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The map label for this gene is coaBC [H]

Identifier: 78067315

GI number: 78067315

Start: 2961897

End: 2963108

Strand: Direct

Name: coaBC [H]

Synonym: Bcep18194_A5846

Alternate gene names: 78067315

Gene position: 2961897-2963108 (Clockwise)

Preceding gene: 78067314

Following gene: 78067316

Centisome position: 80.18

GC content: 69.06

Gene sequence:

>1212_bases
TTGGCACACGCAGAACTCGCAGGAAAACACCTCGTTCTCGGCCTGACGGGCGGCATCGCCTGCTACAAGATCGCCGAGCT
CACCCGGCTGCTCACGAAGGCCGGCGCGACCGTACAGGTCGCGATGACCGAAGCCGCTACCCAGTTCATCACGCCCGTCA
CGATGCAGGCGCTGTCGGGCCGGCCCGTCTACACGAGCCAGTGGGACGCGCGCGTCGACAACAACATGGCACACATCGAC
CTGTCGCGCGAAGCCGATGCAATCGTGATCGCGCCTGCGTCGACGGACTTCCTCGCGAAGCTCGCGCACGGATTCGCGGA
CGACCTGCTGTCGACGCTGTGCGTCGCGCGCGATTGCCCGCTGCTCGTCGTTCCCGCCATGAACCGCCAGATGTGGCAGA
ACCCGGCCACGCAGCGCAACGCAGCGCAACTGCGCGCGGACGGCGTGTCGGTGCTCGGCCCGGATTCGGGCGCGCAGGCC
TGCGGCGAAGTCGGCGACGGCCGCATGCTCGAACCCGAGGCGATCTACGAAGCGATCGTCGCGCACTTCGCGCCGAAGGT
GCTCGCGCACCGGCGCGTGCTGATCACGGCCGGGCCGACGTTCGAACCGCTCGACCCGGTGCGCGGCCTCACGAACCGCT
CGAGCGGCAAGATGGGCTTCGCGCTCGCGCGTGCCGCACAGCAAGCCGGCGCCGACGTGCATCTCGTCGCGGGGCCGGTG
GCGCTCGACACGCCGTGGGGCGTCTACCGGCAGGACGTGCAGACGGCCCAGCAGATGTACGACGCGGTCATGCATGCTGT
CGCCGATGCCGATATCTTCATTGCGGTCGCTGCGGTCGCCGACTGGCGCGCCGCCCAGCCGGCCGAGCACAAGATGAAGA
AGACGGCCGACCACAAGGTGCCCGCGCTCGCGTTCGTCGAGAATCCCGACATCCTCGCGTCGGTCGCGGCGCTGCCCGAT
CCGCCGTTCTGCGTCGGGTTCGCGGCCGAAAGCGGCGACCTCGACGTGCACGGCGACGAGAAGCGCAAGCGCAAGAACGT
ACCGTTGCTCGTCGGCAACCTCGGCCCGCTGACGTTCGGCCGCGACGACAACGAAGTCGTGCTGTTCGAAGCCGCCGGCC
TCACGCGCCTGCCGCGTGCGCCGAAGGACGAACTCGCGCACACGCTCGTCGCGGAAATCGCGAAGCGCCTGCCCGACAAC
CGCCTGATCTGA

Upstream 100 bases:

>100_bases
GACGAACTGCGTCGCGTGCGCGGCTCGCGCTAAGCGCGCATACTCGGCGTCGACGGCCGGCTTCGCGCCGGCCGTTCCGT
TTGACCCTTGGAGGCCTGAG

Downstream 100 bases:

>100_bases
TCTCCCGCGCGGCAGCGTTGCTGCCGCGCCCTTCCCGCCCCATCCGACGACCGCATGAAACTCGACCTGAAGATTCTCGA
CGCGCGCATGCGCGACTACC

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MAHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVAMTEAATQFITPVTMQALSGRPVYTSQWDARVDNNMAHID
LSREADAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQA
CGEVGDGRMLEPEAIYEAIVAHFAPKVLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPV
ALDTPWGVYRQDVQTAQQMYDAVMHAVADADIFIAVAAVADWRAAQPAEHKMKKTADHKVPALAFVENPDILASVAALPD
PPFCVGFAAESGDLDVHGDEKRKRKNVPLLVGNLGPLTFGRDDNEVVLFEAAGLTRLPRAPKDELAHTLVAEIAKRLPDN
RLI

Sequences:

>Translated_403_residues
MAHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVAMTEAATQFITPVTMQALSGRPVYTSQWDARVDNNMAHID
LSREADAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQA
CGEVGDGRMLEPEAIYEAIVAHFAPKVLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPV
ALDTPWGVYRQDVQTAQQMYDAVMHAVADADIFIAVAAVADWRAAQPAEHKMKKTADHKVPALAFVENPDILASVAALPD
PPFCVGFAAESGDLDVHGDEKRKRKNVPLLVGNLGPLTFGRDDNEVVLFEAAGLTRLPRAPKDELAHTLVAEIAKRLPDN
RLI
>Mature_402_residues
AHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVAMTEAATQFITPVTMQALSGRPVYTSQWDARVDNNMAHIDL
SREADAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQAC
GEVGDGRMLEPEAIYEAIVAHFAPKVLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPVA
LDTPWGVYRQDVQTAQQMYDAVMHAVADADIFIAVAAVADWRAAQPAEHKMKKTADHKVPALAFVENPDILASVAALPDP
PFCVGFAAESGDLDVHGDEKRKRKNVPLLVGNLGPLTFGRDDNEVVLFEAAGLTRLPRAPKDELAHTLVAEIAKRLPDNR
LI

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=177, Percent_Identity=35.0282485875706, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI87082301, Length=398, Percent_Identity=49.748743718593, Blast_Score=337, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI17560194, Length=177, Percent_Identity=33.8983050847458, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=189, Percent_Identity=31.2169312169312, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24657262, Length=190, Percent_Identity=33.1578947368421, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42978; Mature: 42847

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVAMTEAATQFITPVTMQALSG
CCCCHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCC
RPVYTSQWDARVDNNMAHIDLSREADAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCP
CCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
LLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQACGEVGDGRMLEPEAIYEAIV
EEEEECCCHHHHCCCCCCHHHHHHHHCCEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHH
AHFAPKVLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPV
HHHHHHHHHCCEEEEEECCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCE
ALDTPWGVYRQDVQTAQQMYDAVMHAVADADIFIAVAAVADWRAAQPAEHKMKKTADHKV
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHCCCCCCHHHHHHHHHCCCC
PALAFVENPDILASVAALPDPPFCVGFAAESGDLDVHGDEKRKRKNVPLLVGNLGPLTFG
CEEEEECCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCEEEECCCCEEEC
RDDNEVVLFEAAGLTRLPRAPKDELAHTLVAEIAKRLPDNRLI
CCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVAMTEAATQFITPVTMQALSG
CCCHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCC
RPVYTSQWDARVDNNMAHIDLSREADAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCP
CCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
LLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQACGEVGDGRMLEPEAIYEAIV
EEEEECCCHHHHCCCCCCHHHHHHHHCCEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHH
AHFAPKVLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPV
HHHHHHHHHCCEEEEEECCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCE
ALDTPWGVYRQDVQTAQQMYDAVMHAVADADIFIAVAAVADWRAAQPAEHKMKKTADHKV
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHCCCCCCHHHHHHHHHCCCC
PALAFVENPDILASVAALPDPPFCVGFAAESGDLDVHGDEKRKRKNVPLLVGNLGPLTFG
CEEEEECCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCEEEECCCCEEEC
RDDNEVVLFEAAGLTRLPRAPKDELAHTLVAEIAKRLPDNRLI
CCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]