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The map label for this gene is dctA [H]

Identifier: 78067684

GI number: 78067684

Start: 3370431

End: 3371720

Strand: Reverse

Name: dctA [H]

Synonym: Bcep18194_A6215

Alternate gene names: 78067684

Gene position: 3371720-3370431 (Counterclockwise)

Preceding gene: 78067685

Following gene: 78067683

Centisome position: 91.27

GC content: 64.03

Gene sequence:

>1290_bases
GTGAAGAAGAAACCCTTCTACAAAGTGCTCTATGTGCAGGTGATCTTCGCCATCATCGTCGGCGTGATCCTCGGCCACTA
CTATCCGGCGCTCGCCACCGACATGAAGCCGCTCGGCGACGGCTTCATCAAGCTGATCAAGATGGTGATCGGCCCGATCA
TCTTCTGTACGGTCGTTACCGGCATCGCCGGCATGGAGGACATGAAGAAGGTGGGCCGCGTCGGCGGCAAGGCGCTGCTG
TACTTCGAGATCGTGTCGACCTTCGCGCTGCTGCTCGGCCTCGCGGCCACGCACATCCTGCGTCCGGGCGTCGGCTTCAA
CATCGATCCGGCGACGCTCGACGGCAAGGCCGTCGCGTCGTACGCGGCGAAGGCGCACGGGCAGTCGACGGTCGACTTCC
TGATGCACATCATCCCGAACACGATGGTCGATGCGTTCGCGCAGGGTGAAATCCTGCAGATCCTGCTGATCGCACTGCTG
TTCGGCAGCGTGCTCGCGCACCTCGGCGAGCGCGGCAAGGTCGTCACCGACTTTATCGACGGCCTCACGCGCGTGCTGTT
CGGCATCGTGCACATCGTCACGAAGCTCGCACCGATCGGCGCATTCGGCGCGATGGCGTTCACGATCGGCAAGTACGGCG
TCGGCTCGCTGGTGCCGCTGCTCAAGCTGATCGGCACGTTCTACCTGACGTCGGTCGTGTTCGTGCTCGTCGTGCTCGGC
ACGATCGCGCGCTTCACGGGCTTTTCGATCATCCGCTTCGTGTCGTACATCAAGGAAGAGCTGCTGATCGTGCTCGGCAC
GAGCTCGTCGGAAGCCGCGCTGCCGCAACTGATGGAAAAGCTCGAGAAGGCAGGCTGCTCGCGTTCGGTCGTCGGCCTCG
TCGTGCCGACCGGCTATTCGTTCAACCTCGACGGCACCAACATCTACATGACGATGGCCGTGCTGTTCATCGCGCAGGCG
ACCAACATCGAGCTGACGTGGATGCAGCAGCTCACGCTGCTGGCCGTCGCGATGCTGACATCGAAGGGTGCGAGCGGCGT
CACGGGCGCGGGCTTCATCACGCTCGCTGCGACGCTGGCCGTCGTGCCGACGATCCCGCTGTCGGGCATGGTGCTGATCC
TCGGTATCGACCGCTTCATGAGCGAGTGCCGTGCGCTGACCAACATCGTCGGCAACGGCGTCGCGACGGTCGTCGTGTCG
GCCTGGGAGAAGGAACTCGACCGCAACAAGCTGCGCCAGGCGCTGACCGGCGGCGGCGAGGTCACGACGACCGAGACGGC
CGGCGTCTGA

Upstream 100 bases:

>100_bases
CGGCACGGCAGCCGCGCGGGCGAGTGAATCTTCCCCTGTGACATTCGTCCGCGCGCGTGACGCCGTTTCAATCGGCTCAT
CTACTTCTGCAGGAACCATC

Downstream 100 bases:

>100_bases
CGTCATGAAGGAGCAGGCGGCGGCACCGCCCGCCGGCCGCACGGCCCGCGGCGGCCAGGGCAGGGAGGCGGAGGCCTATG
ACACAATAGGCGATCCGCAT

Product: C4-dicarboxylate transporter DctA

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKKKPFYKVLYVQVIFAIIVGVILGHYYPALATDMKPLGDGFIKLIKMVIGPIIFCTVVTGIAGMEDMKKVGRVGGKALL
YFEIVSTFALLLGLAATHILRPGVGFNIDPATLDGKAVASYAAKAHGQSTVDFLMHIIPNTMVDAFAQGEILQILLIALL
FGSVLAHLGERGKVVTDFIDGLTRVLFGIVHIVTKLAPIGAFGAMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVLVVLG
TIARFTGFSIIRFVSYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQA
TNIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVS
AWEKELDRNKLRQALTGGGEVTTTETAGV

Sequences:

>Translated_429_residues
MKKKPFYKVLYVQVIFAIIVGVILGHYYPALATDMKPLGDGFIKLIKMVIGPIIFCTVVTGIAGMEDMKKVGRVGGKALL
YFEIVSTFALLLGLAATHILRPGVGFNIDPATLDGKAVASYAAKAHGQSTVDFLMHIIPNTMVDAFAQGEILQILLIALL
FGSVLAHLGERGKVVTDFIDGLTRVLFGIVHIVTKLAPIGAFGAMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVLVVLG
TIARFTGFSIIRFVSYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQA
TNIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVS
AWEKELDRNKLRQALTGGGEVTTTETAGV
>Mature_429_residues
MKKKPFYKVLYVQVIFAIIVGVILGHYYPALATDMKPLGDGFIKLIKMVIGPIIFCTVVTGIAGMEDMKKVGRVGGKALL
YFEIVSTFALLLGLAATHILRPGVGFNIDPATLDGKAVASYAAKAHGQSTVDFLMHIIPNTMVDAFAQGEILQILLIALL
FGSVLAHLGERGKVVTDFIDGLTRVLFGIVHIVTKLAPIGAFGAMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVLVVLG
TIARFTGFSIIRFVSYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQA
TNIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVS
AWEKELDRNKLRQALTGGGEVTTTETAGV

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=478, Percent_Identity=24.6861924686192, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI4827012, Length=274, Percent_Identity=29.9270072992701, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI21314632, Length=431, Percent_Identity=25.0580046403712, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI66773030, Length=408, Percent_Identity=24.5098039215686, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI194239697, Length=495, Percent_Identity=24.040404040404, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI5032093, Length=396, Percent_Identity=27.020202020202, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI223468564, Length=268, Percent_Identity=29.1044776119403, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI223468566, Length=268, Percent_Identity=29.1044776119403, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI262359914, Length=418, Percent_Identity=24.1626794258373, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI40254478, Length=277, Percent_Identity=26.3537906137184, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI301601644, Length=149, Percent_Identity=30.2013422818792, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1789947, Length=414, Percent_Identity=62.3188405797101, Blast_Score=537, Evalue=1e-154,
Organism=Escherichia coli, GI1790514, Length=411, Percent_Identity=38.6861313868613, Blast_Score=297, Evalue=8e-82,
Organism=Escherichia coli, GI1789473, Length=323, Percent_Identity=25.077399380805, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788024, Length=393, Percent_Identity=20.8651399491094, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17537407, Length=399, Percent_Identity=27.5689223057644, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI193206505, Length=458, Percent_Identity=24.6724890829694, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71996953, Length=486, Percent_Identity=23.8683127572016, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71983106, Length=449, Percent_Identity=23.6080178173719, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71983099, Length=449, Percent_Identity=23.6080178173719, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193206654, Length=413, Percent_Identity=23.2445520581114, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17541374, Length=424, Percent_Identity=22.6415094339623, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583025, Length=414, Percent_Identity=23.6714975845411, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI17137668, Length=414, Percent_Identity=23.6714975845411, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24583023, Length=414, Percent_Identity=23.6714975845411, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI281360481, Length=427, Percent_Identity=24.824355971897, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281360483, Length=427, Percent_Identity=24.824355971897, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17137666, Length=427, Percent_Identity=24.824355971897, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45544; Mature: 45544

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EECCCCCCC
>Mature Secondary Structure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EECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA