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The map label for this gene is bioF [H]

Identifier: 78067745

GI number: 78067745

Start: 3438075

End: 3439277

Strand: Direct

Name: bioF [H]

Synonym: Bcep18194_A6276

Alternate gene names: 78067745

Gene position: 3438075-3439277 (Clockwise)

Preceding gene: 78067744

Following gene: 78067746

Centisome position: 93.07

GC content: 70.99

Gene sequence:

>1203_bases
ATGAGTCTGCTCGATACCCTGCAACGCGGCCTCGCCGATCTCGACGCGCAAGGGCTGCGCCGCGTGCGCCGCACCGCCGA
CACCGCGTGCGATGCGCACATGACCGTCGACGGTCGCGAGATCGTCGGCTTCGCAAGCAACGACTATCTCGGCCTCGCCG
CGCATCCGGCACTCATCGCCGCGTTCGCCGAAGGCGCGCAGCGCTACGGCTCCGGCAGCGGCGGCTCGCACCTGCTCGGT
GGTCATTCGCGCGCGCACGCGACGCTCGAAGATGAACTCGCGGCCTTCTCGGGCGGCTTCTCCGACGCACCGCGCGCGCT
GTACTTCAGCACCGGCTACATGGCGAACCTCGCCGCGATGACGGCGCTCACCGGCAAGGCCGCGACGATCTTCTCCGACG
CGCTGAACCACGCTTCGCTGATCGACGGCATGCGGCTGTCGCGCGCGAACGTCCAGGTCTATCCGCATGCGGACACGGCC
GCGCTCGCCGCGTTGCTCGACGCATCGGATGCCGAAACGAAGCTGATCGTCAGCGACACCGTGTTCAGCATGGATGGCGA
CCTCGCCCCGCTCGCCGAACTCGTCGCGCTGGCCGAACGCCACGGCGCATGGCTCGTCGTCGACGACGCGCACGGCTTCG
GCGTGCTCGGCCCGCAGGGCCGCGGCGCGCTCGCGGCCGCCGCGCTGCGCTCGCCGAACCTCGTGTACGTCGGCACGCTC
GGCAAGGCCGCCGGCGTCGCAGGCGCATTCGTGATCGCGCACGAGACCGTGATCGAATGGATGATCCAGCGCGCGCGCAG
CTACATCTTCACGACGGCCGCGCCGCCTGCCGTGGCGCACGCGGTATCCGCCAGCCTGAAAGTGATCGCGGGCGACGAAG
GCGACGCGCGACGTGCGCATCTCGCCGCGCTGATCGAACGCACGCGCGCGCTGTTGCGCAACACGCGCTGGCAGCCGGTC
GATTCGCACACGGCCGTGCAGCCGCTCGTGATCGGCAGCAACGACGCGACGCTCGCGGCGATGCGCTCGCTCGACGCGCA
TGGCCTGTGGGTGCCCGCGATCCGGCCGCCGACGGTGCCGGTCGGCACGTCGCGGCTGCGCGTGTCGCTGTCGGCCGCGC
ATTCGTTCGACGATCTCGCGCGGCTCGAAGCCGCGCTGATCGAAGCCAGCGAAGCGCAGGCCGTGCAGAAGGCCGCCGCA
TGA

Upstream 100 bases:

>100_bases
TGTACCTGATGCCGCCGTACGTGATGAGCGACGACGACATCGCGTGGCTCGCGCAAAGCACGCGCGACACGCTCGACGCA
ACGCTGGAGGACATCACCCG

Downstream 100 bases:

>100_bases
CCGCTCCGCTCTCGCTGTTCGTCACCGGCACCGACACCGAAATCGGCAAGACCTTCGTGTCGGCCGCGCTGCTGCACGGC
TTCGCGCGCCACGGCCTGCG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSLLDTLQRGLADLDAQGLRRVRRTADTACDAHMTVDGREIVGFASNDYLGLAAHPALIAAFAEGAQRYGSGSGGSHLLG
GHSRAHATLEDELAAFSGGFSDAPRALYFSTGYMANLAAMTALTGKAATIFSDALNHASLIDGMRLSRANVQVYPHADTA
ALAALLDASDAETKLIVSDTVFSMDGDLAPLAELVALAERHGAWLVVDDAHGFGVLGPQGRGALAAAALRSPNLVYVGTL
GKAAGVAGAFVIAHETVIEWMIQRARSYIFTTAAPPAVAHAVSASLKVIAGDEGDARRAHLAALIERTRALLRNTRWQPV
DSHTAVQPLVIGSNDATLAAMRSLDAHGLWVPAIRPPTVPVGTSRLRVSLSAAHSFDDLARLEAALIEASEAQAVQKAAA

Sequences:

