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The map label for this gene is def

Identifier: 78067947

GI number: 78067947

Start: 3646226

End: 3646729

Strand: Reverse

Name: def

Synonym: Bcep18194_A6478

Alternate gene names: 78067947

Gene position: 3646729-3646226 (Counterclockwise)

Preceding gene: 78067951

Following gene: 78067946

Centisome position: 98.72

GC content: 61.31

Gene sequence:

>504_bases
ATGGCTTTACTCAATATTCTTCATTACCCCGACAAGCGGCTGCACAAGGTCGCGAAGCCCGTCGACAAGGTCGACGACCG
GATCCGCAAGCTCGTCGCCGACATGGCCGAGACCATGTATGCGGCGCCGGGCATCGGCCTGGCGGCCACGCAGGTCGACG
TGCACGAGCGCGTGATCGTGATCGACGTCTCCGAGGAGAAGAACGAGCTGCGCGCGTTCATCAACCCCGAGATCGTGTGG
TCGAGCGACGAGAAGCAGATCTATGAAGAGGGCTGCCTGTCGGTGCCCGGCATCTACGATGAAGTCGAGCGTCCCGATCA
CGTGCGCGTGCGCGCGCTCAACGAGCAGGGCGAGACTTTCGAGCTCGACTGCGAAGGCCTGCTGGCCGTGTGCGTCCAGC
ATGAGATGGATCACCTGATGGGGCGCGTGTTCGTCGAATACCTGTCGCCGCTCAAGCAGACGCGCATCAAGACGAAGATG
AAGAAACTCGAACGCGCGATGTAA

Upstream 100 bases:

>100_bases
GATTCGCCGCGCGTCCGCCTCATCTTCATTGCATCCCGGCGGCAGCGCCAGCTGGCCGGATGGCCGATGCGGCACGCCGC
TCCACCGAATACCGAACGCC

Downstream 100 bases:

>100_bases
CGCGCGTTCGCCCAGCCCGATCCCGAACGCTGTCATGACCCATACGTTGCGCGTAGTTTTTGCCGGCACGCCGGAATTCG
CCGCGGCTGCCCTCGCCGCG

Product: peptide deformylase

Products: NA

Alternate protein names: PDF 1; Polypeptide deformylase 1 [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MALLNILHYPDKRLHKVAKPVDKVDDRIRKLVADMAETMYAAPGIGLAATQVDVHERVIVIDVSEEKNELRAFINPEIVW
SSDEKQIYEEGCLSVPGIYDEVERPDHVRVRALNEQGETFELDCEGLLAVCVQHEMDHLMGRVFVEYLSPLKQTRIKTKM
KKLERAM

Sequences:

>Translated_167_residues
MALLNILHYPDKRLHKVAKPVDKVDDRIRKLVADMAETMYAAPGIGLAATQVDVHERVIVIDVSEEKNELRAFINPEIVW
SSDEKQIYEEGCLSVPGIYDEVERPDHVRVRALNEQGETFELDCEGLLAVCVQHEMDHLMGRVFVEYLSPLKQTRIKTKM
KKLERAM
>Mature_166_residues
ALLNILHYPDKRLHKVAKPVDKVDDRIRKLVADMAETMYAAPGIGLAATQVDVHERVIVIDVSEEKNELRAFINPEIVWS
SDEKQIYEEGCLSVPGIYDEVERPDHVRVRALNEQGETFELDCEGLLAVCVQHEMDHLMGRVFVEYLSPLKQTRIKTKMK
KLERAM

Specific function: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions

COG id: COG0242

COG function: function code J; N-formylmethionyl-tRNA deformylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polypeptide deformylase family [H]

Homologues:

Organism=Homo sapiens, GI11641243, Length=155, Percent_Identity=28.3870967741935, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1789682, Length=165, Percent_Identity=57.5757575757576, Blast_Score=197, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24645728, Length=146, Percent_Identity=33.5616438356164, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24645726, Length=137, Percent_Identity=31.3868613138686, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000181 [H]

Pfam domain/function: PF01327 Pep_deformylase [H]

EC number: =3.5.1.88 [H]

Molecular weight: Translated: 19170; Mature: 19039

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLNILHYPDKRLHKVAKPVDKVDDRIRKLVADMAETMYAAPGIGLAATQVDVHERVIV
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHCEEEE
IDVSEEKNELRAFINPEIVWSSDEKQIYEEGCLSVPGIYDEVERPDHVRVRALNEQGETF
EECCCCHHHHHHHCCCCEEECCCHHHHHHHCCCCCCCCHHHHCCCCCEEEEEECCCCCEE
ELDCEGLLAVCVQHEMDHLMGRVFVEYLSPLKQTRIKTKMKKLERAM
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALLNILHYPDKRLHKVAKPVDKVDDRIRKLVADMAETMYAAPGIGLAATQVDVHERVIV
CHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHCEEEE
IDVSEEKNELRAFINPEIVWSSDEKQIYEEGCLSVPGIYDEVERPDHVRVRALNEQGETF
EECCCCHHHHHHHCCCCEEECCCHHHHHHHCCCCCCCCHHHHCCCCCEEEEEECCCCCEE
ELDCEGLLAVCVQHEMDHLMGRVFVEYLSPLKQTRIKTKMKKLERAM
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]