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The map label for this gene is adk

Identifier: 78067348

GI number: 78067348

Start: 2999998

End: 3000660

Strand: Direct

Name: adk

Synonym: Bcep18194_A5879

Alternate gene names: 78067348

Gene position: 2999998-3000660 (Clockwise)

Preceding gene: 78067347

Following gene: 78067349

Centisome position: 81.21

GC content: 64.56

Gene sequence:

>663_bases
ATGCGTTTGATCCTGTTGGGCGCGCCCGGCGCGGGAAAGGGCACCCAGGCAAACTTCATCAAGGAAAAATTCGGCATCCC
GCAAATCTCGACGGGCGACATGCTGCGCGCGGCCGTGAAGGCCGGCACGCCGCTCGGCGTCGAGGCGAAGGGCTACATGG
ACGCCGGCAAGCTGGTGCCGGACGCGCTGATCATCGGCCTCGTCAAGGAGCGCCTGAAGGAATCCGACTGCGCGAACGGC
TATCTGTTCGACGGTTTCCCGCGCACGATCGCGCAGGCTGACGCCATGAAGGAAGCCGGCGTCGCGATCGACTACGTGCT
CGAGATCGACGTGCCGTTCTCGGAAATCATCGAGCGCATGAGCGGCCGCCGCACGCACCCGGCATCGGGCCGCACGTACC
ACGTCAAGTTCAACCCGCCGAAGGTCGAAGGCCACGACGACGTGACGGGCGAGCCGCTGATCCAGCGCGACGACGACAAG
GAAGAAACCGTCAAGAAGCGCCTCGAAGTGTACGAAGCGCAGACCAAGCCGCTGATCACGTACTACGGCGACTGGGCGCA
GCGCGGCGAGGAAAACGGCCTGAAGGCTCCGCAGTATCGCAAGATCTCGGGCCTCGGCAGCGTCGAGGAAATCCGCGAGC
GCGCGTTTGGCGCACTGAAGTAA

Upstream 100 bases:

>100_bases
GCATCAGACCGGTCCGCCACGCGCCAGGCAAGCCCCGCGCACACCGTCGCCGGCGCTTTTTGCGTCTCGCCACACGAATC
TACATACTGGAGATATCACC

Downstream 100 bases:

>100_bases
GCAACGCATCGCGCACCCGCAAGCCGCCCTTTCCGGGCGGCTTTTTTTTGCCCGGGCGGAACGCGCACGGCCGTTCCGGT
CTCGCCGTCGCGCGAAGGCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDAGKLVPDALIIGLVKERLKESDCANG
YLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGHDDVTGEPLIQRDDDK
EETVKKRLEVYEAQTKPLITYYGDWAQRGEENGLKAPQYRKISGLGSVEEIRERAFGALK

Sequences:

>Translated_220_residues
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDAGKLVPDALIIGLVKERLKESDCANG
YLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGHDDVTGEPLIQRDDDK
EETVKKRLEVYEAQTKPLITYYGDWAQRGEENGLKAPQYRKISGLGSVEEIRERAFGALK
>Mature_220_residues
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDAGKLVPDALIIGLVKERLKESDCANG
YLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGHDDVTGEPLIQRDDDK
EETVKKRLEVYEAQTKPLITYYGDWAQRGEENGLKAPQYRKISGLGSVEEIRERAFGALK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=202, Percent_Identity=49.009900990099, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI4502013, Length=202, Percent_Identity=49.009900990099, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI19923437, Length=182, Percent_Identity=50, Blast_Score=187, Evalue=9e-48,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=44.5054945054945, Blast_Score=164, Evalue=6e-41,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=44.5054945054945, Blast_Score=164, Evalue=6e-41,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=44.5054945054945, Blast_Score=164, Evalue=6e-41,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=44.5054945054945, Blast_Score=164, Evalue=6e-41,
Organism=Homo sapiens, GI22749187, Length=183, Percent_Identity=30.6010928961749, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI4502011, Length=210, Percent_Identity=29.0476190476191, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI7706497, Length=217, Percent_Identity=29.9539170506912, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI237858799, Length=152, Percent_Identity=26.9736842105263, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI21450759, Length=152, Percent_Identity=26.9736842105263, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI28144899, Length=199, Percent_Identity=26.1306532663317, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI28144897, Length=199, Percent_Identity=26.1306532663317, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786680, Length=212, Percent_Identity=65.0943396226415, Blast_Score=276, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17552384, Length=186, Percent_Identity=45.6989247311828, Blast_Score=177, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17537943, Length=185, Percent_Identity=38.3783783783784, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=211, Percent_Identity=30.8056872037915, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=29.8913043478261, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=30.9782608695652, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=194, Percent_Identity=47.4226804123711, Blast_Score=191, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6321018, Length=184, Percent_Identity=46.7391304347826, Blast_Score=160, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=28.9617486338798, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI22026816, Length=184, Percent_Identity=52.1739130434783, Blast_Score=200, Evalue=7e-52,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=48.3516483516484, Blast_Score=170, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=48.3516483516484, Blast_Score=170, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24663208, Length=179, Percent_Identity=26.8156424581006, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17647141, Length=179, Percent_Identity=26.8156424581006, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI221459597, Length=185, Percent_Identity=29.7297297297297, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356893, Length=185, Percent_Identity=29.7297297297297, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24180; Mature: 24180

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDAGKLVP
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
DALIIGLVKERLKESDCANGYLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERM
HHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRTHPASGRTYHVKFNPPKVEGHDDVTGEPLIQRDDDKEETVKKRLEVYEAQTKPLIT
HCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
YYGDWAQRGEENGLKAPQYRKISGLGSVEEIRERAFGALK
EECCHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDAGKLVP
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
DALIIGLVKERLKESDCANGYLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERM
HHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRTHPASGRTYHVKFNPPKVEGHDDVTGEPLIQRDDDKEETVKKRLEVYEAQTKPLIT
HCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
YYGDWAQRGEENGLKAPQYRKISGLGSVEEIRERAFGALK
EECCHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA