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The map label for this gene is glmS [H]

Identifier: 78187989

GI number: 78187989

Start: 5321

End: 7048

Strand: Reverse

Name: glmS [H]

Synonym: Cag_0005

Alternate gene names: 78187989

Gene position: 7048-5321 (Counterclockwise)

Preceding gene: 78187990

Following gene: 78187988

Centisome position: 0.27

GC content: 45.66

Gene sequence:

>1728_bases
TTGCTGAATAGCACTATTTCGGTGGCGAAGCAAAAAGGGCGCGTTAAAGAGCTTGAATCGGAAGCCAATGCACTTGCACC
TGCCACTATTGGTATTGGACATACACGCTGGGCAACGCATGGTGAGCCAAACCACCGCAATGCACATCCCCACCTTAACA
AAGCGGGCGATATTGCACTTATCCATAATGGCATTATTGAGAATTACTCTCTTCTCAAACAAGAGCTACAAGCTGAAGGC
TACACCTTTGTAAGCGATACCGATTCAGAGGTACTTGTTCACTTAATTGACCGCATTTGGCAGCGCGACCCCTCGCTTGA
TCTTGAAAGCGCCGTGCGCCAAACCTTGCGCCATGTTGAAGGTGCCTATGGAGTCTGCGTTATCTCTTCACGCGAACCCG
ATAAAATTGTGGTAGCTCGCAAAGGGAGCCCATTGGTAATTGGGTTGGGGAAGGATGAATTTTTTATTGCCTCCGATGGT
GCGCCAATTGTAGAGCACACCAATAAAGTTATCTATCTCTCTGATGGTGAAATGGCAACGGTAACGCGCCACGGTTACTG
CATTAAAACCATTGAAAACATTGAGCAATATAAAGAGGTTACTGAGCTTGATTTTTCCCTTGAAAAAATTGAGAAAGGCG
GTTTTGAACACTTTATGCTGAAGGAAATTTACGAACAACCCACCGTTATGCACGATGTAATGCGAGGGCGCATTCGTGCT
GATGAAGGTAAAATTATGCTGGGTGGCATTGCTGACTACCTTGATAAATTAAAACATGCAAAACGCATTATTATTTGCGC
TTGCGGTACCAGTTGGCACGCCTCATTAATTGGCGAATACTTAATTGAAGAATTTGCTCGTATTCCTGTTGAAGTGGAGT
ATGCCTCAGAATTTCGCTATCGCAATCCCATTATTACGAGTGATGATGTGGTGATTGTGGTTTCACAATCGGGCGAAACG
GCTGATACGTTGGCAGCTCTACGCACCGCAAAAGAGAAAGGTGCCTTAGTGATGGGTATTTGCAACGTTGTGGGTTCAAC
CATTGCTCGCGAAACGCTTTGTGGCATGTATACTCATGCAGGACCTGAAATTGGCGTAGCATCCACCAAAGCCTTTACCG
CTCAAGTGATGATGCTGTACATGTTAGCCTTACTGCTTGGTAAAGGACGAACTATTGCACAAAGTGAGCTTTCGCTGAGT
TTACGTGAACTTGCCGCTTTACCTGAAAAAGCTGCACGCATTTTAGAGCTTGATAGCCAAATCCGCCAAATTGCTGATCG
CTACAAAGAGGCTCGCAATGTGCTCTACCTTGGTCGTGGTTACAATTTCCCCGTAGCACTTGAAGGTGCCCTCAAGCTTA
AAGAAATCTCCTACATTCATGCTGAAGGGTATCCTGCTGCTGAAATGAAGCATGGACCTATTGCCTTAATTGATGAAGAT
ATGCCGGTTGTAATTATTGCCACACGCGATAACACCTACGCGAAAATTCTCAGCAACATTGAAGAGGTGCGAAGCCGCAA
AGGGCGCGTAATTGCAATTGCCAGCGAAGGCGATCAAGAAGTGAAGCGCCTTGCCGAAGAGGTAATTTACATTCCGCAAG
CCAGCAATGCTATTACGCCACTCCTTGCAGTAATTCCTTTACAACTTCTTTCATACCACATTGCAACATTGCGAGGCTGC
AATGTTGATCGTCCACGCAATTTGGCAAAATCGGTAACGGTTGAATAA

Upstream 100 bases:

>100_bases
TGGAATTGTTGGATATATTGGATGGCAAAATGCAGCTCCGTTGCTACTGAAAGGCTTAAAACGGCTTGAATATCGTGGAT
ACGACTCGGCTGGTATTGCA

Downstream 100 bases:

>100_bases
TTATAAAAGTGAACGGAAGACCATTATGAATAATCACATTGTAATAACAGGCGCAACGGGCGTTATTGGTGTTGAACTTG
CTCAAAAGCTCATAAAGCGC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MLNSTISVAKQKGRVKELESEANALAPATIGIGHTRWATHGEPNHRNAHPHLNKAGDIALIHNGIIENYSLLKQELQAEG
YTFVSDTDSEVLVHLIDRIWQRDPSLDLESAVRQTLRHVEGAYGVCVISSREPDKIVVARKGSPLVIGLGKDEFFIASDG
APIVEHTNKVIYLSDGEMATVTRHGYCIKTIENIEQYKEVTELDFSLEKIEKGGFEHFMLKEIYEQPTVMHDVMRGRIRA
DEGKIMLGGIADYLDKLKHAKRIIICACGTSWHASLIGEYLIEEFARIPVEVEYASEFRYRNPIITSDDVVIVVSQSGET
ADTLAALRTAKEKGALVMGICNVVGSTIARETLCGMYTHAGPEIGVASTKAFTAQVMMLYMLALLLGKGRTIAQSELSLS
LRELAALPEKAARILELDSQIRQIADRYKEARNVLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDED
MPVVIIATRDNTYAKILSNIEEVRSRKGRVIAIASEGDQEVKRLAEEVIYIPQASNAITPLLAVIPLQLLSYHIATLRGC
NVDRPRNLAKSVTVE

Sequences:

>Translated_575_residues
MLNSTISVAKQKGRVKELESEANALAPATIGIGHTRWATHGEPNHRNAHPHLNKAGDIALIHNGIIENYSLLKQELQAEG
YTFVSDTDSEVLVHLIDRIWQRDPSLDLESAVRQTLRHVEGAYGVCVISSREPDKIVVARKGSPLVIGLGKDEFFIASDG
APIVEHTNKVIYLSDGEMATVTRHGYCIKTIENIEQYKEVTELDFSLEKIEKGGFEHFMLKEIYEQPTVMHDVMRGRIRA
DEGKIMLGGIADYLDKLKHAKRIIICACGTSWHASLIGEYLIEEFARIPVEVEYASEFRYRNPIITSDDVVIVVSQSGET
ADTLAALRTAKEKGALVMGICNVVGSTIARETLCGMYTHAGPEIGVASTKAFTAQVMMLYMLALLLGKGRTIAQSELSLS
LRELAALPEKAARILELDSQIRQIADRYKEARNVLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDED
MPVVIIATRDNTYAKILSNIEEVRSRKGRVIAIASEGDQEVKRLAEEVIYIPQASNAITPLLAVIPLQLLSYHIATLRGC
NVDRPRNLAKSVTVE
>Mature_575_residues
MLNSTISVAKQKGRVKELESEANALAPATIGIGHTRWATHGEPNHRNAHPHLNKAGDIALIHNGIIENYSLLKQELQAEG
YTFVSDTDSEVLVHLIDRIWQRDPSLDLESAVRQTLRHVEGAYGVCVISSREPDKIVVARKGSPLVIGLGKDEFFIASDG
APIVEHTNKVIYLSDGEMATVTRHGYCIKTIENIEQYKEVTELDFSLEKIEKGGFEHFMLKEIYEQPTVMHDVMRGRIRA
DEGKIMLGGIADYLDKLKHAKRIIICACGTSWHASLIGEYLIEEFARIPVEVEYASEFRYRNPIITSDDVVIVVSQSGET
ADTLAALRTAKEKGALVMGICNVVGSTIARETLCGMYTHAGPEIGVASTKAFTAQVMMLYMLALLLGKGRTIAQSELSLS
LRELAALPEKAARILELDSQIRQIADRYKEARNVLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDED
MPVVIIATRDNTYAKILSNIEEVRSRKGRVIAIASEGDQEVKRLAEEVIYIPQASNAITPLLAVIPLQLLSYHIATLRGC
NVDRPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=629, Percent_Identity=39.5866454689984, Blast_Score=478, Evalue=1e-135,
Organism=Homo sapiens, GI205277386, Length=625, Percent_Identity=40.64, Blast_Score=477, Evalue=1e-134,
Organism=Escherichia coli, GI1790167, Length=547, Percent_Identity=45.7038391224863, Blast_Score=481, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17532897, Length=433, Percent_Identity=45.9584295612009, Blast_Score=380, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17532899, Length=433, Percent_Identity=45.9584295612009, Blast_Score=380, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17539970, Length=429, Percent_Identity=44.988344988345, Blast_Score=372, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6322745, Length=449, Percent_Identity=43.4298440979955, Blast_Score=371, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323731, Length=427, Percent_Identity=37.9391100702576, Blast_Score=296, Evalue=6e-81,
Organism=Saccharomyces cerevisiae, GI6323730, Length=157, Percent_Identity=38.8535031847134, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21357745, Length=632, Percent_Identity=41.4556962025316, Blast_Score=509, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 63574; Mature: 63574

