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The map label for this gene is dctB [H]

Identifier: 78067683

GI number: 78067683

Start: 3368417

End: 3370426

Strand: Reverse

Name: dctB [H]

Synonym: Bcep18194_A6214

Alternate gene names: 78067683

Gene position: 3370426-3368417 (Counterclockwise)

Preceding gene: 78067684

Following gene: 78067682

Centisome position: 91.24

GC content: 69.9

Gene sequence:

>2010_bases
ATGAAGGAGCAGGCGGCGGCACCGCCCGCCGGCCGCACGGCCCGCGGCGGCCAGGGCAGGGAGGCGGAGGCCTATGACAC
AATAGGCGATCCGCATCGCCAGGAAGCCTCGACCGTGACGCGCCGTCTGCTCATTCTCGTCGTGCTTGCCGCCGCGCTCG
CCGCGGCGTGCACGCTGACGTGGACGATCACCTGGCGGCGCGGCGTTGCCGAGCTGCAGCGCAACGCCGCGGTGCGCGTC
GACCGCACCACCAACGCGCTGAAGAGCACGCTCGACCGCTACGAATCGCTGCCCTATTTGCTCGGCAGCCATCCGTACGT
GCAGGACCTGCTCGCCGAGCCGAAGCGCGCCGACTACACCGCGCGCGTCAACCGCTATCTCGAAGACCTCAACGAACACG
CGCACGCGACCGTCACCTACGTGATCGGCGCGGACGGCCTGTGCGTCGCCGCCAGCAACTGGCGCGCGCCCGACAGTTTC
GTCGGGATCGAATACCGCTTCCGCCCGTATTTCCTCGATGCGATGAACGGCCAGGTCGGCCGCTTCTTCGGGATCGGCAC
GATTTCGCGCGATCCCGGTTACTACATTTCGCAACCGGTGTGGCGCGACGGCAAGATCGCGGGTGTCGTCGTCGTGAAGC
TCAACCTCGAATGGTTCCAGGGCGCCGATGCGTCCGAGCCGCTCGTCGTCGCGGACGACCACGGCGTCGTGTTCCTGTCG
TCGGTGCCCGCCTGGAAGTACCACACGCTGCGCCCGCTGACGGGCCCCGTCGCCGCGTCGATCTACGAGACGCGCCAGTA
TGCGCAGCAACCGGTCACGCCGCTGCCGCTGCGCATCGAGCAGGTGCGCGGCCCCGATGCGGAGATCGTGCGCCTCGGCC
CTGGCCTGCGCGCGCCGCGCTTCCTCGCGAGCAAGCGCCGGATCGGCGAGCCCGACTGGCTGCTCGTCACGCTCGCGCCG
ATCGCACCCGTCGACGCCGATGCGCGCAACGCGACGATCGTCACGGGTTTCGGCTTCGTGTCGGTCGCGCTGCTTGCGTT
CTACTGGCGGATGCGCCGGGCGCGCGTGCGTGAAATGATCCGCGGCCGCGCGCTGTTGCAGCAGGCGTATGCGGAACTGA
ACCGGCGCGTCGAGGAGCGCACGGCCGACCTGTCGGAAGCGAACGAGCAATTGCAGAAGGAAGTCGGCGACCGGATCCGC
GCGGAGCAGGAGCTGCGCGCTGCGCACGACGAACTGATCCAGGCGAGCAAGCTCGCCGCGCTCGGCCAGATGGCGGCCGG
CATCACACACGAACTGAACCAGCCGCTCGCGGCGCTGCGCAGCTTCTCGGACAACACGCGCGTGCTGCTCGACCGCGGCG
AGCAGGCGGCCGCGCGCGAAAACCTCGAGGCGATCGCCGCGCTCACCGAGCGGATGGGCAAGATCACGAACCAGCTGAAG
CTGTTCGTCGGCCGCGCGAAGCCGCGCAACGAGCAGGCGCTCGTCGTGCGCGCGCTGCGCAGCGTGCTGTCGCTGCTCGA
CGAGCGCATGCGCGGCGTCGCGCTCACGCTGACGCTGCAGGACGCGACCGTGTCGCCTGCGCACGATGCGCCGCTCGACC
TGGCGCGCGACTATCCCGAGCTCGTCGCCCGTTGCGAGGATCTGCGCCTCGAGCAGGTGCTGATCAACCTGCTTGGCAAC
GCGCTCGATGCGGTCGCCGGGGTGGCGGTGCCGGCGATCGAGGTGACCATCGCGGTGTCGGCGGCGACGCTCGCGGTCGA
AGTGCGCGACAACGGCTACGGCATTGCGCCCGACCTGCTGCCGCGCCTGTTCGAGCCGTTCTTCACGACGAAGGAAATGG
GGCGCGGGCTTGGGCTCGGCCTTGCGATCTCGTCGTCGATCGCGAGCGACGCGGGCGGTGCGCTCACAGCGCGCAACGCG
CCGTCGGGCGGCGCGCTGTTCGTCTTGACGCTGCGACGCGCACGCACGCATCATCCGGACTCCGTGTCCGAGTCGGCGAA
TTCGCGCTAG

