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The map label for this gene is emrK [H]

Identifier: 78188024

GI number: 78188024

Start: 44199

End: 45227

Strand: Reverse

Name: emrK [H]

Synonym: Cag_0040

Alternate gene names: 78188024

Gene position: 45227-44199 (Counterclockwise)

Preceding gene: 78188025

Following gene: 78188023

Centisome position: 1.76

GC content: 50.34

Gene sequence:

>1029_bases
ATGGCTGATAATACAACGCCCCCTGAAGGCACAAATAATGGCTCAAAAAAATCCTCTTCTCCTCTCCGCATGGGAATTAT
TGGGGTACTGCTTGTAAGCGCACTTGGCGTTGGCGGAAGCTACCTCTACCACTCCATGCTGTACGAAAAAACCGATAATG
CTCAAATTGAGGGCGATATTTATCCCGTTATTTCTCGTATAGCGGGCAAAGTTGCTGAAGTACGCGTGCGCGATAATCAA
ATGGTTGCTCGTGGCGATACGTTGCTCACACTTGATCGTTCCGATGAGCTTGTGCGGCTGAATATGATGGCGGCGGAATT
GCAAAGCGCCCAAGCGGCGGTAAGCGTGGCACAGAGCCAAGCGGAAGCGGCACATGCTGCCGTAAGTGCTGCCGAAGCCA
CTAACCGTAAAGAGCAAAGCGATTTACAGCGTTACAGTAAGTTGTTAAAGCAAGAGGTGATTTCGCCCGCTGAGTTTGAT
GGTGTAAAAGCACGAGCTGAAGCCGCTGCCGCTCAACTGCTTGCACTCCGCAGTCGTTACCAAGCGGCACAAGCCGAACT
TCCACTCAAACAAGCGGACGCGCTCAAGCGGCAAGCCACCTTGCAGGAAGCCGAGCTGAAACTCTCCTACACCGCCCTTA
CGGCACCAGCCAATGGACGAGTTGCAAAGAAAAACGTTCACATTGGGCAATACGTAGCGCCCGGGCAGCAACTGATTGCG
CTGGTTGGCAATAACGATCTATGGGTTGTGGCAAATTTTAAAGAGACGCAATTGGAACACCTTGTTCCCAATCAAGCGGT
GATTATTGAAGTGGATGCTTACCCCGGTAAGGAATTTAGCGGCACCATTGAATCGCTTTCATCGGGCACAGGAGCAAAAT
TCGCTCTTCTCCCACCCGATAACGCCAGCGGCAACTTTGTAAAAGTAACGCAGCGCGTACCCGTTAAAATTCTCTTTACA
GAAAAATTAGATAAACGCTACCCCCTTGCGGCTGGTATGAATGTAACCGTAGCCGTTAAGGTGAAATAA

Upstream 100 bases:

>100_bases
GAGCCTGAATAATTCATTGAATCTTTTGCCTTTTTGTCATTCCCGCGCAAGCGGGAATCCAGAAAGAATCTGAATAAATC
CGATAGAAAACAAAACAACA

Downstream 100 bases:

>100_bases
CGCTATGGCAAACGCACCTTCTCTTTCAGCCTCGCCAAAGCTACTCGGCACCACCGAAGAGCATTACGAAACAGGGTGGC
GCAAGCTCATTATCACCTTG

Product: multidrug resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MADNTTPPEGTNNGSKKSSSPLRMGIIGVLLVSALGVGGSYLYHSMLYEKTDNAQIEGDIYPVISRIAGKVAEVRVRDNQ
MVARGDTLLTLDRSDELVRLNMMAAELQSAQAAVSVAQSQAEAAHAAVSAAEATNRKEQSDLQRYSKLLKQEVISPAEFD
GVKARAEAAAAQLLALRSRYQAAQAELPLKQADALKRQATLQEAELKLSYTALTAPANGRVAKKNVHIGQYVAPGQQLIA
LVGNNDLWVVANFKETQLEHLVPNQAVIIEVDAYPGKEFSGTIESLSSGTGAKFALLPPDNASGNFVKVTQRVPVKILFT
EKLDKRYPLAAGMNVTVAVKVK

Sequences:

>Translated_342_residues
MADNTTPPEGTNNGSKKSSSPLRMGIIGVLLVSALGVGGSYLYHSMLYEKTDNAQIEGDIYPVISRIAGKVAEVRVRDNQ
MVARGDTLLTLDRSDELVRLNMMAAELQSAQAAVSVAQSQAEAAHAAVSAAEATNRKEQSDLQRYSKLLKQEVISPAEFD
GVKARAEAAAAQLLALRSRYQAAQAELPLKQADALKRQATLQEAELKLSYTALTAPANGRVAKKNVHIGQYVAPGQQLIA
LVGNNDLWVVANFKETQLEHLVPNQAVIIEVDAYPGKEFSGTIESLSSGTGAKFALLPPDNASGNFVKVTQRVPVKILFT
EKLDKRYPLAAGMNVTVAVKVK
>Mature_341_residues
ADNTTPPEGTNNGSKKSSSPLRMGIIGVLLVSALGVGGSYLYHSMLYEKTDNAQIEGDIYPVISRIAGKVAEVRVRDNQM
VARGDTLLTLDRSDELVRLNMMAAELQSAQAAVSVAQSQAEAAHAAVSAAEATNRKEQSDLQRYSKLLKQEVISPAEFDG
VKARAEAAAAQLLALRSRYQAAQAELPLKQADALKRQATLQEAELKLSYTALTAPANGRVAKKNVHIGQYVAPGQQLIAL
VGNNDLWVVANFKETQLEHLVPNQAVIIEVDAYPGKEFSGTIESLSSGTGAKFALLPPDNASGNFVKVTQRVPVKILFTE
KLDKRYPLAAGMNVTVAVKVK

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=343, Percent_Identity=32.6530612244898, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI1789041, Length=320, Percent_Identity=31.25, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1790519, Length=285, Percent_Identity=29.4736842105263, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87081951, Length=323, Percent_Identity=26.0061919504644, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1789637, Length=327, Percent_Identity=26.9113149847095, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790024, Length=267, Percent_Identity=26.9662921348315, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790012, Length=236, Percent_Identity=27.1186440677966, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 36694; Mature: 36563

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNTTPPEGTNNGSKKSSSPLRMGIIGVLLVSALGVGGSYLYHSMLYEKTDNAQIEGDI
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEECCHH
YPVISRIAGKVAEVRVRDNQMVARGDTLLTLDRSDELVRLNMMAAELQSAQAAVSVAQSQ
HHHHHHHHCHHEEEEECCCEEEECCCEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHH
AEAAHAAVSAAEATNRKEQSDLQRYSKLLKQEVISPAEFDGVKARAEAAAAQLLALRSRY
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QAAQAELPLKQADALKRQATLQEAELKLSYTALTAPANGRVAKKNVHIGQYVAPGQQLIA
HHHHHCCCHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCEEECCCCCCCEECCCCCEEE
LVGNNDLWVVANFKETQLEHLVPNQAVIIEVDAYPGKEFSGTIESLSSGTGAKFALLPPD
EECCCCEEEEECCCHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCEEEEECCC
NASGNFVKVTQRVPVKILFTEKLDKRYPLAAGMNVTVAVKVK
CCCCCEEEEECCCCEEEEEECCCCCCCCEECCCEEEEEEEEC
>Mature Secondary Structure 
ADNTTPPEGTNNGSKKSSSPLRMGIIGVLLVSALGVGGSYLYHSMLYEKTDNAQIEGDI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEECCHH
YPVISRIAGKVAEVRVRDNQMVARGDTLLTLDRSDELVRLNMMAAELQSAQAAVSVAQSQ
HHHHHHHHCHHEEEEECCCEEEECCCEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHH
AEAAHAAVSAAEATNRKEQSDLQRYSKLLKQEVISPAEFDGVKARAEAAAAQLLALRSRY
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QAAQAELPLKQADALKRQATLQEAELKLSYTALTAPANGRVAKKNVHIGQYVAPGQQLIA
HHHHHCCCHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCEEECCCCCCCEECCCCCEEE
LVGNNDLWVVANFKETQLEHLVPNQAVIIEVDAYPGKEFSGTIESLSSGTGAKFALLPPD
EECCCCEEEEECCCHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCEEEEECCC
NASGNFVKVTQRVPVKILFTEKLDKRYPLAAGMNVTVAVKVK
CCCCCEEEEECCCCEEEEEECCCCCCCCEECCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]