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The map label for this gene is corA [H]

Identifier: 78066482

GI number: 78066482

Start: 2049402

End: 2050379

Strand: Reverse

Name: corA [H]

Synonym: Bcep18194_A5013

Alternate gene names: 78066482

Gene position: 2050379-2049402 (Counterclockwise)

Preceding gene: 78066485

Following gene: 78066479

Centisome position: 55.5

GC content: 61.76

Gene sequence:

>978_bases
ATGCTGATCAACTGTGCTGCATACCAGGACGGCCGCAAGCTGGCCGACATCGATATCGACGCCATCAGCGACTACGTGTC
GAAGCCCGAATGCTTCGTGTGGGTCGCGCTGAAGGATCCGACGCCTGCCGAACTCGACCTGATGGGCGAGGAGTTCGGGC
TGCACGAACTGGCGCTCGAGGATGCCCGCAAGGGGCATCAGCGACCGAAGATCGAGGAGTACGGCGATTCGCTGTTCGCG
GTGCTGCATATGGTCGAGCTGGACGACGACGATGAATTGAATGTCGGCGAGCTGAACGTGTTCGTCGGACCGAATTACGT
GCTGTCGATCCGCAACCATACCGAGCAGGATTTCCGCGACGTGCGCAAGCGTTGCGAGCGCGAGCCGCATCTGCTCCAGG
AAGGCTCGGCATTCGTGTTCTACGCGCTGATGGACCAGGTCGTCGACCGCTATTTCCCGATCCTCGAAACGCTCGGCACC
GAGCTCGAGGAACTCGAGGACCGCATTTTCGCGAAGGCCACGCCCGCGTCGTCGCGTGCAATCATCGAGGATCTCTATTC
GCTGAAGCGCCGGCTCGTGATGCTGTACCAGCACACGGCGCCGCTGATCGAGCCGCTTGCGAAGCTCACCGGCGGGCGCA
TTCCGCAGGTCTGCAGCGGGATGGAGCCGTACTTTCGCGACGTGTACGACCATCTGCAGCGGATCGTGAAGACGATCGAA
GGGCGGCGCGAGATGGTGGTCACGGCGATCCAGGTCAATCTCGGGATGATTTCGCTGGCCGAGAGCGAGGTGACGAAGCG
GCTCGGCTCGTTCGCCGCGCTGTTCGCGATTCCGACGATGATCGCCGGCATCTACGGGATGAACTTCGCGAACATGCCCG
AACTGCACCTGAAATACGGTTTCTACGGTTGCATCGCCGCGATGGTCGTCGCCGATTTCGCGCTGTGGTGGCGATTCAAG
CGGGCAGGGTGGCTGTAG

Upstream 100 bases:

>100_bases
ACGCAGCCCGATCATGACCAATATCGCCGTGCCGCGCAAGCCGGGCCGCCCGCGCAGCAAACCGGTAAACTGATGCGCAA
ACCGCAACATCACGGACAAC

Downstream 100 bases:

>100_bases
TCTCGCTTCACGCGCGGGGCGGCGCGTGCTTGCCGATCACGACGCGCCACGGACGCACGCGCCACGATTTCACGAGGCCG
TTCTGCACGTATGGATCGGC

Product: magnesium/cobalt transporter CorA

Products: Ni2; [Cytoplasm]; Co; 2 [Cytoplasm]; Mg (II) [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MLINCAAYQDGRKLADIDIDAISDYVSKPECFVWVALKDPTPAELDLMGEEFGLHELALEDARKGHQRPKIEEYGDSLFA
VLHMVELDDDDELNVGELNVFVGPNYVLSIRNHTEQDFRDVRKRCEREPHLLQEGSAFVFYALMDQVVDRYFPILETLGT
ELEELEDRIFAKATPASSRAIIEDLYSLKRRLVMLYQHTAPLIEPLAKLTGGRIPQVCSGMEPYFRDVYDHLQRIVKTIE
GRREMVVTAIQVNLGMISLAESEVTKRLGSFAALFAIPTMIAGIYGMNFANMPELHLKYGFYGCIAAMVVADFALWWRFK
RAGWL

Sequences:

