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The map label for this gene is glxR [H]

Identifier: 78066733

GI number: 78066733

Start: 2320610

End: 2321473

Strand: Reverse

Name: glxR [H]

Synonym: Bcep18194_A5264

Alternate gene names: 78066733

Gene position: 2321473-2320610 (Counterclockwise)

Preceding gene: 78066736

Following gene: 78066728

Centisome position: 62.84

GC content: 71.76

Gene sequence:

>864_bases
ATGGGCGCGCCGATGATTCGGCATTTGCTGGCGGCCGGGCATCGGGTCAGCGTGTGGAATCGCTCGCGCGACAAGGCCGA
GGCGCTCGTGAAGGACGGCGCGCAGGTGGTCGGCACGCCGCGCGAACTGGCGGAGCGCGTCGATACGGTATTCGTGTGCG
TGCTCGACGGCCGTGCGGTGGGCGATGTCGTGTTCGGCGAGCACGGGCTGCTCTCCGGCGACGCCGCTGCGCGTCGCCTG
CAGCGCATCGTCGATCATTCGAGCATCCCGCCTGCCGCGACGCGTGATTACGCGGCGCGTGCGACCGCACTCGGCGTCGG
CTGGGTCGATGCGCCGGTGTCGGGCGGCGTGCCCGGCGCGCAGGCCGGCACGCTTGCGGTGATGGCCGGCGGCCGGGCGG
CCGATCTCGACGCGGTGCGGCCGCTGATCGACACGTATGCGTCGCGGATCACGCACATGGGCGACGCGGGCGCGGGGCAG
ACGGCGAAGCTGTGCAACCAGGCGATCGTCACCGCGACGGTGACCGCGATTGCCGAGGCCGTCGGTCTTGCACAGGCGAG
CGGCATCGATGCCGCGCGGCTGGCCGAAGCGCTGGCCGGCGGCTGGGCCGATTCGGTACTGTTGCAGACGTTCGTGCCGC
GCATGACGTCGGGCGGTCATCCGCCGATCGGCGCGCTCAGCACGTTTCAGAAGGACGTCGATGCGATCGCCGACGCAGCG
CGCGACACCGGCGCGGTGATGCCGGTATCGGCCACCGTGCAGCAGGTGTTGCGGCTCGGCGCTGCGCAAGGGCTCGCCGG
CGCCGATTTCGCCGCGTTCATCGACATCGTGCGGCCCGGCAACGGTCGTCAGCAGGCGTCGTGA

Upstream 100 bases:

>100_bases
CGTGCCCGGCTTCTTGAGTGATAGGTATGATGGGCGGCAAGTTCAACCCATATCGGAGACGAGGAACATCGTGGAAGTCG
GATTTTGCGGACCGGGATTG

Downstream 100 bases:

>100_bases
CGGGCAAGCGGGGCGCGTGAATGGCAGATGGGCCGCCCGGAGGCGGCCCATCGAATGGCAGGTAGATCAGCCGAGGGAGC
GTGGTGTCGTATCGCCGGCG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MGAPMIRHLLAAGHRVSVWNRSRDKAEALVKDGAQVVGTPRELAERVDTVFVCVLDGRAVGDVVFGEHGLLSGDAAARRL
QRIVDHSSIPPAATRDYAARATALGVGWVDAPVSGGVPGAQAGTLAVMAGGRAADLDAVRPLIDTYASRITHMGDAGAGQ
TAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTSGGHPPIGALSTFQKDVDAIADAA
RDTGAVMPVSATVQQVLRLGAAQGLAGADFAAFIDIVRPGNGRQQAS

Sequences:

>Translated_287_residues
MGAPMIRHLLAAGHRVSVWNRSRDKAEALVKDGAQVVGTPRELAERVDTVFVCVLDGRAVGDVVFGEHGLLSGDAAARRL
QRIVDHSSIPPAATRDYAARATALGVGWVDAPVSGGVPGAQAGTLAVMAGGRAADLDAVRPLIDTYASRITHMGDAGAGQ
TAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTSGGHPPIGALSTFQKDVDAIADAA
RDTGAVMPVSATVQQVLRLGAAQGLAGADFAAFIDIVRPGNGRQQAS
>Mature_286_residues
GAPMIRHLLAAGHRVSVWNRSRDKAEALVKDGAQVVGTPRELAERVDTVFVCVLDGRAVGDVVFGEHGLLSGDAAARRLQ
RIVDHSSIPPAATRDYAARATALGVGWVDAPVSGGVPGAQAGTLAVMAGGRAADLDAVRPLIDTYASRITHMGDAGAGQT
AKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTSGGHPPIGALSTFQKDVDAIADAAR
DTGAVMPVSATVQQVLRLGAAQGLAGADFAAFIDIVRPGNGRQQAS

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=289, Percent_Identity=26.643598615917, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI40556376, Length=275, Percent_Identity=26.9090909090909, Blast_Score=98, Evalue=9e-21,
Organism=Escherichia coli, GI1786719, Length=274, Percent_Identity=36.4963503649635, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI145693186, Length=273, Percent_Identity=33.3333333333333, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1790315, Length=282, Percent_Identity=28.3687943262411, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789092, Length=238, Percent_Identity=26.4705882352941, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17557316, Length=274, Percent_Identity=25.1824817518248, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24655230, Length=291, Percent_Identity=30.9278350515464, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI19922568, Length=291, Percent_Identity=30.9278350515464, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI28574115, Length=274, Percent_Identity=27.007299270073, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 29194; Mature: 29063

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAPMIRHLLAAGHRVSVWNRSRDKAEALVKDGAQVVGTPRELAERVDTVFVCVLDGRAV
CCCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCHHHCCCHHHHHHHHHEEEEEEECCCCH
GDVVFGEHGLLSGDAAARRLQRIVDHSSIPPAATRDYAARATALGVGWVDAPVSGGVPGA
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
QAGTLAVMAGGRAADLDAVRPLIDTYASRITHMGDAGAGQTAKLCNQAIVTATVTAIAEA
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTSGGHPPIGALSTFQKDVDAIADAA
HHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
RDTGAVMPVSATVQQVLRLGAAQGLAGADFAAFIDIVRPGNGRQQAS
HHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
GAPMIRHLLAAGHRVSVWNRSRDKAEALVKDGAQVVGTPRELAERVDTVFVCVLDGRAV
CCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCHHHCCCHHHHHHHHHEEEEEEECCCCH
GDVVFGEHGLLSGDAAARRLQRIVDHSSIPPAATRDYAARATALGVGWVDAPVSGGVPGA
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
QAGTLAVMAGGRAADLDAVRPLIDTYASRITHMGDAGAGQTAKLCNQAIVTATVTAIAEA
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTSGGHPPIGALSTFQKDVDAIADAA
HHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
RDTGAVMPVSATVQQVLRLGAAQGLAGADFAAFIDIVRPGNGRQQAS
HHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]