>Translated_400_residues
MSLLDTLQRGLADLDAQGLRRVRRTADTACDAHMTVDGREIVGFASNDYLGLAAHPALIAAFAEGAQRYGSGSGGSHLLG
GHSRAHATLEDELAAFSGGFSDAPRALYFSTGYMANLAAMTALTGKAATIFSDALNHASLIDGMRLSRANVQVYPHADTA
ALAALLDASDAETKLIVSDTVFSMDGDLAPLAELVALAERHGAWLVVDDAHGFGVLGPQGRGALAAAALRSPNLVYVGTL
GKAAGVAGAFVIAHETVIEWMIQRARSYIFTTAAPPAVAHAVSASLKVIAGDEGDARRAHLAALIERTRALLRNTRWQPV
DSHTAVQPLVIGSNDATLAAMRSLDAHGLWVPAIRPPTVPVGTSRLRVSLSAAHSFDDLARLEAALIEASEAQAVQKAAA
>Mature_399_residues
SLLDTLQRGLADLDAQGLRRVRRTADTACDAHMTVDGREIVGFASNDYLGLAAHPALIAAFAEGAQRYGSGSGGSHLLGG
HSRAHATLEDELAAFSGGFSDAPRALYFSTGYMANLAAMTALTGKAATIFSDALNHASLIDGMRLSRANVQVYPHADTAA
LAALLDASDAETKLIVSDTVFSMDGDLAPLAELVALAERHGAWLVVDDAHGFGVLGPQGRGALAAAALRSPNLVYVGTLG
KAAGVAGAFVIAHETVIEWMIQRARSYIFTTAAPPAVAHAVSASLKVIAGDEGDARRAHLAALIERTRALLRNTRWQPVD
SHTAVQPLVIGSNDATLAAMRSLDAHGLWVPAIRPPTVPVGTSRLRVSLSAAHSFDDLARLEAALIEASEAQAVQKAAA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=391, Percent_Identity=32.9923273657289, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI284448556, Length=364, Percent_Identity=33.5164835164835, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI83977442, Length=375, Percent_Identity=34.9333333333333, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI83977440, Length=375, Percent_Identity=34.9333333333333, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI83977444, Length=373, Percent_Identity=34.0482573726542, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4502025, Length=344, Percent_Identity=31.6860465116279, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI40316939, Length=344, Percent_Identity=31.6860465116279, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI4758668, Length=369, Percent_Identity=28.9972899728997, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI119220554, Length=373, Percent_Identity=28.1501340482574, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI5454084, Length=276, Percent_Identity=26.8115942028986, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1786993, Length=349, Percent_Identity=46.1318051575931, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1790046, Length=374, Percent_Identity=36.6310160427808, Blast_Score=204, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI71994529, Length=389, Percent_Identity=32.9048843187661, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI32566772, Length=402, Percent_Identity=26.3681592039801, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17560914, Length=363, Percent_Identity=25.8953168044077, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17560912, Length=363, Percent_Identity=25.8953168044077, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71982625, Length=287, Percent_Identity=25.4355400696864, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71982617, Length=287, Percent_Identity=25.4355400696864, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320438, Length=410, Percent_Identity=29.7560975609756, Blast_Score=169, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6320267, Length=406, Percent_Identity=26.8472906403941, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323954, Length=301, Percent_Identity=26.578073089701, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24662918, Length=405, Percent_Identity=32.0987654320988, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17137420, Length=345, Percent_Identity=30.7246376811594, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI17136286, Length=374, Percent_Identity=25.4010695187166, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24653280, Length=325, Percent_Identity=23.3846153846154, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24653276, Length=325, Percent_Identity=23.3846153846154, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24653278, Length=325, Percent_Identity=23.3846153846154, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 41627; Mature: 41495

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLDTLQRGLADLDAQGLRRVRRTADTACDAHMTVDGREIVGFASNDYLGLAAHPALIA
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCCCEEEHHHHHHHH
AFAEGAQRYGSGSGGSHLLGGHSRAHATLEDELAAFSGGFSDAPRALYFSTGYMANLAAM
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHH
TALTGKAATIFSDALNHASLIDGMRLSRANVQVYPHADTAALAALLDASDAETKLIVSDT
HHHCCCHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCHHHHHHHHCCCCCCCEEEEECE
VFSMDGDLAPLAELVALAERHGAWLVVDDAHGFGVLGPQGRGALAAAALRSPNLVYVGTL
EEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHCCCCEEEEECC
GKAAGVAGAFVIAHETVIEWMIQRARSYIFTTAAPPAVAHAVSASLKVIAGDEGDARRAH
CCHHCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHCCEEEEECCCCCHHHHH
LAALIERTRALLRNTRWQPVDSHTAVQPLVIGSNDATLAAMRSLDAHGLWVPAIRPPTVP
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCEEECCCCCCCCC
VGTSRLRVSLSAAHSFDDLARLEAALIEASEAQAVQKAAA
CCCHHEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLLDTLQRGLADLDAQGLRRVRRTADTACDAHMTVDGREIVGFASNDYLGLAAHPALIA
CHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCCCEEEHHHHHHHH
AFAEGAQRYGSGSGGSHLLGGHSRAHATLEDELAAFSGGFSDAPRALYFSTGYMANLAAM
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHH
TALTGKAATIFSDALNHASLIDGMRLSRANVQVYPHADTAALAALLDASDAETKLIVSDT
HHHCCCHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCHHHHHHHHCCCCCCCEEEEECE
VFSMDGDLAPLAELVALAERHGAWLVVDDAHGFGVLGPQGRGALAAAALRSPNLVYVGTL
EEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHCCCCEEEEECC
GKAAGVAGAFVIAHETVIEWMIQRARSYIFTTAAPPAVAHAVSASLKVIAGDEGDARRAH
CCHHCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHCCEEEEECCCCCHHHHH
LAALIERTRALLRNTRWQPVDSHTAVQPLVIGSNDATLAAMRSLDAHGLWVPAIRPPTVP
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCEEECCCCCCCCC
VGTSRLRVSLSAAHSFDDLARLEAALIEASEAQAVQKAAA
CCCHHEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA