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The map label for this gene is aceK

Identifier: 78067738

GI number: 78067738

Start: 3430719

End: 3432578

Strand: Direct

Name: aceK

Synonym: Bcep18194_A6269

Alternate gene names: 78067738

Gene position: 3430719-3432578 (Clockwise)

Preceding gene: 78067736

Following gene: 78067739

Centisome position: 92.87

GC content: 63.23

Gene sequence:

>1860_bases
ATGGCGAGTGCTTACAGCCCCTCCCGAACGAGCCTGCACGCGATGAATCACTTCCCCAAACTGCTGTCTTCGCAGATCGG
TTTCGACGTCGCGCAGACGATGCTCGAAAACTTCGACCGCCACTACCGGATCTTCCGCGAGGCGGCCGTCGAGGCGAAGA
CGCTGTACGAGCATGGCGACTGGCACGGGCTGCAGCGGCTCGCGCGCGAGCGGATCACGTCGTACGACGATCGCGTGAAG
GAATGCGTCGAGGTGCTGGAAGACGAATACGACGCGGAAAACATCGACGACGAAGTGTGGCAGCAGATCAAGCTGCACTA
CATCGGCCTGCTCACGTCGCACCGCCAGCCCGAGTGCGCGGAGACCTTCTTCAATTCGGTGTGCTGCAAGATCCTGCACC
GCTCGTACTTCAGCAACGATTTCATCTTCGTGCGCCCGGCGATCTCGACCGAGTATCTGGAGAACGACGAGCCGGCCGCG
AAGCCGACCTACCGCGCGTACTATCCGGGCACCGACGGGCTCGCGACCACGCTCGAGCGGATCGTCACCAACTTCCAGCT
CGAGCCGGCGTTCGACGATCTCCCGCGCGACATCGGGTGCGTGATGCAGGCGATCCACGACGAATTCGGCCACTTCGACG
AAGCACCGAATTTCCAGATCCACGTGCTGTCGTCGCTGTTCTTCCGCAACAAGAGCGCGTACATCGTCGGCCGCATCATC
AACGCCGACCGCGTGCTGCCGTTCGCGGTGCCGATCCGCCACGTGCGTCCGGGCGTGCTGTCGCTCGACACCGTGCTGCT
GCGCCGCGACCAGCTGATGATCATCTTCGGCTTCTCGCACTCGTATTTCCTCGTCGACATGGGCGTGCCGTCCGCGTACG
TCGACTTCCTGTGCACGATCATGCCCGGCAAGCCGAAGGCGGAGATCTACACGTCGGTCGGCCTGCAAAAGCAGGGCAAG
AACCTGTTCTATCGCGATCTGCTGCACCACCTGTCGCATTCGAGCGACCGCTTCATCATCGCGCCCGGGATCAAGGGCCT
CGTGATGCTCGTGTTCACGCTGCCGTCGTTCCCGTACGTGTTCAAGATCATCAAGGATCACTTCCCGCCGCCGAAGGAAA
CGACGCGCGCGCAGATCATGGAGAAGTACCAGCTCGTGAAGCGCCACGACCGCCTCGGGCGGATGGCCGACACGCTCGAA
TATTCGAGCGTCGCGCTGCCGATCGCGCGGCTCGACCACGCGCTCGTGCGCGAGCTGGAAAAGGAAGTGCCGTCGCTGCT
CGAATACGAGGACGGCAATCTCGTGATCGAGCACCTGTACATCGAGCGCCGGATGACGCCGCTCAACCTGTACCTGCAGA
ACGGCTCCGACAGCGACGTCGAGCACGGCGTGAAGGAGTACGGCAACGCGGTGAAGGAGCTGATGAAGGCGAACATCTTC
CCCGGCGACATGCTGTACAAGAACTTCGGCGTGACGCGCCACGGCCGCGTGGTGTTCTACGACTACGACGAAATCGAGTA
CCTGACCGACTGCAACGTGCGCCGCGTGCCGCCGCCGCGCAACGAGGAAGACGAGCTGTCCGGCGAACCGTGGTATACCG
TCGGCCCGCACGACATCTTTCCGGAGACCTACGGGCCATTCCTGCTCGGCGACCCGCGCGTGCGCGACGTATTCATGAAG
CATCACGCGGACTTTTTCGATCCCGCGCTGTGGCAAGCCAGCAAGGACAAGCTGATCCAGGGCGAATTGCCCGACTTTTA
CCCGTACGACACCGCGCTGCGCTTCTGCACGCGCTACCCCGCGCGCTTCGGCGCGACGGACCAGAACGATGGCGCAGGCG
ACGCGCAGCGCGCCGCCTGA