Upstream 100 bases:

>100_bases
GTGTCGGCCTGGGAGAAGGAACTCGACCGCAACAAGCTGCGCCAGGCGCTGACCGGCGGCGGCGAGGTCACGACGACCGA
GACGGCCGGCGTCTGACGTC

Downstream 100 bases:

>100_bases
GCGGCGTCCCGCCACCCGCCCGATCGGCGCACGATCGGTATCAACGACGCCGCGCGCGCTGCCGCCGCGCGGCCCGTCAG
GAGCAAGTGAGTACGATGGC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 669; Mature: 669

Protein sequence:

>669_residues
MKEQAAAPPAGRTARGGQGREAEAYDTIGDPHRQEASTVTRRLLILVVLAAALAAACTLTWTITWRRGVAELQRNAAVRV
DRTTNALKSTLDRYESLPYLLGSHPYVQDLLAEPKRADYTARVNRYLEDLNEHAHATVTYVIGADGLCVAASNWRAPDSF
VGIEYRFRPYFLDAMNGQVGRFFGIGTISRDPGYYISQPVWRDGKIAGVVVVKLNLEWFQGADASEPLVVADDHGVVFLS
SVPAWKYHTLRPLTGPVAASIYETRQYAQQPVTPLPLRIEQVRGPDAEIVRLGPGLRAPRFLASKRRIGEPDWLLVTLAP
IAPVDADARNATIVTGFGFVSVALLAFYWRMRRARVREMIRGRALLQQAYAELNRRVEERTADLSEANEQLQKEVGDRIR
AEQELRAAHDELIQASKLAALGQMAAGITHELNQPLAALRSFSDNTRVLLDRGEQAAARENLEAIAALTERMGKITNQLK
LFVGRAKPRNEQALVVRALRSVLSLLDERMRGVALTLTLQDATVSPAHDAPLDLARDYPELVARCEDLRLEQVLINLLGN
ALDAVAGVAVPAIEVTIAVSAATLAVEVRDNGYGIAPDLLPRLFEPFFTTKEMGRGLGLGLAISSSIASDAGGALTARNA
PSGGALFVLTLRRARTHHPDSVSESANSR

Sequences:

>Translated_669_residues
MKEQAAAPPAGRTARGGQGREAEAYDTIGDPHRQEASTVTRRLLILVVLAAALAAACTLTWTITWRRGVAELQRNAAVRV
DRTTNALKSTLDRYESLPYLLGSHPYVQDLLAEPKRADYTARVNRYLEDLNEHAHATVTYVIGADGLCVAASNWRAPDSF
VGIEYRFRPYFLDAMNGQVGRFFGIGTISRDPGYYISQPVWRDGKIAGVVVVKLNLEWFQGADASEPLVVADDHGVVFLS
SVPAWKYHTLRPLTGPVAASIYETRQYAQQPVTPLPLRIEQVRGPDAEIVRLGPGLRAPRFLASKRRIGEPDWLLVTLAP
IAPVDADARNATIVTGFGFVSVALLAFYWRMRRARVREMIRGRALLQQAYAELNRRVEERTADLSEANEQLQKEVGDRIR
AEQELRAAHDELIQASKLAALGQMAAGITHELNQPLAALRSFSDNTRVLLDRGEQAAARENLEAIAALTERMGKITNQLK
LFVGRAKPRNEQALVVRALRSVLSLLDERMRGVALTLTLQDATVSPAHDAPLDLARDYPELVARCEDLRLEQVLINLLGN
ALDAVAGVAVPAIEVTIAVSAATLAVEVRDNGYGIAPDLLPRLFEPFFTTKEMGRGLGLGLAISSSIASDAGGALTARNA
PSGGALFVLTLRRARTHHPDSVSESANSR
>Mature_669_residues
MKEQAAAPPAGRTARGGQGREAEAYDTIGDPHRQEASTVTRRLLILVVLAAALAAACTLTWTITWRRGVAELQRNAAVRV
DRTTNALKSTLDRYESLPYLLGSHPYVQDLLAEPKRADYTARVNRYLEDLNEHAHATVTYVIGADGLCVAASNWRAPDSF
VGIEYRFRPYFLDAMNGQVGRFFGIGTISRDPGYYISQPVWRDGKIAGVVVVKLNLEWFQGADASEPLVVADDHGVVFLS
SVPAWKYHTLRPLTGPVAASIYETRQYAQQPVTPLPLRIEQVRGPDAEIVRLGPGLRAPRFLASKRRIGEPDWLLVTLAP
IAPVDADARNATIVTGFGFVSVALLAFYWRMRRARVREMIRGRALLQQAYAELNRRVEERTADLSEANEQLQKEVGDRIR
AEQELRAAHDELIQASKLAALGQMAAGITHELNQPLAALRSFSDNTRVLLDRGEQAAARENLEAIAALTERMGKITNQLK
LFVGRAKPRNEQALVVRALRSVLSLLDERMRGVALTLTLQDATVSPAHDAPLDLARDYPELVARCEDLRLEQVLINLLGN
ALDAVAGVAVPAIEVTIAVSAATLAVEVRDNGYGIAPDLLPRLFEPFFTTKEMGRGLGLGLAISSSIASDAGGALTARNA
PSGGALFVLTLRRARTHHPDSVSESANSR

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: COG4191

COG function: function code T; Signal transduction histidine kinase regulating C4-dicarboxylate transport system

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=284, Percent_Identity=30.2816901408451, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1790436, Length=256, Percent_Identity=31.25, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1787894, Length=325, Percent_Identity=28, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=296, Percent_Identity=29.7297297297297, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789149, Length=289, Percent_Identity=25.6055363321799, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786912, Length=294, Percent_Identity=27.5510204081633, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 73149; Mature: 73149

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS50109 HIS_KIN ; PS00210 HEMOCYANIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEQAAAPPAGRTARGGQGREAEAYDTIGDPHRQEASTVTRRLLILVVLAAALAAACTLT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEE
WTITWRRGVAELQRNAAVRVDRTTNALKSTLDRYESLPYLLGSHPYVQDLLAEPKRADYT
EEEEHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHCCCHHHCCCHHHHHHHCCCCCCCHH
ARVNRYLEDLNEHAHATVTYVIGADGLCVAASNWRAPDSFVGIEYRFRPYFLDAMNGQVG
HHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCEEEEEEEECCEEEECCCCCCC
RFFGIGTISRDPGYYISQPVWRDGKIAGVVVVKLNLEWFQGADASEPLVVADDHGVVFLS
EEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEHHHCCCCCCCCEEEECCCCEEEEE
SVPAWKYHTLRPLTGPVAASIYETRQYAQQPVTPLPLRIEQVRGPDAEIVRLGPGLRAPR
CCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCEEEEECCCCCCCH
FLASKRRIGEPDWLLVTLAPIAPVDADARNATIVTGFGFVSVALLAFYWRMRRARVREMI
HHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
RGRALLQQAYAELNRRVEERTADLSEANEQLQKEVGDRIRAEQELRAAHDELIQASKLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGQMAAGITHELNQPLAALRSFSDNTRVLLDRGEQAAARENLEAIAALTERMGKITNQLK
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LFVGRAKPRNEQALVVRALRSVLSLLDERMRGVALTLTLQDATVSPAHDAPLDLARDYPE
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCHHHHCCHHH
LVARCEDLRLEQVLINLLGNALDAVAGVAVPAIEVTIAVSAATLAVEVRDNGYGIAPDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEEEEEECCCCCCCHHHH
PRLFEPFFTTKEMGRGLGLGLAISSSIASDAGGALTARNAPSGGALFVLTLRRARTHHPD
HHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEEHHHHCCCCC
SVSESANSR
CHHHCCCCC
>Mature Secondary Structure
MKEQAAAPPAGRTARGGQGREAEAYDTIGDPHRQEASTVTRRLLILVVLAAALAAACTLT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEE
WTITWRRGVAELQRNAAVRVDRTTNALKSTLDRYESLPYLLGSHPYVQDLLAEPKRADYT
EEEEHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHCCCHHHCCCHHHHHHHCCCCCCCHH
ARVNRYLEDLNEHAHATVTYVIGADGLCVAASNWRAPDSFVGIEYRFRPYFLDAMNGQVG
HHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCEEEEEEEECCEEEECCCCCCC
RFFGIGTISRDPGYYISQPVWRDGKIAGVVVVKLNLEWFQGADASEPLVVADDHGVVFLS
EEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEHHHCCCCCCCCEEEECCCCEEEEE
SVPAWKYHTLRPLTGPVAASIYETRQYAQQPVTPLPLRIEQVRGPDAEIVRLGPGLRAPR
CCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCEEEEECCCCCCCH
FLASKRRIGEPDWLLVTLAPIAPVDADARNATIVTGFGFVSVALLAFYWRMRRARVREMI
HHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
RGRALLQQAYAELNRRVEERTADLSEANEQLQKEVGDRIRAEQELRAAHDELIQASKLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGQMAAGITHELNQPLAALRSFSDNTRVLLDRGEQAAARENLEAIAALTERMGKITNQLK
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LFVGRAKPRNEQALVVRALRSVLSLLDERMRGVALTLTLQDATVSPAHDAPLDLARDYPE
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCHHHHCCHHH
LVARCEDLRLEQVLINLLGNALDAVAGVAVPAIEVTIAVSAATLAVEVRDNGYGIAPDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEEEEEECCCCCCCHHHH
PRLFEPFFTTKEMGRGLGLGLAISSSIASDAGGALTARNAPSGGALFVLTLRRARTHHPD
HHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEEHHHHCCCCC
SVSESANSR
CHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3671068 [H]