRTAR
EADAAVILVADIDRGGVFAQVVGTLAVIPPEDRALVKGVIINRFRGDSELFREGITMLEEMSGVPVLGVIPYFRHFAIDA
EDAVPLSAKVDPAQEPETGKVGVAAIYFPHISNFTDLSPLEHDPSVTLHYLHHPKPLSAYKVLILPGSKNVRGDYAWLQQ
MGWEKEIRAFREAGGLVIGICGGYQMLGCSIADPYGVEGESGTTQTLGLLETETLLEQEKYLANSEGVLVGTSIKAFGYE
IHNGRTTVGANCHPLMNIVARNNHPESDVDGVVSADGRVIGTYFHGIFNEPAVKQWFLQQADSTYTLQPHERGRQESYEL
LADHFRQHLDVNKLFELIDYEQSLLP

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_CHLCH (Q3ARV1)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379317.1
- ProteinModelPortal:   Q3ARV1
- SMR:   Q3ARV1
- STRING:   Q3ARV1
- GeneID:   3746740
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1012
- eggNOG:   COG1492
- HOGENOM:   HBG302271
- OMA:   AHTDLNP
- ProtClustDB:   PRK00784
- BioCyc:   CCHL340177:CAG_1012-MONOMER
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 55308; Mature: 55308

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 341-341 ACT_SITE 445-445

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTPTKTYRSLAILGTASDVGKSIVATALCRIFRNAGIDVAPYKAQNMSNNSGVTPDGLE
CCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHH
IGRAQIAQAEAACVVPTADMNPVLLKPNTDIGAQVVLQGRVCSNESAQGYFRDTSRWAEA
HCHHHHHHCCCEEEEECCCCCCEEECCCCCCCCEEEEECCCCCCCCCCCEEHHHHHHHHH
ARESLLRLKQKHELLVIEGAGSCAEMNLYPRDFVNFRTAREADAAVILVADIDRGGVFAQ
HHHHHHHHHHCCCEEEEECCCCEEECCCCHHHHHHHHHCCCCCCEEEEEEECCCCCHHHH
VVGTLAVIPPEDRALVKGVIINRFRGDSELFREGITMLEEMSGVPVLGVIPYFRHFAIDA
HHHHEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCC
EDAVPLSAKVDPAQEPETGKVGVAAIYFPHISNFTDLSPLEHDPSVTLHYLHHPKPLSAY
CCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCEE
KVLILPGSKNVRGDYAWLQQMGWEKEIRAFREAGGLVIGICGGYQMLGCSIADPYGVEGE
EEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCEEECCCCCCCCCCCCC
SGTTQTLGLLETETLLEQEKYLANSEGVLVGTSIKAFGYEIHNGRTTVGANCHPLMNIVA
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHEEEEEEECCCEEECCCCHHHHHHHH
RNNHPESDVDGVVSADGRVIGTYFHGIFNEPAVKQWFLQQADSTYTLQPHERGRQESYEL
CCCCCCCCCCCEEECCCEEEEEEHHHHCCCHHHHHHHHHHCCCEEEECCHHCCHHHHHHH
LADHFRQHLDVNKLFELIDYEQSLLP
HHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVTPTKTYRSLAILGTASDVGKSIVATALCRIFRNAGIDVAPYKAQNMSNNSGVTPDGLE
CCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHH
IGRAQIAQAEAACVVPTADMNPVLLKPNTDIGAQVVLQGRVCSNESAQGYFRDTSRWAEA
HCHHHHHHCCCEEEEECCCCCCEEECCCCCCCCEEEEECCCCCCCCCCCEEHHHHHHHHH
ARESLLRLKQKHELLVIEGAGSCAEMNLYPRDFVNFRTAREADAAVILVADIDRGGVFAQ
HHHHHHHHHHCCCEEEEECCCCEEECCCCHHHHHHHHHCCCCCCEEEEEEECCCCCHHHH
VVGTLAVIPPEDRALVKGVIINRFRGDSELFREGITMLEEMSGVPVLGVIPYFRHFAIDA
HHHHEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCC
EDAVPLSAKVDPAQEPETGKVGVAAIYFPHISNFTDLSPLEHDPSVTLHYLHHPKPLSAY
CCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCEE
KVLILPGSKNVRGDYAWLQQMGWEKEIRAFREAGGLVIGICGGYQMLGCSIADPYGVEGE
EEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCEEECCCCCCCCCCCCC
SGTTQTLGLLETETLLEQEKYLANSEGVLVGTSIKAFGYEIHNGRTTVGANCHPLMNIVA
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHEEEEEEECCCEEECCCCHHHHHHHH
RNNHPESDVDGVVSADGRVIGTYFHGIFNEPAVKQWFLQQADSTYTLQPHERGRQESYEL
CCCCCCCCCCCEEECCCEEEEEEHHHHCCCHHHHHHHHHHCCCEEEECCHHCCHHHHHHH
LADHFRQHLDVNKLFELIDYEQSLLP
HHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA