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The map label for this gene is dmlR [H]

Identifier: 78067489

GI number: 78067489

Start: 3154168

End: 3155100

Strand: Direct

Name: dmlR [H]

Synonym: Bcep18194_A6020

Alternate gene names: 78067489

Gene position: 3154168-3155100 (Clockwise)

Preceding gene: 78067484

Following gene: 78067490

Centisome position: 85.38

GC content: 71.6

Gene sequence:

>933_bases
ATGGATCGACTGGGCGATATCCGGCTGTTCGTCGAGGCGGCCGAGCTGGGCAGCCTGTCCGCCGCCGGGCGCAAGCTGAA
CCTCACGCCGGCCGCCGCGAGCGCGCGCCTCGCCAAGCTCGAGGCGGCGGTCGCCACCCGGCTGTTCGACCGCTCGACCC
GGCAGTTGCGGCTCACCGACGAGGGCCGCCTGTACCTGAACGGCTGCCGGCAGGCATTGCAGGCGCTCGACGACGCGAAC
GCGCTGCTGCAGGCCGGCCGCAATGTCGTCGGCGGCCGGGTGCGGCTGTCGGCGACGTCCGATTTCGGCCGCCGCCGGCT
GCTCGACTGGCTCGACGAATTCACCGCGCGCTACCCGGACGTGACGTTCTCGCTGACGGCGTCCGACTCGACGGTGAACC
TGTGGCAGGACGAGATCGACCTCGCGATCCGCTTCGCCGCGCCGCCCGACGGCGCACTGATCGCCCGCCGGCTCGCCGCG
GACCGGCGCGTGCCGTGCGCGGCGCCGTCCTTCATCGAGCGCCACGGCGTGCCGAACGACCCCCACGATCTGGCCCGCTT
TCCGTGCAACGTGATCACGGTGGCGTCCGGGCCGATGAACACGTGGCGCTTCACGCGCGGCGACGACACGCAAACCTGCA
CGGTGCCGCTCGGCACCGCATTCGAGACCAACGACGGCGGCCTCGCCCGCGAGTGGGCGCTGCGTGGCCGCGGCATCGTG
CTGAACTCGATCTGGGATGTCGCCGACGACATCCGTGCCGGGCGGCTCAAGGTCCTGCTGCCCGACTGGCGGCACCAGAG
CGCGCCGCTGCACGCGATCTATCCCGGCAAGCGCTACATGGCGCCACGCGTGCGCGTGCTGCTCGACTTTCTCGCCGAAC
GCTTCGCGCGCGAGGAAGCCGCGCATGAAGACCTGTTGAATGCGTGCCGCTGA

Upstream 100 bases:

>100_bases
CACCGCACAAAAGGCAGGTTGTGCGCATTGTCCCGAAGATGCCTATATTTGATAATTGGCGTGGCATTTGAACCATTTTC
AAATATTTCTGAAAAATCCC

Downstream 100 bases:

>100_bases
CGGCCGGCACGCCACCATTCAAGGGTCGGAACGTGACGGACGGCGTCGCGCGGCCGCAACCCGCCGCCCGTCCCGACCAG
CATGAAAAGCTATAATGGAA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: D-malate degradation protein R [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MDRLGDIRLFVEAAELGSLSAAGRKLNLTPAAASARLAKLEAAVATRLFDRSTRQLRLTDEGRLYLNGCRQALQALDDAN
ALLQAGRNVVGGRVRLSATSDFGRRRLLDWLDEFTARYPDVTFSLTASDSTVNLWQDEIDLAIRFAAPPDGALIARRLAA
DRRVPCAAPSFIERHGVPNDPHDLARFPCNVITVASGPMNTWRFTRGDDTQTCTVPLGTAFETNDGGLAREWALRGRGIV
LNSIWDVADDIRAGRLKVLLPDWRHQSAPLHAIYPGKRYMAPRVRVLLDFLAERFAREEAAHEDLLNACR

Sequences:

