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The map label for this gene is thrC [H]

Identifier: 78188121

GI number: 78188121

Start: 151639

End: 152958

Strand: Reverse

Name: thrC [H]

Synonym: Cag_0138

Alternate gene names: 78188121

Gene position: 152958-151639 (Counterclockwise)

Preceding gene: 78188122

Following gene: 78188120

Centisome position: 5.95

GC content: 46.67

Gene sequence:

>1320_bases
ATGATTTACTTTAGTACCAACAAATCCTCAGTTCCTGTCTCATTAAAAAAAGCCACCCTTGAAGGGCTTGCGCCTGATGG
TGGACTTTATATCCCTTCCGAAATTCCTCATTTTTCTGAGGCTGAAATAAAGCAGCTCAAAGGCGCATCGTTTACCAACG
TAGCGTTTGCAATTGCTCAGAAATTTGCGGGCAGCGATATTGCAGCAGAGCGTTTACGCGCAATTATTGAAGAGTGCTAC
AACTTCCCCACCCCACTTGTGCCGCTTGGCAGCAACACCTTTATTGAAGAGCTTTTTTGCGGACCAACCTTAGCCTTTAA
AGATTACGGCGCTCGCTTTCTTGCTCGTATGACGGGCTATTTTGCCGAAGAGGAGCATAAGCTGATTACGGTTTTAGTTG
CCACTTCGGGCGATACGGGAAGTGCGGTTGCCTATGGTTTTCAAGGCATTAAAAATACGCGCGTGGTGCTACTTTATCCA
TCGGGCAAAGTAAGCCCATTGCAAGAGCAGCAATTAACCACAGCAGGCGACAACGTGTTTGCCCTTGAAGTACAAGGCGA
TTTTGACGATTGCCAACGCATGGTTAAAGAGGCGTTTGTTGACCCCACATTACATGAGGCGTTAACGCTTACCTCTGCTA
ACTCGATTAATATTTCGCGCCTTATCCCGCAATCATTTTACTATGCGTGGGCATCGCTCTCTATTGATGAGGCGTTTGGC
TTGCAAAACCCAATATTTTCGGTGCCAAGCGGCAATTATGGCAATGTAACAGCGGGCATTTTGGCAAAAAAGATGGGCTT
CCCTATTGGGCACTTTATTGCTGCATCAAACGCTAACGATAGCGTAACTCGTTACTTAGTACATGGGCGTTATGAGCCAC
ACCCAACCATTGCCACCCTTTCAACCGCAATGGATGTAGGGAACCCCAGCAACTTTGCTCGCCTCCGCTACTTCTACAAC
AACGACTTTGCGGCAATGGCAGATGATATAAGCGGCATTGCTGTTTCGGATGAAGAGACGCGTGCAACCATCAGCAAAGT
GCATAAGCAATTTGGTGGATATATTATGGATCCACACACGGCAGTAGGCTACCGTGCGCTTGAAAAATATCGTGAAAGCA
CCAACAATGCCAACACACCAGCCATTGTGCTCTCTACGGCACATCCGGCAAAATTCCTTGAAGCCATTGAAGCAACGCTC
CAAATTCCCGTACCTATTCCCGACCATTTGCAAGCATTAATGGCAAAAGAAAAACGCTCCACCATTATTGGAGCGCACTA
TCAAGAGCTTGCTACTTTTTTAAAGCGATTAGATCGCTAA

Upstream 100 bases:

>100_bases
GAGTCCGACGTATGGATAACTCCCGTTTGTACGCAAGGTGCTCGCGTTCTCTAATAAATCAATATTTAAAGAATTTTTGA
TCTCCATAGAAGCTAAAGCC

Downstream 100 bases:

>100_bases
CTCGTTAGCCAACAGCGCCATGAATTTCGGTACCATTTTATTTTTTCTTGTACTGATTCCTGTAATGTTTGCAGGAATGT
CGCTATGGCTACTTATTAGC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MIYFSTNKSSVPVSLKKATLEGLAPDGGLYIPSEIPHFSEAEIKQLKGASFTNVAFAIAQKFAGSDIAAERLRAIIEECY
NFPTPLVPLGSNTFIEELFCGPTLAFKDYGARFLARMTGYFAEEEHKLITVLVATSGDTGSAVAYGFQGIKNTRVVLLYP
SGKVSPLQEQQLTTAGDNVFALEVQGDFDDCQRMVKEAFVDPTLHEALTLTSANSINISRLIPQSFYYAWASLSIDEAFG
LQNPIFSVPSGNYGNVTAGILAKKMGFPIGHFIAASNANDSVTRYLVHGRYEPHPTIATLSTAMDVGNPSNFARLRYFYN
NDFAAMADDISGIAVSDEETRATISKVHKQFGGYIMDPHTAVGYRALEKYRESTNNANTPAIVLSTAHPAKFLEAIEATL
QIPVPIPDHLQALMAKEKRSTIIGAHYQELATFLKRLDR

Sequences:

>Translated_439_residues
MIYFSTNKSSVPVSLKKATLEGLAPDGGLYIPSEIPHFSEAEIKQLKGASFTNVAFAIAQKFAGSDIAAERLRAIIEECY
NFPTPLVPLGSNTFIEELFCGPTLAFKDYGARFLARMTGYFAEEEHKLITVLVATSGDTGSAVAYGFQGIKNTRVVLLYP
SGKVSPLQEQQLTTAGDNVFALEVQGDFDDCQRMVKEAFVDPTLHEALTLTSANSINISRLIPQSFYYAWASLSIDEAFG
LQNPIFSVPSGNYGNVTAGILAKKMGFPIGHFIAASNANDSVTRYLVHGRYEPHPTIATLSTAMDVGNPSNFARLRYFYN
NDFAAMADDISGIAVSDEETRATISKVHKQFGGYIMDPHTAVGYRALEKYRESTNNANTPAIVLSTAHPAKFLEAIEATL
QIPVPIPDHLQALMAKEKRSTIIGAHYQELATFLKRLDR
>Mature_439_residues
MIYFSTNKSSVPVSLKKATLEGLAPDGGLYIPSEIPHFSEAEIKQLKGASFTNVAFAIAQKFAGSDIAAERLRAIIEECY
NFPTPLVPLGSNTFIEELFCGPTLAFKDYGARFLARMTGYFAEEEHKLITVLVATSGDTGSAVAYGFQGIKNTRVVLLYP
SGKVSPLQEQQLTTAGDNVFALEVQGDFDDCQRMVKEAFVDPTLHEALTLTSANSINISRLIPQSFYYAWASLSIDEAFG
LQNPIFSVPSGNYGNVTAGILAKKMGFPIGHFIAASNANDSVTRYLVHGRYEPHPTIATLSTAMDVGNPSNFARLRYFYN
NDFAAMADDISGIAVSDEETRATISKVHKQFGGYIMDPHTAVGYRALEKYRESTNNANTPAIVLSTAHPAKFLEAIEATL
QIPVPIPDHLQALMAKEKRSTIIGAHYQELATFLKRLDR

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=435, Percent_Identity=35.4022988505747, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI149193323, Length=463, Percent_Identity=29.1576673866091, Blast_Score=183, Evalue=3e-46,
Organism=Escherichia coli, GI1786185, Length=410, Percent_Identity=42.4390243902439, Blast_Score=301, Evalue=5e-83,
Organism=Saccharomyces cerevisiae, GI6319901, Length=457, Percent_Identity=38.5120350109409, Blast_Score=264, Evalue=2e-71,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 47978; Mature: 47978

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYFSTNKSSVPVSLKKATLEGLAPDGGLYIPSEIPHFSEAEIKQLKGASFTNVAFAIAQ
CEEECCCCCCCCEEEHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
KFAGSDIAAERLRAIIEECYNFPTPLVPLGSNTFIEELFCGPTLAFKDYGARFLARMTGY
HHCCCHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FAEEEHKLITVLVATSGDTGSAVAYGFQGIKNTRVVLLYPSGKVSPLQEQQLTTAGDNVF
HCCCCCEEEEEEEEECCCCCCCHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCEE
ALEVQGDFDDCQRMVKEAFVDPTLHEALTLTSANSINISRLIPQSFYYAWASLSIDEAFG
EEEECCCHHHHHHHHHHHHCCCHHHHHEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHCC
LQNPIFSVPSGNYGNVTAGILAKKMGFPIGHFIAASNANDSVTRYLVHGRYEPHPTIATL
CCCCCEECCCCCCCCCHHHHHHHHHCCCHHHEEEECCCCCHHHHHHEECCCCCCCCHHHH
STAMDVGNPSNFARLRYFYNNDFAAMADDISGIAVSDEETRATISKVHKQFGGYIMDPHT
HHHHCCCCCCCCEEEEEEECCCHHHHHCCCCCEEECCHHHHHHHHHHHHHHCCEEECCCH
AVGYRALEKYRESTNNANTPAIVLSTAHPAKFLEAIEATLQIPVPIPDHLQALMAKEKRS
HHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHH
TIIGAHYQELATFLKRLDR
HEECHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIYFSTNKSSVPVSLKKATLEGLAPDGGLYIPSEIPHFSEAEIKQLKGASFTNVAFAIAQ
CEEECCCCCCCCEEEHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
KFAGSDIAAERLRAIIEECYNFPTPLVPLGSNTFIEELFCGPTLAFKDYGARFLARMTGY
HHCCCHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FAEEEHKLITVLVATSGDTGSAVAYGFQGIKNTRVVLLYPSGKVSPLQEQQLTTAGDNVF
HCCCCCEEEEEEEEECCCCCCCHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCEE
ALEVQGDFDDCQRMVKEAFVDPTLHEALTLTSANSINISRLIPQSFYYAWASLSIDEAFG
EEEECCCHHHHHHHHHHHHCCCHHHHHEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHCC
LQNPIFSVPSGNYGNVTAGILAKKMGFPIGHFIAASNANDSVTRYLVHGRYEPHPTIATL
CCCCCEECCCCCCCCCHHHHHHHHHCCCHHHEEEECCCCCHHHHHHEECCCCCCCCHHHH
STAMDVGNPSNFARLRYFYNNDFAAMADDISGIAVSDEETRATISKVHKQFGGYIMDPHT
HHHHCCCCCCCCEEEEEEECCCHHHHHCCCCCEEECCHHHHHHHHHHHHHHCCEEECCCH
AVGYRALEKYRESTNNANTPAIVLSTAHPAKFLEAIEATLQIPVPIPDHLQALMAKEKRS
HHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHH
TIIGAHYQELATFLKRLDR
HEECHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8423151 [H]