Upstream 100 bases:

>100_bases
CGAAGATGCACCGAACGGCCCCCAACGGCGGATAACCCGCCGCTTGCCGGCCGGCCGCGCATCGCCGCGAAGCCCTTGAA
CCGCCCGCTTGGGCGCTAAA

Downstream 100 bases:

>100_bases
CGCCCGCTACACCGCACCGATTGCGACCTGATTTCCGCCAACGGAATCCACACCGATGAACACCCAAGACCATCCGCTTT
CACACCTGTTCGACAACAAC

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase protein

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P [H]

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MASAYSPSRTSLHAMNHFPKLLSSQIGFDVAQTMLENFDRHYRIFREAAVEAKTLYEHGDWHGLQRLARERITSYDDRVK
ECVEVLEDEYDAENIDDEVWQQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRSYFSNDFIFVRPAISTEYLENDEPAA
KPTYRAYYPGTDGLATTLERIVTNFQLEPAFDDLPRDIGCVMQAIHDEFGHFDEAPNFQIHVLSSLFFRNKSAYIVGRII
NADRVLPFAVPIRHVRPGVLSLDTVLLRRDQLMIIFGFSHSYFLVDMGVPSAYVDFLCTIMPGKPKAEIYTSVGLQKQGK
NLFYRDLLHHLSHSSDRFIIAPGIKGLVMLVFTLPSFPYVFKIIKDHFPPPKETTRAQIMEKYQLVKRHDRLGRMADTLE
YSSVALPIARLDHALVRELEKEVPSLLEYEDGNLVIEHLYIERRMTPLNLYLQNGSDSDVEHGVKEYGNAVKELMKANIF
PGDMLYKNFGVTRHGRVVFYDYDEIEYLTDCNVRRVPPPRNEEDELSGEPWYTVGPHDIFPETYGPFLLGDPRVRDVFMK
HHADFFDPALWQASKDKLIQGELPDFYPYDTALRFCTRYPARFGATDQNDGAGDAQRAA

Sequences:

>Translated_619_residues
MASAYSPSRTSLHAMNHFPKLLSSQIGFDVAQTMLENFDRHYRIFREAAVEAKTLYEHGDWHGLQRLARERITSYDDRVK
ECVEVLEDEYDAENIDDEVWQQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRSYFSNDFIFVRPAISTEYLENDEPAA
KPTYRAYYPGTDGLATTLERIVTNFQLEPAFDDLPRDIGCVMQAIHDEFGHFDEAPNFQIHVLSSLFFRNKSAYIVGRII
NADRVLPFAVPIRHVRPGVLSLDTVLLRRDQLMIIFGFSHSYFLVDMGVPSAYVDFLCTIMPGKPKAEIYTSVGLQKQGK
NLFYRDLLHHLSHSSDRFIIAPGIKGLVMLVFTLPSFPYVFKIIKDHFPPPKETTRAQIMEKYQLVKRHDRLGRMADTLE
YSSVALPIARLDHALVRELEKEVPSLLEYEDGNLVIEHLYIERRMTPLNLYLQNGSDSDVEHGVKEYGNAVKELMKANIF
PGDMLYKNFGVTRHGRVVFYDYDEIEYLTDCNVRRVPPPRNEEDELSGEPWYTVGPHDIFPETYGPFLLGDPRVRDVFMK
HHADFFDPALWQASKDKLIQGELPDFYPYDTALRFCTRYPARFGATDQNDGAGDAQRAA
>Mature_618_residues
ASAYSPSRTSLHAMNHFPKLLSSQIGFDVAQTMLENFDRHYRIFREAAVEAKTLYEHGDWHGLQRLARERITSYDDRVKE
CVEVLEDEYDAENIDDEVWQQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRSYFSNDFIFVRPAISTEYLENDEPAAK
PTYRAYYPGTDGLATTLERIVTNFQLEPAFDDLPRDIGCVMQAIHDEFGHFDEAPNFQIHVLSSLFFRNKSAYIVGRIIN
ADRVLPFAVPIRHVRPGVLSLDTVLLRRDQLMIIFGFSHSYFLVDMGVPSAYVDFLCTIMPGKPKAEIYTSVGLQKQGKN
LFYRDLLHHLSHSSDRFIIAPGIKGLVMLVFTLPSFPYVFKIIKDHFPPPKETTRAQIMEKYQLVKRHDRLGRMADTLEY
SSVALPIARLDHALVRELEKEVPSLLEYEDGNLVIEHLYIERRMTPLNLYLQNGSDSDVEHGVKEYGNAVKELMKANIFP
GDMLYKNFGVTRHGRVVFYDYDEIEYLTDCNVRRVPPPRNEEDELSGEPWYTVGPHDIFPETYGPFLLGDPRVRDVFMKH
HADFFDPALWQASKDKLIQGELPDFYPYDTALRFCTRYPARFGATDQNDGAGDAQRAA

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family [H]

Homologues:

Organism=Escherichia coli, GI1790446, Length=570, Percent_Identity=41.0526315789474, Blast_Score=453, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010452
- ProDom:   PD043552 [H]

Pfam domain/function: PF06315 AceK [H]

EC number: =2.7.11.5 [H]

Molecular weight: Translated: 71387; Mature: 71256

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASAYSPSRTSLHAMNHFPKLLSSQIGFDVAQTMLENFDRHYRIFREAAVEAKTLYEHGD
CCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WHGLQRLARERITSYDDRVKECVEVLEDEYDAENIDDEVWQQIKLHYIGLLTSHRQPECA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHH
ETFFNSVCCKILHRSYFSNDFIFVRPAISTEYLENDEPAAKPTYRAYYPGTDGLATTLER
HHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCCCCCCCCCCEEECCCCCHHHHHHHH
IVTNFQLEPAFDDLPRDIGCVMQAIHDEFGHFDEAPNFQIHVLSSLFFRNKSAYIVGRII
HHHCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHCCCCCEEEEEEE
NADRVLPFAVPIRHVRPGVLSLDTVLLRRDQLMIIFGFSHSYFLVDMGVPSAYVDFLCTI
CCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHH
MPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHSSDRFIIAPGIKGLVMLVFTLPSFPYV
CCCCCCHHHHHHCCCHHCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCHHHH
FKIIKDHFPPPKETTRAQIMEKYQLVKRHDRLGRMADTLEYSSVALPIARLDHALVRELE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEVPSLLEYEDGNLVIEHLYIERRMTPLNLYLQNGSDSDVEHGVKEYGNAVKELMKANIF
HHHHHHHEECCCCEEEEEEHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
PGDMLYKNFGVTRHGRVVFYDYDEIEYLTDCNVRRVPPPRNEEDELSGEPWYTVGPHDIF
CCHHHHHHCCCCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCHHCC
PETYGPFLLGDPRVRDVFMKHHADFFDPALWQASKDKLIQGELPDFYPYDTALRFCTRYP
CCCCCCCEECCHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
ARFGATDQNDGAGDAQRAA
HHCCCCCCCCCCCCHHCCC
>Mature Secondary Structure 
ASAYSPSRTSLHAMNHFPKLLSSQIGFDVAQTMLENFDRHYRIFREAAVEAKTLYEHGD
CCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WHGLQRLARERITSYDDRVKECVEVLEDEYDAENIDDEVWQQIKLHYIGLLTSHRQPECA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHH
ETFFNSVCCKILHRSYFSNDFIFVRPAISTEYLENDEPAAKPTYRAYYPGTDGLATTLER
HHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCCCCCCCCCCEEECCCCCHHHHHHHH
IVTNFQLEPAFDDLPRDIGCVMQAIHDEFGHFDEAPNFQIHVLSSLFFRNKSAYIVGRII
HHHCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHCCCCCEEEEEEE
NADRVLPFAVPIRHVRPGVLSLDTVLLRRDQLMIIFGFSHSYFLVDMGVPSAYVDFLCTI
CCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHH
MPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHSSDRFIIAPGIKGLVMLVFTLPSFPYV
CCCCCCHHHHHHCCCHHCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCHHHH
FKIIKDHFPPPKETTRAQIMEKYQLVKRHDRLGRMADTLEYSSVALPIARLDHALVRELE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEVPSLLEYEDGNLVIEHLYIERRMTPLNLYLQNGSDSDVEHGVKEYGNAVKELMKANIF
HHHHHHHEECCCCEEEEEEHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
PGDMLYKNFGVTRHGRVVFYDYDEIEYLTDCNVRRVPPPRNEEDELSGEPWYTVGPHDIF
CCHHHHHHCCCCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCHHCC
PETYGPFLLGDPRVRDVFMKHHADFFDPALWQASKDKLIQGELPDFYPYDTALRFCTRYP
CCCCCCCEECCHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
ARFGATDQNDGAGDAQRAA
HHCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA