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The map label for this gene is cbs [H]

Identifier: 78066479

GI number: 78066479

Start: 2047266

End: 2048243

Strand: Reverse

Name: cbs [H]

Synonym: Bcep18194_A5010

Alternate gene names: 78066479

Gene position: 2048243-2047266 (Counterclockwise)

Preceding gene: 78066482

Following gene: 78066478

Centisome position: 55.45

GC content: 66.56

Gene sequence:

>978_bases
ATGGACGTGCGACAAGGCTTCGTCGACTGCGTCGGGCGCACGCCGCTGATTCGCTTGACGAAGCTCAGCGCGGAGACGGG
CTGCGAGATCCTGGGCAAGGCGGAATTCATGAATCCGGGCGGGTCGGTGAAGGACCGCGCGGCACTGTACATCATCCGCG
ACGCCGAGCGGCGTGGCGTGCTGAAGCCGGGCGGCACCGTCGTCGAGGGTACGGCGGGCAACACCGGCATCGGTCTGGCG
CATATCTGCGCGGCGCGCGGCTATCGCTGCGTGATCGTGATTCCTGACACACAATCGCCGGACAAGCTGGCGATCCTGCG
CACGCTCGGCGCCGAGGTGCGCCCGGTGCCGGCGGCGCCTTACCGTGACCCGAACAACTATCAGAAGATTGCCGGGCGGC
TCGCGGACGAACTCGACAACGCGGTGTGGGCCAATCAGTTCGACAACGTCGTCAATCGTCAGGCGCACTACGAGACGACC
GGGCCCGAAATCTGGCGCGATACGGCGGGCACGATCGATGCGTTCGTCTGCGCGACCGGAACGGGCGGCACGCTGGCCGG
CGTGAGCCGCTATCTGAAAGAGCAGAATCCGGACGTCCGGATCGTGCTGGCCGACCCGTGCGGCAGCGGGCTCTATGGGT
ACGTGAAAACGGGCGACCTCGGCGCAGAAGGCAGCTCGATCACCGAAGGCATCGGATCGACGCGCGTCACCATGAACCTC
GCGGGCACGCCGATCGACGACGCGGTGCGGATCGACGATCAGCAGTGCGTGACGATGGTCTACCGGCTGCTGCGCGAGGA
AGGGCTGTATGTCGGCGGATCGAGCGGCATCAACGTCGCGGCAGCGGTCTGGTTGGCCCGCCGGATGGGCCCGGGGCACA
CGATCGTGACCTTGCTGTGCGATCGTGGCGACATCTATCGCGCGCGGCTTTTCAATCGGGAATGGCTGCGCGAAAAGGGC
CTGGATCCGGGGGACTGA

Upstream 100 bases:

>100_bases
CTTCAAGCTTAATACGCGGCGGCCGGCGACGAAAGCCGCGAGGGCGGCCTATCCTTCGTTGTGTGTGGCGCGAGCGCTGC
ACGAAGGAATGGAGGCTGAC

Downstream 100 bases:

>100_bases
ACCCGTGCGTTGAGCGCGTGCGAGGTGCGGGAGCGGTGAGGATTTCCATCCGCCGGAATGCGACCTATGCTGAACGAATC
CGGTGCGAACGCCGTTCGCC

Product: pyridoxal-5'-phosphate-dependent enzyme, beta subunit

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MDVRQGFVDCVGRTPLIRLTKLSAETGCEILGKAEFMNPGGSVKDRAALYIIRDAERRGVLKPGGTVVEGTAGNTGIGLA
HICAARGYRCVIVIPDTQSPDKLAILRTLGAEVRPVPAAPYRDPNNYQKIAGRLADELDNAVWANQFDNVVNRQAHYETT
GPEIWRDTAGTIDAFVCATGTGGTLAGVSRYLKEQNPDVRIVLADPCGSGLYGYVKTGDLGAEGSSITEGIGSTRVTMNL
AGTPIDDAVRIDDQQCVTMVYRLLREEGLYVGGSSGINVAAAVWLARRMGPGHTIVTLLCDRGDIYRARLFNREWLREKG
LDPGD

Sequences:

>Translated_325_residues
MDVRQGFVDCVGRTPLIRLTKLSAETGCEILGKAEFMNPGGSVKDRAALYIIRDAERRGVLKPGGTVVEGTAGNTGIGLA
HICAARGYRCVIVIPDTQSPDKLAILRTLGAEVRPVPAAPYRDPNNYQKIAGRLADELDNAVWANQFDNVVNRQAHYETT
GPEIWRDTAGTIDAFVCATGTGGTLAGVSRYLKEQNPDVRIVLADPCGSGLYGYVKTGDLGAEGSSITEGIGSTRVTMNL
AGTPIDDAVRIDDQQCVTMVYRLLREEGLYVGGSSGINVAAAVWLARRMGPGHTIVTLLCDRGDIYRARLFNREWLREKG
LDPGD
>Mature_325_residues
MDVRQGFVDCVGRTPLIRLTKLSAETGCEILGKAEFMNPGGSVKDRAALYIIRDAERRGVLKPGGTVVEGTAGNTGIGLA
HICAARGYRCVIVIPDTQSPDKLAILRTLGAEVRPVPAAPYRDPNNYQKIAGRLADELDNAVWANQFDNVVNRQAHYETT
GPEIWRDTAGTIDAFVCATGTGGTLAGVSRYLKEQNPDVRIVLADPCGSGLYGYVKTGDLGAEGSSITEGIGSTRVTMNL
AGTPIDDAVRIDDQQCVTMVYRLLREEGLYVGGSSGINVAAAVWLARRMGPGHTIVTLLCDRGDIYRARLFNREWLREKG
LDPGD

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=40.4458598726115, Blast_Score=231, Evalue=6e-61,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=40.4458598726115, Blast_Score=231, Evalue=6e-61,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=40.4458598726115, Blast_Score=231, Evalue=6e-61,
Organism=Homo sapiens, GI11345492, Length=304, Percent_Identity=27.3026315789474, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI2367138, Length=301, Percent_Identity=37.5415282392027, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=37.0253164556962, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17562970, Length=312, Percent_Identity=39.4230769230769, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI32566674, Length=300, Percent_Identity=40.3333333333333, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17535051, Length=304, Percent_Identity=38.1578947368421, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI115535073, Length=298, Percent_Identity=40.6040268456376, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17534315, Length=329, Percent_Identity=35.8662613981763, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI25147552, Length=323, Percent_Identity=35.9133126934984, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17561720, Length=309, Percent_Identity=37.2168284789644, Blast_Score=161, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI32566672, Length=226, Percent_Identity=36.283185840708, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71996324, Length=342, Percent_Identity=28.6549707602339, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17539800, Length=346, Percent_Identity=26.3005780346821, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17539640, Length=340, Percent_Identity=25.2941176470588, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6321449, Length=341, Percent_Identity=41.6422287390029, Blast_Score=229, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6321594, Length=332, Percent_Identity=37.9518072289157, Blast_Score=200, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24643623, Length=322, Percent_Identity=38.1987577639752, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI20129101, Length=322, Percent_Identity=38.1987577639752, Blast_Score=201, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 34954; Mature: 34954

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVRQGFVDCVGRTPLIRLTKLSAETGCEILGKAEFMNPGGSVKDRAALYIIRDAERRGV
CCHHHHHHHHHCCCCEEEEEECCHHCCCCEEECCEECCCCCCCCCCEEEEEEEECCCCCC
LKPGGTVVEGTAGNTGIGLAHICAARGYRCVIVIPDTQSPDKLAILRTLGAEVRPVPAAP
CCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCC
YRDPNNYQKIAGRLADELDNAVWANQFDNVVNRQAHYETTGPEIWRDTAGTIDAFVCATG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEEEECC
TGGTLAGVSRYLKEQNPDVRIVLADPCGSGLYGYVKTGDLGAEGSSITEGIGSTRVTMNL
CCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCCCHHHHCCCCEEEEEEE
AGTPIDDAVRIDDQQCVTMVYRLLREEGLYVGGSSGINVAAAVWLARRMGPGHTIVTLLC
CCCCCCCCEEECHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEEEE
DRGDIYRARLFNREWLREKGLDPGD
CCCCCHHHHHHCHHHHHHCCCCCCC
>Mature Secondary Structure
MDVRQGFVDCVGRTPLIRLTKLSAETGCEILGKAEFMNPGGSVKDRAALYIIRDAERRGV
CCHHHHHHHHHCCCCEEEEEECCHHCCCCEEECCEECCCCCCCCCCEEEEEEEECCCCCC
LKPGGTVVEGTAGNTGIGLAHICAARGYRCVIVIPDTQSPDKLAILRTLGAEVRPVPAAP
CCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCC
YRDPNNYQKIAGRLADELDNAVWANQFDNVVNRQAHYETTGPEIWRDTAGTIDAFVCATG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEEEECC
TGGTLAGVSRYLKEQNPDVRIVLADPCGSGLYGYVKTGDLGAEGSSITEGIGSTRVTMNL
CCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCCCHHHHCCCCEEEEEEE
AGTPIDDAVRIDDQQCVTMVYRLLREEGLYVGGSSGINVAAAVWLARRMGPGHTIVTLLC
CCCCCCCCEEECHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEEEE
DRGDIYRARLFNREWLREKGLDPGD
CCCCCHHHHHHCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]