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The map label for this gene is bioA [H]

Identifier: 78067744

GI number: 78067744

Start: 3436732

End: 3438078

Strand: Direct

Name: bioA [H]

Synonym: Bcep18194_A6275

Alternate gene names: 78067744

Gene position: 3436732-3438078 (Clockwise)

Preceding gene: 78067743

Following gene: 78067745

Centisome position: 93.03

GC content: 69.56

Gene sequence:

>1347_bases
TTGAGTACGCCAGCCACCGACGACTGGGTCGCGCGCAGCCTGCGCGCGGTCTGGCATCCCTGCACCCAGATGAAGCATCA
CGAGCGCCTGCCGCTCATCCCCGTCGCGCGCGGCGCGGGCCTGTGGCTGTACGACCGTGACGGCCGCCGCTACTTCGATG
CGATCAGCTCGTGGTGGGTCAACCTGTTCGGCCATGCGAACCCGGACATCAACGCGGCGCTGAAGGACCAGCTCGACACG
CTCGAGCACGCGATGCTCGCCGGCTGCACGCACGAGCCCGCGATCGAGCTCGCGGAGCGGTTGCACACGCTCACCGCGCG
CACGCTCGGCCATGCGTTCTTCGCATCGGACGGCGCATCGGCGGTCGAGATCGCGCTGAAGATGAGCTTCCATGCGTGGC
GCAACCGTGGCCGCGCGAACAAGCAGGAATTCGTCTGCGTAGCGAACAGCTATCACGGCGAGACGATCGGCGCGCTCGGC
GTGACCGACGTCGCACTGTTCAAGGACGCGTACGACCCGCTGATCCGCCATGCGCACGTGGTCGCGTCACCCGACGCGCG
CGGCGCGCTGGCAGGCGAAACGGCCGCCGACGTCGCCGGCCGCGCGCTGGCCGACGTGCGACGCCTGTTCGTCGAACGCG
GCGACCGGATCGCCGCGCTGATCGTCGAGCCGCTCGTGCAGTGCGCAGCCGGCATGGCGATGCACGATCCGTCGTACGTG
CGCGGGCTGCGCGCGCTGTGCGACGAATTCGGCGTGCACCTGATCGCCGACGAGATCGCGGTTGGCTGCGGCCGCACCGG
CACCTTCTTCGCGTGCGAGCAGGCCGGTGTCTGGCCCGATTTCATGTGCCTGTCGAAAGGCATCAGCGGCGGCTACTTGC
CGCTGTCGCTCGTGCTCACGCGCGACGACGTGTTCAACGCGTTCTACGACGACGACACGACGCGCGGCTTCCTGCACTCG
CATTCGTACACCGGCAACCCGCTCGCGTGCCGCGCGGCGGTCGCGACGCTCGACCTGTTCGAGCGCGACGACGTGATCGC
GGCCAATGCCCGCAAGTCGGCGACGCTGCGTGCGGCGCTCGCGCCGCTCGATGCGCACCCGCAGGTACGCCACCTGCGCG
AGCGCGGCACGCTGTTCGCATTCGACGTCGCGCTCGACGGCGACGGGGCGCGCGGCTTCTCGCGCCGCTTCTTCGAACGC
GCGCTGGAACGCGAGCTGCTGCTGCGCCCGATCGGCACGACCGTGTACCTGATGCCGCCGTACGTGATGAGCGACGACGA
CATCGCGTGGCTCGCGCAAAGCACGCGCGACACGCTCGACGCAACGCTGGAGGACATCACCCGATGA

Upstream 100 bases:

>100_bases
GTGCAACGGGTCGCGGAACACGCTAATCTCAGCGCGATTCGTGTCTCGCCGCGCGGCATCCCGTCGATGCCGCGCAGCCG
TTTTATCCCCCGGAGCCGCC

Downstream 100 bases:

>100_bases
GTCTGCTCGATACCCTGCAACGCGGCCTCGCCGATCTCGACGCGCAAGGGCTGCGCCGCGTGCGCCGCACCGCCGACACC
GCGTGCGATGCGCACATGAC

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSTPATDDWVARSLRAVWHPCTQMKHHERLPLIPVARGAGLWLYDRDGRRYFDAISSWWVNLFGHANPDINAALKDQLDT
LEHAMLAGCTHEPAIELAERLHTLTARTLGHAFFASDGASAVEIALKMSFHAWRNRGRANKQEFVCVANSYHGETIGALG
VTDVALFKDAYDPLIRHAHVVASPDARGALAGETAADVAGRALADVRRLFVERGDRIAALIVEPLVQCAAGMAMHDPSYV
RGLRALCDEFGVHLIADEIAVGCGRTGTFFACEQAGVWPDFMCLSKGISGGYLPLSLVLTRDDVFNAFYDDDTTRGFLHS
HSYTGNPLACRAAVATLDLFERDDVIAANARKSATLRAALAPLDAHPQVRHLRERGTLFAFDVALDGDGARGFSRRFFER
ALERELLLRPIGTTVYLMPPYVMSDDDIAWLAQSTRDTLDATLEDITR

Sequences:

>Translated_448_residues
MSTPATDDWVARSLRAVWHPCTQMKHHERLPLIPVARGAGLWLYDRDGRRYFDAISSWWVNLFGHANPDINAALKDQLDT
LEHAMLAGCTHEPAIELAERLHTLTARTLGHAFFASDGASAVEIALKMSFHAWRNRGRANKQEFVCVANSYHGETIGALG
VTDVALFKDAYDPLIRHAHVVASPDARGALAGETAADVAGRALADVRRLFVERGDRIAALIVEPLVQCAAGMAMHDPSYV
RGLRALCDEFGVHLIADEIAVGCGRTGTFFACEQAGVWPDFMCLSKGISGGYLPLSLVLTRDDVFNAFYDDDTTRGFLHS
HSYTGNPLACRAAVATLDLFERDDVIAANARKSATLRAALAPLDAHPQVRHLRERGTLFAFDVALDGDGARGFSRRFFER
ALERELLLRPIGTTVYLMPPYVMSDDDIAWLAQSTRDTLDATLEDITR
>Mature_447_residues
STPATDDWVARSLRAVWHPCTQMKHHERLPLIPVARGAGLWLYDRDGRRYFDAISSWWVNLFGHANPDINAALKDQLDTL
EHAMLAGCTHEPAIELAERLHTLTARTLGHAFFASDGASAVEIALKMSFHAWRNRGRANKQEFVCVANSYHGETIGALGV
TDVALFKDAYDPLIRHAHVVASPDARGALAGETAADVAGRALADVRRLFVERGDRIAALIVEPLVQCAAGMAMHDPSYVR
GLRALCDEFGVHLIADEIAVGCGRTGTFFACEQAGVWPDFMCLSKGISGGYLPLSLVLTRDDVFNAFYDDDTTRGFLHSH
SYTGNPLACRAAVATLDLFERDDVIAANARKSATLRAALAPLDAHPQVRHLRERGTLFAFDVALDGDGARGFSRRFFERA
LERELLLRPIGTTVYLMPPYVMSDDDIAWLAQSTRDTLDATLEDITR

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=430, Percent_Identity=30, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI37574042, Length=424, Percent_Identity=24.7641509433962, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI226442705, Length=424, Percent_Identity=24.7641509433962, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI13994255, Length=387, Percent_Identity=24.8062015503876, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI284507298, Length=317, Percent_Identity=30.5993690851735, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI226442709, Length=394, Percent_Identity=24.6192893401015, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI24119277, Length=428, Percent_Identity=25, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1786991, Length=424, Percent_Identity=38.4433962264151, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI145693181, Length=402, Percent_Identity=30.3482587064677, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789016, Length=403, Percent_Identity=30.7692307692308, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1789759, Length=399, Percent_Identity=28.0701754385965, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1788044, Length=349, Percent_Identity=29.7994269340974, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1787560, Length=412, Percent_Identity=29.6116504854369, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1786349, Length=309, Percent_Identity=28.8025889967638, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=433, Percent_Identity=24.9422632794457, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI32564660, Length=426, Percent_Identity=25.3521126760563, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=237, Percent_Identity=27.8481012658228, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71992977, Length=371, Percent_Identity=23.4501347708895, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=470, Percent_Identity=27.4468085106383, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6323470, Length=454, Percent_Identity=27.3127753303965, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324432, Length=438, Percent_Identity=25.7990867579909, Blast_Score=123, Evalue=7e-29,
Organism=Drosophila melanogaster, GI21357415, Length=420, Percent_Identity=27.6190476190476, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21356575, Length=318, Percent_Identity=25.1572327044025, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI28574759, Length=341, Percent_Identity=26.9794721407625, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI161085790, Length=341, Percent_Identity=26.9794721407625, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 49284; Mature: 49153

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00436 PEROXIDASE_2 ; PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPATDDWVARSLRAVWHPCTQMKHHERLPLIPVARGAGLWLYDRDGRRYFDAISSWWV
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCCHHHHHHHHHHHH
NLFGHANPDINAALKDQLDTLEHAMLAGCTHEPAIELAERLHTLTARTLGHAFFASDGAS
HHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
AVEIALKMSFHAWRNRGRANKQEFVCVANSYHGETIGALGVTDVALFKDAYDPLIRHAHV
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHEE
VASPDARGALAGETAADVAGRALADVRRLFVERGDRIAALIVEPLVQCAAGMAMHDPSYV
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHH
RGLRALCDEFGVHLIADEIAVGCGRTGTFFACEQAGVWPDFMCLSKGISGGYLPLSLVLT
HHHHHHHHHHCCEEEHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCEEEEEEEE
RDDVFNAFYDDDTTRGFLHSHSYTGNPLACRAAVATLDLFERDDVIAANARKSATLRAAL
CHHHHHHHCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
APLDAHPQVRHLRERGTLFAFDVALDGDGARGFSRRFFERALERELLLRPIGTTVYLMPP
CCCCCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECC
YVMSDDDIAWLAQSTRDTLDATLEDITR
EEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STPATDDWVARSLRAVWHPCTQMKHHERLPLIPVARGAGLWLYDRDGRRYFDAISSWWV
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCCHHHHHHHHHHHH
NLFGHANPDINAALKDQLDTLEHAMLAGCTHEPAIELAERLHTLTARTLGHAFFASDGAS
HHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
AVEIALKMSFHAWRNRGRANKQEFVCVANSYHGETIGALGVTDVALFKDAYDPLIRHAHV
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHEE
VASPDARGALAGETAADVAGRALADVRRLFVERGDRIAALIVEPLVQCAAGMAMHDPSYV
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHH
RGLRALCDEFGVHLIADEIAVGCGRTGTFFACEQAGVWPDFMCLSKGISGGYLPLSLVLT
HHHHHHHHHHCCEEEHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCEEEEEEEE
RDDVFNAFYDDDTTRGFLHSHSYTGNPLACRAAVATLDLFERDDVIAANARKSATLRAAL
CHHHHHHHCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
APLDAHPQVRHLRERGTLFAFDVALDGDGARGFSRRFFERALERELLLRPIGTTVYLMPP
CCCCCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECC
YVMSDDDIAWLAQSTRDTLDATLEDITR
EEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]