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The map label for this gene is thrB [H]

Identifier: 78188122

GI number: 78188122

Start: 153005

End: 153967

Strand: Reverse

Name: thrB [H]

Synonym: Cag_0139

Alternate gene names: 78188122

Gene position: 153967-153005 (Counterclockwise)

Preceding gene: 78188130

Following gene: 78188121

Centisome position: 5.99

GC content: 47.87

Gene sequence:

>963_bases
ATGAGAAAGGCTATAGGATTTGCCTCCGCAACCGTTGGCAATGTTGCTTGCGGTTTTGATGTTTTGGGCTTTGCCATTAC
CGCACCGGGTGATGAGGTAATTCTTACGCTTTCCGATACAGCTCAATCCGATTTGCCCGTCTCAATTACTCGCATTGAGG
GGGATGGTGGTGCTTTGCCACTTGATCCACGCAAAAACACCTCCAGCTTTGTGGTACTGAAGTTTTTAGACTACATCCGT
CACCACAAAAACATTGCGTTTGATGGTCATATTTCATTAGAACTCATTAAGCACCTGCCGCTAAGCAGTGGCATGGGTAG
TAGTGCCGCAAGTGGTGCCGCCGCTTTAGTGGCAGCAAATGCTTTATTTGGCAACCCTTGCACAAAAATGGAGTTAGTCC
ATTTTGCTATTGAGGGCGAACGAGTTGCTTGTGGCTCGGCTCATGCCGATAATGCCGCACCAGCTCTGCTTGGTAATTTT
GTTTTGATTCGCAGTTACACCCCTCTCGACATTATTACCATACCATCTCCTGCAAATCTTTATTGTTCTTTAGTGCATCC
GCACACCGAATTACGCACCTCGTATGCACGCTCCGTGTTACCAACCAATCTGCCACTTAAAACTGCAATTCAGCAATGGG
GCAACGTTGGGGCACTTGTTGCTGGTTTATTAACTTCTGATTATGAGCTGATCGGGCGCTCGTTAGTGGATGTGGTAGCT
GAGCCAAAACGCGCTCCGCTAATTCCCGGTTTTGTAGAGGTAAAAAAAGCCGCACTACAAGCAGGAGCTCTTGGGTGCAG
CATTGCAGGCTCAGGTCCATCGGTGTTTGCATTTTCCACCTCTGAAGAAATTGCTACGCGTGTAGGAATGGCTATGAAAG
AGGCATTTTTACACAGCAACGCTCATCTTGAGTCCGACGTATGGATAACTCCCGTTTGTACGCAAGGTGCTCGCGTTCTC
TAA

Upstream 100 bases:

>100_bases
AAAATTTTTGAAGCAACAGTAAATCCGACTCTCCCTTACGTAGAAAAGTTCCCCCATTATAACAGCTATAACACCTTACA
TAGTGCTTGAAGAAACACGC

Downstream 100 bases:

>100_bases
TAAATCAATATTTAAAGAATTTTTGATCTCCATAGAAGCTAAAGCCATGATTTACTTTAGTACCAACAAATCCTCAGTTC
CTGTCTCATTAAAAAAAGCC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRKAIGFASATVGNVACGFDVLGFAITAPGDEVILTLSDTAQSDLPVSITRIEGDGGALPLDPRKNTSSFVVLKFLDYIR
HHKNIAFDGHISLELIKHLPLSSGMGSSAASGAAALVAANALFGNPCTKMELVHFAIEGERVACGSAHADNAAPALLGNF
VLIRSYTPLDIITIPSPANLYCSLVHPHTELRTSYARSVLPTNLPLKTAIQQWGNVGALVAGLLTSDYELIGRSLVDVVA
EPKRAPLIPGFVEVKKAALQAGALGCSIAGSGPSVFAFSTSEEIATRVGMAMKEAFLHSNAHLESDVWITPVCTQGARVL

Sequences:

>Translated_320_residues
MRKAIGFASATVGNVACGFDVLGFAITAPGDEVILTLSDTAQSDLPVSITRIEGDGGALPLDPRKNTSSFVVLKFLDYIR
HHKNIAFDGHISLELIKHLPLSSGMGSSAASGAAALVAANALFGNPCTKMELVHFAIEGERVACGSAHADNAAPALLGNF
VLIRSYTPLDIITIPSPANLYCSLVHPHTELRTSYARSVLPTNLPLKTAIQQWGNVGALVAGLLTSDYELIGRSLVDVVA
EPKRAPLIPGFVEVKKAALQAGALGCSIAGSGPSVFAFSTSEEIATRVGMAMKEAFLHSNAHLESDVWITPVCTQGARVL
>Mature_320_residues
MRKAIGFASATVGNVACGFDVLGFAITAPGDEVILTLSDTAQSDLPVSITRIEGDGGALPLDPRKNTSSFVVLKFLDYIR
HHKNIAFDGHISLELIKHLPLSSGMGSSAASGAAALVAANALFGNPCTKMELVHFAIEGERVACGSAHADNAAPALLGNF
VLIRSYTPLDIITIPSPANLYCSLVHPHTELRTSYARSVLPTNLPLKTAIQQWGNVGALVAGLLTSDYELIGRSLVDVVA
EPKRAPLIPGFVEVKKAALQAGALGCSIAGSGPSVFAFSTSEEIATRVGMAMKEAFLHSNAHLESDVWITPVCTQGARVL

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=314, Percent_Identity=30.8917197452229, Blast_Score=140, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33510; Mature: 33510

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKAIGFASATVGNVACGFDVLGFAITAPGDEVILTLSDTAQSDLPVSITRIEGDGGALP
CCCCCCCCCCCCCCHHHCCHHEEEEEECCCCEEEEEEECCCCCCCCEEEEEEECCCCCCC
LDPRKNTSSFVVLKFLDYIRHHKNIAFDGHISLELIKHLPLSSGMGSSAASGAAALVAAN
CCCCCCCCHHHHHHHHHHHHHHCCEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
ALFGNPCTKMELVHFAIEGERVACGSAHADNAAPALLGNFVLIRSYTPLDIITIPSPANL
HHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHHCEEEEEECCCEEEEECCCCCCE
YCSLVHPHTELRTSYARSVLPTNLPLKTAIQQWGNVGALVAGLLTSDYELIGRSLVDVVA
EEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHC
EPKRAPLIPGFVEVKKAALQAGALGCSIAGSGPSVFAFSTSEEIATRVGMAMKEAFLHSN
CCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHCC
AHLESDVWITPVCTQGARVL
CCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MRKAIGFASATVGNVACGFDVLGFAITAPGDEVILTLSDTAQSDLPVSITRIEGDGGALP
CCCCCCCCCCCCCCHHHCCHHEEEEEECCCCEEEEEEECCCCCCCCEEEEEEECCCCCCC
LDPRKNTSSFVVLKFLDYIRHHKNIAFDGHISLELIKHLPLSSGMGSSAASGAAALVAAN
CCCCCCCCHHHHHHHHHHHHHHCCEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
ALFGNPCTKMELVHFAIEGERVACGSAHADNAAPALLGNFVLIRSYTPLDIITIPSPANL
HHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHHCEEEEEECCCEEEEECCCCCCE
YCSLVHPHTELRTSYARSVLPTNLPLKTAIQQWGNVGALVAGLLTSDYELIGRSLVDVVA
EEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHC
EPKRAPLIPGFVEVKKAALQAGALGCSIAGSGPSVFAFSTSEEIATRVGMAMKEAFLHSN
CCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHCC
AHLESDVWITPVCTQGARVL
CCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA