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The map label for this gene is cyaA [H]

Identifier: 78066844

GI number: 78066844

Start: 2437462

End: 2439468

Strand: Reverse

Name: cyaA [H]

Synonym: Bcep18194_A5375

Alternate gene names: 78066844

Gene position: 2439468-2437462 (Counterclockwise)

Preceding gene: 78066845

Following gene: 78066843

Centisome position: 66.04

GC content: 62.08

Gene sequence:

>2007_bases
ATGTTCGGCAAACTCACACTCTCGGCGATCCCGTTCGATCAGCCCATCATCATGGGGGCCGGTGCCTTCATGGGGCTGAT
CGTGCTGGGCATTCTCGCCGCGCTGACGATCACCGGCCGGTGGAAATGGCTGTGGACGCAATGGCTGACCACGGTCGACC
ACAAGAAACTCGGCGTGATGTACATCATCGTCGCGCTGATCATGCTGCTGCGCGGCTTCGCGGACGCGATCATGATGCGC
ATGCAGCTCGCGCTCTCGTACAACGGGCCCGGCTACCTGCCGCCGCACCACTATGACCAGGTATTCACGGCACACGGCGT
GATCATGATCTTCTTCATGGCGATGGTGTTCATGGTCGGCCTGATGAACCTGATCGTGCCGCTGCAGATCGGTGCGCGCG
ACGTCGCATTCCCGTTCATCAACTCGCTGTCGTTCTGGATGACGGCGGTCAGCGCGATCCTGATCAACGTTTCGCTCGTG
ATCGGCGAATTCGCGCAGACGGGCTGGCTCGCGTATCCGCCGCTGTCGGAGCTGCAGTTCAGTCCAGGGGTAGGGGTCGA
CTACTACCTGTGGGCGCTGCAGATCTCGGGCGTCGGCACGCTGCTGACCGGCGTGAACTTCTTCGTGACGATCATCAAGA
TGCGCGCGCCGGGCATGACGCTGATGAAGATGCCGGTGTTCACGTGGACCGCGCTCTGCACTAACGTGCTGATCATGGCG
TCGTTCCCGATCCTGACCGCGACGCTCGCGCTGCTCGGCCTCGACCGTTACCTCGGCATGCACTTCTTCACGAACGAAGC
CGGCGGCAACGCGATGCTGTACCTGAACCTGATCTGGGCATGGGGTCACCCGGAGGTGTACATCCTGATCCTGCCGGCGT
TCGGCATTTTCTCGGAAGTCATCTCGACGTTCGCGAAGAAGCCGCTGTTCGGCTACAAGACGATGGTGTACGCGACCTGC
GCGATCATGGTGCTGTCGTTCCTCGTGTGGCTGCATCACTTCTTCACGATGGGCTCGGGTGCGAACGTGAACGCGTTCTT
CGGCATCATGACGATGATCATCGCGATCCCGACGGGCGTGAAGGTGTTCAACTGGCTGTTCACGATGTATCGCGGCCGGA
TCGAATTCACGACGCCCGTGCTGTGGACGATCGGCTTCATGGTCACGTTCACGCTCGGCGGCATGACCGGCGTGATGATG
GCGATTCCGGGTGCGGACTTCGTGCTGCACAACAGCCTGTTCCTGATTGCGCACTTTCACAACGTGATCATCGGCGGCGT
GCTGTTCGGCTATCTCGCGGGCTTCAACTACTGGTTCCCGAAGGCGTTCGGCTTCAAGCTGAACGAGAAGCTCGGCAAGG
CGGCGTTCTGGTTCTGGCAGATCGGTTTCTACGTTGCATTCGTACCGCTCTACGTGCTCGGCTTCATGGGCATGACGCGC
CGGATCAACCATTACGACAACCCGGCCTGGCATCCGTGGCTGCTGGTCGCCGCATTCGGCGCCGTGCTGATCGCGATCGG
CATTGCATGCCAGCTGCTGCAACTGGTGGTCAGCATCCGCAACCGCAACCTGCCCGAGTACCGCGACACGACGGGCGATC
CGTGGGGTGGCCGCACGCTGGAATGGGCGACCTCGTCGCCGCCGGCCGACTACAACTTCGCGGTGATCCCGCAAGTGCGC
ACGCTCGACGCGTATGCGGACATGAAGGCACGCGGTGAAGGCCGGCCGAATCCGGCAGCGATTCGCGACATCCACATGCC
GTCGAATACCTGCGCGGGCCTCGTGGTTGCGATCTTCAGCCTGGTGCTCGGCTTCGCGCTGGTGTGGCACATCTGGTGGA
TGGCGATCGGCGGGCTCGTCGGAATCGTCGCGACGCTCGTGATCTACAGCTCGCGCGATAACGACGGGTATTACATCCCC
GCGTCGACGGTGCGGAAGATCGAAGACAAGCAGCCGACGCAGCGCGTGGCCGCGCGCGTCGACGACGTGGAACTGGAGGC
CAACTGA

Upstream 100 bases:

>100_bases
GTCGGTCGATCCGCGACTCTTCCACAACATCATCGCGAAATACAACGATGGCCACGTCCTCGACCTGAAGGACGCCGCCT
GCGGCACGAAGGGGTAACGC

Downstream 100 bases:

>100_bases
TGTTGCAGAAAACCTTGAGCGCAACCCTGCTCGAGCACGACGACCATCCGCCGTCGCATTCGGTGTTCGGGTTCTGGCTG
TACCTGATGACCGACTGCGT

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Cytochrome A1 subunit 1; Oxidase BA(3) subunit 1; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MFGKLTLSAIPFDQPIIMGAGAFMGLIVLGILAALTITGRWKWLWTQWLTTVDHKKLGVMYIIVALIMLLRGFADAIMMR
MQLALSYNGPGYLPPHHYDQVFTAHGVIMIFFMAMVFMVGLMNLIVPLQIGARDVAFPFINSLSFWMTAVSAILINVSLV
IGEFAQTGWLAYPPLSELQFSPGVGVDYYLWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
SFPILTATLALLGLDRYLGMHFFTNEAGGNAMLYLNLIWAWGHPEVYILILPAFGIFSEVISTFAKKPLFGYKTMVYATC
AIMVLSFLVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGVKVFNWLFTMYRGRIEFTTPVLWTIGFMVTFTLGGMTGVMM
AIPGADFVLHNSLFLIAHFHNVIIGGVLFGYLAGFNYWFPKAFGFKLNEKLGKAAFWFWQIGFYVAFVPLYVLGFMGMTR
RINHYDNPAWHPWLLVAAFGAVLIAIGIACQLLQLVVSIRNRNLPEYRDTTGDPWGGRTLEWATSSPPADYNFAVIPQVR
TLDAYADMKARGEGRPNPAAIRDIHMPSNTCAGLVVAIFSLVLGFALVWHIWWMAIGGLVGIVATLVIYSSRDNDGYYIP
ASTVRKIEDKQPTQRVAARVDDVELEAN

Sequences:

>Translated_668_residues
MFGKLTLSAIPFDQPIIMGAGAFMGLIVLGILAALTITGRWKWLWTQWLTTVDHKKLGVMYIIVALIMLLRGFADAIMMR
MQLALSYNGPGYLPPHHYDQVFTAHGVIMIFFMAMVFMVGLMNLIVPLQIGARDVAFPFINSLSFWMTAVSAILINVSLV
IGEFAQTGWLAYPPLSELQFSPGVGVDYYLWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
SFPILTATLALLGLDRYLGMHFFTNEAGGNAMLYLNLIWAWGHPEVYILILPAFGIFSEVISTFAKKPLFGYKTMVYATC
AIMVLSFLVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGVKVFNWLFTMYRGRIEFTTPVLWTIGFMVTFTLGGMTGVMM
AIPGADFVLHNSLFLIAHFHNVIIGGVLFGYLAGFNYWFPKAFGFKLNEKLGKAAFWFWQIGFYVAFVPLYVLGFMGMTR
RINHYDNPAWHPWLLVAAFGAVLIAIGIACQLLQLVVSIRNRNLPEYRDTTGDPWGGRTLEWATSSPPADYNFAVIPQVR
TLDAYADMKARGEGRPNPAAIRDIHMPSNTCAGLVVAIFSLVLGFALVWHIWWMAIGGLVGIVATLVIYSSRDNDGYYIP
ASTVRKIEDKQPTQRVAARVDDVELEAN
>Mature_668_residues
MFGKLTLSAIPFDQPIIMGAGAFMGLIVLGILAALTITGRWKWLWTQWLTTVDHKKLGVMYIIVALIMLLRGFADAIMMR
MQLALSYNGPGYLPPHHYDQVFTAHGVIMIFFMAMVFMVGLMNLIVPLQIGARDVAFPFINSLSFWMTAVSAILINVSLV
IGEFAQTGWLAYPPLSELQFSPGVGVDYYLWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
SFPILTATLALLGLDRYLGMHFFTNEAGGNAMLYLNLIWAWGHPEVYILILPAFGIFSEVISTFAKKPLFGYKTMVYATC
AIMVLSFLVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGVKVFNWLFTMYRGRIEFTTPVLWTIGFMVTFTLGGMTGVMM
AIPGADFVLHNSLFLIAHFHNVIIGGVLFGYLAGFNYWFPKAFGFKLNEKLGKAAFWFWQIGFYVAFVPLYVLGFMGMTR
RINHYDNPAWHPWLLVAAFGAVLIAIGIACQLLQLVVSIRNRNLPEYRDTTGDPWGGRTLEWATSSPPADYNFAVIPQVR
TLDAYADMKARGEGRPNPAAIRDIHMPSNTCAGLVVAIFSLVLGFALVWHIWWMAIGGLVGIVATLVIYSSRDNDGYYIP
ASTVRKIEDKQPTQRVAARVDDVELEAN

Specific function: Catalytic subunit of the enzyme. Electrons originating in a quinol are transferred to the bimetallic center formed by heme a and copper B [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=509, Percent_Identity=38.5068762278978, Blast_Score=325, Evalue=9e-89,
Organism=Escherichia coli, GI1786634, Length=663, Percent_Identity=66.5158371040724, Blast_Score=927, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=537, Percent_Identity=38.3612662942272, Blast_Score=358, Evalue=2e-99,
Organism=Saccharomyces cerevisiae, GI6226524, Length=325, Percent_Identity=42.4615384615385, Blast_Score=253, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6226523, Length=245, Percent_Identity=33.8775510204082, Blast_Score=137, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 74388; Mature: 74388

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGKLTLSAIPFDQPIIMGAGAFMGLIVLGILAALTITGRWKWLWTQWLTTVDHKKLGVM
CCCCEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YIIVALIMLLRGFADAIMMRMQLALSYNGPGYLPPHHYDQVFTAHGVIMIFFMAMVFMVG
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LMNLIVPLQIGARDVAFPFINSLSFWMTAVSAILINVSLVIGEFAQTGWLAYPPLSELQF
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHCCC
SPGVGVDYYLWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
CCCCCCHHEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SFPILTATLALLGLDRYLGMHFFTNEAGGNAMLYLNLIWAWGHPEVYILILPAFGIFSEV
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEEEEEECCCCCEEEEEECHHHHHHHH
ISTFAKKPLFGYKTMVYATCAIMVLSFLVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCH
KVFNWLFTMYRGRIEFTTPVLWTIGFMVTFTLGGMTGVMMAIPGADFVLHNSLFLIAHFH
HHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHCCHHHHHHHH
NVIIGGVLFGYLAGFNYWFPKAFGFKLNEKLGKAAFWFWQIGFYVAFVPLYVLGFMGMTR
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RINHYDNPAWHPWLLVAAFGAVLIAIGIACQLLQLVVSIRNRNLPEYRDTTGDPWGGRTL
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
EWATSSPPADYNFAVIPQVRTLDAYADMKARGEGRPNPAAIRDIHMPSNTCAGLVVAIFS
EECCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
LVLGFALVWHIWWMAIGGLVGIVATLVIYSSRDNDGYYIPASTVRKIEDKQPTQRVAARV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECHHHHHHHHCCCHHHHHHHHH
DDVELEAN
CCEEECCC
>Mature Secondary Structure
MFGKLTLSAIPFDQPIIMGAGAFMGLIVLGILAALTITGRWKWLWTQWLTTVDHKKLGVM
CCCCEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YIIVALIMLLRGFADAIMMRMQLALSYNGPGYLPPHHYDQVFTAHGVIMIFFMAMVFMVG
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LMNLIVPLQIGARDVAFPFINSLSFWMTAVSAILINVSLVIGEFAQTGWLAYPPLSELQF
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHCCC
SPGVGVDYYLWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
CCCCCCHHEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SFPILTATLALLGLDRYLGMHFFTNEAGGNAMLYLNLIWAWGHPEVYILILPAFGIFSEV
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEEEEEECCCCCEEEEEECHHHHHHHH
ISTFAKKPLFGYKTMVYATCAIMVLSFLVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCH
KVFNWLFTMYRGRIEFTTPVLWTIGFMVTFTLGGMTGVMMAIPGADFVLHNSLFLIAHFH
HHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHCCHHHHHHHH
NVIIGGVLFGYLAGFNYWFPKAFGFKLNEKLGKAAFWFWQIGFYVAFVPLYVLGFMGMTR
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RINHYDNPAWHPWLLVAAFGAVLIAIGIACQLLQLVVSIRNRNLPEYRDTTGDPWGGRTL
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
EWATSSPPADYNFAVIPQVRTLDAYADMKARGEGRPNPAAIRDIHMPSNTCAGLVVAIFS
EECCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
LVLGFALVWHIWWMAIGGLVGIVATLVIYSSRDNDGYYIPASTVRKIEDKQPTQRVAARV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECHHHHHHHHCCCHHHHHHHHH
DDVELEAN
CCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8392509 [H]