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNSTISVAKQKGRVKELESEANALAPATIGIGHTRWATHGEPNHRNAHPHLNKAGDIAL
CCCCHHHHHHHCCHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
IHNGIIENYSLLKQELQAEGYTFVSDTDSEVLVHLIDRIWQRDPSLDLESAVRQTLRHVE
EECCHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GAYGVCVISSREPDKIVVARKGSPLVIGLGKDEFFIASDGAPIVEHTNKVIYLSDGEMAT
CCCEEEEECCCCCCEEEEEECCCCEEEEECCCCEEEECCCCCHHHCCCEEEEEECCCEEE
VTRHGYCIKTIENIEQYKEVTELDFSLEKIEKGGFEHFMLKEIYEQPTVMHDVMRGRIRA
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHCCEEC
DEGKIMLGGIADYLDKLKHAKRIIICACGTSWHASLIGEYLIEEFARIPVEVEYASEFRY
CCCCEEECHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHC
RNPIITSDDVVIVVSQSGETADTLAALRTAKEKGALVMGICNVVGSTIARETLCGMYTHA
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCC
GPEIGVASTKAFTAQVMMLYMLALLLGKGRTIAQSELSLSLRELAALPEKAARILELDSQ
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCHHHHHHHHHHHHH
IRQIADRYKEARNVLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDED
HHHHHHHHHHHCCEEEEECCCCCCEEECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECC
MPVVIIATRDNTYAKILSNIEEVRSRKGRVIAIASEGDQEVKRLAEEVIYIPQASNAITP
CCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHEEECCCCCCHHHH
LLAVIPLQLLSYHIATLRGCNVDRPRNLAKSVTVE
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MLNSTISVAKQKGRVKELESEANALAPATIGIGHTRWATHGEPNHRNAHPHLNKAGDIAL
CCCCHHHHHHHCCHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
IHNGIIENYSLLKQELQAEGYTFVSDTDSEVLVHLIDRIWQRDPSLDLESAVRQTLRHVE
EECCHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GAYGVCVISSREPDKIVVARKGSPLVIGLGKDEFFIASDGAPIVEHTNKVIYLSDGEMAT
CCCEEEEECCCCCCEEEEEECCCCEEEEECCCCEEEECCCCCHHHCCCEEEEEECCCEEE
VTRHGYCIKTIENIEQYKEVTELDFSLEKIEKGGFEHFMLKEIYEQPTVMHDVMRGRIRA
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHCCEEC
DEGKIMLGGIADYLDKLKHAKRIIICACGTSWHASLIGEYLIEEFARIPVEVEYASEFRY
CCCCEEECHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHC
RNPIITSDDVVIVVSQSGETADTLAALRTAKEKGALVMGICNVVGSTIARETLCGMYTHA
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCC
GPEIGVASTKAFTAQVMMLYMLALLLGKGRTIAQSELSLSLRELAALPEKAARILELDSQ
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCHHHHHHHHHHHHH
IRQIADRYKEARNVLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDED
HHHHHHHHHHHCCEEEEECCCCCCEEECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECC
MPVVIIATRDNTYAKILSNIEEVRSRKGRVIAIASEGDQEVKRLAEEVIYIPQASNAITP
CCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHEEECCCCCCHHHH
LLAVIPLQLLSYHIATLRGCNVDRPRNLAKSVTVE
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]