>Translated_325_residues
MLINCAAYQDGRKLADIDIDAISDYVSKPECFVWVALKDPTPAELDLMGEEFGLHELALEDARKGHQRPKIEEYGDSLFA
VLHMVELDDDDELNVGELNVFVGPNYVLSIRNHTEQDFRDVRKRCEREPHLLQEGSAFVFYALMDQVVDRYFPILETLGT
ELEELEDRIFAKATPASSRAIIEDLYSLKRRLVMLYQHTAPLIEPLAKLTGGRIPQVCSGMEPYFRDVYDHLQRIVKTIE
GRREMVVTAIQVNLGMISLAESEVTKRLGSFAALFAIPTMIAGIYGMNFANMPELHLKYGFYGCIAAMVVADFALWWRFK
RAGWL
>Mature_325_residues
MLINCAAYQDGRKLADIDIDAISDYVSKPECFVWVALKDPTPAELDLMGEEFGLHELALEDARKGHQRPKIEEYGDSLFA
VLHMVELDDDDELNVGELNVFVGPNYVLSIRNHTEQDFRDVRKRCEREPHLLQEGSAFVFYALMDQVVDRYFPILETLGT
ELEELEDRIFAKATPASSRAIIEDLYSLKRRLVMLYQHTAPLIEPLAKLTGGRIPQVCSGMEPYFRDVYDHLQRIVKTIE
GRREMVVTAIQVNLGMISLAESEVTKRLGSFAALFAIPTMIAGIYGMNFANMPELHLKYGFYGCIAAMVVADFALWWRFK
RAGWL

Specific function: Mediates influx of magnesium ions [H]

COG id: COG0598

COG function: function code P; Mg2+ and Co2+ transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family [H]

Homologues:

Organism=Escherichia coli, GI2367297, Length=231, Percent_Identity=25.1082251082251, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321058, Length=139, Percent_Identity=26.6187050359712, Blast_Score=63, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324442, Length=139, Percent_Identity=27.3381294964029, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004488
- InterPro:   IPR002523 [H]

Pfam domain/function: PF01544 CorA [H]

EC number: NA

Molecular weight: Translated: 37035; Mature: 37035

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLINCAAYQDGRKLADIDIDAISDYVSKPECFVWVALKDPTPAELDLMGEEFGLHELALE
CEEEECCCCCCCEEECCCHHHHHHHHCCCCEEEEEEECCCCCCHHHHCCHHHCHHHHHHH
DARKGHQRPKIEEYGDSLFAVLHMVELDDDDELNVGELNVFVGPNYVLSIRNHTEQDFRD
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEECCCCHHHHHH
VRKRCEREPHLLQEGSAFVFYALMDQVVDRYFPILETLGTELEELEDRIFAKATPASSRA
HHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHH
IIEDLYSLKRRLVMLYQHTAPLIEPLAKLTGGRIPQVCSGMEPYFRDVYDHLQRIVKTIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHC
GRREMVVTAIQVNLGMISLAESEVTKRLGSFAALFAIPTMIAGIYGMNFANMPELHLKYG
CCHHHEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
FYGCIAAMVVADFALWWRFKRAGWL
HHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLINCAAYQDGRKLADIDIDAISDYVSKPECFVWVALKDPTPAELDLMGEEFGLHELALE
CEEEECCCCCCCEEECCCHHHHHHHHCCCCEEEEEEECCCCCCHHHHCCHHHCHHHHHHH
DARKGHQRPKIEEYGDSLFAVLHMVELDDDDELNVGELNVFVGPNYVLSIRNHTEQDFRD
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEECCCCHHHHHH
VRKRCEREPHLLQEGSAFVFYALMDQVVDRYFPILETLGTELEELEDRIFAKATPASSRA
HHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHH
IIEDLYSLKRRLVMLYQHTAPLIEPLAKLTGGRIPQVCSGMEPYFRDVYDHLQRIVKTIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHC
GRREMVVTAIQVNLGMISLAESEVTKRLGSFAALFAIPTMIAGIYGMNFANMPELHLKYG
CCHHHEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
FYGCIAAMVVADFALWWRFKRAGWL
HHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Ni2; [Periplasm]; Co; 2 [Periplasm]; Mg (II) [Periplasm] [C]

Specific reaction: Ni2+ [Periplasm] = Ni2+ [Cytoplasm] Co+2 [Periplasm] = Co+2 [Cytoplasm] Mg (II) [Periplasm] = Mg (II) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]