>Translated_310_residues
MDRLGDIRLFVEAAELGSLSAAGRKLNLTPAAASARLAKLEAAVATRLFDRSTRQLRLTDEGRLYLNGCRQALQALDDAN
ALLQAGRNVVGGRVRLSATSDFGRRRLLDWLDEFTARYPDVTFSLTASDSTVNLWQDEIDLAIRFAAPPDGALIARRLAA
DRRVPCAAPSFIERHGVPNDPHDLARFPCNVITVASGPMNTWRFTRGDDTQTCTVPLGTAFETNDGGLAREWALRGRGIV
LNSIWDVADDIRAGRLKVLLPDWRHQSAPLHAIYPGKRYMAPRVRVLLDFLAERFAREEAAHEDLLNACR
>Mature_310_residues
MDRLGDIRLFVEAAELGSLSAAGRKLNLTPAAASARLAKLEAAVATRLFDRSTRQLRLTDEGRLYLNGCRQALQALDDAN
ALLQAGRNVVGGRVRLSATSDFGRRRLLDWLDEFTARYPDVTFSLTASDSTVNLWQDEIDLAIRFAAPPDGALIARRLAA
DRRVPCAAPSFIERHGVPNDPHDLARFPCNVITVASGPMNTWRFTRGDDTQTCTVPLGTAFETNDGGLAREWALRGRGIV
LNSIWDVADDIRAGRLKVLLPDWRHQSAPLHAIYPGKRYMAPRVRVLLDFLAERFAREEAAHEDLLNACR

Specific function: Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081978, Length=297, Percent_Identity=32.3232323232323, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1789639, Length=296, Percent_Identity=30.4054054054054, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1789440, Length=291, Percent_Identity=31.2714776632302, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786401, Length=289, Percent_Identity=32.5259515570934, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI145693193, Length=292, Percent_Identity=29.1095890410959, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1787128, Length=289, Percent_Identity=27.3356401384083, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786448, Length=253, Percent_Identity=27.6679841897233, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788706, Length=177, Percent_Identity=29.3785310734463, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1789173, Length=254, Percent_Identity=26.3779527559055, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790011, Length=310, Percent_Identity=23.2258064516129, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI157672245, Length=143, Percent_Identity=32.1678321678322, Blast_Score=71, Evalue=7e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34339; Mature: 34339

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRLGDIRLFVEAAELGSLSAAGRKLNLTPAAASARLAKLEAAVATRLFDRSTRQLRLTD
CCCCCCEEEEEEHHHHCCHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
EGRLYLNGCRQALQALDDANALLQAGRNVVGGRVRLSATSDFGRRRLLDWLDEFTARYPD
CCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCC
VTFSLTASDSTVNLWQDEIDLAIRFAAPPDGALIARRLAADRRVPCAAPSFIERHGVPND
EEEEEECCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCC
PHDLARFPCNVITVASGPMNTWRFTRGDDTQTCTVPLGTAFETNDGGLAREWALRGRGIV
HHHHHHCCCCEEEECCCCCCCCEEECCCCCCEEEEECCCEEECCCCCCHHHHHHCCCCEE
LNSIWDVADDIRAGRLKVLLPDWRHQSAPLHAIYPGKRYMAPRVRVLLDFLAERFAREEA
EHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
AHEDLLNACR
HHHHHHHHCC
>Mature Secondary Structure
MDRLGDIRLFVEAAELGSLSAAGRKLNLTPAAASARLAKLEAAVATRLFDRSTRQLRLTD
CCCCCCEEEEEEHHHHCCHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
EGRLYLNGCRQALQALDDANALLQAGRNVVGGRVRLSATSDFGRRRLLDWLDEFTARYPD
CCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCC
VTFSLTASDSTVNLWQDEIDLAIRFAAPPDGALIARRLAADRRVPCAAPSFIERHGVPND
EEEEEECCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCC
PHDLARFPCNVITVASGPMNTWRFTRGDDTQTCTVPLGTAFETNDGGLAREWALRGRGIV
HHHHHHCCCCEEEECCCCCCCCEEECCCCCCEEEEECCCEEECCCCCCHHHHHHCCCCEE
LNSIWDVADDIRAGRLKVLLPDWRHQSAPLHAIYPGKRYMAPRVRVLLDFLAERFAREEA
EHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
AHEDLLNACR
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]