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The map label for this gene is kipI [H]

Identifier: 78067752

GI number: 78067752

Start: 3444834

End: 3445709

Strand: Direct

Name: kipI [H]

Synonym: Bcep18194_A6283

Alternate gene names: 78067752

Gene position: 3444834-3445709 (Clockwise)

Preceding gene: 78067751

Following gene: 78067753

Centisome position: 93.25

GC content: 65.75

Gene sequence:

>876_bases
GTGACGACCCGTTATACGTTCGGCGGCGACGAGTTCGTGTTCGTCGAAATCAGCGAATCGATGTCGCTCGATGCGTTCTT
CAAGGGCACGGCAATCACGCGCGAACTACAGCGCCGCGCGGTGCCGGGCATCACCGAGATCTGTCCGGCGAATGCGTCGT
ACCAGGTGCGCTACGACCCGGACGTGATCGAGCCCGACGCGCTCGTCGCGCTGTTGAAGACGATCGAGGCCGAAGTCGGC
GACGCGCCGCTCGAACTCGACACGCGCATCGTCGAGGTGCCGGTGCTCTACAACGACCCGTGGACGCACGAGACGCTGAT
GCGGTTCCGCGAACGCCATCAGGATCCGTCGTCGACCGATCTCGAATACGCGGCCCGCATCAACGGCAAGCGCGACGTCG
ACGCATTCATCGCCGCGCACTCGGGCTCGCCGTGGTTCGTGTCGATGGTCGGCTTCGTCGCGGGCCTGCCGTTCATGTAC
CAGATGGTCGAGCGCGAACGCCAGCTCGAAGTGCCGAAGTACCTGCGGCCGCGCACCGACACGCCGAAGCTGACGGTCGG
CCACGGCGGCTGTTTCGGCTGCATCTACTCGGTGCGCGGCGCGGGCGGCTACCAGATGTTCGGCGTGACGCCGGCGCCGA
TCTTCGACCCCGCGCAGCGGCTCGACTACCTGCACGACTTCATGGTGTTCTTCCGGCCCGGCGACATCGTGAAATTCCAG
CCGATCGATCGCGATGCGTACGACGCGGCAGTGGCGGCCGTCGAGGCCGGCACCTTCTCGCTGCGCGTGCGCCCGGTGAA
ATTCTCGCTCGACGCATTCCTGCGCGATCCCGATGCGGTCAACCGCTCTCTCGTCGAGGTGCTGCATGCAAACTGA

Upstream 100 bases:

>100_bases
TCCTCGAGGCGTGGATGCCGCGCTGGCGCGAAGCCGCCACCGCCGCCGCGCAACGACACGCAACCGACAATGCAGACGCC
GTGCGCGTCGGGGAGGCGAT

Downstream 100 bases:

>100_bases
CGCGCACAACCTGATCGAAGTCGTGAAACCCGGCCTCGCGACGTCGGTCCAGGACATGGGCCGGCAAGGCTATTACCACG
TCGGCATTCCGCCGTCGGGC

Product: allophanate hydrolase subunit 1

Products: NA

Alternate protein names: Sporulation inhibitor kipI [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTTRYTFGGDEFVFVEISESMSLDAFFKGTAITRELQRRAVPGITEICPANASYQVRYDPDVIEPDALVALLKTIEAEVG
DAPLELDTRIVEVPVLYNDPWTHETLMRFRERHQDPSSTDLEYAARINGKRDVDAFIAAHSGSPWFVSMVGFVAGLPFMY
QMVERERQLEVPKYLRPRTDTPKLTVGHGGCFGCIYSVRGAGGYQMFGVTPAPIFDPAQRLDYLHDFMVFFRPGDIVKFQ
PIDRDAYDAAVAAVEAGTFSLRVRPVKFSLDAFLRDPDAVNRSLVEVLHAN

Sequences:

>Translated_291_residues
MTTRYTFGGDEFVFVEISESMSLDAFFKGTAITRELQRRAVPGITEICPANASYQVRYDPDVIEPDALVALLKTIEAEVG
DAPLELDTRIVEVPVLYNDPWTHETLMRFRERHQDPSSTDLEYAARINGKRDVDAFIAAHSGSPWFVSMVGFVAGLPFMY
QMVERERQLEVPKYLRPRTDTPKLTVGHGGCFGCIYSVRGAGGYQMFGVTPAPIFDPAQRLDYLHDFMVFFRPGDIVKFQ
PIDRDAYDAAVAAVEAGTFSLRVRPVKFSLDAFLRDPDAVNRSLVEVLHAN
>Mature_290_residues
TTRYTFGGDEFVFVEISESMSLDAFFKGTAITRELQRRAVPGITEICPANASYQVRYDPDVIEPDALVALLKTIEAEVGD
APLELDTRIVEVPVLYNDPWTHETLMRFRERHQDPSSTDLEYAARINGKRDVDAFIAAHSGSPWFVSMVGFVAGLPFMYQ
MVERERQLEVPKYLRPRTDTPKLTVGHGGCFGCIYSVRGAGGYQMFGVTPAPIFDPAQRLDYLHDFMVFFRPGDIVKFQP
IDRDAYDAAVAAVEAGTFSLRVRPVKFSLDAFLRDPDAVNRSLVEVLHAN

Specific function: Is a potent inhibitor of the autophosphorylation reaction of kinase A and its reverse reaction, but does not inhibit phosphate transfer to the Spo0F response regulator once kinase A is phosphorylated. KipI is an inhibitor of the catalytic domain of kinase

COG id: COG2049

COG function: function code E; Allophanate hydrolase subunit 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786929, Length=235, Percent_Identity=27.2340425531915, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319685, Length=285, Percent_Identity=23.859649122807, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003833
- InterPro:   IPR020899
- InterPro:   IPR010016
- InterPro:   IPR002130 [H]

Pfam domain/function: PF02682 AHS1 [H]

EC number: NA

Molecular weight: Translated: 32686; Mature: 32554

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRYTFGGDEFVFVEISESMSLDAFFKGTAITRELQRRAVPGITEICPANASYQVRYDP
CCCEEECCCCEEEEEEECCCCCCHHHHCCHHHHHHHHHHCCCCHHHHCCCCCCEEEEECC
DVIEPDALVALLKTIEAEVGDAPLELDTRIVEVPVLYNDPWTHETLMRFRERHQDPSSTD
CCCCHHHHHHHHHHHHHHCCCCCEEECCEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCC
LEYAARINGKRDVDAFIAAHSGSPWFVSMVGFVAGLPFMYQMVERERQLEVPKYLRPRTD
CHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHCCCCC
TPKLTVGHGGCFGCIYSVRGAGGYQMFGVTPAPIFDPAQRLDYLHDFMVFFRPGDIVKFQ
CCEEEECCCCHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHEECCCCEEEEE
PIDRDAYDAAVAAVEAGTFSLRVRPVKFSLDAFLRDPDAVNRSLVEVLHAN
CCCCCHHHHHHHHEECCEEEEEEEEEEEEHHHHHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTRYTFGGDEFVFVEISESMSLDAFFKGTAITRELQRRAVPGITEICPANASYQVRYDP
CCEEECCCCEEEEEEECCCCCCHHHHCCHHHHHHHHHHCCCCHHHHCCCCCCEEEEECC
DVIEPDALVALLKTIEAEVGDAPLELDTRIVEVPVLYNDPWTHETLMRFRERHQDPSSTD
CCCCHHHHHHHHHHHHHHCCCCCEEECCEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCC
LEYAARINGKRDVDAFIAAHSGSPWFVSMVGFVAGLPFMYQMVERERQLEVPKYLRPRTD
CHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHCCCCC
TPKLTVGHGGCFGCIYSVRGAGGYQMFGVTPAPIFDPAQRLDYLHDFMVFFRPGDIVKFQ
CCEEEECCCCHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHEECCCCEEEEE
PIDRDAYDAAVAAVEAGTFSLRVRPVKFSLDAFLRDPDAVNRSLVEVLHAN
CCCCCHHHHHHHHEECCEEEEEEEEEEEEHHHHHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10568751 [H]