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The map label for this gene is hisM [H]

Identifier: 78065760

GI number: 78065760

Start: 1225869

End: 1226582

Strand: Direct

Name: hisM [H]

Synonym: Bcep18194_A4288

Alternate gene names: 78065760

Gene position: 1225869-1226582 (Clockwise)

Preceding gene: 78065759

Following gene: 78065761

Centisome position: 33.18

GC content: 65.13

Gene sequence:

>714_bases
ATGATCGAGATTCTCCAGGAATTCGGCCAGGCGTTCCTTTACTGGGACGGCCAGCGCCTCTCCGGCCTCGCGGTGACGCT
GTGGCTGCTCGTCGCGTCGATTTCGCTCGGCTTCGTGTGCGCGGTGCCGCTCGCGGTGGCGCGCGTGTCGAAGAACAAGT
GGGTGTCGACGCCGGTGCGGTTCTACACGTACGTGTTCCGCGGCACGCCGCTCTACGTGCAGTTGCTGCTGCTGTACACG
GGTATGTACAGCCTCGAGTTCGTGCGTTCGCACTCGCTGCTCGACGCGTTCTTCCGCAGCGGTTTCAACTGCGCGATTCT
CGCGTTCGCGCTGAACACCTGCGCGTACACGACCGAGATCTTCGCGGGGGCGATCCGCGCGATTCCGCACGGTGAGGTCG
AGGCTGCGCGTGCGTACGGGATGTCGCCGTTCACGATGTATCGCCGCGTGATCCTGCCGTCGGCGTTGCGCCGCGCGCTG
CCGCTGTACAGCAACGAGGTGATCCTGATGCTGCACGCGACGACCGTCGCGTTCACCGCGACCGTGCCGGACATCCTGAA
GGTCGCGCGCGATGCGAATTCCGCGACCTACATGGCGTTCCAGTCGTTCGGAATCGCCGCGCTGATCTATCTTGCGGTAT
CGTTCGCACTCGTCGCGGCGTTTCGCCGCGCGGAGCGCCACTGGCTTGCGTATCTCGCGGCCGCCCGTCATTGA

Upstream 100 bases:

>100_bases
TCGTCGCGGCGCTGATCTATCTCGCGATCACGACCGTTTCCAACCTCGTGCTGATCCAGCTCGAGAAGCGTTATTCCATG
GGCGTGCGGCACGCAGATCT

Downstream 100 bases:

>100_bases
ATCACTTCGAGGAGAGCCAGTTGGCCGAGATCACTCAAACGAGCGCTGCCGCTTCCACCAAGCTTGCCGCGGTCGACATT
CACAAGCGCTACGGTGACAA

Product: ABC polar amino acid transporter, inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIEILQEFGQAFLYWDGQRLSGLAVTLWLLVASISLGFVCAVPLAVARVSKNKWVSTPVRFYTYVFRGTPLYVQLLLLYT
GMYSLEFVRSHSLLDAFFRSGFNCAILAFALNTCAYTTEIFAGAIRAIPHGEVEAARAYGMSPFTMYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAARH

Sequences:

>Translated_237_residues
MIEILQEFGQAFLYWDGQRLSGLAVTLWLLVASISLGFVCAVPLAVARVSKNKWVSTPVRFYTYVFRGTPLYVQLLLLYT
GMYSLEFVRSHSLLDAFFRSGFNCAILAFALNTCAYTTEIFAGAIRAIPHGEVEAARAYGMSPFTMYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAARH
>Mature_237_residues
MIEILQEFGQAFLYWDGQRLSGLAVTLWLLVASISLGFVCAVPLAVARVSKNKWVSTPVRFYTYVFRGTPLYVQLLLLYT
GMYSLEFVRSHSLLDAFFRSGFNCAILAFALNTCAYTTEIFAGAIRAIPHGEVEAARAYGMSPFTMYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAARH

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=235, Percent_Identity=62.5531914893617, Blast_Score=317, Evalue=5e-88,
Organism=Escherichia coli, GI1787086, Length=214, Percent_Identity=35.0467289719626, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788226, Length=193, Percent_Identity=36.2694300518135, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1787030, Length=209, Percent_Identity=29.1866028708134, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788646, Length=198, Percent_Identity=29.2929292929293, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1787087, Length=209, Percent_Identity=25.3588516746411, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786873, Length=212, Percent_Identity=27.8301886792453, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1786874, Length=210, Percent_Identity=25.2380952380952, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26418; Mature: 26418

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEILQEFGQAFLYWDGQRLSGLAVTLWLLVASISLGFVCAVPLAVARVSKNKWVSTPVR
CHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
FYTYVFRGTPLYVQLLLLYTGMYSLEFVRSHSLLDAFFRSGFNCAILAFALNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FAGAIRAIPHGEVEAARAYGMSPFTMYRRVILPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAARH
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIEILQEFGQAFLYWDGQRLSGLAVTLWLLVASISLGFVCAVPLAVARVSKNKWVSTPVR
CHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
FYTYVFRGTPLYVQLLLLYTGMYSLEFVRSHSLLDAFFRSGFNCAILAFALNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FAGAIRAIPHGEVEAARAYGMSPFTMYRRVILPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAARH
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]