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The map label for this gene is dut

Identifier: 78067316

GI number: 78067316

Start: 2963163

End: 2963609

Strand: Direct

Name: dut

Synonym: Bcep18194_A5847

Alternate gene names: 78067316

Gene position: 2963163-2963609 (Clockwise)

Preceding gene: 78067315

Following gene: 78067321

Centisome position: 80.21

GC content: 67.11

Gene sequence:

>447_bases
ATGAAACTCGACCTGAAGATTCTCGACGCGCGCATGCGCGACTACCTGCCCGCCTATGCAACCACCGGCAGCGCGGGCCT
CGACCTGCGTGCGTGCCTCGATGCACCGGTCACGCTGCAGCCGGGCGAAACGACGCTCGTGCCGACCGGCCTCGCGATCC
ACCTCGCTGACCCCGGCTACGCGGCGCTGATCCTGCCGCGCTCGGGCCTCGGCCACAAGCACGGCATCGTGCTCGGCAAC
CTCGTCGGCCTGATCGATTCCGACTACCAGGGCCAGTTGATGATCTCGACGTGGAACCGCGGCCAGACCGAGTTCGTGCT
GAATCCGTTCGAGCGGCTCGCCCAGCTCGTGATCGTGCCGGTCGTCCAGGCGCAGTTCAACATCGTCGACGACTTCGCGG
AAAGCGATCGTGGCGACGGCGGCTTCGGCAGCACCGGCCGTCACTGA

Upstream 100 bases:

>100_bases
CGTCGCGGAAATCGCGAAGCGCCTGCCCGACAACCGCCTGATCTGATCTCCCGCGCGGCAGCGTTGCTGCCGCGCCCTTC
CCGCCCCATCCGACGACCGC

Downstream 100 bases:

>100_bases
ACGGCGCAACAAAAAAGGGGCCTCGCGGCCCCTTTTTCTTTTCCTGCGCCGTCATTCCTCGACGGCTTGCGCGATCCGCA
CGGGTGTCAGGTCGCGCTGC

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MKLDLKILDARMRDYLPAYATTGSAGLDLRACLDAPVTLQPGETTLVPTGLAIHLADPGYAALILPRSGLGHKHGIVLGN
LVGLIDSDYQGQLMISTWNRGQTEFVLNPFERLAQLVIVPVVQAQFNIVDDFAESDRGDGGFGSTGRH

Sequences:

>Translated_148_residues
MKLDLKILDARMRDYLPAYATTGSAGLDLRACLDAPVTLQPGETTLVPTGLAIHLADPGYAALILPRSGLGHKHGIVLGN
LVGLIDSDYQGQLMISTWNRGQTEFVLNPFERLAQLVIVPVVQAQFNIVDDFAESDRGDGGFGSTGRH
>Mature_148_residues
MKLDLKILDARMRDYLPAYATTGSAGLDLRACLDAPVTLQPGETTLVPTGLAIHLADPGYAALILPRSGLGHKHGIVLGN
LVGLIDSDYQGQLMISTWNRGQTEFVLNPFERLAQLVIVPVVQAQFNIVDDFAESDRGDGGFGSTGRH

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI4503423, Length=146, Percent_Identity=32.8767123287671, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI70906444, Length=132, Percent_Identity=34.8484848484849, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI70906441, Length=146, Percent_Identity=32.8767123287671, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1790071, Length=149, Percent_Identity=71.1409395973154, Blast_Score=221, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71988561, Length=134, Percent_Identity=38.0597014925373, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319729, Length=145, Percent_Identity=36.551724137931, Blast_Score=78, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24583610, Length=149, Percent_Identity=31.5436241610738, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19921126, Length=149, Percent_Identity=31.5436241610738, Blast_Score=73, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15899; Mature: 15899

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDLKILDARMRDYLPAYATTGSAGLDLRACLDAPVTLQPGETTLVPTGLAIHLADPGY
CCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEEECCCCEEEEECCEEEEECCCCE
AALILPRSGLGHKHGIVLGNLVGLIDSDYQGQLMISTWNRGQTEFVLNPFERLAQLVIVP
EEEEEECCCCCCCCCEEEHHEEHHCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHHHH
VVQAQFNIVDDFAESDRGDGGFGSTGRH
HHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLDLKILDARMRDYLPAYATTGSAGLDLRACLDAPVTLQPGETTLVPTGLAIHLADPGY
CCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEEECCCCEEEEECCEEEEECCCCE
AALILPRSGLGHKHGIVLGNLVGLIDSDYQGQLMISTWNRGQTEFVLNPFERLAQLVIVP
EEEEEECCCCCCCCCEEEHHEEHHCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHHHH
VVQAQFNIVDDFAESDRGDGGFGSTGRH
HHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA